A nonpeptidic reverse-turn scaffold stabilized by urea-based dual intramolecular hydrogen bonding

Organic Letters

Volumn 13, Issue 13, 2011, Pages 3486-3489

  Medda, Amiya K ^a   Park, Chul Min ^a,b   Jeon, Aram ^a   Kim, Hyunwoo ^a   Sohn, Jeong Hun ^c   Lee, Hee Seung ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXYLAMINE DERIVATIVE; DRUG DERIVATIVE; PEPTIDE; PROLINE; UREA;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; HYDROGEN BOND;

CYCLOHEXYLAMINES; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PEPTIDES; PROLINE; UREA;

EID: 79959753189     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol201247x     Document Type: Article

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40. The compound numbering is arbitrary and different from those in the NMR structure.
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44. An IR study of 6 also supported the existence of the hydrogen bonding (see SI). In addition, the computational analysis is consistent with the experimental results (see SI).