Epithelial Na+ channel subunit stoichiometry

Biophysical Journal

Volumn 88, Issue 6, 2005, Pages 3966-3975

  Staruschenko, Alexander ^a   Adams, Emily ^a   Booth, Rachell E ^b   Stockand, James D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Texas State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEIN SUBUNIT; SODIUM CHANNEL; SODIUM CHANNEL ALPHA SUBUNIT; SODIUM CHANNEL BETA SUBUNIT; SODIUM CHANNEL GAMMA SUBUNIT; SODIUM CHANNEL SUBUNIT; SODIUM ION; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; ELECTROPHYSIOLOGY; EPITHELIAL SODIUM CHANNEL; EPITHELIUM; FLUORESCENCE ANALYSIS; FLUORESCENCE INTENSITY RATIO; FLUORESCENCE MICROSCOPY; PROTEIN ASSEMBLY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STEADY STATE; STOICHIOMETRY; TOTAL REFLECTION FLUORESCENCE MICROSCOPY;

EID: 22244458247     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.056804     Document Type: Article

References (42)

1. Adachi, M., K. Tachibana, Y. Asakura, S. Abe, J. Nakae, T. Tajima, and K. Fujieda. 2001. Compound heterozygous mutations in the gamma subunit gene of ENaC (1627delG and 1570-1G→A) in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1. J. Clin. Endocrinol. Metab. 86:9-12.
2. Benos, D. J., and B. A. Stanton. 1999. Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. J. Physiol. (Lond.). 520:631-644.
3. Canessa, C. M., J. D. Horisberger, and B. C. Rossier. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 361:467-470.
4. Canessa, C. M., L. Schild, G. Buell, B. Thorens, I. Gautschi, J. D. Horisberger, and B. C. Rossier. 1994. Amiloride-sensitive epithelial Na channel is made of three homologous subunits. Nature. 367:463-467.
5. Corey, S., G. Krapivinsky, L. Krapivinsky, and D. E. Clapham. 1998. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J. Biol. Chem. 273:5271-5278.
6. Doyle, D. A., C. J. Morais, R. A. Pfuetzner, A. Kuo, J. M. Gulbis, S. L. Cohen, B. T. Chait, and R. MacKinnon. 1998. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science. 280:69-77.
7. Eskandari, S., P. M. Snyder, M. Kreman, G. A. Zampighi, M. J. Welsh, and E. M. Wright. 1999. Number of subunits comprising the epithelial sodium channel. J. Biol. Chem. 274:27281-27286.
8. Firsov, D., I. Gautschi, A. M. Merillat, B. C. Rossier, and L. Schild. 1998. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 17:344-352.
9. Fyfe, G. K., and C. M. Canessa. 1998. Subunit composition determines the single channel kinetics of the epithelial sodium channel. J. Gen. Physiol. 112:423-432.
10. Hughey, R. P., J. B. Bruns, C. L. Kinlough, and T. R. Kleyman. 2004. Distinct pools of epithelial sodium channels are expressed at the plasma membrane. J. Biol. Chem. 279:48491-48494.
11. Hummler, E., and J. D. Horisberger. 1999. Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases. Am. J. Physiol. 276:G567-G571.
12. Kellenberger, S., and L. Schild. 2002. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. 82:735-767.
13. Khakh, B. S., G. Burnstock, C. Kennedy, B. F. King, R. A. North, P. Seguela, M. Voigt, and P. P. Humphrey. 2001. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol. Rev. 53:107-118.
14. Kofuji, P., N. Davidson, and H. A. Lester. 1995. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proc. Natl. Acad. Sci. USA. 92:6542-6546.
15. Kosari, F., S. Sheng, J. Li, D. O. Mak, J. K. Foskett, and T. R. Kleyman. 1998. Subunit stoichiometry of the epithelial sodium channel. J. Biol. Chem. 273:13469-13474.
16. Krapivinsky, G., E. A. Gordon, K. Wickman, B. Velimirovic, L. Krapivinsky, and D. E. Clapham. 1995. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 374:135-141.
17. Lifton, R. P., A. G. Gharavi, and D. S. Geller. 2001. Molecular mechanisms of human hypertension. Cell. 104:545-556.
18. MacKinnon, R. 2003. Potassium channels. FEBS Lett. 555:62-65.
19. MacKinnon, R. 2004. Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew. Chem. Int. Ed. Engl. 43:4265-4277.
20. Mall, M., B. Grubb, J. Harkema, W. O'Neal, and R. Boucher. 2004. Increased airway epithelial Na(+) absorption produces cystic fibrosis-like lung disease in mice. Nat. Med. 10:487-493.
21. McNicholas, C. M., and C. M. Canessa. 1997. Diversity of channels generated by different combinations of epithelial sodium channel subunits. J. Gen. Physiol. 109:681-692.
22. Newbolt, A., R. Stoop, C. Virginio, A. Surprenant, R. A. North, G. Buell, and F. Rassendren. 1998. Membrane topology of an ATP-gated ion channel (P2X receptor). J. Biol. Chem. 273:15177-15182.
23. Nicke, A., H. G. Baumert, J. Rettinger, A. Eichele, G. Lambrecht, E. Mutschier, and G. Schmalzing. 1998. P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J. 17:3016-3028.
24. Nicke, A., J. Rettinger, and G. Schmalzing. 2003. Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers. Mol. Pharmacol. 63:243-252.
25. North, R. A. 1996. Families of ion channels with two hydrophobic segments. Curr. Opin. Cell Biol. 8:474-483.
26. Robertson, S. J., S. J. Ennion, R. J. Evans, and F. A. Edwards. 2001. Synaptic P2X receptors. Curr. Opin. Neurobiol. 11:378-386.
27. Rohatgi, R., A. Greenberg, G. Burrow, P. Wilson, and L. Satlin. 2003. Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells. J. Am. Soc. Nephrol. 14:827-836.
28. Saxena, A., I. Hanukoglu, D. Saxena, R. J. Thompson, R. M. Gardiner, and A. Hanukoglu. 2002. Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes. J. Clin. Endocrinol. Metab. 87:3344-3350.
29. Snyder, P. M. 2002. The epithelial Na(+) channel: cell surface insertion and retrieval in Na(+) homeostasis and hypertension. Endocr. Rev. 23:258-275.
30. Snyder, P. M., C. Cheng, L. S. Prince, J. C. Rogers, and M. J. Welsh. 1998. Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J. Biol. Chem. 273:681-684.
31. Staruschenko, A., J. L. Medina, P. Patel, M. S. Shapiro, R. E. Booth, and J. D. Stockand. 2004a. Fluorescence resonance energy transfer analysis of subunit stoichiometry of the epithelial Na+ channel. J. Biol. Chem. 279:27729-27734.
32. Staruschenko, A., A. Nichols, J. L. Medina, P. Camacho, N. N. Zheleznova, and J. D. Stockand. 2004b. Rho small GTPases activate the epithelial Na+ channel. J. Biol. Chem. 279:49989-49994.
33. Staruschenko, A., P. Patel, Q. Tong, J. L. Medina, and J. D. Stockand. 2004c. Ras activates the epithelial Na(+) channel through phosphoinositide 3-OH kinase signaling. J. Biol. Chem. 279:37771-37778.
34. Steyer, J. A., and W. Almers. 2001. A real-time view of life within 100 nm of the plasma membrane. Nat. Rev. Mol. Cell Biol. 2:268-275.
35. Stoop, R., S. Thomas, F. Rassendren, E. Kawashima, G. Buell, A. Surprenant, and R. A. North. 1999. Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C. Mol. Pharmacol. 56:973-981.
36. Taraska, J. W., D. Perrais, M. Ohara-Imaizumi, S. Nagamatsu, and W. Almers. 2003. Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells. Proc. Natl. Acad. Sci. USA. 100:2070-2075.
37. Thomas, C. P., J. Zhou, K. Z. Liu, V. E. Mick, E. MacLaughlin, and M. Knowles. 2002. Systemic pseudohypoaldosteronism from deletion of the promoter region of the human beta epithelial Na(+) channel subunit. Am. J. Respir. Cell Mol. Biol. 27:314-319.
38. Tong, Q., N. Gamper, J. L. Medina, M. S. Shapiro, and J. D. Stockand. 2004. Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J. Biol. Chem. 279:22654-22663.
39. Veizis, E., C. Carlin, and C. Cotton. 2004. Decreased amiloride-sensitive Na+ absorption in collecting duct principal cells isolated from BPK ARPKD mice. Am. J. Physiol. 286:F244-F254.
40. Yang, J., Y. N. Jan, and L. Y. Jan. 1995. Determination of the subunit stoichiometry of an inwardly rectifying potassium channel. Neuron. 15:1441-1447.
41. Zheng, J., and W. N. Zagotta. 2004. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron. 42:411-421.
42. Zhou, Y., J. H. Morais-Cabral, A. Kaufman, and R. MacKinnon. 2001. Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature. 414:43-48.