Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress

Acta Pharmacologica Sinica

Volumn 32, Issue 5, 2011, Pages 619-625

  Fan, Wen Hai ^a   Hou, Yi ^b   Meng, Fan Kai ^a   Wang, Xiao Fei ^c   Luo, Yi Nan ^a   Ge, Peng Fei ^a  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

apoptosis; Bax; Bcl 2; C6 glioma cells; caspase 3; MG 132; oxidative stress; PARP; proteasome inhibitor; tiron; X chromosome linked inhibitor of apoptosis (XIAP)

Indexed keywords

BAG 1 PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TIRON; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; OXIDATIVE STRESS; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOMA; INHIBITORY CONCENTRATION 50; LEUPEPTINS; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 79959741778     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.16     Document Type: Article

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