β-Adrenergic Receptor Subtype Signaling in the Heart: From Bench to the Bedside

Current Topics in Membranes

Volumn 67, Issue , 2011, Pages 191-204

  Zhu, Weizhong ^a   Woo, Anthony Yiu Ho ^b   Zhang, Yan ^b   Cao, Chun Mei ^b   Xiao, Rui Ping ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b PEKING UNIVERSITY   (China)

Author keywords

Cardiac function; Cardiomyocyte; Cardiotoxic; Pathogenic; Remodeling; Transgenic

Indexed keywords

BETA ADRENERGIC RECEPTOR;

BOOK; CLASSIFICATION; CYTOLOGY; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CELL; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH;

HEART FAILURE; HUMANS; MYOCARDIUM; MYOCYTES, CARDIAC; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; TRANSLATIONAL MEDICAL RESEARCH;

EID: 79959725606     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-384921-2.00009-4     Document Type: Book

References (67)

1. Ahmet I., Krawczyk M., Heller P., Moon C., Lakatta E.G., Talan M.I. Beneficial effects of chronic pharmacological manipulation of β-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation 2004, 110(9):1083-1090.
2. Ahmet I., Krawczyk M., Zhu W., Woo A.Y., Morrell C., Poosala S., et al. Cardioprotective and survival benefits of long-term combined therapy with β2-adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. J Pharmacol Exp Ther 2008, 325(2):491-499.
3. Ahmet I., Lakatta E.G., Talan M.I. Pharmacological stimulation of β2-adrenergic receptors (β2AR) enhances therapeutic effectiveness of β1AR blockade in rodent dilated ischemic cardiomyopathy. Heart Fail Rev 2005, 10(4):289-296.
4. Antos C.L., Frey N., Marx S.O., Reiken S., Gaburjakova M., Richardson J.A., et al. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a. Circ Res 2001, 89(11):997-1004.
5. Bernstein L.S., Ramineni S., Hague C., Cladman W., Chidiac P., Levey A.I., et al. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem 2004, 279(20):21248-21256.
6. Bisognano J.D., Weinberger H.D., Bohlmeyer T.J., Pende A., Raynolds M.V., Sastravaha A., et al. Myocardial-directed overexpression of the human β1-adrenergic receptor in transgenic mice. J Mol Cell Cardiol 2000, 32(5):817-830.
7. Bristow M.R. Mechanistic and clinical rationales for using β-blockers in heart failure. J Card Fail 2000, 6(2 Suppl 1):8-14.
8. Bristow M.R., Ginsburg R., Umans V., Fowler M., Minobe W., Rasmussen R., et al. β1- and β2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 1986, 59(3):297-309.
9. Chakir K., Daya S.K., Aiba T., Tunin R.S., Dimaano V.L., Abraham T.P., et al. Mechanisms of enhanced β-adrenergic reserve from cardiac resynchronization therapy. Circulation 2009, 119(9):1231-1240.
10. Chakir K., Zhu W., Tsang S., Woo A.Y.H., Yang D., Wang X., et al. RGS2 Is a primary terminator of β2-adrenergic receptor-mediated Gi signaling. J Mol Cell Cardiol 2011, in press.
11. Chesley A., Lundberg M.S., Asai T., Xiao R.P., Ohtani S., Lakatta E.G., et al. The β2-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gi-dependent coupling to phosphatidylinositol 3'-kinase. Circ Res 2000, 87(12):1172-1179.
12. Choi D.J., Koch W.J., Hunter J.J., Rockman H.A. Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase. J Biol Chem 1997, 272(27):17223-17229.
13. Daaka Y., Luttrell L.M., Lefkowitz R.J. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997, 390(6655):88-91.
14. Engelhardt S., Hein L., Wiesmann F., Lohse M.J. Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 1999, 96(12):7059-7064.
15. Eschenhagen T., Mende U., Nose M., Schmitz W., Scholz H., Haverich A., et al. Increased messenger RNA level of the inhibitory G protein alpha subunit Giα-2 in human end-stage heart failure. Circ Res 1992, 70(4):688-696.
16. Hague C., Bernstein L.S., Ramineni S., Chen Z., Minneman K.P., Hepler J.R. Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. J Biol Chem 2005, 280(29):27289-27295.
17. Hao J., Michalek C., Zhang W., Zhu M., Xu X., Mende U. Regulation of cardiomyocyte signaling by RGS proteins: Differential selectivity towards G proteins and susceptibility to regulation. J Mol Cell Cardiol 2006, 41(1):51-61.
18. Hausdorff W.P., Lohse M.J., Bouvier M., Liggett S.B., Caron M.G., Lefkowitz R.J. Two kinases mediate agonist-dependent phosphorylation and desensitization of the β2-adrenergic receptor. Symp Soc Exp Biol 1990, 44:225-240.
19. Hebert T.E. Anti-beta1AR antibodies in dilated cardiomyopathy: Are these a new class of receptor agonists?. Cardiovasc Res 2007, 76(1):5-7.
20. Heximer S.P., Knutsen R.H., Sun X., Kaltenbronn K.M., Rhee M.H., Peng N., et al. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 2003, 111(4):445-452.
21. Heximer S.P., Watson N., Linder M.E., Blumer K.J., Hepler J.R. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci USA 1997, 94(26):14389-14393.
22. Hollinger S., Hepler J.R. Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling. Pharmacol Rev 2002, 54(3):527-559.
23. Iaccarino G., Tomhave E.D., Lefkowitz R.J., Koch W.J. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade. Circulation 1998, 98(17):1783-1789.
24. Iwase M., Uechi M., Vatner D.E., Asai K., Shannon R.P., Kudej R.K., et al. Cardiomyopathy induced by cardiac Gsα overexpression. Am J Physiol 1997, 272(1 Pt 2):H585-H589.
25. Kilts J.D., Gerhardt M.A., Richardson M.D., Sreeram G., Mackensen G.B., Grocott H.P., et al. β2-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both Gs and Gi. Circ Res 2000, 87(8):705-709.
26. Koch W.J., Rockman H.A., Samama P., Hamilton R.A., Bond R.A., Milano C.A., et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 1995, 268(5215):1350-1353.
27. Lai N.C., Tang T., Gao M.H., Saito M., Takahashi T., Roth D.M., et al. Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol 2008, 51(15):1490-1497.
28. Liggett S.B., Tepe N.M., Lorenz J.N., Canning A.M., Jantz T.D., Mitarai S., et al. Early and delayed consequences of β2-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation 2000, 101(14):1707-1714.
29. Liu R., Ramani B., Soto D., De Arcangelis V., Xiang Y. Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates β2-adrenoceptor coupling to Gi proteins in cardiomyocytes. J Biol Chem 2009, 284(47):32279-32287.
30. Lokuta A.J., Maertz N.A., Meethal S.V., Potter K.T., Kamp T.J., Valdivia H.H., et al. Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure. Circulation 2005, 111(8):988-995.
31. Nishii M., Inomata T., Niwano H., Takehana H., Takeuchi I., Nakano H., et al. β2-Adrenergic agonists suppress rat autoimmune myocarditis: Potential role of beta2-adrenergic stimulants as new therapeutic agents for myocarditis. Circulation 2006, 114(9):936-944.
32. Patterson A.J., Zhu W., Chow A., Agrawal R., Kosek J., Xiao R.P., et al. Protecting the myocardium: A role for the β2-adrenergic receptor in the heart. Crit Care Med 2004, 32(4):1041-1048.
33. Perrino C., Naga Prasad S.V., Schroder J.N., Hata J.A., Milano C., Rockman H.A. Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the βARK1/phosphoinositide 3-kinase complex. Circulation 2005, 111(20):2579-2587.
34. Rengo G., Lymperopoulos A., Leosco D., Koch W.J. GRK2 as a novel gene therapy target in heart failure. J Mol Cell Cardiol. 2011, 50(5):785-792.
35. Riddle E.L., Schwartzman R.A., Bond M., Insel P.A. Multi-tasking RGS proteins in the heart: the next therapeutic target?. Circ Res 2005, 96(4):401-411.
36. Rockman H.A., Koch W.J., Lefkowitz R.J. Seven-transmembrane-spanning receptors and heart function. Nature 2002, 415(6868):206-212.
37. Ross E.M., Wilkie T.M. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 2000, 69:795-827.
38. Roth D.M., Bayat H., Drumm J.D., Gao M.H., Swaney J.S., Ander A., et al. Adenylyl cyclase increases survival in cardiomyopathy. Circulation 2002, 105(16):1989-1994.
39. Roth D.M., Gao M.H., Lai N.C., Drumm J., Dalton N., Zhou J.Y., et al. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 1999, 99(24):3099-3102.
40. Roy A.A., Lemberg K.E., Chidiac P. Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. Mol Pharmacol 2003, 64(3):587-593.
41. Sabbah H.N. The cellular and physiologic effects of beta blockers in heart failure. Clin Cardiol 1999, 22(Suppl 5):V16-V20.
42. Sato M., Gong H., Terracciano C.M., Ranu H., Harding S.E. Loss of β-adrenoceptor response in myocytes overexpressing the Na+/Ca2+-exchanger. J Mol Cell Cardiol 2004, 36(1):43-48.
43. Seifert R., Dove S. Functional selectivity of GPCR ligand stereoisomers: New pharmacological opportunities. Mol Pharmacol 2009, 75(1):13-18.
44. Sucharov C.C., Mariner P.D., Nunley K.R., Long C., Leinwand L., Bristow M.R. A β1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction. Am J Physiol Heart Circ Physiol 2006, 291(3):H1299-H1308.
45. Tachibana H., Naga Prasad S.V., Lefkowitz R.J., Koch W.J., Rockman H.A. Level of β-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation 2005, 111(5):591-597.
46. Takimoto E., Koitabashi N., Hsu S., Ketner E.A., Zhang M., Nagayama T., et al. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 2009, 119(2):408-420.
47. Tang T., Gao M.H., Roth D.M., Guo T., Hammond H.K. Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. Am J Physiol Heart Circ Physiol 2004, 287(5):H1906-H1912.
48. Tsang S., Woo A.Y., Zhu W., Xiao R.P. Deregulation of RGS2 in cardiovascular diseases. Front Biosci (Schol Ed) 2010, 2:547-557.
49. Ungerer M., Bohm M., Elce J.S., Erdmann E., Lohse M.J. Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart. Circulation 1993, 87(2):454-463.
50. Wang X., Adams L.D., Pabon L.M., Mahoney W.M., Beaudry D., Gunaje J., et al. RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy. J Mol Cell Cardiol 2008, 44(3):539-550.
51. White D.C., Hata J.A., Shah A.S., Glower D.D., Lefkowitz R.J., Koch W.J. Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proc Natl Acad Sci USA 2000, 97(10):5428-5433.
52. Wieland T., Lutz S., Chidiac P. Regulators of G protein signalling: A spotlight on emerging functions in the cardiovascular system. Curr Opin Pharmacol 2007, 7(2):201-207.
53. Woo A.Y., Wang T.B., Zeng X., Zhu W., Abernethy D.R., Wainer I.W., et al. Stereochemistry of an agonist determines coupling preference of β2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol 2009, 75(1):158-165.
54. Xiao R.P. β-adrenergic signaling in the heart: dual coupling of the β2-adrenergic receptor to Gs and Gi proteins. Sci STKE 2001, 2001(104):re15.
55. Xiao R.P., Balke C.W. Na+/Ca2+ exchange linking β2-adrenergic Gi signaling to heart failure: Associated defect of adrenergic contractile support. J Mol Cell Cardiol 2004, 36(1):7-11.
56. Xiao R.P., Cheng H., Zhou Y.Y., Kuschel M., Lakatta E.G. Recent advances in cardiac beta(2)-adrenergic signal transduction. Circ Res 1999, 85(11):1092-1100.
57. Xiao R.P., Hohl C., Altschuld R., Jones L., Livingston B., Ziman B., et al. β2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation. J Biol Chem 1994, 269(29):19151-19156.
58. Xiao R.P., Zhang S.J., Chakir K., Avdonin P., Zhu W., Bond R.A., et al. Enhanced Gi signaling selectively negates β2-adrenergic receptor (AR) - but not β1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation 2003, 108(13):1633-1639.
59. Xiao R.P., Zhu W., Zheng M., Cao C., Zhang Y., Lakatta E.G., et al. Subtype-specific α1- and β-adrenoceptor signaling in the heart. Trends Pharmacol Sci 2006, 27(6):330-337.
60. Zhang R., Khoo M.S., Wu Y., Yang Y., Grueter C.E., Ni G., et al. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med 2005, 11(4):409-417.
61. Zhang S., Watson N., Zahner J., Rottman J.N., Blumer K.J., Muslin A.J. RGS3 and RGS4 are GTPase activating proteins in the heart. J Mol Cell Cardiol 1998, 30(2):269-276.
62. Zhang T., Maier L.S., Dalton N.D., Miyamoto S., Ross J., Bers D.M., et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res 2003, 92(8):912-919.
63. Zhang W., Anger T., Su J., Hao J., Xu X., Zhu M., et al. Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem 2006, 281(9):5811-5820.
64. Zhu W.Z., Chakir K., Zhang S., Yang D., Lavoie C., Bouvier M., et al. Heterodimerization of β1- and β2-adrenergic receptor subtypes optimizes β-adrenergic modulation of cardiac contractility. Circ Res 2005, 97(3):244-251.
65. Zhu W.Z., Wang S.Q., Chakir K., Yang D., Zhang T., Brown J.H., et al. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest 2003, 111(5):617-625.
66. Zhu W.Z., Zheng M., Koch W.J., Lefkowitz R.J., Kobilka B.K., Xiao R.P. Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci USA 2001, 98(4):1607-1612.
67. Zou M.X., Roy A.A., Zhao Q., Kirshenbaum L.A., Karmazyn M., Chidiac P. RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes. Cell Signal 2006, 18(10):1655-1663.