Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 43335-43343

  Gu, Jian Ming ^a   Crawley, James T B ^a   Ferrell, Gary ^a   Zhang, Fangjiu ^a   Li, Weihong ^a   Esmon, Naomi L ^a   Esmon, Charles T ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; GENES; PHYSIOLOGY; RNA; TISSUE;

IMMUNOHISTOCHEMISTRY;

PROTEINS;

ACTIVATED PROTEIN C; ENDOTHELIAL CELL PROTEIN C RECEPTOR; ENOXAPARIN; MEMBRANE PROTEIN; PROTEIN C; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; FIBRIN DEPOSITION; GENOTYPE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PLACENTA CIRCULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOSIS; TROPHOBLAST;

ANIMALS; BASE SEQUENCE; BLOOD COAGULATION FACTORS; DNA PRIMERS; EMBRYO; FEMALE; FETAL DEATH; GENOTYPE; GESTATIONAL AGE; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; PLACENTA DISEASES; PREGNANCY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; THROMBOSIS;

ANIMALIA;

EID: 0037044806     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207538200     Document Type: Article

References (32)

1. Esmon, C. T., Gu, J.-M., Xu, J., Qu, D., Stearns-Kurosawa, D. J., and Kurosawa, S. (1999) Haematologia 84, 363-368
2. Esmon, C. T., and Owen, W. G. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 2249-2252
3. Esmon, C. T., Esmon, N. L., and Harris, K. W. (1982) J. Biol. Chem. 257, 7944-7947
4. Stearns-Kurosawa, D. J., Kurosawa, S., Mollica, J. S., Ferrell, G. L., and Esmon, C. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10212-10216
5. Taylor, F. B., Jr., Peer, G. T., Lockhart, M. S., Ferrell, G., and Esmon, C. T. (2001) Blood 97, 1685-1688
6. Fukudome, K., and Esmon, C. T. (1995) J. Biol. Chem. 270, 5571-5577
7. Simmonds, R. E., and Lane, D. A. (1999) Blood 94, 632-641
8. Oganesyan, V., Oganesyan, N., Terzyan, S., Qu, D., Dauter, Z., Esmon, N. L., and Esmon, C. T. (2002) J. Biol. Chem, 277, 24851-24854
9. Laszik, Z., Mitro, A., Taylor, F. B., Jr., Ferrell, G., and Esmon, C. T. (1997) Circulation 96, 3633-3640
10. Crawley, J. T. B., Gu, J.-M., Ferrell, G., and Esmon, C. T. (2002) Thromb. Haemostasis (2002) 88, 259-266
11. Kurosawa, S., Stearns-Kurosawa, D. J., Hidari, N., and Esmon, C. T. (1997) J. Clin. Invest. 100, 411-418
12. Xu, J., Qu, D., Esmon, N. L. and Esmon, C. T. (1999) J. Biol. Chem. 275, 6038-6044
13. Kurosawa, S., Stearns-Kurosawa, D. J., Carson, C. W., D'Angelo, A., Della Valle, P., and Esmon, C. T. (1998) Blood 91, 725-727
14. Gu, J.-M., Katsuura, Y., Ferrell, G. L., Grammas, P., and Esmon, C. T. (2000) Blood 95, 1687-1693
15. Kurosawa, S., Esmon, C. T., and Stearns-Kurosawa, D. J. (2000) J. Immunol. 166, 4697-4703
16. Taylor, F. B., Jr., Stearns-Kurosawa, D. J., Kurosawa, S., Ferrell, G., Chang, A. C. K., Laszik, Z., Kosanke, S., Peer, G., and Esmon, C. T. (2000) Blood 95, 1680-1686
17. Biguzzi, E., Merati, G., Liaw, P. C. Y., Bucciarelli, P., Oganesyan, N., Qu, D., Gu, J.-M., Fetiveau, R., Esmon, C. T., Mannucci, P. M., and Faioni, E. M. (2001) Thromb. Haemostasis 86, 945-948
18. Soriano, P., Montgomery, C., Geske, R., and Bradley, A. (1991) Cell 64, 693-702
19. Liang, Z., Rosen, E. D., and Castellino, F. J. (1999) Thromb. Haemostasis 81, 585-588
20. Gu, J. M., Fukudome, K, and Esmon, C. T. (2000) J. Biol. Chem. 275, 12481-12488
21. Baldwin, H. S., Lloyd, T. R., and Solursh, M. (1994) Circ. Res. 74, 244-252
22. Healy, A. M., Rayburn, H. B., Rosenberg, R. D., and Weiler, H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 850-854
23. Healy, A. M., Hancock, W. W., Christie, P. D., Rayburn, H. B., and Rosenberg, R. D. (1998) Blood 92, 4188-4197
24. Jalbert, L. R., Rosen, E. D., Moons, L., Chan, J. C., Carmeliet, P., Collen, D., and Castellino, F. J. (1998) J. Clin. Invest. 102, 1481-1488
25. Isermann, B., Hendrickson, S. B., Hutley, K., Wing, M., and Weiler, H. (2001) Development 128, 827-838
26. Xu, J., Esmon, N. L., and Esmon, C. T. (1999) J. Biol. Chem. 274, 6704-6710
27. Erlich, J., Parry, G. C. N., Fearns, C., Carmeliet, P., Luther, T., and Mackman, N. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 8138-8143
28. Iwaki, T., Sandoval-Cooper, M. J., Paiva, M., Kobayashi, T., Ploplis, V. A., and Castellino, F. J. (2002) Am. J. Pathol. 160, 1021-1034
29. Weiler, H., Lindner, V., Kerlin, B., Isermann, B. H., Hendrickson, S. B., Cooley, B. C., Meh, D. A., Mosesson, M. W., Shworak, N. W., Post, M. J., Conway, E. M., Ulfman, L. H., von Andrian, U. H., and Weitz, J. I. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 1531-1537
30. Esmon, C. T. (2000) Thromb. Haemostasis 83, 639-643
31. Shu, F., Kobayashi, H., Fukudome, K., Tsuneyoshi, N., Kimoto, M., and Terao, T. (2000) FEBS Lett. 477, 208-212
32. Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., and Ruf, W. (2002) Science 296, 1880-1882