Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity

Journal of Biological Chemistry

Volumn 283, Issue 13, 2008, Pages 8283-8290

  Friedman, Meyer J ^a   Wang, Chuan En ^a   Li, Xiao Jiang ^a   Li, Shihua ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AMINO ACIDS; FLOW INTERACTIONS; GENES; LITHIUM; NUCLEIC ACIDS; ORGANIC ACIDS; PLANTS (BOTANY); TRANSCRIPTION; TRANSCRIPTION FACTORS;

BINDING PROTEINS; C TERMINUSES; CULTURED CELLS; DNA BINDINGS; DO-MAINS; DOUBLE MUTANTS; EUKARYOTIC GENES; HUNTINGTON DISEASES; IN VITRO; IN VITRO BINDINGS; MOUSE BRAINS; N TERMINUSES; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS; NEURONAL TOXICITIES; NEUROTOXICITY; POLYGLUTAMINE; POLYGLUTAMINE (POLYQ); PROMOTER DNAS; SPINOCEREBELLAR ATAXIAS; TRANSCRIPTION ACTIVITIES; TRANSGENIC; TRANSGENIC MOUSE;

DNA;

DNA; POLYGLUTAMINE; TATA BINDING PROTEIN; PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; DNA BINDING; EMBRYO; GENE DELETION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; CELL LINE; CELL NUCLEUS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PROTEIN BINDING; TRINUCLEOTIDE REPEAT;

EUKARYOTA; MUS; MUS MUSCULUS;

ANIMALS; CELL LINE; CELL NUCLEUS; DNA; HUMANS; INTRANUCLEAR INCLUSION BODIES; MICE; MICE, TRANSGENIC; NEURONS; PEPTIDES; PROTEIN BINDING; TATA-BOX BINDING PROTEIN; TRANSCRIPTION, GENETIC; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 43749091298     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709674200     Document Type: Article

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