Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 7, 2011, Pages 1643-1652

  Schreier, Barbara ^a   Döhler, Maria ^a   Rabe, Sindy ^a   Schneider, Bettina ^a   Schwerdt, Gerald ^a   Ruhs, Stefanie ^a   Sibilia, Maria ^b   Gotthardt, Michael ^c   Gekle, Michael ^a   Grossmann, Claudia ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

growth factors; receptors; signal transduction; vascular biology; vascular muscle

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA 1 ADRENERGIC RECEPTOR; CASPASE 3; COLLAGEN TYPE 3; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHENYLEPHRINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MUSCLE CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; MOUSE; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ANIMALS; CALCIUM SIGNALING; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIN-1; EXTRACELLULAR MATRIX; GENOTYPE; HOMEOSTASIS; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OXIDANTS; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; PHENOTYPE; PHENYLEPHRINE; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 79959692331     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.223537     Document Type: Article

References (58)

1. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 1999;402:884-888.
2. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2:127-137. (Pubitemid 33674041)
3. Singh AB, Harris RC. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal. 2005;17:1183-1193. (Pubitemid 40984037)
4. Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006;439:168-174. (Pubitemid 43083134)
5. Holbro T, Hynes NE. ERBB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol. 2004;44:195-217. (Pubitemid 38263839)
6. Dreux AC, Lamb DJ, Modjtahedi H, Ferns GAA. The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. Atherosclerosis. 2006;186:38-53.
7. Wetzker R, Bohmer FD. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol. 2003;4:651-657. (Pubitemid 36934967)
8. Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res. 2000;2:203-210. (Pubitemid 32223586)
9. Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol. 1999;146: 697-702. (Pubitemid 29408896)
10. Kagiyama S, Eguchi S, Frank GD, Inagami T, Zhang YC, Phillips MI. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation. 2002;106:909-912. (Pubitemid 34925322)
11. Seshiah PN, Weber DS, Rocic P, Valppu L, Taniyama Y, Griendling KK. Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators. Circ Res. 2002;91:406-413. (Pubitemid 35034208)
12. Hao L, Nishimura T, Wo H, Fernandez-Patron C. Vascular Responses toα1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species. Arterioscler Thromb Vasc Biol. 2006; 26:819-825. (Pubitemid 43732157)
13. Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA.α-Arrestin- mediatedα1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest. 2007;117:2445-2458.
14. Hsieh HL, Sun CC, Wang TS, Yang CM. PKC-α/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE2 production in rat vascular smooth muscle cells. Biochim Biophysica Acta. 2008;1783:1563-1575.
15. Flamant M, Tharaux PL, Placier S, Henrion D, Coffman T, Chatziantoniou C, Dussaule JC. Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J. 2003;17:327-329.
16. Northcott C, Florian JA, Dorrance A, Watts SW. Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension. Hypertension. 2001;38:1337-1341. (Pubitemid 34033412)
17. Chansel D, Ciroldi M, Vandermeersch S, Jackson LF, Gomez AM, Henrion D, Lee DC, Coffman TM, Richard S, Dussaule JC, Tharaux PL. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J. 2006;20:1936-1938.
18. Morris JB, Pham TM, Kenney B, Sheppard KE, Woodcock EA. UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide. J Biol Chem. 2004;279: 8740-8746. (Pubitemid 38295930)
19. Mazak I, Fiebeler A, Muller DN, Park JK, Shagdarsuren E, Lindschau C, Dechend R, Viedt C, Pilz B, Haller H, Luft FC. Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation. 2004;109:2792-2800. (Pubitemid 38737927)
20. Buchanan FG, Wang D, Bargiacchi F, DuBois RN. Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem. 2003;278:35451-35457. (Pubitemid 37102315)
21. Lemarie CA, Tharaux PL, Esposito B, Tedgui A, Lehoux S. Transforming growth factor-αmediates nuclear factorB activation in strained arteries. Circ Res. 2006;99:434-441. (Pubitemid 44253700)
22. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension. 2006;47:488-495. (Pubitemid 43740295)
23. Terzi F, Burtin M, Hekmati M, Federici P, Grimber G, Briand P, Friedlander G. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest. 2000;106:225-234. (Pubitemid 30483126)
24. Kagiyama S, Qian K, Kagiyama T, Phillips MI. Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Hypertension. 2003;41:824-829. (Pubitemid 36314598)
25. Bokemeyer D, Schmitz U, Kramer HJ. Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor. Kidney Int. 2000;58:549-558. (Pubitemid 30620004)
26. Thomas WG, Brandenburger Y, Autelitano DJ, Pham T, Qian H, Hannan RD. Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ Res. 2002;90:135-142. (Pubitemid 34627081)
27. Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, Ohmoto H, Node K, Yoshino K, Ishiguro H, Asanuma H, Sanada S, Matsumura Y, Takeda H, Beppu S, Tada M, Hori M, Higashiyama S. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med. 2002;8:35-40. (Pubitemid 34101726)
28. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000; 103:211-225.
29. Oda K, Matsuoka Y, Funahashi A, Kitano H. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol. 2005; 1:msb4100014-msb41000E1.
30. Lovisolo D, Distasi C, Antoniotti S, Munaron L. Mitogens and calcium channels. Physiology. 1997;12:279-285.
31. Tinhofer I, Maly K, Dietl P, Hochholdinger F, Mayr S, Obermeier A, Grunicke HH. Differential Ca2α signaling induced by activation of the epidermal growth factor and nerve growth factor receptors. J Biol Chem. 1996;271:30505-30509.
32. Han HJ, Park SH, Lee YJ. Epidermal growth factor regulates Ca2α uptake in primary cultured renal proximal tubule cells: involvement of cAMP, PKC and cPLA2. Kidney Blood Press Res. 2003;26:155-164. (Pubitemid 36928701)
33. Che Q, Carmines PK. Angiotensin II triggers EGFR tyrosine kinasedependent Ca2α influx in afferent arterioles. Hypertension. 2002;40: 700-706. (Pubitemid 35278607)
34. Natarajan A, Wagner B, Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci USA. 2007;104: 17081-17086. (Pubitemid 350210995)
35. Holtwick R, Gotthardt M, Skryabin B, Steinmetz M, Potthast R, Zetsche B, Hammer RE, Herz J, Kuhn M. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci USA. 2002;99:7142-7147. (Pubitemid 34526269)
36. Ray JL, Leach R, Herbert JM, Benson M. Isolation of vascular smooth muscle cells from a single murine aorta. Methods Cell Sci. 2001;23: 185-188. (Pubitemid 34863290)
37. Gekle M, Freudinger R, Mildenberger S, Silbernagl S. Aldosterone interaction with epidermal growth factor receptor signaling in MDCK cells. Am J Physiol Renal Physiol. 2002;282:F669-F679. (Pubitemid 34654514)
38. Schwerdt G, Holzinger H, Sauvant C, Königs M, Humpf HU, Gekle M. Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture. Toxicology. 2007; 232:57-67. (Pubitemid 46283174)
39. Leopold JA, Loscalzo J. Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells. Am J Physiol Heart Circ Physiol. 2000;279:H2477-H2485.
40. Esposito C, Fornoni A, Cornacchia F, Bellotti N, Fasoli G, Foschi A, Mazzucchelli I, Mazzullo T, Semeraro L, Dal Canton A. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int. 2000;58:123-130. (Pubitemid 30429856)
41. Vesey DA, Cheung CWY, Cuttle L, Endre ZA, Gobe G, Johnson DW. Interleukin-1α induces human proximal tubule cell injuryα-smooth muscle actin expression and fibronectin production1. Kidney International. 2002;62:31-40. (Pubitemid 34754045)
42. Amos S, Martin PM, Polar GA, Parsons SJ, Hussaini IM. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cα/c-Src pathways in glioblastoma cells. J Biol Chem. 2005;280:7729-7738. (Pubitemid 40349666)
43. Watts SW. Endothelin receptors: what's new and what do we need to know? Am J Physiol Regul Integr Comp Physiol. 2010;298: R254-R260.
44. Takemura H, Hughes AR, Thastrup O, Putney JWJ. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. J Biol Chem. 1989;264:12266-12271.
45. Zhang H, Chalothorn D, Jackson LF, Lee DC, Faber JE. Transactivation of Epidermal Growth Factor Receptor Mediates Catecholamine-Induced Growth of Vascular Smooth Muscle. Circ Res. 2004; 95:989-997. (Pubitemid 39532329)
46. Zang Wj, Zacharia J, Lamont C, Wier WG. Sympathetically evoked Ca2α signaling in arterial smooth muscle. Acta Pharmacol Sin. 2006;27: 1515-1525. (Pubitemid 44813887)
47. Burnstock G. Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol. 2002;22:364-373. (Pubitemid 34218740)
48. Tabet F, Schiffrin EL, Touyz RM. Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinasedependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats. J Hypertens. 2005;23:2005-2012. (Pubitemid 41830395)
49. Griendling KK, Sorescu D, Lassegue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol. 2000;20:2175-2183.
50. Hecquet CM, Malik AB. Role of H2O2-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb Haemost. 2009; 101:619-625.
51. Eguchi S, Frank GD, Mifune M, Inagami T. Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling. Biochem Soc Trans. 2003;31:1198-1202. (Pubitemid 38030938)
52. Daub H, Weiss FU, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature. 1996; 379:557-560. (Pubitemid 26049585)
53. Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol. 2006;291:C1-C10.
54. Sibilia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 1995;269:234-238.
55. Yoshimoto K, Nakamura T, Ichihara A. Reciprocal effects of epidermal growth factor on key lipogenic enzymes in primary cultures of adult rat hepatocytes. Induction of glucose-6-phosphate dehydrogenase and suppression of malic enzyme and lipogenesis. J Biol Chem. 1983;258: 12355-12360. (Pubitemid 14231160)
56. Molero C, Benito M, Lorenzo M. Glucose-6-phosphate dehydrogenase gene expression in fetal hepatocyte primary cultures under nonproliferative and proliferative conditions. Exp Cell Res. 1994;210:26-32. (Pubitemid 24168490)
57. Alimandi M, Wang LM, Bottaro D, Lee CC, Kuo A, Frankel M, Fedi P, Tang C, Lippman M, Pierce JH. Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. EMBO J. 1997;16:5608-5617. (Pubitemid 27399853)
58. Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res. 2003;284:54-65. (Pubitemid 36342255)