Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

European Journal of Immunology

Volumn 41, Issue 7, 2011, Pages 1980-1991

  Dubrac, Sandrine ^a   Elentner, Andreas ^a   Schoonjans, Kristina ^b   Auwerx, Johan ^b   Schmuth, Matthias ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b EPFL   (Switzerland)

Author keywords

Inflammation; Nuclear hormone receptors; Skin

Indexed keywords

INTERLEUKIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RECOMBINANT INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HORMONE DEFICIENCY; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPH NODE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN ALLERGY; SKIN INFLAMMATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD4; DERMATITIS, ALLERGIC CONTACT; GRANZYMES; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PERFORIN; PPAR ALPHA; T-LYMPHOCYTES, REGULATORY;

EID: 79959692049     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041357     Document Type: Article

References (38)

1. Mangelsdorf, D. J. and Evans, R. M., The RXR heterodimers and orphan receptors. Cell 1995. 1583: 841-850.
2. Desvergne, B., Michalik, L. and Wahli, W., Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol. Endocrinol. 2004. 18: 1321-1332.
3. Chakravarthy, M. V., Lodhi, I. J., Yin, L., Malapaka, R. R., Xu, H. E., Turk, J. and Semenkovich, C. F., Identification of a physiologically relevant endogenous ligand for PPAR-alpha in liver. Cell 2009. 138: 476-488.
4. Narala, V. R., Adapala, R. K., Suresh, M. V., Brock, T. G., Peters-Golden, M. and Reddy, R. C., Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J. Biol. Chem. 2010. 285: 22067-22074.
5. Glass, C. K. and Ogawa, S., Combinatorial roles of nuclear receptors in inflammation and immunity. Nature 2006. 6: 44-55.
6. Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J. and Wahli, W., The PPAR alpha-leukotriene B4 pathway to inflammation control. Nature 1996. 384: 39-43.
7. Dubrac, S., Stoitzner, P., Pirkebner, D., Elentener, A., Shoonjans, K., Auwrex, J., Saeland, S. et al., Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function. J. Immunol. 2007. 178: 4362-4372.
8. Daynes, R. and Jones, D. C., Emerging roles of PPARs in inflammation and immunity. Nat. Rev. Immunol. 2002. 2: 748-759.
9. Kippenberger, S., Loitsch, S. M., Grundmann-Kollmann, M., Simon, S., Dang, T., Hardt-Weinelt, K., Kaufmann, R. and Bernd, A., Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation. J. Invest. Dermatol. 2001. 117: 1430-1436.
10. Sheu, M. Y., Fowler, A. J., Kao, J., Schmuth, M., Schoonjans, K., Auwerx, J., Fluhr, J. W. et al., Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J. Invest. Dermatol. 2002. 118: 94-101.
11. Dunn, S. E., Ousman, S. S., Sobel, R. A., Zuniga, L., Baranzini, S. E., Youssef, S., Crowell, A. et al., Peroxisome proliferator-activated receptor (PPAR)-alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J. Exp. Med. 2004. 204: 321-330.
12. Jones, D. C., Ding, X., Zhang, T. Y. and Daynes, R. A., Peroxisome proliferator-activated receptor-alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation. J. Immunol. 2003. 171: 196-203.
13. Cuzzocrea, S., Mazzon, E., Di Paola, R., Peli, A., Bonato, A., Britti, D., Genovese, T. et al., The role of the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the regulation of acute inflammation. J. Leukoc. Biol. 2006. 79: 999-1010.
14. Yang, Q. and Gonzalez, F. J., Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice. Biochem. Pharmacol. 2004. 68: 2143-2150.
15. Izcue, A., Coombes, J. L. and Powrie, F., Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 2006. 212: 256-271.
16. + T cell-mediated protection against colitis. J. Immunol. 2007. 178: 2940-2949.
17. Hayashi, M., Higashi, K., Kato, H. and Kaneko, H., Assessment of preferential Th1 or Th2 induction by low-molecular-weight compounds using a reverse transcription-polymerase chain reaction method: comparison of two mouse strains, C57BL/6 and Balb/c. Toxicol. Appl. Pharmacol. 2001. 177: 38-45.
18. + regulatory T Cells. Int. J. Clin. Exp. Med. 2008. 1: 192-202.
19. Staumont-Sallé, D., Abboud, G., Brénuchon, C., Kanda, A., Roumier, T., Lavogiez, C., Fleury, S. et al., Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. J. Allergy Clin. Immunol. 2008. 121: 962-968.
20. + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 2005. 201: 723-735.
21. + T cell development for contact hypersensitivity responses. J. Leukoc. Biol. 2005. 78:725-735.
22. Murawski, M. R., Litherland, S. A., Clare-Salzler, M. J. and Davoodi-Semiromi, A., Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesis. Ann. N. Y. Acad. Sci. 2006. 1079: 198-204.
23. + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006. 108: 1571-1579.
24. + T cells but not T(H)17 cells. Eur. J. Immunol. 2010. 40: 671-676.
25. Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y., A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005. 6: 1142-1151.
26. + regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J. Exp. Med. 2010. 207: 1393-1407.
27. Saito, M., Nagasawa, M., Tadaka, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M. et al., Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med. 2011. 208: 235-249.
28. + T cells secreting IL-10 and TGF-beta1 mediates suppression in the tumor microenvironment. Clin. Cancer Res. 2007. 13: 4345-4354.
29. Miyara, M. and Sakaguchi, S., Natural regulatory T cells: mechanisms of suppression. Trends Mol. Med. 2007. 13: 108-116.
30. + regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur. J. Immunol. 2006. 36: 2981-2992.
31. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 1969-1980.
32. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287-296.
33. Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P. and Ley, T. J., Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004. 21: 589-601.
34. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 2005. 174: 1783-1786.
35. Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R. and Ley, T. J., Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007. 27: 635-646.
36. + T cells selectively kill B lymphocytes. Blood 2006. 107: 3925-3932.
37. Schmuth, M., Schoonjans, K., Yu, Q. C., Fluhr, J. W., Crumrine, D., Hachem, J. P., Lau, P. et al., Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. J. Invest. Dermatol. 2002. 119: 1298-1303.
38. Elentner, A., Finke, D., Schmuth, M., Chappaz, S., Ebner, S., Malissen, B., Kissenpfennig, A. et al., Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice. J. Cell Mol. Med. 2009. 13: 2658-2672.