Peroxisome proliferator-activated receptor α negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation

Journal of Immunology

Volumn 171, Issue 1, 2003, Pages 196-203

  Jones, Dallas C ^a   Ding, Xiaohong ^a   Zhang, Tian Y ^a   Daynes, Raymond A ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; GAMMA INTERFERON; HORMONE RECEPTOR; INTERLEUKIN 2; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HELPER CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; WILD TYPE;

EID: 0038544686     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.1.196     Document Type: Article

References (45)

1. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645.
2. Berger, J., and D. E. Moller. 2002. The mechanisms of action of PPARs. Annu. Rev. Med. 53:409.
3. Desvergne, B., and W. Wahli. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20:649.
4. IJpenberg, A., E. Jeannin, W. Wahli, and B. Desvergne. 1997. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA: a functional analysis of the malic enzyme gene PPAR response element. J. Biol. Chem. 272:20108.
5. Li, M., G. Pascual, and C. K. Glass. 2000. Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20:4699.
6. Staels, B., W. Koenig, A. Habib, R. Merval, M. Lebret, I. P. Torra, P. Delerive, A. Fadel, G. Chinetti, J. C. Fruchart, et al. 1998. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393:790.
7. Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82.
8. Jones, D. C., X. Ding, and R. A. Daynes. 2002. Nuclear receptor peroxisome proliferator-activated receptor α (PPARα) is expressed in resting murine lymphocytes: the PPARα in T and B lymphocytes is both transactivation and transrepression competent. J. Biol. Chem. 277:6838.
9. Cunard, R., M. Ricote, D. DiCampli, D. C. Archer, D. A. Kahn, C. K. Glass, and C. J. Kelly. 2002. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J. Immunol. 168:2795.
10. Cunard, R., D. DiCampli, D. C. Archer, J. L. Stevenson, M. Ricote, C. K. Glass, and C. J. Kelly. 2002. WY14,643, a PPARα ligand, has profound effects on immune responses in vivo. J. Immunol. 169:6806.
11. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655.
12. Lee, S. S., T. Pineau, J. Drago, E. J. Lee, J. W. Owens, D. L. Kroetz, P. M. Fernandez-Salguero, H. Westphal, and F. J. Gonzalez. 1995. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:3012.
13. Brown, P. J., D. A. Winegar, K. D. Plunket, L. B. Moore, M. C. Lewis, J. G. Wilson, S. S. Sundseth, C. S. Koble, Z. Wu, J. M. Chapman, et al. 1999. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity. J. Med. Chem. 42:3785.
14. Brown, P. J., L. W. Stuart, K. P. Hurley, M. C. Lewis, D. A. Winegar, J. G. Wilson, W. O. Wilkison, O. R. Ittoop, and T. M. Willson. 2001. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg. Med. Chem. Lett. 11:1225.
15. Zabel, M. D., B. L. Byrne, J. J. Weis, and J. H. Weis. 2000. Cell-specific expression of the murine CD21 gene depends on accessibility of promoter and intronic elements. J. Immunol. 165:4437.
16. Spencer, N. F. L., S. D. Norton, L. L. Harrison, G. Z. Li, and R. A. Daynes. 1996. Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative. Exp. Gerontol. 31:393.
17. Poynter, M. E., and R. A. Daynes. 1998. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273:32833.
18. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
19. Morrison, T. B., Y. Ma, J. H. Weis, and J. J. Weis. 1999. Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR. J. Clin. Microbiol. 37:987.
20. Das, J., C. H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray. 2001. A critical role for NF-κB in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat. Immun. 2:45.
21. Zhang, J., K. V. Salojin, J. X. Gao, M. J. Cameron, I. Bergerot, and T. L. Delovitch. 1999. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J. Immunol. 162:3819.
22. Umlauf, S. W., B. Beverly, O. Lantz, and R. H. Schwartz. 1995. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
23. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907.
24. Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295:338.
25. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, and J. J. O'Shea, 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98:15137.
26. + T cells. Nat. Immun. 3:549.
27. Shi, Y., M. Hon, and R. M. Evans. 2002. The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 99:2613.
28. Rincon, M., H. Enslen, J. Raingeaud, M. Recht, T. Zapton, M. S. Su, L. A. Penix, R. J. Davis, and R. A. Flavell. 1998. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:2817.
29. Lu, B., H. Yu, C. Chow, B. Li, W. Zheng, R. J. Davis, and R. A. Flavell. 2001. GADD45γ mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 14:583.
30. Miyaura, H., and M. Iwata. 2002. Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J. Immunol. 168:1087.
31. Liu, G., Y. Zhang, A. M. Bode, W. Y. Ma, and Z. Dong. 2002. Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J. Biol. Chem. 277:8810.
32. Caelles, C., J. M. Gonzalez-Sancho, and A. Munoz. 1997. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11:3351.
33. Gonzalez, M. V., B. Jimenez, M. T. Berciano, J. M. Gonzalez-Sancho, C. Caelles. M. Lafarga, and A. Munoz. 2000. Glucocorticoids antagonize AP-1 by inhibiting the activation/phosphorylation of JNK without affecting its subcellular distribution. J. Cell Biol. 150:1199.
34. Desreumaux, P., L. Dubuquoy, S. Nutten, M. Peuchmaur, W. Englaro, K. Schoonjans, B. Derijard, B. Desvergne, W. Wahli, P. Chambon, et al. 2001. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor γ (PPARγ) heterodimer: a basis for new therapeutic strategies. J. Exp. Med. 193:827.
35. Syrovets, T., A. Schule, M. Jendrach, B. Buchele, and T. Simmet. 2002. Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity. Thromb. Haemostasis 88:274.
36. + T cells. Annu. Rev. Immunol. 12:635.
37. Ho, I. C., and L. H. Glimcher. 2002. Transcription: tantalizing times for T cells. Cell 109:S109.
38. Neurath, M. F., B. Weigmann, S. Finotto, J. Glickman, E. Nieuwenhuis, H. Iijima, A. Mizoguchi, E. Mizoguchi, J. Mudter, P. R. Galle, et al. 2002. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195:1129.
39. Finotto, S., M. F. Neurath, J. N. Glickman, S. Qin, H. A. Lehr, F. H. Green, K. Ackerman, K. Haley, P. R. Galle, S. J. Szabo. et al. 2002. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295:336.
40. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, and J. J. O'Shea. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98:15137.
41. Grohmann, U., C. Orabona, F. Fallarino, C. Vacca, F. Calcinaro, A. Falorni, P. Candeloro, M. L. Belladonna, R. Bianchi, M. C. Fioretti, and P. Puccetti. 2002. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immun. 3:1097.
42. Frucht, D. M., T. Fukao, C. Bogdan, H. Schindler, J. J. O'Shea, and S. Koyasu. 2001. IFN-γ production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22:556.
43. Zhang, J., M. Kalkum, B. T. Chait, and R. G. Roeder. 2002. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell 9:611.
44. Lu, B., H. Yu, C. Chow, B. Li, W. Zheng, R. J. Davis, and R. A. Flavell. 2001. GADD45γ mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 14:583.
45. Zlotnik, A., W. K. Roberts, A. Vasil, E. Blumenthal, F. Larosa, H. J. Leibson, R. O. Endres, S. D. Graham, Jr., J. White, J. Hill, et al. 1983. Coordinate production by a T cell hybridoma of γ interferon and three other lymphokine activities: multiple activities of a single lymphokine? J. Immunol. 131:794.