Role of peroxisome proliferator-activated receptor α in epidermal development in Utero

Journal of Investigative Dermatology

Volumn 119, Issue 6, 2002, Pages 1298-1303

  Schmuth, Matthias ^a,d   Schoonjans, Kristina ^c   Yu, Qian Chun ^b   Fluhr, Joachim W ^b   Crumrine, Debra ^b   Hachem, Jean Pierre ^b   Lau, Peggy ^b   Auwerx, Johan ^c   Elias, Peter M ^b   Feingold, Kenneth R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d Metabolism Section (111F)   (United States)

Author keywords

Cornified envelope; Differentiation; Keratinocyte; Nuclear hormone receptor; Stratum corneum

Indexed keywords

GLUCOSYLCERAMIDASE; INVOLUCRIN; LORICRIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDERMIS; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRATUM CORNEUM;

EID: 0036916063     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.19605.x     Document Type: Article

References (32)

1. Aszterbaum M, Menon GK, Feingold KR, Williams ML: Ontogeny of the epidermal barrier to water loss in the rat: Correlation of function with stratum corneum structure and lipid content. Pediatr Res 31:308-317, 1992
2. Behne M, Uchida Y, Seki T, de Montellano PO, Elias PM, Holleran WM: ω-Hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol 114:185-192, 2000
3. Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR: Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol 104:405-410, 1995
4. Braissant O, Wahli W: Differential expression of peroxisome proliferator-activated receptor-α, -β, and -γ during rat embryonic development. Endocrinology 139:2748-2754, 1998
5. Downing DT: Lipid and protein structures in the permeability barrier of mammalian epidermis. J Lipid Res 33:301-313, 1992
6. Elias PM, Menon GK: Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24:1-26, 1991
7. Elias PM, et al: Skin as an organ of protection. In: Freedberg IM, et al, eds. Dermatology in General Medicine. New York: McGraw-Hill, in press
8. Hanley K, Rassner U, Elias PM, Williams ML, Feingold KR: Epidermal barrier ontogenesis. Maturation in serum-free media and acceleration by glucocorticoids and thyroid hormone but not selected growth factors. J Invest Dermatol 106:404-411, 1996a
9. Hanley K, Rassner U, Jiang Y, et al: Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone. J Clin Invest 97:2576-2584, 1996b
10. Hanley K, Devaskar UP, Hicks SJ, et al: Hypothyroidism delays fetal stratum corneum development in mice. Pediatr Res 42:610-614, 1997a
11. Hanley K, Jiang Y, Holleran WM, Elias PM, Williams ML, Feingold KR: Glucosyl-ceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat. J Lipid Res 38:576-584, 1997b
12. Hanley K, Jiang Y, Katagiri C, Feingold KR, Williams ML: Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat. J Invest Dermatol 108:871-875, 1997c
13. Hanley K, Feingold KR, Komuves LG, Elias PM, Muglia LJ, Majzoub JA, Williams ML: Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. J Invest Dermatol 111:440-444, 1998
14. Hanley K, Komuves LG, Bass NM, et al: Fetal epidermal differentiation and barrier development in vivo is accelerated by nuclear hormone receptor activators. J Invest Dermatol 113:788-795, 1999
15. Hanley K, Komuves LG, Ng DC, et al: Farnesol stimulates differentiation in epidermal keratinocytes via PPAR α. J Biol Chem 275:11484-11491, 2000
16. Hardman MJ, Sisi P, Banbury DN, Byrne C: Patterned acquisition of skin barrier function during development. Development 125:1541-1552, 1998
17. Holleran WM, Takagi Y, Menon GK, Legler G, Feingold KR, Elias PM: Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest 91:1656-1664, 1993
18. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM: Membrane structures in normal and essential fatty acid-deficient stratum corneum: Characterization by ruthenium tetroxide staining and x-ray diffraction. J Invest Dermatol 96:215-223, 1991
19. Hurt CM, Hanley K, Williams ML, Feingold KR: Cutaneous lipid synthesis during late fetal development in the rat. Arch Dermatol Res 287:754-760, 1995
20. Jackson SM, Williams ML, Feingold KR, Elias PM: Pathobiology of the stratum corneum. West J Med 158:279-285, 1993
21. Komuves LG, Hanley K, Jiang Y, Elias PM, Williams ML, Feingold KR: Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. J Invest Dermatol 111:429-433, 1998
22. Komuves LG, Hanley K, Lefebvre AM, et al: Stimulation of PPARα promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol 115:353-360, 2000
23. Lee SS, Pineau T, Drago J, et al: Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-3022, 1995
24. Menefee MG: Some fine structure changes occurring in the epidermis of embryo mice during differentiation. J Ultrastruct Res 1:49-61, 1957
25. Michalik L, Desvergne B, Tan NS, et al: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR) α and PPAR β mutant mice. J Cell Biol 154:799-814, 2001
26. Potts RO, Francoeur ML: Lipid biophysics of water loss through the skin. Proc Natl Acad Sci USA 87:3871-3873, 1990
27. Segre JA, Bauer C, Fuchs E: Klf4 is a transcription factor required for establishing the barrier function of the skin. Nature Genet 22:356-360, 1999
28. Steinert PM: The complexity and redundancy of epithelial barrier function. J Cell Biol 151:F5-F8, 2000
29. Steinert PM, Marekov LN: Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia. Mol Biol Cell 10:4247-4261, 1999
30. Takagi Y, Krichuber E, Imokowa G, Elias PM, Holleran WM: Beta-glucocerebrosidase activity in mammalian stratum corneum. J Lipid Res 40:861-869, 1999
31. Turksen K, Troy TC: Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development 129:1775-1784, 2002
32. Wertz PW, Swartzendruber DC, Kitko DJ, Madison KC, Downing DT: The role of the corneocyte lipid envelopes in cohesion of the stratum corneum. J Invest Dermatol 93:169-172, 1989