A "click chemistry" approach to the efficient synthesis of multiple imaging probes derived from a single precursor

Bioconjugate Chemistry

Volumn 20, Issue 10, 2009, Pages 1940-1949

  Mindt, Thomas L ^a,c   Müller, Cristina ^b   Stuker, Florian ^a   Salazar, Jean Frédéric ^a,d   Hohn, Alexander ^b   Mueggler, Thomas ^a   Rudin, Markus ^a   Schibli, Roger ^a,b  

^a ETH ZURICH   (Switzerland)

^b ETH Zurich   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER COMPOUNDS; CYCLOADDITION; HYDROCARBONS; MAGNETIC RESONANCE IMAGING; MOLECULAR IMAGING; PROBES; SYNTHESIS (CHEMICAL);

ACID PRECURSORS; ACID RECEPTORS; CLICK CHEMISTRY; FOLIC ACIDS; IMAGING MODALITY; IMAGING PROBE; IN-VITRO; SINGLE PRECURSORS; SYNTHETIC APPROACH; VITRO AND IN VIVO;

ORGANIC ACIDS;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID FOLIC ACID GA 67; ALKYNE DERIVATIVE; AZIDE; CUPROUS ION; FLUORINE 18; FOLIC ACID DERIVATIVE; PENTETATE INDIUM FOLIC ACID IN 111; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CHELATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYCLOADDITION; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MALE; MOLECULAR IMAGING; MOUSE; NEAR INFRARED REFLECTANCE SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT;

MUS MUSCULUS;

ANIMALS; CHELATING AGENTS; CLICK CHEMISTRY; FOLATE RECEPTORS, GPI-ANCHORED; FOLIC ACID; HUMANS; KB CELLS; LIGANDS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR IMAGING; MOLECULAR PROBES; NEOPLASM TRANSPLANTATION; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 70350304285     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc900276b     Document Type: Article

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