The effect of alcoholic garlic (Allium sativum) extract on ABCA1 expression in human thp-1 macrophages

Tehran University Medical Journal

Volumn 69, Issue 3, 2011, Pages

  Malekpour Dehkordi, Zahra ^a   Javadi, Ebrahim ^a   Doosti, Mahmood ^a   Paknejad, Maliheh ^a   Nourbakhsh, Mitra ^a   Yassa, Narguess ^b   Gerayesh Nejad, Siavash ^a   Heshmat, Ramin ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Alcoholic garlic extract; Atherosclerosis; ATP binding cassette transporter a1

Indexed keywords

ABC TRANSPORTER A1; GARLIC EXTRACT; MESSENGER RNA;

ARTICLE; ATHEROSCLEROSIS; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; MACROPHAGE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

EID: 79959638441     PISSN: 16831764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340(2):115-126.
2. Rahman K. Historical perspective on garlic and cardiovascular disease. J Nutr 2001;131(3s):977S-979S.
3. Genkinger JM, Platz EA, Hoffman SC, Comstock GW, Helzlsouer KJ. Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. Am J Epidemiol 2004;160(12):1223-1233.
4. Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996;64(6):866-870.
5. Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. Ann Pharmacother 2008;42(12):1766-1771. Epub 2008 Nov 18.
6. Dillon SA, Burmi RS, Lowe GM, Billington D, Rahman K. Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein. Life Sci 2003;72(14):1583-94.
7. Lau BH. Suppression of LDL oxidation by garlic. J Nutr 2001;131(3s):985S-988S. Review.
8. Okuhara T. Clinical study of aged garlic extract on peripheral circulation. Jpn Pharmacol Ther 1994;22:3695-3701.
9. Ho SE, Ide N, Lau BH. S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process. Phytomedicine 2001;8(1):39-46.
10. Campbell JH, Efendy JL, Smith NJ, Campbell GR. Molecular basis by which garlic suppresses atherosclerosis. J Nutr 2001;131(3s):1006S-1009S.
11. Efendy JL, Simmons DL, Campbell GR, Campbell JH. The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis. Atherosclerosis 1997;132(1):37-42.
12. Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis 1998;141(1):1-15.
13. Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem 2000;275(34):26293-26299.
14. Hegyi L, Skepper JN, Cary NR, Mitchinson MJ. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J Pathol 1996;180(4):423-429.
15. Lusis AJ. Atherosclerosis. Nature 2000;407(6801):233-241.
16. Panagotopulos SE, Witting SR, Horace EM, Hui DY, Maiorano JN, Davidson WS. The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1. J Biol Chem 2002;277(42):39477-39484. Epub 2002 Aug 13.
17. Oram JF, Vaughan AM. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr Opin Lipidol 2000;11(3):253-260.
18. Feingold KR, Hardardottir I, Memon R, Krul EJ, Moser AH, Taylor JM, Grunfeld C. Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters. J Lipid Res 1993;34(12):2147-2158.
19. Attie AD, Kastelein JP, Hayden MR. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J Lipid Res 2001;42(11):1717-1726.
20. Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 2000;275(36):28240-2825.
21. Scott J. Heart disease. Good cholesterol news. J Nutr 1999;400(6747):816-817, 819.
22. Chen W, Silver DL, Smith JD, Tall AR. Scavenger receptor-BI inhibits ATP-binding cassette transporter 1- mediated cholesterol efflux in macrophages. J Biol Chem 2000;275(40):30794-30800.
23. Sakr SW, Williams DL, Stoudt GW, Phillips MC, Rothblat GH. Induction of cellular cholesterol efflux to lipid-free apolipoprotein A-I by cAMP. Biochim Biophys Acta 1999;1438(1):85-98.
24. Oram JF. HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. Arterioscler Thromb Vasc Biol 2003;23(5):720-727. Epub 2003 Jan 9.
25. van Dam MJ, de Groot E, Clee SM, Hovingh GK, Roelants R, Brooks-Wilson A, et al. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. Lancet 2002;359(9300):37-42.
26. Aiello RJ, Brees D, Bourassa PA, Royer L, Lindsey S, Coskran T, et al. Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Arterioscler Thromb Vasc Biol 2002;22(4):630-637.
27. Vaisman BL, Lambert G, Amar M, Joyce C, Ito T, Shamburek RD, et al. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest 2001;108(2):303-309.
28. Albrecht C, Soumian S, Amey JS, Sardini A, Higgins CF, Davies AH, Gibbs RG. ABCA1 expression in carotid atherosclerotic plaques. Stroke 2004;35(12):2801-2806. Epub 2004 Nov 4.
29. Wang MD, Franklin V, Marcel YL. In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired. Arterioscler Thromb Vasc Biol 2007;27(8):1837-1842. Epub 2007 May 31.
30. Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, et al. Aged garlic extract supplemented with B vitamins, folic acid and Larginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med 2009;49(2-3):101-107. Epub 2009 Jun 30.