Erythropoietin increases survival and attenuates fulminant hepatic failure injury induced by d-galactosamine/lipopolysaccharide in mice

Transplantation

Volumn 92, Issue 1, 2011, Pages 18-24

  Ben Ari, Ziv ^a,b   Zilbermints, Veacheslav ^a,b   Pappo, Orit ^a   Avlas, Orna ^b   Sharon, Eran ^a,b   Greif, Franklin ^a,b   Cheporko, Yelena ^b   Ravid, Amiram ^b   Shapiro, Rivka ^b,c   Hochhauser, Edith ^b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

Author keywords

Erythropoietin; Fulminant hepatic failure; JNK; NF B; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; GALACTOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG MEGADOSE; ENZYME ACTIVATION; FULMINANT HEPATIC FAILURE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL; MORTALITY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; SURVIVAL RATE; TREATMENT OUTCOME; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN, RECOMBINANT; GALACTOSAMINE; HUMANS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KAPLAN-MEIER ESTIMATE; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE, ACUTE; MICE; MICE, INBRED C57BL; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79959636893     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31821cdea5     Document Type: Article

References (38)

1. Lee WM, Squires RH Jr, Nyberg SL, et al. Acute liver failure: Summary of a workshop. Hepatology 2008; 47: 1401.
2. Rolando N, Philpott-Howard J, Williams R. Bacterial and fungal infection in acute liver failure. Semin Liver Dis 1996; 16: 389.
3. Xiong Q, Hase K, Tezuka Y, et al. Acteoside inhibits apoptosis in Dgalactosamine and lipopolysaccharide-induced liver injury. Life Sci 1999; 65: 421.
4. Galanos C, Freudenberg MA, Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 1979; 76: 5939.
5. Leist M, Gantner F, Bohlinger I, et al. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995; 146: 1220.
6. Bohlinger I, Leist M, Gantner F, et al. DNA fragmentation in mouse organs during endotoxin shock. Am J Pathol 1996; 149: 1381.
7. Martich GD, Danner RL, Ceska M, et al. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: The effect of antiinflammatory agents. J Exp Med 1991; 173: 1021.
8. Leist M, Gantner F, Jilg S, et al. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol 1995; 154: 1307.
9. Chosay JG, Essani NA, Dunn CJ, et al. Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxininduced injury. Am J Physiol 1997; 272: G1195.
10. Kawaguchi K, Kikuchi S, Hasegawa H, et al. Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. Eur J Pharmacol 1999; 368: 245.
11. Lewis LD. Preclinical and clinical studies: A preview of potential future applications of erythropoietic agents. Semin Hematol 2004; 41(suppl 7): 217.
12. Liu X, Xie W, Liu P, et al. Mechanism of cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemiareperfusion. Life Sci 2006; 78: 2255.
13. Bogoyevitch MA. An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection. Cradiovasc Res 2004; 63: 208.
14. Yang CW, Li C, Jung JY, et al. Preconditioning with erythropoietin protects against subsequent ischemia-reperfusion injury in rat kidney. FASEB J 2003; 17: 1754.
15. Hochhauser E, Pappo O, Ribakovsky E, et al. Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/reperfusion in an isolated mouse liver model. Apoptosis 2008; 13: 77.
16. Greif F, Ben-Ari Z, Taya R, et al. Dual effect of erythropoietin on liver protection and regeneration after subtotal hepatectomy in rats. Liver Transpl 2010; 16: 631.
17. Bernal W, Auzinger G, Dhawan A, et al. Acute liver failure. Lancet 2010; 376: 190.
18. Joyeux-Faure M. Cellular protection by erythropoietin: New therapeutic implications? J Pharmacol Exp Ther 2007; 323: 759.
19. Bernhardt WM, Eckardt KU. Physiological basis for the use of erythropoietin in critically ill patients at risk for acute kidney injury. Curr Opin Crit Care 2008; 14: 621.
20. Le Minh K, Klemm K, Abshagen K, et al. Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol 2007; 170: 1954.
21. Weidemann A, Johnson RS. Nonrenal regulation of EPO synthesis. Kid Int 2009; 75: 682.
22. Ramadori P, Ahmad G, Ramadori G. Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acutephase response: A role for IL-6. Lab Invest 2010; 90: 1306.
23. Wu WT, Hu TM, Lin NT, et al. Low-dose erythropoietin aggravates endotoxin-induced organ damage in conscious rats. Cytokine 2010; 49: 155.
24. Tanaka H, Uchida Y, Kaibori M, et al. Na/H exchanger inhibitor, FR183998, has protective effect in lethal acute liver failure and prevents iNOS induction in rats. J Hepatol 2008; 48: 289.
25. Wheeler MD, Yamashina S, Froh M, et al. Adenoviral gene delivery can inactivate Kupffer cells: Role of oxidants in NF-kappaB activation and cytokine production. J Leukoc Biol 2001; 69: 622.
26. Hoffmann F, Sass G, Zillies J, et al. A novel technique for selective NF-kappaB inhibition in Kupffer cells: Contrary effects in fulminant hepatitis and ischaemia-reperfusion. Gut 2009; 58: 1670.
27. Lu JW, Wang H, Yan-Li J, et al. Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis. J Hepatol 2008; 48: 442.
28. Wang Y, Singh R, Lefkowitch JH, et al. Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 2006; 281: 15258.
29. Takamura M, Matsuda Y, Yamagiwa S, et al. An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/ lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins. Life Sci 2007; 80: 1335.
30. Decker K, Keppler D. Galactosamine hepatitis: Key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol 1974; 71: 77.
31. Silverstein R. Uridine protection against d-galN-sensitized LPS lethality in mice is complete. J Endotoxin Res 1997; 4: 463.
32. Pfeffer K, Matsuyama T, Kündig TM, et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993; 73: 457.
33. Marino MW, Dunn A, Grail D, et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997; 94: 8093.
34. Freudenberg MA, Keppler D, Galanos C. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect Immun 1986; 51: 891.
35. Alcorn JM, Fierer J, Chojkier M. The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-alpha. Hepatology 1992; 15: 122.
36. Diaz-Buxo JA, Blumenthal S, Hayes D, et al. Galactosamine-induced fulminant hepatic necrosis in unanesthetized canines. Hepatology 1997; 25: 950.
37. Wang H, Yan-Li J, Zhang C, et al. Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis. J Hepatol 2008; 48: 442.
38. Duan GJ, Zhu J, Xu CY, et al. Protective effect of Gö6976, a PKD inhibitor, on LPS/d-GalN-induced acute liver injury in mice. Inflamm Res 2011; 60: 357.