Dual effect of erythropoietin on liver protection and regeneration after subtotal hepatectomy in rats

Liver Transplantation

Volumn 16, Issue 5, 2010, Pages 631-638

  Greif, Franklin ^a   Ben Ari, Ziv ^a   Taya, Rasim ^a   Pappo, Orit ^a   Kurtzwald, Efrat ^b   Cheporko, Yelena ^b   Ravid, Amiram ^b   Hochhauser, Edith ^b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CASPASE 3; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT ERYTHROPOIETIN; VON WILLEBRAND FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; INTERNATIONAL NORMALIZED RATIO; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; LIVER REGENERATION; LIVER WEIGHT; LOW DRUG DOSE; MALE; NICK END LABELING; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CASPASE 3; ERYTHROPOIETIN, RECOMBINANT; HEPATECTOMY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTERNATIONAL NORMALIZED RATIO; KI-67 ANTIGEN; LIVER; LIVER REGENERATION; MALE; ORGAN SIZE; POSTOPERATIVE COMPLICATIONS; RATS; RATS, WISTAR; REPERFUSION INJURY; VON WILLEBRAND FACTOR;

EID: 77951752137     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22046     Document Type: Article

References (38)

1. Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 2000;191:38-46. (Pubitemid 30439557)
2. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in peri-operative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397-406.
3. Garcea G, Maddern GJ. Liver failure after major hepatic resection. J Hepatobiliary Pancreat Surg 2009;16:145-155.
4. Nagasue N, Yukaya H, Ogawa Y, Kohno H, Nakamura T. Human liver regeneration after major hepatic resection: a study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 1987;206:30-39. (Pubitemid 17101849)
5. Abdalla EK, Noun R, Belghiti J. Hepatic vascular occlusion: which technique? Surg Clin North Am 2004;84:563-585.
6. Fan ST. Protection of the liver during partial hepatectomy. Hepatobiliary Pancreat Dis Int 2004;3:490-494.
7. Takeda K, Togo S, Kunihiro O, Fujii Y, Kurosawa H, Tanaka K, et al. Clinicohistological features of liver failure after excessive hepatectomy. Hepatogastroenterology 2002;49:354-358. (Pubitemid 34606550)
8. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004;5:836-847.
9. Clavien PA, Petrowsky H, DeOliveira ML, Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med 2007;356:1545-1559. (Pubitemid 46588419)
10. Taub R, Greenbaum LE, Peng Y. Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis 1999;19:117-127. (Pubitemid 29326119)
11. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003;37:824-832. (Pubitemid 36397393)
12. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. p18INK4c collaborates with other CDK inhibitory proteins in the regenerating liver. Hepatology 2003;37:833-841. (Pubitemid 36397394)
13. Behrens A, Sibilia M, David JP, Möhle-Steinlein U, Tronche F, Schü tz G, Wagner EF. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002;21:1782-1790.
14. Talarmin H, Rescan C, Cariou S, Glaise D, Zanninelli G, Bilodeau M, et al. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signaling pathway involved in the regulation of G (1) phase progression in proliferating hepatocytes. Mol Cell Biol 1999;19:6003-6011.
15. Sakamoto T, Liu Z, Murase N, Ezure T, Yokomuro S, Poli V, Demetris AJ. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 1999;29:403-411. (Pubitemid 29088443)
16. Yoshida N, Iwata H, Yamada T, Sekino T, Matsuo H, Shirahashi K, et al. Improvement of the survival rate after rat massive hepatectomy due to the reduction of apoptosis by caspase inhibitor. J Gastroenterol Hepatol 2007;22:2015-2021. (Pubitemid 47525092)
17. Neuman MG. Apoptosis in diseases of the liver. Crit Rev Clin Lab Sci 2001;38:109-166.
18. Lewis LD. Preclinical and clinical studies: a preview of potential future applications of erythropoietic agents. Semin Hematol 2004;41:17-25.
19. Liu X, Xie W, Liu P, Duan M, Jia Z, Li W, Xu J. Mechanism of cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemiareperfusion. Life Sci 2006;78:2255-2264.
20. Bogoyevitch MA. An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection. Cardiovasc Res 2004;63:208-216.
21. Yang CW, Li C, Jung JY, Shin SJ, Choi BS, Lim SW, et al. Preconditioning with erythropoietin protects against subsequent ischemia-reperfusion injury in rat kidney. FASEB J 2003;17:1754-1755.
22. Calvillo L, Latini R, Kajstura J, Leri A, Anversa P, Ghezzi P, et al. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci 2003; 100:4802-4806. (Pubitemid 36457809)
23. Chong ZZ, Kang JQ, Maiese K. Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab 2002;22:503-514. (Pubitemid 34477771)
24. Chan CY, Chen YS, Lee HH, Huang HS, Lai YL, Chen CF, Ma MC. Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: role of Jak2-ERK pathway. Life Sci 2007;81:717-723.
25. Hochhauser E, Pappo O, Ribakovsky E, Ravid A, Kurtzwald E, Cheporko Y, et al. Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/ reperfusion in an isolated mouse liver model. Apoptosis 2008;13:77-86.
26. Selzner M, Clavien PA. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 2000;31:35-42. (Pubitemid 30033686)
27. Schmeding M, Boas-Knoop S, Lippert S, Ruehl M, Somasundaram R, Dagdelen T, et al. Erythropoietin promotes hepatic regeneration after extended liver resection in rats. J Gastroenterol Hepatol 2008;23:1125-1131. (Pubitemid 352019375)
28. Bockhorn M, Fingas CD, Rauen U, Canbay A, Sotiropoulos GC, Frey U, et al. Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantation. Transplantation 2008;86:1578-1585.
29. Anagnostou A, Liu Z, Steiner M, Chin K, Lee ES, Kessimian N, Noguchi CT. Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci USA 1994;91:3974-3978. (Pubitemid 24139555)
30. Baruch Y, Neubauer K, Shenkar L, Sabo E, Ritzel A, Wilfling T, Ramadori G. Von Willebrand factor in plasma and in liver tissue after partial hepatectomy in the rat. J Hepatol 2002;37:471-477.
31. Drixler TA, Vogten MJ, Ritchie ED, van Vroonhoven TJ, Gebbink MF, Voest EE, Borel Rinkes IH. Liver regeneration is an angiogenesis-associated phenomenon. Ann Surg 2002;236:703-711.
32. Sato T, El-Assal ON, Ono T, Yamanoi A, Dhar DK, Nagasue N. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol 2001;34:690-698. (Pubitemid 32488784)
33. Bustos M, Beraza N, Lasarte JJ, Baixeras E, Alzuguren P, Bordet T, Prieto J. Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats. Gastroenterology 2003;125:192-201. (Pubitemid 36799119)
34. Zhande R, Karsan A. Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL. Am J Physiol Heart Circ Physiol 2007;292:H2467-H2474. (Pubitemid 47084630)
35. Laugsch M, Metzen E, Svensson T, Depping R, Jelkmann W. Lack of functional erythropoietin receptors of cancer cell lines. Int J Cancer 2008;122:1005-1011. (Pubitemid 351213997)
36. Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D, et al. IkappaB alpha and Ikappa B beta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 2004;113:746-755. (Pubitemid 38544168)
37. Tewari M, Dobrzanski P, Mohn KL, Cressman DE, Hsu JC, Bravo R, Taub R. Rapid induction in regenerating liver of RL/IF-1 (an IKB that inhibits NF-KB, RelB-p50, and c-Rel-pS0) and PHF, a novel jB site-binding complex. Mol Cell Biol 1992;12:2898-2908.
38. Fan G, Kren BT, Steer CJ. Regulation of apoptosis associated genes in the regenerating liver. Semin Liver Dis 1998;18:123-140. (Pubitemid 28224004)