Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Toyoshima, Fumihiko ^a   Oshima, Tadayuki ^a   Nakajima, Shigemi ^b   Sakurai, Jun ^a   Tanaka, Junji ^a   Tomita, Toshihiko ^a   Hori, Kazutoshi ^a   Matsumoto, Takayuki ^a   Miwa, Hiroto ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b Social Insurance Shiga Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYTRYPTAMIN TRANSPORTER GENE LINKED POLYMORPHIC REGION; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; SLC6A4 PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DYSPEPSIA; EPIGASTRIC PAIN; FEMALE; FUNCTIONAL DYSPEPSIA; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POPULATION; PROMOTER REGION; SEX DIFFERENCE; ASIAN; CLUSTER ANALYSIS; GENETIC POLYMORPHISM; GENETICS; JAPAN; MIDDLE AGED; POSTPRANDIAL STATE; RISK; RISK FACTOR; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CLUSTER ANALYSIS; DYSPEPSIA; FEMALE; GENOTYPE; HUMANS; JAPAN; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; POSTPRANDIAL PERIOD; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 79959629232     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-88     Document Type: Article

References (49)

1. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology 2006, 130(5):1466-1479. 10.1053/j.gastro.2005.11.059, 16678560.
2. Trimble KC, Farouk R, Pryde A, Douglas S, Heading RC. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995, 40(8):1607-1613. 10.1007/BF02212678, 7648957.
3. Salet GA, Samsom M, Roelofs JM, van Berge Henegouwen GP, Smout AJ, Akkermans LM. Responses to gastric distension in functional dyspepsia. Gut 1998, 42(6):823-829. 10.1136/gut.42.6.823, 1727131, 9691921.
4. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998, 115(6):1346-1352. 10.1016/S0016-5085(98)70012-5, 9834261.
5. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, Marengo M, Corinaldesi R. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996, 110(4):1036-1042. 10.1053/gast.1996.v110.pm8612991, 8612991.
6. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM. Neurohormonal factors in functional dyspepsia: insights on pathophysiological mechanisms. Gastroenterology 1991, 100(5 Pt 1):1311-1318.
7. Drossman DA, McKee DC, Sandler RS, Mitchell CM, Cramer EM, Lowman BC, Burger AL. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988, 95(3):701-708.
8. Locke GR, Weaver AL, Melton LJ, Talley NJ. Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case-control study. Am J Gastroenterol 2004, 99(2):350-357. 10.1111/j.1572-0241.2004.04043.x, 15046228.
9. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol 2006, 12(17):2661-2666.
10. Oshima T, Nakajima S, Yokoyama T, Toyoshima F, Sakurai J, Tanaka J, Tomita T, Kim Y, Hori K, Matsumoto T, Miwa H. The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. BMC Med Genet 2010, 11:13. 2825227, 20102604.
11. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Yoshioka D, Arima Y, Okubo M, Hirata I, Nakano H. Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia. Int J Mol Med 2007, 20(5):717-723.
12. Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Hirata I. COMT gene val158met polymorphism in patients with dyspeptic symptoms. Hepatogastroenterology 2008, 55(84):979-982.
13. Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Yoshioka D, Okubo M, Maruyama N, Kamano T, Kamiya Y, Fujita H, Nagasaka M, Iwata M, Takahama K, Watanabe M, Yamashita H, Nakano H, Hirata I. 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. Hepatogastroenterology 2009, 56(93):1245-1248.
14. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Yoshioka D, Arima Y, Okubo M, Hirata I, Nakano H. Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women. J Womens Health (Larchmt) 2008, 17(6):1039-1043.
15. Tahara T, Shibata T, Wang F, Nakamura M, Sakata M, Nakano H, Hirata I, Arisawa T. A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals. Eur J Gastroenterol Hepatol 2009, 21(12):1363-1368. 10.1097/MEG.0b013e32830e2871, 19531958.
16. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Hirata I, Arisawa T. Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia. J Clin Gastroenterol 2010, 44(1):e1-7. 10.1097/MCG.0b013e3181b5745e, 19770677.
17. Tahara T, Shibata T, Yamashita H, Hirata I, Arisawa T. The Role of RANTES Promoter Polymorphism in Functional Dyspepsia. J Clin Biochem Nutr 2009, 45(2):235-240. 10.3164/jcbn.09-31, 2735638, 19794934.
18. Kim D, Camilleri M. Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 2000, 95(10):2698-2709.
19. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch K. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996, 66(6):2621-2624.
20. Lesch K, Bengel D, Heils A, Sabol S, Greenberg B, Petri S, Benjamin J, Müller C, Hamer D, Murphy D. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274(5292):1527-1531. 10.1126/science.274.5292.1527, 8929413.
21. Ogilvie A, Battersby S, Bubb V, Fink G, Harmar A, Goodwim G, Smith C. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996, 347(9003):731-733. 10.1016/S0140-6736(96)90079-3, 8602004.
22. Lin P, Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 2004, 55(10):1023-1030. 10.1016/j.biopsych.2004.02.006, 15121487.
23. Kremer I, Bachner-Melman R, Reshef A, Broude L, Nemanov L, Gritsenko I, Heresco-Levy U, Elizur Y, Ebstein R. Association of the serotonin transporter gene with smoking behavior. Am J Psychiatry 2005, 162(5):924-930. 10.1176/appi.ajp.162.5.924, 15863794.
24. Ho P, Shih M, Ma K, Huang W, Ho K, Yen C, Lu R, Huang S. Availability of the serotonin transporter in patients with alcohol dependence. World J Biol Psychiatry 2010,
25. Pata C, Erdal M, Derici E, Yazar A, Kanik A, Ulu O. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 2002, 97(7):1780-1784. 10.1111/j.1572-0241.2002.05841.x, 12135035.
26. Yeo A, Boyd P, Lumsden S, Saunders T, Handley A, Stubbins M, Knaggs A, Asquith S, Taylor I, Bahari B, Rallan R, Varsani S, Montgomery D, Alpers DH, Dukes GE, Purvis I, Hicks GA. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 2004, 53(10):1452-1458. 10.1136/gut.2003.035451, 1774243, 15361494.
27. Park J, Choi M, Park J, Oh J, Cho Y, Lee I, Kim S, Choi K, Chung I. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil 2006, 18(11):995-1000. 10.1111/j.1365-2982.2006.00829.x, 17040410.
28. Li Y, Nie Y, Xie J, Tang W, Liang P, Sha W, Yang H, Zhou Y. The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci 2007, 52(11):2942-2949. 10.1007/s10620-006-9679-y, 17394071.
29. Saito Y, Locke G, Zimmerman J, Holtmann G, Slusser J, De Andrade M, Petersen G, Talley N. A genetic association study of 5-HTT LPR and GN beta 3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterology and Motility 2007, 465-470.
30. Sikander A, Rana S, Sinha S, Prasad K, Arora S, Sharma S, Singh K. Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gastroenterol 2009, 43(10):957-961. 10.1097/MCG.0b013e3181b37e8c, 19687750.
31. Niesler B, Kapeller J, Fell C, Atkinson W, Möller D, Fischer C, Whorwell P, Houghton LA. 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex. Eur J Gastroenterol Hepatol 2010, 22(7):856-861. 10.1097/MEG.0b013e32832e9d6b, 19561511.
32. Markoutsaki T, Karantanos T, Gazouli M, Anagnou NP, Ladas SD, Karamanolis DG. Serotonin Transporter and G Protein Beta 3 Subunit Gene Polymorphisms in Greeks with Irritable Bowel Syndrome. Dig Dis Sci 2011,
33. Camilleri C, Carlson P, Camilleri M, Castillo E, Locke G, Geno D, Stephens D, Zinsmeister A, Urrutia R. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 2006, 101(3):581-592. 10.1111/j.1572-0241.2006.00481.x, 16464220.
34. van Lelyveld N, Linde J, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil 2008, 20(7):767-773. 10.1111/j.1365-2982.2008.01102.x, 18331431.
35. Katsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, Akiyoshi J. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry 1999, 45(3):368-370. 10.1016/S0006-3223(98)00090-0, 10023516.
36. Kumakiri C, Kodama K, Shimizu E, Yamanouchi N, Okada S, Noda S, Okamoto H, Sato T, Shirasawa H. Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neurosci Lett 1999, 263(2-3):205-207. 10.1016/S0304-3940(99)00098-1, 10213171.
37. Faure C, Patey N, Gauthier C, Brooks E, Mawe G. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 2010, 139(1):249-258. 10.1053/j.gastro.2010.03.032, 2902614, 20303355.
38. Ford A, Talley N, Schoenfeld P, Quigley E, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 2009, 58(3):367-378. 10.1136/gut.2008.163162, 19001059.
39. Wu C, Chou L, Chen H, Chang C, Wong P, Chen G. Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia. Hepatogastroenterology 2003, 50(49):278-283.
40. van Kerkhoven L, Laheij R, Aparicio N, De Boer W, Van den Hazel S, Tan A, Witteman B, Jansen J. Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2008, 6(7):746-752. quiz 718, 10.1016/j.cgh.2008.02.051, 18424191.
41. Miwa H, Nagahara A, Tominaga K, Yokoyama T, Sawada Y, Inoue K, Ashida K, Fukuchi T, Hojo M, Yamashita H, Tomita T, Hori K, Oshima T. Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. Am J Gastroenterol 2009, 104(11):2779-2787. 10.1038/ajg.2009.427, 19638966.
42. Tack J, Van Den Elzen B, Tytgat G, Wajs E, Van Nueten L, De Ridder F, Boeckxstaens G. A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia. Neurogastroenterol Motil 2009, 21(6):619-626. e623-614, 10.1111/j.1365-2982.2008.01260.x, 19220756.
43. Boeckxstaens G, Tytgat G, Wajs E, van Nueten L, de Ridder F, Meulemans A, Tack J. The influence of the novel 5-HT1A agonist R137696 on the proximal stomach function in healthy volunteers. Neurogastroenterol Motil 2006, 18(10):919-926. 10.1111/j.1365-2982.2006.00812.x, 16961695.
44. Talley N, Van Zanten S, Saez L, Dukes G, Perschy T, Heath M, Kleoudis C, Mangel A. A dose-ranging, placebo-controlled, randomized trial of alosetron in patients with functional dyspepsia. Aliment Pharmacol Ther 2001, 15(4):525-537. 10.1046/j.1365-2036.2001.00941.x, 11284782.
45. Maxton D, Morris J, Whorwell P. Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia?. Aliment Pharmacol Ther 1996, 10(4):595-599. 10.1046/j.1365-2036.1996.30172000.x, 8853764.
46. Kuo B, Camilleri M, Burton D, Viramontes B, McKinzie S, Thomforde G, O'Connor M, Brinkmann B. Effects of 5-HT(3) antagonism on postprandial gastric volume and symptoms in humans. Aliment Pharmacol Ther 2002, 16(2):225-233. 10.1046/j.1365-2036.2002.01144.x, 11860405.
47. Vakil N, Laine L, Talley N, Zakko S, Tack J, Chey W, Kralstein J, Earnest D, Ligozio G, Cohard-Radice M. Tegaserod treatment for dysmotility-like functional dyspepsia: results of two randomized, controlled trials. Am J Gastroenterol 2008, 103(8):1906-1919.
48. Colucci R, Blandizzi C, Bellini M, Ghisu N, Tonini M, Del Tacca M. The genetics of the serotonin transporter and irritable bowel syndrome. Trends Mol Med 2008, 14(7):295-304. 10.1016/j.molmed.2008.05.001, 18550438.
49. Mizuno T, Aoki M, Shimada Y, Inoue M, Nakaya K, Takahashi T, Itoyama Y, Kanazawa M, Utsumi A, Endo Y, Nomura T, Hiratsuka M, Mizugaki M, Goto J, Hongo M, Fukudo S. Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. J Psychosom Res 2006, 60(1):91-97. 10.1016/j.jpsychores.2005.06.068, 16380315.