Effect of the Antidepressant Venlafaxine in Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Trial

Clinical Gastroenterology and Hepatology

Volumn 6, Issue 7, 2008, Pages 746-752

  van Kerkhoven, Lieke A S ^a   Laheij, Robert J F ^a   Aparicio, Nives ^b   De Boer, Wink A ^c   Van Den Hazel, Sven ^d   Tan, Adriaan C I T L ^e   Witteman, Ben J M ^f   Jansen, Jan B M J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

^c BERNHOVEN HOSPITAL   (Netherlands)

^d SLINGELAND HOSPITAL   (Netherlands)

^e CANISIUS WILHELMINA HOSPITAL   (Netherlands)

^f GELDERSE VALLEI HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; VENLAFAXINE;

ADULT; ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DYSPEPSIA; FEMALE; GASTROINTESTINAL ENDOSCOPY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SYMPTOMATOLOGY; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANXIETY; CYCLOHEXANOLS; DEPRESSION; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; QUALITY OF LIFE;

EID: 45849126828     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2008.02.051     Document Type: Article

References (31)

1. Koloski N.A., Talley N.J., and Boyce P.M. Epidemiology and health care seeking in the functional GI disorders: a population-based study. Am J Gastroenterol 97 (2002) 2290-2299
2. Talley N.J., Silverstein M.D., Agreus L., et al. AGA technical review: evaluation of dyspepsia-American Gastroenterological Association. Gastroenterology 114 (1998) 582-595
3. Shaib Y., and El-Serag H.B. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol 99 (2004) 2210-2216
4. Wang W.H., Huang J.Q., Zheng G.F., et al. Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials. Clin Gastroenterol Hepatol 5 (2007) 178-185
5. Saad R.J., and Chey W.D. Review article: current and emerging therapies for functional dyspepsia. Aliment Pharmacol Ther 24 (2006) 475-492
6. Bouin M., Lupien F., Riberdy M., et al. Intolerance to visceral distension in functional dyspepsia or irritable bowel syndrome: an organ specific defect or a pan intestinal dysregulation?. Neurogastroenterol Motil 16 (2004) 311-314
7. Trimble K.C., Farouk R., Pryde A., et al. Heightened visceral sensation in functional gastrointestinal disease is not site-specific: evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 40 (1995) 1607-1613
8. Jones M.P., and Maganti K. Symptoms, gastric function, and psychosocial factors in functional dyspepsia. J Clin Gastroenterol 38 (2004) 866-872
9. Lanng C., Mortensen D., Friis M., et al. Gastrointestinal dysfunction in a community sample of subjects with symptoms of irritable bowel syndrome. Digestion 67 (2003) 14-19
10. Jackson J.L., O'Malley P.G., Tomkins G., et al. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 108 (2000) 65-72
11. Hojo M., Miwa H., Yokoyama T., et al. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol 40 (2005) 1036-1042
12. van Kerkhoven L.A., van Rossum L.G., van Oijen M.G., et al. Anxiety, depression and psychotropic medication use in patients with persistent upper and lower gastrointestinal symptoms. Aliment Pharmacol Ther 21 (2005) 1001-1006
13. van Kerkhoven L.A., van Rossum L.G., van Oijen M.G., et al. Upper gastrointestinal endoscopy does not reassure patients with functional dyspepsia. Endoscopy 38 (2006) 879-885
14. Bovenschen H.J., Janssen M.J., van Oijen M.G., et al. Evaluation of a gastrointestinal symptoms questionnaire. Dig Dis Sci 51 (2006) 1509-1515
15. Laheij R.J., van Rossum L.G., Krabbe P.F., et al. The impact of gastrointestinal symptoms on health status in patients with cardiovascular disease. Aliment Pharmacol Ther 17 (2003) 881-885
16. Johnston M., Pollard B., and Hennessey P. Construct validation of the hospital anxiety and depression scale with clinical populations. J Psychosom Res 48 (2000) 579-584
17. Herrmann C. International experiences with the Hospital Anxiety and Depression Scale: a review of validation data and clinical results. J Psychosom Res 42 (1997) 17-41
18. Crawford J.R., Henry J.D., Crombie C., et al. Normative data for the HADS from a large non-clinical sample. Br J Clin Psychol 40 (2001) 429-434
19. Greiner W., Weijnen T., Nieuwenhuizen M., et al. A single European currency for EQ-5D health states: results from a six-country study. Eur J Health Econ 4 (2003) 222-231
20. van Agt H.M., Essink-Bot M.L., Krabbe P.F., et al. Test-retest reliability of health state valuations collected with the EuroQol questionnaire. Soc Sci Med 39 (1994) 1537-1544
21. Trimble K.C., Farouk R., Pryde A., et al. Heightened visceral sensation in functional gastrointestinal disease is not site-specific: evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 40 (1995) 1607-1613
22. Thompson C.J., and Ernst E. Systematic review: herbal medicinal products for non-ulcer dyspepsia. Aliment Pharmacol Ther 16 (2002) 1689-1699
23. Soo S., Forman D., Delaney B.C., et al. A systematic review of psychological therapies for nonulcer dyspepsia. Am J Gastroenterol 99 (2004) 1817-1822
24. Laheij R.J., De Koning R.W., Horrevorts A.M., et al. Predominant symptom behavior in patients with persistent dyspepsia during treatment. J Clin Gastroenterol 38 (2004) 490-495
25. Meineche-Schmidt V., and Jorgensen T. Fluctuation in dyspepsia subgroups over time: a three-year follow-up of patients consulting general practice for dyspepsia. Dig Liver Dis 34 (2002) 332-338
26. Haag S., Senf W., Tagay S., et al. Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?. Aliment Pharmacol Ther 25 (2007) 973-986
27. Hu W.H., Wong W.M., Lam C.L., et al. Anxiety but not depression determines health care-seeking behaviour in Chinese patients with dyspepsia and irritable bowel syndrome: a population-based study. Aliment Pharmacol Ther 16 (2002) 2081-2088
28. Wellington K., and Perry C.M. Venlafaxine extended-release: a review of its use in the management of major depression. CNS Drugs 15 (2001) 643-669
29. Machado M., Iskedjian M., Ruiz I., et al. Remission, dropouts, and adverse drug reaction rates in major depressive disorder: a meta-analysis of head-to-head trials. Curr Med Res Opin 22 (2006) 1825-1837
30. Talley N.J., Locke G.R., Lahr B.D., et al. Predictors of the placebo response in functional dyspepsia. Aliment Pharmacol Ther 23 (2006) 923-936
31. Tack J., Broekaert D., Fischler B., et al. A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome. Gut 55 (2006) 1095-1103