The G-Protein β3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Oshima, Tadayuki ^a   Nakajima, Shigemi ^b   Yokoyama, Tetsuji ^c   Toyoshima, Fumihiko ^a   Sakurai, Jun ^a   Tanaka, Junji ^a   Tomita, Toshihiko ^a   Kim, Yongmin ^a   Hori, Kazutoshi ^a   Matsumoto, Takayuki ^a   Miwa, Hiroto ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b Social Insurance Shiga Hospital   (Japan)

^c NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; G PROTEIN BETA3 SUBUNIT; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; DYSPEPSIA; EPIGASTRIC PAIN; FEMALE; GENOTYPE; HOMOZYGOSITY; HUMAN; JAPANESE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATIENT CODING; PERIODIC MEDICAL EXAMINATION; PROTEIN POLYMORPHISM; RISK ASSESSMENT; ABDOMINAL PAIN; ASIAN; CASE CONTROL STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; JAPAN; MIDDLE AGED; PATHOPHYSIOLOGY; POSTPRANDIAL STATE; SINGLE NUCLEOTIDE POLYMORPHISM; SYNDROME;

ABDOMINAL PAIN; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DYSPEPSIA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HOMOZYGOTE; HUMANS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD; SYNDROME; YOUNG ADULT;

EID: 77349125419     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-13     Document Type: Article

References (25)

1. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology 2006, 130:1466-1479. 10.1053/j.gastro.2005.11.059, 16678560.
2. Trimble KC, Farouk R, Pryde A, Douglas S, Heading RC. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995, 40:1607-1613. 10.1007/BF02212678, 7648957.
3. Salet GA, Samsom M, Roelofs JM, van Berge Henegouwen GP, Smout AJ, Akkermans LM. Responses to gastric distension in functional dyspepsia. Gut 1998, 42:823-829. 1727131, 9691921.
4. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998, 115:1346-1352. 10.1016/S0016-5085(98)70012-5, 9834261.
5. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, Marengo M, Corinaldesi R. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996, 110:1036-1042. 10.1053/gast.1996.v110.pm8612991, 8612991.
6. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM. Neurohormonal factors in functional dyspepsia: insights on pathophysiological mechanisms. Gastroenterology 1991, 100:1311-1318.
7. Drossman DA, McKee DC, Sandler RS, Mitchell CM, Cramer EM, Lowman BC, Burger AL. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988, 95:701-708.
8. Locke GR, Weaver AL, Melton LJ, Talley NJ. Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case-control study. Am J Gastroenterol 2004, 99:350-357. 10.1111/j.1572-0241.2004.04043.x, 15046228.
9. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol 2006, 12:2661-2666.
10. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma AM, Ritz E, Wichmann HE, Jakobs KH, Horsthemke B. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998, 18:45-48. 10.1038/ng0198-45, 9425898.
11. Matsunaga T, Nagasumi K, Yamamura T, Gu N, Nishikino M, Ueda Y, Moritani T, Aoki N, Tsuda K, Yasuda K. Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals. Am J Hypertens 2005, 18:523-529. 10.1016/j.amjhyper.2004.11.008, 15831363.
12. Lin CN, Tsai SJ, Hong CJ. Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disorders. Neuropsychobiology 2001, 44:118-121. 10.1159/000054929, 11586049.
13. Bishop JR, Moline J, Ellingrod VL, Schultz SK, Clayton AH. Serotonin 2A-1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacology 2006, 31:2281-2288.
14. Holtmann G, Siffert W, Haag S, Mueller N, Langkafel M, Senf W, Zotz R, Talley NJ. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 2004, 126:971-979. 10.1053/j.gastro.2004.01.006, 15057736.
15. Camilleri CE, Carlson PJ, Camilleri M, Castillo EJ, Locke GR, Geno DM, Stephens DA, Zinsmeister AR, Urrutia R. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 2006, 101:581-592. 10.1111/j.1572-0241.2006.00481.x, 16464220.
16. Tahara T, Arisawa T, Shibata T, Wang F, Nakamura M, Sakata M, Hirata I, Nakano H. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. Dig Dis Sci 2008, 53:642-646. 10.1007/s10620-007-9923-0, 17717746.
17. van Lelyveld N, Linde JT, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil 2008, 20:767-773. 10.1111/j.1365-2982.2008.01102.x, 18331431.
18. Suwazono Y, Kobayashi E, Uetani M, Miura K, Morikawa Y, Ishizaki M, Kido T, Nakagawa H, Nogawa K. G-protein beta3 subunit variant C825T is a risk factor for hypertension in Japanese females--a prospective cohort study over 5 years. Ann Hum Genet 2006, 70:767-777. 10.1111/j.1469-1809.2006.00284.x, 17044851.
19. Shaib Y, El-Serag HB. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol 2004, 99:2210-2216. 10.1111/j.1572-0241.2004.40052.x, 15555004.
20. Locke GR, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000, 75:907-912. 10.4065/75.9.907, 10994826.
21. Morris-Yates A, Talley NJ, Boyce PM, Nandurkar S, Andrews G. Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol 1998, 93:1311-1317. 10.1111/j.1572-0241.1998.440_j.x, 9707057.
22. Zill P, Baghai TC, Zwanzger P, Schule C, Minov C, Riedel M, Neumeier K, Rupprecht R, Bondy B. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 2000, 11:1893-1897. 10.1097/00001756-200006260-00018, 10884039.
23. de Vries DR, ter Linde JJ, van Herwaarden MA, Smout AJ, Samsom M. Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3). Am J Gastroenterol 2009, 104:281-285. 10.1038/ajg.2008.139, 19174793.
24. Locke GR. Prevalence, incidence and natural history of dyspepsia and functional dyspepsia. Baillieres Clin Gastroenterol 1998, 12:435-442. 10.1016/S0950-3528(98)90016-1, 9890080.
25. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 1992, 102:1259-1268.