High dna methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Siegmund, Kimberly D ^a   Marjoram, Paul ^a   Tavaré, Simon ^b,c   Shibata, Darryl ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER PATIENT; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MISMATCH REPAIR; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPIC PLASTICITY; POPULATION GENETICS; SELECTIVE SWEEP; XENOGRAFT; ANIMAL; COLORECTAL TUMOR; DRUG SCREENING; GENETICS; IN VITRO STUDY; PATHOLOGY;

ANIMALS; COLORECTAL NEOPLASMS; DNA METHYLATION; HUMANS; MICE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79959599767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021657     Document Type: Article

References (30)

1. Nowell PC, (1976) The clonal evolution of tumor cell populations. Science 194: 23-28.
2. Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105: 4283-4288.
3. Bernards R, Weinberg RA, (2002) A progression puzzle. Nature 418: 823.
4. Marusyk A, Polyak K, (2010) Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 1805: 105-117.
5. Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, et al. (2010) Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 18: 510-523.
6. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
7. Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, et al. (2010) A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463: 191-196.
8. Charlesworth B, Morgan MT, Charlesworth D, (1993) The effect of deleterious mutations on neutral molecular variation. Genetics 134: 1289-1303.
9. Kimura M, Ohta T, (1969) The average number of generations until fixation of a mutant gene in a finite population. Genetics 61: 763-771.
10. Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99: 3076-3080.
11. Shibata D, Tavaré S, (2006) Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle 5: 610-614.
12. Siegmund KD, Marjoram P, Woo YJ, Tavaré S, Shibata D, (2009) Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci USA 106: 4828-4833.
13. Drewinko B, Romshdahl MM, Vang LY, Ahearn MJ, Trujillo JM, (1976) Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line. Cancer Res 36: 467-475.
14. Hill RP, Perris R, (2007) "Destemming" cancer stem cells. J Natl Cancer Inst 99: 1435-1440.
15. Hong YJ, Marjoram P, Shibata D, Siegmund KD, (2010) Using DNA methylation patterns to infer tumor ancestry. PLoS One 5: e12002.
16. Bhattacharyya NP, Skandalis A, Ganesh A, Groden J, Meuth M, (1994) Mutator phenotypes in human colorectal carcinoma cell lines. Proc Natl Acad Sci USA 91: 6319-6323.
17. Hoeijmakers JH, (2009) DNA damage, aging, and cancer. N Engl J Med 361: 1475-1485.
18. Ding L, Ellis MJ, Li S, Larson DE, Chen K, et al. (2010) Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464: 999-1005.
19. Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, et al. (2010) Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci USA 107: 18545-18550.
20. Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, et al. (2008) Systemic spread is an early step in breast cancer. Cancer Cell 13: 58-68.
21. Dy GK, Adjei AA, (2008) Systemic cancer therapy: evolution over the last 60 years. Cancer 113: 1857-1887.
22. Felsenstein J, (1974) The evolutionary advantage of recombination. Genetics 78: 737-756.
23. Sinicrope FA, Rego RL, Foster N, Sargent DJ, Windschitl HE, et al. (2006) Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. Am J Gastroenterol 101: 2818-2825.
24. Norton LA, (1988) Gompertzian model of human breast cancer growth. Cancer Res 48: 7067-7071.
25. Umar A, Boyer JC, Thomas DC, Nguyen DC, Risinger JI, et al. (1994) Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 269: 14367-14370.
26. Drescher KM, Sharma P, Lynch HT, (2010) Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients. Clin Dev Immunol 2010 170432.
27. Shibata D, (2011) Mutation and epigenetic molecular clocks in cancer. Carcinogenesis 32: 123-128.
28. Navin N, Kendall J, Troge J, Andrews P, Rodgers L, et al. (2011) Tumour evolution inferred by single-cell sequencing. Nature 472: 90-94.
29. Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, et al. (2010) The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467: 1109-1113.
30. Yachida S, Jones S, Bozic I, Antal T, Leary R, et al. (2010) Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467: 1114-1117.