Synergistic effects of glutathione and vitamin E on ROS mediated ethanol toxicity in isolated rat hepatocytes

Asian Journal of Biochemistry

Volumn 6, Issue 4, 2011, Pages 347-356

  Gupta, Ankush ^a   Singh, Aangram ^a   Jamal, Sarrukh ^a   Nath, Som ^b   Mehrotra, Sudhir ^b   Sharma, Bechan ^c  

^a DR RAM MANOHAR LOHIA AVADH UNIVERSITY   (India)

^b UNIVERSITY OF LUCKNOW   (India)

^c UNIVERSITY OF ALLAHABAD   (India)

Author keywords

Antioxidants; Ethanol; Hepatotoxicity; Oxidative stress; Rotenone

Indexed keywords

RATTUS;

EID: 79959590875     PISSN: 18159923     EISSN: None     Source Type: Journal    
DOI: 10.3923/ajb.2011.347.356     Document Type: Article

References (44)

1. Abdel-Hamid, N.M., L.M. Faddah, M.A. Al-Rehany and A.A. Awad, 2008. Oxidative stress in the liver of diabetic rats treated with a combination of sildenafil citrate and a free radical scavenger. Asian J. Biochem., 3: 32-37.
2. Adachi, M. and H. Ishii, 2002. Role of mitochondria in alcoholic liver injury. Free Radic. Biol. Med., 32: 487-491.
3. Adachi, M., H. Higuchi, S. Miura, T. Azuma and S. Inokuchi et al., 2004. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Am. J. Physiol, 287: 695-705.
4. Bailey, S.M, E.C. Pietsch and C.C. Cunningham, 1999. Ethanol stimulates the production of reactive oxygen species at mitochondria complex I and III. Free Radic. Biol. Med, 27: 891-900.
5. Bansal, A.K, M. Bansal, G. Soni and D. Bhatnagar, 2005. Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem. Biol. Interact, 156: 101-111.
6. Brand, M.D, C. Affourtit, T.C. Esteves, K. Green and A.J. Lambert et al, 2004. Mitochondrial superoxide: Production, biological effects and activation of uncoupling proteins. Free Radic. Biol. Med, 37: 755-767.
7. Cadenas, E. and K.J. Davies, 2000. Mitochondrial free radical generation, oxidative stress and aging. Free Radic. Biol. Med, 29: 222-230.
8. Caetano R, P.A.C. Vaeth, S. Ramisetty-Milder and L.A. Rodriguez, 2009. The Hispanic Americans baseline alcohol survey: Alcoholic beverage preference across Hispanic national groups. Alcohol. Clin. Exp. Res, 33: 150-159.
9. Cunningham, C.C, W.B. Coleman and P.I. Spach, 1990. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol, 25: 127-136.
10. Draper, H.H. and M. Hadley, 1990. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol, 186: 421-431.
11. Duke, R.C, D.M. Ojcius and J.D.E. Young, 1996. Cell suicide in health and disease. Scientific Am, 275: 79-87.
12. Fukami, J, T. Shishido, K. Fukunaga and J.E. Casida, 1996. Oxidative metabolism of rotenone in mammals, fish and insects and its relation to selective toxicity. J. Agric. Food Chem, 17: 1217-1226.
13. Griffith, O.W, 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinlypyridine. Anal. Biochem, 106: 207-212.
14. Guerri, C. and S. Grisolia, 1980. Influence of prolonged ethanol intake on the level and turn of alcohol and aldehyde dehydrogenase and glutathione. Adv. Exp. Med. Biol, 126: 365-384.
15. Hao, W, Z. Su, B. Liu, K. Zhang and H. Yang et al., 2004. Drinking and drinking patterns and health status in the general population of five areas of China. Alcohol Alcohol, 39: 43-52.
16. Higuchi, H, M. Adachi, S. Miura, G.J. Gores and H. Ishii, 2001. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology, 34: 320-328.
17. Jordao AA. P.G. Chiarello Jr., M.R. Arantes, M.S. Meirelles and H. Vannucchi, 2004. Effect of an acute dose of ethanol on lipid peroxidation in rats: Action of vitamin E. Food Chem. Toxicol, 42: 459-464.
18. Koch, O, S. Farre, M.E De Leo, P. Palozza and B. Palazzotti et al., 2000. Regulation of manganese superoxide dismutase (MnSOD) in chronic experimental alcoholism: Effects of vitamin E-supplemented and -deficient diets. Alcohol Alcohol, 35: 159-163.
19. Kypri, K, M.J. Paschall, J. Langley, J. Baxter, M. Cashell-Smith and B. Bourdeau, 2009. Drinking and alcohol-related harmamong New Zealand university students: Findings from a national Web-based survey. Alcohol Clin. Exp. Res, 33: 307-314.
20. Leedle, R.A. and S.D. Aust, 1990. The effect of glutathione on the vitamin E requirement for inhibition of liver microsomal lipid peroxidation. Lipids, 25: 241-245.
21. Li, J., B.A. French, P. Fu, F. Bardag-Gorce and S.W. French, 2004. Catecholamines are involved in the metabolism of the urinary alcohol level cycle in rats fed ethanol intragastric ally at a constant rate. Life Sci., 75: 3043-3051.
22. Li, J., B.A. French, P. Fu, F. Bardag-Gorce and S.W. French, 2003. Mechanism of the alcohol cyclic pattern: Role of catecholamines. Am. J. Physiol. Gastroenterol. Liver Physiol., 285: 442-448.
23. Machlin, L.J., 1980. Vitamin E: A Comprehensive Treatise. Marcel Dekker, New York, USA., ISBN-13: 9780824768423, pp: 660.
24. Mahmoud, A.H., 2006. Changes in proteins, total lipids and phospholipids in mice liver treated with Urticapilulifera extracts. Asian J. Biochem., 1: 189-196.
25. Mahmoud, A.H., H.M. Motawa, H.E. Wahba and A.Y. Ebrahim, 2006. Study of some antioxidant parameters in mice livers affected with Urtica pilulifera extracts. Asian J. Biochem., 1: 67-74.
26. Marjani, A., M. Abolvahab and G.A. Berdie, 2007. Alterations in plasma lipid peroxidation and erythrocyte superoxide dismutase and glutathione peroxidase enzyme activities during storage of blood. Asian J. Biochem., 2: 118-123.
27. Marks, D.B., A.D. Marks and CM. Smith, 1996. Oxygen Metabolism and Toxicity, in Basic Medical Biochemistry: A Clinical Approach. Williams and Wilkins, Baltimore MD, pp: 327-340.
28. Molina-Jimenez, M.F., M.I. Sanchez-Reus, D. Andres, M. Cascales and J. Benedi, 2004. Neuroprotective effect of fraxetin and myricetin against rotenone induced apoptosis in neuroblastoma cells. Brain Res., 1009: 9-16.
29. Morel, Y. and R. Barouki, 1999. Repression of gene expression by oxidative stress. Biochem. J, 342: 481-496.
30. Mosmann, T., 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Method, 65: 55-63.
31. Nagy, L.E., 2004. Molecular aspects of alcohol metabolism: Transcription factors involved in early ethanol-induced liver injury. Ann. Rev. Nutr., 24: 55-78.
32. Ray, D.E., 1991. Pesticides Derived from Plants and other Organisms. 13.2 Pyrethrum and Related Compounds. In: Handbook of Pesticide Toxicology, Hayes, Jr. W.J. and Jr. E.R. Laws (Eds.). Vol. 2. Academic Press, San Diego, California, pp: 585-636.
33. Sakka, N., H. Sawada, Y. Izumi, T. Kume and H. Katsuki et al., 2003. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport, 14: 2425-2428.
34. Seglen, P.O., 1976. Preparation of isolated rat liver cells. Methods Cell Biol., 13: 29-83.
35. Serdevi, M., G. Chandramohan and K.V. Pugalendi, 2007. Protective effect of Solanum surattensi leaf extracts on blood glucose, oxidative stress and hepatic marker enzymes in STZ-diabetic rats. Asian J. Biochem., 2: 247-255.
36. Sherer, T.B., R. Betarbet, CM. Testa, B.B. Seo and J.R. Richardson et al., 2003. Mechanism of toxicity in rotenone models of Parkinsons disease. J. Neurosci., 23: 10756-10764.
37. Slater, A.F., C. Stefan, I. Nobel, D.J. van den Dobbelsteen and S. Orrenius, 1995. Signalling mechanism and oxidative stress in apoptosis. Toxicol. Lett., 82/83: 149-153.
38. Slater, T.F., 1984. Free-radical mechanisms in tissue injury. J. Biochem., 222: 1-15.
39. Sun, A.Y., M. Ingelman-Sundberg, N. Neve, H. Matsumoto, Y. Nishitani and Y. Mmowa, 2001. Ethanol and oxidative stress. Ale Clin. Exp. Res., 25: 237-243.
40. Turkdogan, M.K, Z. Agaoglu, Z. Yener, R. Sekeroglu, H.A. Akkan and M.E. Avci, 2001. The role of antioxidant vitamins (C and E), selenium and Nigella saliva in the prevention of liver fibrosis and cirrhosis in rabbits: New hopes. Dtsch. Tierarztl. Wochenschr, 108: 71-73.
41. Turrens, J.F. and A. Boveris, 1980. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J, 191: 421-427.
42. Turrens, J.F, 2003. Mitochondrial formation of reactive oxygen species. J. Physiol, 552: 335-344.
43. Wallin, B, B. Rosengren, H.G. Shertzer and G. Camejo, 1993.Lipoprotien oxidation and measurment of thiobarbituric acid reacting substances formation in a single microtiter plate: Its use for evaluation of antioxidants. Anal. Biochem, 208: 10-15.
44. Yu, B.P, 1994. Cellular defenses against damage from reactive oxygen species. Physiol. Rev, 74: 139-162.