Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

Hepatology

Volumn 54, Issue 1, 2011, Pages 229-239

  Ji, Cheng ^a   Kaplowitz, Neil ^a   Lau, Mo Yin ^a   Kao, Eddy ^a   Petrovic, Lydia M ^a   Lee, Amy S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; ADIPOPHILIN; ALANINE AMINOTRANSFERASE; ALCOHOL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH DIFFERENTIATION FACTOR 15; NUCLEAR PROTEIN; NUCLEAR PROTEIN 1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL VIABILITY; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; HOMEOSTASIS; LIPID DIET; LIPID STORAGE; LIPOGENESIS; LIVER CELL; LIVER DISEASE; LIVER FIBROSIS; MALE; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN URINE LEVEL; STRESS; UNFOLDED PROTEIN RESPONSE;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; DIET; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; ENDOPLASMIC RETICULUM; ETHANOL; FATTY LIVER; HEAT-SHOCK PROTEINS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; LIVER CIRRHOSIS; LIVER DISEASES; MALE; MICE; MICE, TRANSGENIC; PROTEIN UNFOLDING;

EID: 79959544189     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24368     Document Type: Article

References (26)

1. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140: 900-917.
2. Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-789.
3. Ron D, Hubbard SR. How IRE1 reacts to ER stress. Cell 2008; 132: 24-26.
4. Ji C. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol 2008; 23( Suppl 1): S16-S24.
5. Ji C, Kaplowitz N. ER stress signaling in hepatic injury. In: Dufour JF, Clavien P-A, eds. Signaling Pathways in Liver Diseases. 2nd ed. Heidelberg, Germany: Springer-Verlag; 2010: 287-304.
6. Pfaffenbach KT, Lee AS. The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol 2010; 23: 1-7.
7. Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009; 119: 1201-1215.
8. Luo S, Mao C, Lee B, Lee AS. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 2006; 26: 5688-5697.
9. Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci U S A 2008; 105: 19444-19449.
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting serum glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
11. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003; 124: 1488-1499.
12. Shinohara M, Ji C, Kaplowitz N. Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. HEPATOLOGY 2010; 51: 796-805.
13. Samet JH, Horton NJ, Meli S, Freedberg KA, Palepu A. Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcohol Clin Exp Res 2004; 28: 572-577.
14. Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008; 322: 1490-1494.
15. Gülow K, Bienert D, Haas IG. BiP is feed-back regulated by control of protein translation efficiency. J Cell Sci 2002; 115( pt 11): 2443-2452.
16. Araki K, Imaizumi T, Okuyama K, Oike Y, Yamamura K. Efficiency of recombination by Cre transient expression in embryonic stem cells: comparison of various promoters. J Biochem 1997; 122: 977-982.
17. Suzuki T, Lu J, Zahed M, Kita K, Suzuki N. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Arch Biochem Biophys 2007; 468: 1-14.
18. Sozio MS, Liangpunsakul S, Crabb D. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin Liver Dis 2010; 30: 378-390.
19. Imai Y, Varela GM, Jackson MB, Graham MJ, Crooke RM, Ahima RS. Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide. Gastroenterology 2007; 132: 1947-1954.
20. Zhou Y, Jiang L, Rui L. Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. J Biol Chem 2009; 284: 11152-11159.
21. Zhou H, Gurley EC, Jarujaron S, Ding H, Fang Y, Xu Z, et al. HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes. Am J Physiol Gastrointest Liver Physiol 2006; 291: G1071-G1080.
22. Tazi KA, Bieche I, Paradis V, Guichard C, Laurendeau I, Dargere D, et al. In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats. J Hepatol 2007; 46: 1075-1088.
23. Goruppi S, Iovanna JL. Stress-inducible protein p8 is involved in several physiological and pathological processes. J Biol Chem 2010; 285: 1577-1581.
24. Oh-Hashi K, Koga H, Ikeda S, Shimada K, Hirata Y, Kiuchi K. CRELD2 is a novel endoplasmic reticulum stress-inducible gene. Biochem Biophys Res Commun 2009; 387: 504-510.
25. Groisman B, Shenkman M, Ron E, Lederkremer GZ. Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J Biol Chem 2011; 286: 1292-1300.
26. Hsiao EC, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, Lee SJ. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol 2000; 20: 3742-3751.