Synthesis and mechanistic studies of a mitomycin dimer containing an eight-membered cyclic disulfide

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 4004-4013

  Park, Hyun Jung ^a   Kim, Jae Jin ^a   Kim, Hyoung Rae ^a   Lee, Eun Kyung ^a   Kim, Eun Sook ^a   Jeong, Choon Sik ^a   Moon, Aree ^a   Lee, Sang Hyup ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Cyclic disulfide; DNA interstrand cross link; Mitomycin dimer; Nucleophilic activation

Indexed keywords

7 N,7' N' (1INCH,2INCH DITHIOCANYL 3INCH,8 DIMETHYLENYL)BISMITOMYCIN C; ALKYLATING AGENT; DISULFIDE; DNA; NUCLEOPHILE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DNA BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; METHANOLYSIS;

ALKYLATING AGENTS; DIMERIZATION; DISULFIDES; DNA; MITOMYCIN; MITOMYCINS;

EID: 79959510070     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.020     Document Type: Article

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