KW-2149 (7-N-[2-[γ-L-glutamylamino]ethyldithio-ethyl] mitomycin C): DNA interactions and drug uptake following serum activation

Biochemical Pharmacology

Volumn 55, Issue 11, 1998, Pages 1777-1783

  McAdam, Simon R ^a   Knox, Richard J ^b   Hartley, John A ^a   Masters, John R W ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c INSTITUTE OF UROLOGY AND NEPHROLOGY   (United Kingdom)

Author keywords

Anticancer agent; DNA damage; Drug metabolism; Drug uptake; KW 2149; Mitomycin C; Serum

Indexed keywords

7 N [2 [[2 (GAMMA GLUTAMYLAMINO)ETHYL]DITHIO]ETHYL]MITOMYCIN C; MITOMYCIN C;

ARTICLE; COMPETITIVE INHIBITION; DNA ADDUCT; DNA CROSS LINKING; DNA SEQUENCE; DRUG ACTIVATION; DRUG BINDING; DRUG DNA INTERACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; HUMAN CELL; PASSIVE TRANSPORT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL FACTORS; CROSS-LINKING REAGENTS; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE; HUMANS; MITOMYCIN; MITOMYCINS; SEQUENCE ANALYSIS, DNA; TAQ POLYMERASE; TUMOR CELLS, CULTURED;

EID: 0032101083     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00603-5     Document Type: Article

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