-
1
-
-
25444482801
-
Speeding disease gene discovery by sequence based candidate prioritization
-
Adie, E.A. et al. (2005) Speeding disease gene discovery by sequence based candidate prioritization. BMC Bioinformatics, 6, 55.
-
(2005)
BMC Bioinformatics
, vol.6
, pp. 55
-
-
Adie, E.A.1
-
2
-
-
33646568805
-
Gene prioritization through genomic data fusion
-
Aerts, S. et al. (2006) Gene prioritization through genomic data fusion. Nat. Biotechnol., 24, 537-544.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 537-544
-
-
Aerts, S.1
-
3
-
-
78649976005
-
An integrated approach to uncover drivers of cancer
-
Akavia, U.D. et al. (2010) An integrated approach to uncover drivers of cancer. Cell, 143, 1005-1017.
-
(2010)
Cell
, vol.143
, pp. 1005-1017
-
-
Akavia, U.D.1
-
4
-
-
0032157143
-
Beyond the flow decomposition barrier
-
Andrew, V. and Goldberg, S.R. (1998) Beyond the flow decomposition barrier. J. ACM, 45, 783-797.
-
(1998)
J. ACM
, vol.45
, pp. 783-797
-
-
Andrew, V.1
Goldberg, S.R.2
-
5
-
-
0037373275
-
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
-
Botstein, D. and Risch, N. (2003) Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet., 33, 228-237.
-
(2003)
Nat. Genet.
, vol.33
, pp. 228-237
-
-
Botstein, D.1
Risch, N.2
-
6
-
-
45549092721
-
Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport
-
Chiaverini, C. et al. (2008) Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport. J. Biol. Chem., 283, 12635-12642.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 12635-12642
-
-
Chiaverini, C.1
-
7
-
-
77950405093
-
Genome-wide association study of CNVs in 16 000 cases of eight common diseases and 3000 shared controls
-
Craddock, N. et al. (2010) Genome-wide association study of CNVs in 16 000 cases of eight common diseases and 3000 shared controls. Nature, 464, 713-720.
-
(2010)
Nature
, vol.464
, pp. 713-720
-
-
Craddock, N.1
-
8
-
-
65549138481
-
Identifying disease-specific genes based on their topological significance in protein networks
-
Dezso, Z. et al. (2009) Identifying disease-specific genes based on their topological significance in protein networks. BMC Syst. Biol., 3, 36.
-
(2009)
BMC Syst. Biol.
, vol.3
, pp. 36
-
-
Dezso, Z.1
-
9
-
-
33646884801
-
Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes
-
Franke, L. et al. (2006) Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. Am. J. Hum. Genet., 78, 1011-1025.
-
(2006)
Am. J. Hum. Genet.
, vol.78
, pp. 1011-1025
-
-
Franke, L.1
-
10
-
-
0037580196
-
A similarity-based method for genomewide prediction of disease-relevant human genes
-
Freudenberg, J. and Propping, P. (2002) A similarity-based method for genomewide prediction of disease-relevant human genes. Bioinformatics, 18 (Suppl. 2), S110-S115.
-
(2002)
Bioinformatics
, vol.18
, Issue.SUPPL. 2
-
-
Freudenberg, J.1
Propping, P.2
-
11
-
-
34249850089
-
Acomputational system to select candidate genes for complex human traits
-
Gaulton, K.J. et al. (2007)Acomputational system to select candidate genes for complex human traits. Bioinformatics, 23, 1132-1140.
-
(2007)
Bioinformatics
, vol.23
, pp. 1132-1140
-
-
Gaulton, K.J.1
-
12
-
-
0037146578
-
Finding genes that underlie complex traits
-
Glazier, A.M. et al. (2002) Finding genes that underlie complex traits. Science, 298, 2345-2349.
-
(2002)
Science
, vol.298
, pp. 2345-2349
-
-
Glazier, A.M.1
-
13
-
-
34547140875
-
The human disease network
-
Goh, K.I. et al. (2007) The human disease network. Proc. Natl Acad. Sci. USA, 104, 8685-8690.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
-
14
-
-
65949107547
-
Common genetic variation and human traits
-
Goldstein, D.B. (2009) Common genetic variation and human traits. N. Engl. J. Med., 360, 1696-1698.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1696-1698
-
-
Goldstein, D.B.1
-
15
-
-
52949087576
-
Agenomewide functional network for the laboratory mouse
-
Guan, Y. et al. (2008)Agenomewide functional network for the laboratory mouse. PLoS Comput. Biol., 4, e1000165.
-
(2008)
PLoS Comput. Biol.
, vol.4
-
-
Guan, Y.1
-
16
-
-
56249119207
-
Novel MITF targets identified using a two-step DNAmicroarray strategy
-
Hoek, K.S. et al. (2008) Novel MITF targets identified using a two-step DNAmicroarray strategy. Pigment Cell Melanoma Res., 21, 665-676.
-
(2008)
Pigment Cell Melanoma Res.
, vol.21
, pp. 665-676
-
-
Hoek, K.S.1
-
17
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang da, W. et al. (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc., 4, 44-57.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 44-57
-
-
Huang da, W.1
-
18
-
-
77955462823
-
KLF6 gene and early melanoma development in a collagen I-rich extracellular environment
-
Huh, S.J. et al. (2010) KLF6 gene and early melanoma development in a collagen I-rich extracellular environment. J. Natl Cancer Inst., 102, 1131-1147.
-
(2010)
J. Natl Cancer Inst.
, vol.102
, pp. 1131-1147
-
-
Huh, S.J.1
-
19
-
-
33748334340
-
Rab7 and Rab27a control two motor protein activities involved in melanosomal transport
-
Jordens, I. et al. (2006) Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Pigment Cell Res., 19, 412-423.
-
(2006)
Pigment Cell Res.
, vol.19
, pp. 412-423
-
-
Jordens, I.1
-
20
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Kan, Z. et al. (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 466, 869-873.
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
-
21
-
-
79251493015
-
A human genome structural variation sequencing resource reveals insights into mutational mechanisms
-
Kidd, J.M. et al. (2010) A human genome structural variation sequencing resource reveals insights into mutational mechanisms. Cell, 143, 837-847.
-
(2010)
Cell
, vol.143
, pp. 837-847
-
-
Kidd, J.M.1
-
22
-
-
41549139527
-
Walking the interactome for prioritization of candidate disease genes
-
Kohler, S. et al. (2008) Walking the interactome for prioritization of candidate disease genes. Am. J. Hum. Genet., 82, 949-958.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 949-958
-
-
Kohler, S.1
-
23
-
-
33947095027
-
A human phenome-interactome network of protein complexes implicated in genetic disorders
-
Lage, K. et al. (2007) A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat. Biotechnol., 25, 309-316.
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 309-316
-
-
Lage, K.1
-
24
-
-
0028090414
-
Genetic dissection of complex traits
-
Lander, E.S. and Schork,N.J. (1994) Genetic dissection of complex traits. Science, 265, 2037-2048.
-
(1994)
Science
, vol.265
, pp. 2037-2048
-
-
Lander, E.S.1
Schork, N.J.2
-
25
-
-
33747882661
-
MITF: master regulator ofmelanocyte development and melanoma oncogene
-
Levy, C. et al. (2006) MITF: master regulator ofmelanocyte development and melanoma oncogene. Trends Mol. Med., 12, 406-414.
-
(2006)
Trends Mol. Med.
, vol.12
, pp. 406-414
-
-
Levy, C.1
-
26
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
Ley, T.J. et al. (2008) DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature, 456, 66-72.
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
-
27
-
-
77952808324
-
Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network
-
Li, Y. and Patra, J.C. (2010) Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics, 26, 1219-1224.
-
(2010)
Bioinformatics
, vol.26
, pp. 1219-1224
-
-
Li, Y.1
Patra, J.C.2
-
28
-
-
33646687963
-
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
-
Lim, J. et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell, 125, 801-814.
-
(2006)
Cell
, vol.125
, pp. 801-814
-
-
Lim, J.1
-
29
-
-
38849166096
-
Modeling genomic diversity and tumor dependency in malignant melanoma
-
Lin, W.M. et al. (2008) Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res., 68, 664-673.
-
(2008)
Cancer Res.
, vol.68
, pp. 664-673
-
-
Lin, W.M.1
-
30
-
-
57049158206
-
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity
-
Managbanag, J.R. et al. (2008) Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One, 3, e3802.
-
(2008)
PLoS One
, vol.3
-
-
Managbanag, J.R.1
-
31
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio, T.A. et al. (2009) Finding the missing heritability of complex diseases. Nature, 461, 747-753.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
-
32
-
-
77951702343
-
Genetic heterogeneity in human disease
-
McClellan, J. and King, M.C. (2010) Genetic heterogeneity in human disease. Cell, 141, 210-217.
-
(2010)
Cell
, vol.141
, pp. 210-217
-
-
McClellan, J.1
King, M.C.2
-
33
-
-
33845545435
-
The modular nature of genetic diseases
-
Oti, M. and Brunner, H.G. (2007) The modular nature of genetic diseases. Clin. Genet., 71, 1-11.
-
(2007)
Clin. Genet.
, vol.71
, pp. 1-11
-
-
Oti, M.1
Brunner, H.G.2
-
34
-
-
33747035889
-
Predicting disease genes using protein-protein interactions
-
Oti, M. et al. (2006) Predicting disease genes using protein-protein interactions. J. Med. Genet., 43, 691-698.
-
(2006)
J. Med. Genet.
, vol.43
, pp. 691-698
-
-
Oti, M.1
-
35
-
-
0036649742
-
Association of genes to genetically inherited diseases using data mining
-
Perez-Iratxeta, C. et al. (2002) Association of genes to genetically inherited diseases using data mining. Nat. Genet., 31, 316-319.
-
(2002)
Nat. Genet.
, vol.31
, pp. 316-319
-
-
Perez-Iratxeta, C.1
-
36
-
-
10744224197
-
Development of human protein reference database as an initial platform for approaching systems biology in humans
-
Peri, S. et al. (2003) Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res., 13, 2363-2371.
-
(2003)
Genome Res.
, vol.13
, pp. 2363-2371
-
-
Peri, S.1
-
37
-
-
0037255084
-
Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
-
Safran, M. et al. (2003) Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE. Nucleic Acids Res., 31, 142-146.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 142-146
-
-
Safran, M.1
-
38
-
-
77953330045
-
JISTIC: identification of significant targets in cancer
-
Sanchez-Garcia, F. et al. (2010) JISTIC: identification of significant targets in cancer. BMC Bioinformatics, 11, 189.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 189
-
-
Sanchez-Garcia, F.1
-
39
-
-
77955460021
-
The ups and downs of transcription factors in melanoma
-
Santiago-Walker, A. and Herlyn, M. (2010) The ups and downs of transcription factors in melanoma. J. Natl Cancer Inst., 102, 1103-1104.
-
(2010)
J. Natl Cancer Inst.
, vol.102
, pp. 1103-1104
-
-
Santiago-Walker, A.1
Herlyn, M.2
-
40
-
-
70249134919
-
Molecular networks as sensors and drivers of common human diseases
-
Schadt, E.E. (2009) Molecular networks as sensors and drivers of common human diseases. Nature, 461, 218-223.
-
(2009)
Nature
, vol.461
, pp. 218-223
-
-
Schadt, E.E.1
-
41
-
-
33947252154
-
Network-based prediction of protein function
-
Sharan, R. et al. (2007) Network-based prediction of protein function. Mol. Syst. Biol., 3, 88.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 88
-
-
Sharan, R.1
-
42
-
-
61649083057
-
BioMart-biological queries made easy
-
Smedley, D. et al. (2009) BioMart-biological queries made easy. BMC Genomics, 10, 22.
-
(2009)
BMC Genomics
, vol.10
, pp. 22
-
-
Smedley, D.1
-
43
-
-
64749094310
-
The cancer genome
-
Stratton, M.R. et al. (2009) The cancer genome. Nature, 458, 719-724.
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
-
44
-
-
78649682830
-
Acomparative study of cancer proteins in the human protein-protein interaction network
-
Sun, J. and Zhao, Z. (2010)Acomparative study of cancer proteins in the human protein-protein interaction network. BMC Genomics, 11 (Suppl. 3), S5.
-
(2010)
BMC Genomics
, vol.11
, Issue.SUPPL. 3
-
-
Sun, J.1
Zhao, Z.2
-
45
-
-
59849125136
-
Dynamic modularity in protein interaction networks predicts breast cancer outcome
-
Taylor, I.W. et al. (2009) Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat. Biotechnol., 27, 199-204.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 199-204
-
-
Taylor, I.W.1
-
46
-
-
1542787787
-
POCUS: mining genomic sequence annotation to predict disease genes
-
Turner, F.S. et al. (2003) POCUS: mining genomic sequence annotation to predict disease genes. Genome Biol., 4, R75.
-
(2003)
Genome Biol.
, vol.4
-
-
Turner, F.S.1
-
47
-
-
33646058032
-
A text-mining analysis of the human phenome
-
van Driel, M.A. et al. (2006) A text-mining analysis of the human phenome. Eur. J. Hum. Genet., 14, 535-542.
-
(2006)
Eur. J. Hum. Genet.
, vol.14
, pp. 535-542
-
-
van Driel, M.A.1
-
48
-
-
0037265647
-
A new web-based data mining tool for the identification of candidate genes for human genetic disorders
-
van Driel, M.A. et al. (2003) A new web-based data mining tool for the identification of candidate genes for human genetic disorders. Eur. J. Hum. Genet., 11, 57-63.
-
(2003)
Eur. J. Hum. Genet.
, vol.11
, pp. 57-63
-
-
van Driel, M.A.1
-
49
-
-
76749134818
-
Associating genes and protein complexes with disease via network propagation
-
Vanunu, O. et al. (2010) Associating genes and protein complexes with disease via network propagation. PLoS Comput. Biol., 6, e1000641.
-
(2010)
PLoS Comput. Biol.
, vol.6
-
-
Vanunu, O.1
-
50
-
-
36248936497
-
The road to modularity
-
Wagner, G.P. et al. (2007) The road to modularity. Nat. Rev. Genet., 8, 921-931.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 921-931
-
-
Wagner, G.P.1
-
51
-
-
70249108504
-
Genome-wide identification of post-translational modulators of transcription factor activity in human B cells
-
Wang, K. et al. (2009) Genome-wide identification of post-translational modulators of transcription factor activity in human B cells. Nat. Biotechnol., 27, 829-839.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 829-839
-
-
Wang, K.1
-
52
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood, L.D. et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science, 318, 1108-1113.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
-
53
-
-
43249114206
-
Network-based global inference of human disease genes
-
Wu, X. et al. (2008) Network-based global inference of human disease genes. Mol. Syst. Biol., 4, 189.
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 189
-
-
Wu, X.1
-
54
-
-
58049220319
-
Align human interactome with phenome to identify causative genes and networks underlying disease families
-
Wu, X. et al. (2009) Align human interactome with phenome to identify causative genes and networks underlying disease families. Bioinformatics, 25, 98-104.
-
(2009)
Bioinformatics
, vol.25
, pp. 98-104
-
-
Wu, X.1
|