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Volumn 11, Issue 6, 2011, Pages 508-518

New and old monoclonal antibodies for the treatment of chronic lymphocytic leukemia

Author keywords

CD20; CD23; CD37; CD40; CD52; Chronic lymphocytic leukemia; Monoclonal antibodies

Indexed keywords

ALEMTUZUMAB; APOLIZUMAB; DACETUMUMAB; DACETUZUMAB; EPRATUZUMAB; FLUDARABINE; GALIXIMAB; LUCATUMUMAB; LUMILIXIMAB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD20; OBINUTUZUMAB; OFATUMUMAB; RITUXIMAB; RO 5072759; TOSITUMOMAB; TRU 016; TRU 106; UNCLASSIFIED DRUG;

EID: 79959474980     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955711795843374     Document Type: Article
Times cited : (2)

References (116)
  • 5
    • 40449108219 scopus 로고    scopus 로고
    • Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia
    • Robak, T. Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia. Curr. Cancer Drug Targets, 2008, 8, 156-171.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 156-171
    • Robak, T.1
  • 6
    • 45149122101 scopus 로고    scopus 로고
    • Newer monoclonal antibodies for hematological malignancies
    • Castillo, J.; Winer, E.; Quesenberry, P. Newer monoclonal antibodies for hematological malignancies. Experimental Hematol., 2008, 36, 755-768.
    • (2008) Experimental Hematol , vol.36 , pp. 755-768
    • Castillo, J.1    Winer, E.2    Quesenberry, P.3
  • 7
    • 41149101246 scopus 로고    scopus 로고
    • Antibody Therapy for Chronic Lymphocytic Leukemia
    • Christian, B.A.; Lin, T.S. Antibody Therapy for Chronic Lymphocytic Leukemia. Semin. Hematol., 2008, 45(2), 95-103.
    • (2008) Semin. Hematol , vol.45 , Issue.2 , pp. 95-103
    • Christian, B.A.1    Lin, T.S.2
  • 8
    • 67949094458 scopus 로고    scopus 로고
    • Novel drugs for chronic lymphoid leukemias: Mechanism of action and therapeutic activity
    • Robak, T. Novel drugs for chronic lymphoid leukemias: mechanism of action and therapeutic activity. Curr. Med. Chem., 2009,16, 2212-2234.
    • (2009) Curr. Med. Chem , vol.16 , pp. 2212-2234
    • Robak, T.1
  • 9
    • 72149089893 scopus 로고    scopus 로고
    • Current and Emerging Treatments for Chronic Lymphocytic Leukaemia
    • Robak, T.; Jamroziak, K.; Robak, P. Current and Emerging Treatments for Chronic Lymphocytic Leukaemia. Drugs, 2009; 69 (17), 2415-2449.
    • (2009) Drugs , vol.69 , Issue.17 , pp. 2415-2449
    • Robak, T.1    Jamroziak, K.2    Robak, P.3
  • 10
    • 77956627474 scopus 로고    scopus 로고
    • Therapy of chronic lymphocytic leukaemia
    • Hallek, M. Therapy of chronic lymphocytic leukaemia. Best Pract. Res. Clin. Haematol., 2010, 23, 85-96.
    • (2010) Best Pract. Res. Clin. Haematol , vol.23 , pp. 85-96
    • Hallek, M.1
  • 11
    • 77956644535 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of chronic lymphocytic leukaemia
    • Cheson, B.D. Monoclonal antibody therapy of chronic lymphocytic leukaemia. Best Pract. Res. Clin. Haematol., 2010, 23, 133-143.
    • (2010) Best Pract. Res. Clin. Haematol , vol.23 , pp. 133-143
    • Cheson, B.D.1
  • 12
    • 77956266018 scopus 로고    scopus 로고
    • Chemoimmunoterapy of chronic lymphocytic leukemia
    • Tam, C.S.; Keating, M.J. Chemoimmunoterapy of chronic lymphocytic leukemia. Clin Oncol., 2010, 7, 521-532
    • (2010) Clin Oncol , vol.7 , pp. 521-532
    • Tam, C.S.1    Keating, M.J.2
  • 13
    • 78149474940 scopus 로고    scopus 로고
    • The clinical application of monoclonal antibodies in chronic lymphocytic leukaemia
    • Jaglowski, S.M.; Alinari, L.; Lapalombella, R.; Muthusamy, N.; Byrd, J.C. The clinical application of monoclonal antibodies in chronic lymphocytic leukaemia. Blood, 2010, 116(19), 3705-3714
    • (2010) Blood , vol.116 , Issue.19 , pp. 3705-3714
    • Jaglowski, S.M.1    Alinari, L.2    Lapalombella, R.3    Muthusamy, N.4    Byrd, J.C.5
  • 14
    • 0037297117 scopus 로고    scopus 로고
    • The mechanisms of action of rituximab in the elimination of tumor cells
    • Johnson, P.; Glennie, M. The mechanisms of action of rituximab in the elimination of tumor cells. Semin. Oncol., 2003, 30(1 Suppl 2), 3-8.
    • (2003) Semin. Oncol , vol.30 , Issue.1 SUPPL 2 , pp. 3-8
    • Johnson, P.1    Glennie, M.2
  • 17
    • 7244248664 scopus 로고    scopus 로고
    • From the bench to the bedside: Ways to improve rituximab efficacy
    • Cartron, G.; Watier, H.; Golay, J.; Solal-Celigny, P. From the bench to the bedside: ways to improve rituximab efficacy. Blood, 2004, 104(9), 2635-2642.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2635-2642
    • Cartron, G.1    Watier, H.2    Golay, J.3    Solal-Celigny, P.4
  • 18
    • 34548221347 scopus 로고    scopus 로고
    • Mechanisms of killing by anti-CD20 monoclonal antibodies
    • Glennie, M.J., French, R.R.; Cragg, M.S.; Taylor, R.P. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol. Immunol., 2007, 44(16), 3823-3837.
    • (2007) Mol. Immunol , vol.44 , Issue.16 , pp. 3823-3837
    • Glennie, M.J.1    French, R.R.2    Cragg, M.S.3    Taylor, R.P.4
  • 19
    • 48549100414 scopus 로고    scopus 로고
    • Immunotherapeutic Mechanisms of Anti-CD20 Monoclonal Antibodies
    • Taylor, R.P.; Lindorfer, M.A. Immunotherapeutic Mechanisms of Anti-CD20 Monoclonal Antibodies. Curr. Opin. Immunol., 2008, 20(4), 444-449.
    • (2008) Curr. Opin. Immunol , vol.20 , Issue.4 , pp. 444-449
    • Taylor, R.P.1    Lindorfer, M.A.2
  • 20
    • 0141704595 scopus 로고    scopus 로고
    • CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100-insoluble membrane rafts
    • Chan, H.T.; Hughes, D.; French, R.R.; Tutt, A.L.; Walshe, C.A.; Teeling, J.L.; Glennie, M.J.; Cragg, M.S. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100-insoluble membrane rafts. Cancer Res., 2003, 63(17), 5480-5489.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5480-5489
    • Chan, H.T.1    Hughes, D.2    French, R.R.3    Tutt, A.L.4    Walshe, C.A.5    Teeling, J.L.6    Glennie, M.J.7    Cragg, M.S.8
  • 21
    • 1642306050 scopus 로고    scopus 로고
    • Antibody specificity controls in vivo effector mechanisms of anti- CD20 reagents
    • Cragg, M.S.; Glennie, M.J. Antibody specificity controls in vivo effector mechanisms of anti- CD20 reagents. Blood, 2004, 103 (7), 2738-2743.
    • (2004) Blood , vol.103 , Issue.7 , pp. 2738-2743
    • Cragg, M.S.1    Glennie, M.J.2
  • 23
    • 58149162030 scopus 로고    scopus 로고
    • Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
    • Beers, S.A.; Chan, C.H.; James, S.: French, R.R; Attfield, K.E.; Brennan, C.M; Ahuja, A.; Shlomchik, M.J.; Cragg, M.S.; Glennie, M.G. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood, 2008; 112(10), 4170-4177.
    • (2008) Blood , vol.112 , Issue.10 , pp. 4170-4177
    • Beers, S.A.1    Chan, C.H.2    James, S.3    French, R.R.4    Attfield, K.E.5    Brennan, C.M.6    Ahuja, A.7    Shlomchik, M.J.8    Cragg, M.S.9    Glennie, M.G.10
  • 24
    • 0034660092 scopus 로고    scopus 로고
    • Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis
    • Golay, J.; Zaffaroni, L.; Vaccari, T.; Lazzari, M.; Borleri, G.M.; Bernasconi, S. Tedesco, F.; Rambaldi, A.; Introna, M. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis. Blood, 2000, 95, 3900-3908.
    • (2000) Blood , vol.95 , pp. 3900-3908
    • Golay, J.1    Zaffaroni, L.2    Vaccari, T.3    Lazzari, M.4    Borleri, G.M.5    Bernasconi, S.6    Tedesco, F.7    Rambaldi, A.8    Introna, M.9
  • 25
    • 0034999619 scopus 로고    scopus 로고
    • Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with Bcell malignancies
    • Treon, S.P.; Mitsiades, C.; Mitsiades, N.; Young, G.; Doss, D.; Schlossman, R.; Anderson, K.C: Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with Bcell malignancies. J. Immunother., 2001, 24, 263-271.
    • (2001) J. Immunother , vol.24 , pp. 263-271
    • Treon, S.P.1    Mitsiades, C.2    Mitsiades, N.3    Young, G.4    Doss, D.5    Schlossman, R.6    Anderson, K.C.7
  • 26
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd, J.C.; Kitada, S.; Flinn, I.W.; Aron, J.L.; Pearson, M.D.; Lucas, D.; Reed, J. C. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood, 2002, 99, 1038-1043.
    • (2002) Blood , vol.99 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3    Aron, J.L.4    Pearson, M.D.5    Lucas, D.6    Reed, J.C.7
  • 27
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cellchronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen, I.M.; Buhl, A.M.; Klausen, P.; Geisler, C.H.; Jurlander, J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cellchronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. Blood, 2002, 99, 1314-1319.
    • (2002) Blood , vol.99 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 30
    • 0033016566 scopus 로고    scopus 로고
    • Rituximab therapy in hematologic malignancy patients with irculating blood tumor cells: Association with increased infusionrelated side effects and rapid blood tumor clearance
    • Byrd, J.C.; Waselenko, J.K.; Maneatis, T.J.; Murphy, T.; Ward, F.T.; Monahan, B.P.; Sipe, M.A.; Donegan, S.; White, C.A. Rituximab therapy in hematologic malignancy patients with irculating blood tumor cells: association with increased infusionrelated side effects and rapid blood tumor clearance. J. Clin. Oncol., 1999, 17(3), 791-795.
    • (1999) J. Clin. Oncol , vol.17 , Issue.3 , pp. 791-795
    • Byrd, J.C.1    Waselenko, J.K.2    Maneatis, T.J.3    Murphy, T.4    Ward, F.T.5    Monahan, B.P.6    Sipe, M.A.7    Donegan, S.8    White, C.A.9
  • 31
    • 0032931320 scopus 로고    scopus 로고
    • IDECC2B8 anti-CD20 (rituximab) immunotherapy in patients with low grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • Nguyen, D.T.; Amess, J.A.; Doughty, H.; Hendry, L.; Diamond, L.W. IDECC2B8 anti-CD20 (rituximab) immunotherapy in patients with low grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur. J. Haematol., 1999, 62, 76-82.
    • (1999) Eur. J. Haematol , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3    Hendry, L.4    Diamond, L.W.5
  • 32
    • 0038811776 scopus 로고    scopus 로고
    • Minnie Pearl Cancer Research Network. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth, J.D.; Litchy, S.; Barton, J.H.; Houston, G.A.; Hermann, R.C.; Bradof, J.E.; Greco, F.A.; Minnie Pearl Cancer Research Network. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J. Clin. Oncol. 2003, 21, 1746-1751.
    • (2003) J. Clin. Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3    Houston, G.A.4    Hermann, R.C.5    Bradof, J.E.6    Greco, F.A.7
  • 33
    • 40449086383 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia CD20 expressionis dependent on the genetic subtype: A study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients
    • Tam, C.S; Otero-Palacios, J.; Abruzzo, L.V.; Jorgensen, J.L.; Ferrajoli, A.; Wierda, W.G., Lerner, S.; O'Brien, S.; Keating, M.J. Chronic lymphocytic leukaemia CD20 expressionis dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients. Br. J. Hematol., 2008, 141, 36-40.
    • (2008) Br. J. Hematol , vol.141 , pp. 36-40
    • Tam, C.S.1    Otero-Palacios, J.2    Abruzzo, L.V.3    Jorgensen, J.L.4    Ferrajoli, A.5    Wierda, W.G.6    Lerner, S.7    O'Brien, S.8    Keating, M.J.9
  • 38
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd, J.C.; Peterson, B.L.; Morrison, V.A.; Park, K.; Jacobson, R.; Hoke, E.; Vardiman, J.W.; Rai, K.; Schiffer, C.A.; Larson, R.A.; Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood, 2003, 101(1), 6-14.
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 41
    • 40949154401 scopus 로고    scopus 로고
    • Rituximab in the treatment of autoimmune haematological disorders
    • Garvey, B. Rituximab in the treatment of autoimmune haematological disorders. Br. J.Hematol., 2008, 141, 149-169.
    • (2008) Br. J.Hematol , vol.141 , pp. 149-169
    • Garvey, B.1
  • 42
    • 0035877988 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibody for the treatment of severe, immunemediated, pure red cell aplasia and hemolytic anemia
    • Zecca, M.; De Stefano, P.; Nobili, B.; Locatelli, F. Anti-CD20 monoclonal antibody for the treatment of severe, immunemediated, pure red cell aplasia and hemolytic anemia. Blood, 2001, 97(12), 3995-3997.
    • (2001) Blood , vol.97 , Issue.12 , pp. 3995-3997
    • Zecca, M.1    de Stefano, P.2    Nobili, B.3    Locatelli, F.4
  • 43
    • 0037105458 scopus 로고    scopus 로고
    • Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia
    • Hegde, U.P.; Wilson, W.H.; White, T.; Cheson, B.D. Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia. Blood, 2002, 100(6), 2260-2262.
    • (2002) Blood , vol.100 , Issue.6 , pp. 2260-2262
    • Hegde, U.P.1    Wilson, W.H.2    White, T.3    Cheson, B.D.4
  • 44
    • 33646362290 scopus 로고    scopus 로고
    • B-cell targeting in rheumatoid arthritis and other autoimmune disease
    • Edwards, JCW, Cambridge, G. B-cell targeting in rheumatoid arthritis and other autoimmune disease. Nat. Rev. Immunol., 2006, 6, 394-403.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 394-403
    • Edwards, J.C.W.1    Cambridge, G.2
  • 45
    • 0035804282 scopus 로고    scopus 로고
    • Acute hepatitis B in a patients with antibodies to hepatitis B surface antigen who was receiving rituximab
    • Dervite, I.; Hober, D.; Morel, P. Acute hepatitis B in a patients with antibodies to hepatitis B surface antigen who was receiving rituximab. N. Engl. J. Med., 2001, 344, 68-69.
    • (2001) N. Engl. J. Med , vol.344 , pp. 68-69
    • Dervite, I.1    Hober, D.2    Morel, P.3
  • 46
    • 67651158993 scopus 로고    scopus 로고
    • Monoclonal antibody-associated progressive multifocal leucoencephalopathy inpatients treated with rituximab, natalizumab, and efalizumab: A Review from the Research on Adverse Drug Events and Reports (RADAR) Project
    • Carson, K.R.; Focosi, D.; Major, E.O.; Petrini, M.; Richey, E.A.; West, D.P.; Bennett, C.L. Monoclonal antibody-associated progressive multifocal leucoencephalopathy inpatients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Lancet Oncol., 2009, 10, 816-824.
    • (2009) Lancet Oncol , vol.10 , pp. 816-824
    • Carson, K.R.1    Focosi, D.2    Major, E.O.3    Petrini, M.4    Richey, E.A.5    West, D.P.6    Bennett, C.L.7
  • 47
    • 48849109653 scopus 로고    scopus 로고
    • Alemtuzumab for B-cell chronic lymphocytic leukemia
    • Robak T. Alemtuzumab for B-cell chronic lymphocytic leukemia. Expert Rev. Anticancer Ther., 2008, 8, 1033-1051.
    • (2008) Expert Rev. Anticancer Ther , vol.8 , pp. 1033-1051
    • Robak, T.1
  • 48
    • 40349114506 scopus 로고    scopus 로고
    • FDA Drug Approval Summary: Alemtuzumab as Single-Agent Treatment for B-Cell Chronic Lymphocytic Leukemia
    • Demko, S.; Summers, J.; Keegan, P.; Pazdur, R. FDA Drug Approval Summary: Alemtuzumab as Single-Agent Treatment for B-Cell Chronic Lymphocytic Leukemia. The Oncol., 2008, 13, 167-174.
    • (2008) The Oncol , vol.13 , pp. 167-174
    • Demko, S.1    Summers, J.2    Keegan, P.3    Pazdur, R.4
  • 50
    • 0023911111 scopus 로고
    • Reshaping human antibodies for therapy
    • Riechmann, L.; Clark, M.; Waldmann, H.; Winter, G. Reshaping human antibodies for therapy. Nature, 1988, 332, 323-327.
    • (1988) Nature , vol.332 , pp. 323-327
    • Riechmann, L.1    Clark, M.2    Waldmann, H.3    Winter, G.4
  • 51
    • 0027283918 scopus 로고
    • Efficient complementmediated lysis of cells containing the CAMPATH-1 (CDw52) antigen
    • Xia, M.Q.; Hale, G.; Waldmann, H. Efficient complementmediated lysis of cells containing the CAMPATH-1 (CDw52) antigen. Mol. Immunol., 1993, 30, 1089-1096.
    • (1993) Mol. Immunol , vol.30 , pp. 1089-1096
    • Xia, M.Q.1    Hale, G.2    Waldmann, H.3
  • 52
    • 31444453579 scopus 로고    scopus 로고
    • Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
    • Mone, A.P.; Cheney, C.; Banks, A.L.; Tridandapani, S.; Mehter, N.; Guster S.; Lin, T.; Eisenbeis, C.F.; Young, D.C.; Byrd, J.C. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia, 2006, 20, 272-279.
    • (2006) Leukemia , vol.20 , pp. 272-279
    • Mone, A.P.1    Cheney, C.2    Banks, A.L.3    Tridandapani, S.4    Mehter, N.5    Guster, S.6    Lin, T.7    Eisenbeis, C.F.8    Young, D.C.9    Byrd, J.C.10
  • 53
    • 12744279711 scopus 로고    scopus 로고
    • Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells
    • Smolewski, P.; Szmigielska-Kaplon, A.; Cebula, B.; Jamroziak, K.; Rogalinska, M.; Kilianska, Z.; Robak, T. Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. Leuk. Lymphoma., 2005, 46, 87-100.
    • (2005) Leuk. Lymphoma , vol.46 , pp. 87-100
    • Smolewski, P.1    Szmigielska-Kaplon, A.2    Cebula, B.3    Jamroziak, K.4    Rogalinska, M.5    Kilianska, Z.6    Robak, T.7
  • 54
    • 4844229401 scopus 로고    scopus 로고
    • Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in Blymphoid cell lines and in chronic lymphocytic leukemia cells
    • Stanglmaier, M.; Reis, S.; Hallek, M. Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in Blymphoid cell lines and in chronic lymphocytic leukemia cells. Ann. Hematol., 2004, 83, 634-645.
    • (2004) Ann. Hematol , vol.83 , pp. 634-645
    • Stanglmaier, M.1    Reis, S.2    Hallek, M.3
  • 55
    • 1842507429 scopus 로고    scopus 로고
    • Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium
    • Zent, C.S.; Chen, J.B.; Kurten, R.C.; Kaushal, G.P.; Lacy, H.M.; Schichman, S.A. Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium. Leuk. Res., 2004, 28, 495-507.
    • (2004) Leuk. Res , vol.28 , pp. 495-507
    • Zent, C.S.1    Chen, J.B.2    Kurten, R.C.3    Kaushal, G.P.4    Lacy, H.M.5    Schichman, S.A.6
  • 56
    • 51649110602 scopus 로고    scopus 로고
    • Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk early-intermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab
    • Zent, C.S.; Secreto, C.R.; Laplant, B.R.; Bone, N.D.; Call, T.G.; Shanafelt, T.D.; Jelinek, D.F.; Tschumper R.C.; Kay N.E. Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk early-intermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab. Leuk. Res., 2008, 32, 1849-1856.
    • (2008) Leuk. Res , vol.32 , pp. 1849-1856
    • Zent, C.S.1    Secreto, C.R.2    Laplant, B.R.3    Bone, N.D.4    Call, T.G.5    Shanafelt, T.D.6    Jelinek, D.F.7    Tschumper, R.C.8    Kay, N.E.9
  • 57
    • 0030897222 scopus 로고    scopus 로고
    • European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • Osterborg, A.; Dyer, M.J.; Bunjes, D.; Pangalis, G.A.; Bastion, Y.; Catovsky, D.; Mellstedt, H. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. J. Clin. Oncol., 1997, 15(4),1567-1574.
    • (1997) J. Clin. Oncol , vol.15 , Issue.4 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6    Mellstedt, H.7
  • 60
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy
    • Stilgenbauer S.; Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N. Engl. J. Med., 2002, 347(6), 452-453.
    • (2002) N. Engl. J. Med , vol.347 , Issue.6 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 62
    • 6344292639 scopus 로고    scopus 로고
    • Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: Incidence and treatment with oral ganciclovir
    • Laurenti, L.; Piccioni, P.; Cattani, P.; Cingolani, A.; Efremov, D.G.; Chiusolo, P.; Tarnani, M.; Fadda, G.; Sica, S.; Leone, G. Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir. Haematologica, 2004, 89(10), 1248-1252.
    • (2004) Haematologica , vol.89 , Issue.10 , pp. 1248-1252
    • Laurenti, L.1    Piccioni, P.2    Cattani, P.3    Cingolani, A.4    Efremov, D.G.5    Chiusolo, P.6    Tarnani, M.7    Fadda, G.8    Sica, S.9    Leone, G.10
  • 64
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti CD- 52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukaemia (B-CLL)
    • Lundin, J.; Kimby, E.; Björkholm, M.; Broliden, P.A.; Celsing, F.; Hjalmar, V.; Möllgård, L.; Rebello, P.; Hale, G.; Waldmann, H.; Mellstedt, H.; Österborg, A. Phase II trial of subcutaneous anti CD- 52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukaemia (B-CLL). Blood, 2002, 100, 768-773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Björkholm, M.3    Broliden, P.A.4    Celsing, F.5    Hjalmar, V.6    Möllgård, L.7    Rebello, P.8    Hale, G.9    Waldmann, H.10    Mellstedt, H.11    Österborg, A.12
  • 67
    • 24944566741 scopus 로고    scopus 로고
    • Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience
    • Laurenti, L.; Piccioni, P.; Tarnani, M.; Efremov, D.G.; Fiorini, A.; Garzia, M.; Sica, S. Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience. Haematologica., 2005, 90(8), 1143-1145.
    • (2005) Haematologica , vol.90 , Issue.8 , pp. 1143-1145
    • Laurenti, L.1    Piccioni, P.2    Tarnani, M.3    Efremov, D.G.4    Fiorini, A.5    Garzia, M.6    Sica, S.7
  • 68
    • 77950928819 scopus 로고    scopus 로고
    • The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia
    • Tarnani, M.; D'Arena, G.; Efremov, D.G.; Marietti, S.; Leone, G., Laurenti, L. The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia. Leukemia, 2010, 24(4), 890-891.
    • (2010) Leukemia , vol.24 , Issue.4 , pp. 890-891
    • Tarnani, M.1    D'Arena, G.2    Efremov, D.G.3    Marietti, S.4    Leone, G.5    Laurenti, L.6
  • 69
    • 1542503801 scopus 로고    scopus 로고
    • Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
    • Lundin, J.; Porwit-MacDonald, A.; Rossmann, E.D.; Karlsson, C.; Edman, P.; Rezvany, M.R.; Kimby, E.; Osterborg, A.; Mellstedt, H. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia, 2004, 18(3), 484-490.
    • (2004) Leukemia , vol.18 , Issue.3 , pp. 484-490
    • Lundin, J.1    Porwit-Macdonald, A.2    Rossmann, E.D.3    Karlsson, C.4    Edman, P.5    Rezvany, M.R.6    Kimby, E.7    Osterborg, A.8    Mellstedt, H.9
  • 70
    • 11844288279 scopus 로고    scopus 로고
    • Immune recovery after lowdose Campath therapy in a group of pretreated patients affected by B-cell chronic lymphocytic leukemia
    • Laurenti, L.; Piccioni, P.; Tarnani, M.; Chiusolo P.; Piccirillo, N.; Rumi, C.; Sora, F.; Sica, S.; Leone, G. Immune recovery after lowdose Campath therapy in a group of pretreated patients affected by B-cell chronic lymphocytic leukemia. Leukemia., 2005, 19(1), 153-154.
    • (2005) Leukemia , vol.19 , Issue.1 , pp. 153-154
    • Laurenti, L.1    Piccioni, P.2    Tarnani, M.3    Chiusolo, P.4    Piccirillo, N.5    Rumi, C.6    Sora, F.7    Sica, S.8    Leone, G.9
  • 71
    • 77956205101 scopus 로고    scopus 로고
    • Improved progression-free survival (PFS) of alemtuzumab (Campath_, Mab-Campath_) plus fludarabine (Fludara_) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: Preliminary results from a phase III randomized trial
    • Engert, A.; Gercheva, L.; Robak, T.; Galina, P.; Wu, J.; Sirard, C.A.; Elter, T. Improved progression-free survival (PFS) of alemtuzumab (Campath_, Mab-Campath_) plus fludarabine (Fludara_) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: preliminary results from a phase III randomized trial. Blood., 2009, 114(22), 537a.
    • (2009) Blood , vol.114 , Issue.22
    • Engert, A.1    Gercheva, L.2    Robak, T.3    Galina, P.4    Wu, J.5    Sirard, C.A.6    Elter, T.7
  • 72
    • 77953446272 scopus 로고    scopus 로고
    • Chemoimmuno-Therapy with Fludarabine, Cyclophosphamide and Alemtuzumab (FC-Cam) in Patients with Relapsed or Genetic High-Risk CLL: Final Analysis of the CLL2L Trial of the German CLL Study Group
    • Elter, T.; James R.; Stilgenbauer, S.; Boettcher, S.; Ritgen, M.; Doehner, H.; Hallek M.; Engert, A. Chemoimmuno-Therapy with Fludarabine, Cyclophosphamide and Alemtuzumab (FC-Cam) in Patients with Relapsed or Genetic High-Risk CLL: Final Analysis of the CLL2L Trial of the German CLL Study Group. Blood, 2009, 114, 209a.
    • (2009) Blood , vol.114
    • Elter, T.1    James, R.2    Stilgenbauer, S.3    Boettcher, S.4    Ritgen, M.5    Doehner, H.6    Hallek, M.7    Engert, A.8
  • 74
    • 44849134493 scopus 로고    scopus 로고
    • Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders
    • Robak, T. Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders. Curr. Opin. Mol. Ther., 2008, 10, 294-309.
    • (2008) Curr. Opin. Mol. Ther , vol.10 , pp. 294-309
    • Robak, T.1
  • 76
    • 77952628343 scopus 로고    scopus 로고
    • Ofatumumab
    • Sanford, M.; McCormack, P.L. Ofatumumab. Drugs, 2010, 70(8), 1013-1019.
    • (2010) Drugs , vol.70 , Issue.8 , pp. 1013-1019
    • Sanford, M.1    McCormack, P.L.2
  • 77
    • 77956250271 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab
    • Lemery, S.J.; Zhang, J.; Rothmann, M.D.; Yang, J.; Earp, J.; Zhao, H.; McDougal A.; Pilaro, A.; Chiang, R.; Gootenberg, J.E.; Keegan, P.; Pazdur, R. U.S. Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab. Clin. Cancer Res., 2010, 16(17), 4331-4338.
    • (2010) Clin. Cancer Res , vol.16 , Issue.17 , pp. 4331-4338
    • Lemery, S.J.1    Zhang, J.2    Rothmann, M.D.3    Yang, J.4    Earp, J.5    Zhao, H.6    McDougal, A.7    Pilaro, A.8    Chiang, R.9    Gootenberg, J.E.10    Keegan, P.11    Pazdur, R.12
  • 78
    • 18144368022 scopus 로고    scopus 로고
    • GlaxoSmithKline; Research Triangle Park (NC), Arzerra (ofatumumab). October 2009
    • GlaxoSmithKline; Research Triangle Park (NC). Prescribing information. Arzerra (ofatumumab). October 2009.
    • Prescribing Information
  • 81
    • 68949129063 scopus 로고    scopus 로고
    • Binding of submaximal C1q promotes complement dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX
    • Pawluczkowycz, A.; Beurskens, F.; Beum, P.V. Lindorfer, M.A., van de Winkel, J.G.; Parren, P.W.; Taylor, R.P. Binding of submaximal C1q promotes complement dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX. J. Immunol., 2009, 183, 749-758.
    • (2009) J. Immunol , vol.183 , pp. 749-758
    • Pawluczkowycz, A.1    Beurskens, F.2    Beum, P.V.3    Lindorfer, M.A.4    van de Winkel, J.G.5    Parren, P.W.6    Taylor, R.P.7
  • 83
    • 79959398254 scopus 로고    scopus 로고
    • GlaxoSmithKline, Accessed 2010 Jan 25
    • GlaxoSmithKline. Arzerra: prescribing information [online]. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125326lbl.pdf [Accessed 2010 Jan 25]
    • Arzerra: Prescribing Information [online]
  • 85
    • 79251473278 scopus 로고    scopus 로고
    • European Medicines Agency, Accessed 2010 Jan 25
    • European Medicines Agency. Arzerra: summary of opinion (initial authorisation) [online]. Available from URL: http://www.emea.europa.eu/pdfs/human/opinion/Arzerra_214261en.pdf [Accessed 2010 Jan 25]
    • Arzerra: Summary of Opinion (initial Authorisation) [online]
  • 88
    • 67650657179 scopus 로고    scopus 로고
    • GA-101, a third-generation, humanized and glycoengineered anti CD20 mAb for the treatment of B-cell lymphoid malignancies
    • Robak, T. GA-101, a third-generation, humanized and glycoengineered anti CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr. Opin. Investig. Drugs, 2009, 10, 588-596.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 588-596
    • Robak, T.1
  • 89
    • 33646172632 scopus 로고    scopus 로고
    • The carbohydrate at FcgammaRIIIa Asn-162: An element required for high affinity binding to non-fucosylated IgG glycoforms
    • Ferrara, C.; Stuart, F.; Sondermann, P.; Brunker, P.; Umana, P.; The carbohydrate at FcgammaRIIIa Asn-162: an element required for high affinity binding to non-fucosylated IgG glycoforms. J. Biol. Chem., 2006, 281(8), 5032-5036.
    • (2006) J. Biol. Chem , vol.281 , Issue.8 , pp. 5032-5036
    • Ferrara, C.1    Stuart, F.2    Sondermann, P.3    Brunker, P.4    Umana, P.5
  • 91
    • 77950312458 scopus 로고    scopus 로고
    • New- Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma
    • Alduaij, W.; Potluri, S.; Ivanov, A.; Honeychurch, J.; Beers, S.A.; Chan C.; Shimada, K.; Glennie, M.J.; Cragg, M.S.; Illidge, T. New- Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma. Blood, 2009, 114(22), 725a.
    • (2009) Blood , vol.114 , Issue.22
    • Alduaij, W.1    Potluri, S.2    Ivanov, A.3    Honeychurch, J.4    Beers, S.A.5    Chan, C.6    Shimada, K.7    Glennie, M.J.8    Cragg, M.S.9    Illidge, T.10
  • 94
    • 77950307720 scopus 로고    scopus 로고
    • Depletion of chronic lymphocytic leukemia cells from whole blood samples mediated by the anti-CD20 antibodies rituximab and GA101
    • Patz M.; Forcob N.; Muller B.; Klein C.; Umana P.; Hallek M.; Krause G. Depletion of chronic lymphocytic leukemia cells from whole blood samples mediated by the anti-CD20 antibodies rituximab and GA101. Blood, 2009, 114(22), 2365a.
    • (2009) Blood , vol.114 , Issue.22
    • Patz, M.1    Forcob, N.2    Muller, B.3    Klein, C.4    Umana, P.5    Hallek, M.6    Krause, G.7
  • 96
    • 0036166593 scopus 로고    scopus 로고
    • Surface antigen expression in chronic lymphocytic leukemia: Clustering analysis, interrelationships and effects of chromosomal abnormalities
    • Hulkkonen, J.; Vilpo, L.; Hurme, M.; Vilpo, J. Surface antigen expression in chronic lymphocytic leukemia: clustering analysis, interrelationships and effects of chromosomal abnormalities. Leukemia, 2002, 16(2), 178-185.
    • (2002) Leukemia , vol.16 , Issue.2 , pp. 178-185
    • Hulkkonen, J.1    Vilpo, L.2    Hurme, M.3    Vilpo, J.4
  • 97
    • 0035180896 scopus 로고    scopus 로고
    • Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/ small lymphocytic lymphoma
    • Gong, J.Z.; Lagoo, A.S.; Peters, D.; Horvatinovich, J.; Benz, P.; Buckley, P.J. Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/ small lymphocytic lymphoma. Am. J. Clin. Pathol., 2001, 116(6), 893-897.
    • (2001) Am. J. Clin. Pathol , vol.116 , Issue.6 , pp. 893-897
    • Gong, J.Z.1    Lagoo, A.S.2    Peters, D.3    Horvatinovich, J.4    Benz, P.5    Buckley, P.J.6
  • 98
    • 38949180269 scopus 로고    scopus 로고
    • Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23_ lymphoma cell lines
    • Pathan, N.I.; Chu, P.; Hariharan, K.; Cheny, C.; Molina, A.; Byrd, J. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23_ lymphoma cell lines. Blood, 2008, 111(3),1594-1602.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1594-1602
    • Pathan, N.I.1    Chu, P.2    Hariharan, K.3    Cheny, C.4    Molina, A.5    Byrd, J.6
  • 99
    • 34547691135 scopus 로고    scopus 로고
    • Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd, JC.; O'Brien, S.; Flinn, IW.; Kipps, TJ.; Weiss, M.; Rai, K.; Lin, TS.; Woodworth, J.; Wynne, D.; Reid, J.; Molina, A.; Leigh, B.; Harris, S. Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin. Cancer Res., 2007, 13(15 pt 1), 4448-4455.
    • (2007) Clin. Cancer Res , vol.13 , Issue.15 PART 1 , pp. 4448-4455
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.W.3    Kipps, T.J.4    Weiss, M.5    Rai, K.6    Lin, T.S.7    Woodworth, J.8    Wynne, D.9    Reid, J.10    Molina, A.11    Leigh, B.12    Harris, S.13
  • 101
    • 71249091846 scopus 로고    scopus 로고
    • TRU-016, a humanized anti- CD37 IgG fusion protein for the potential treatment of B-cell malignancies
    • Robak, T.; Robak, P.; Smolewski, P. TRU-016, a humanized anti- CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr. Opin. Investig. Drugs, 2009, 10, 1383-90.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 1383-1390
    • Robak, T.1    Robak, P.2    Smolewski, P.3
  • 102
    • 72149102570 scopus 로고    scopus 로고
    • A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL
    • Andritsos, L.; Furman, R.; Flinn, I.W. A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL. J. Clin. Oncol., 2009, 27(15), 3017a.
    • (2009) J. Clin. Oncol , vol.27 , Issue.15
    • Andritsos, L.1    Furman, R.2    Flinn, I.W.3
  • 104
    • 77949421075 scopus 로고    scopus 로고
    • Evaluation of the effect of TRU-16, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non- Hodgkin's lymphoma
    • Baum, P.R.; Cerveny, C.; Gordon, B.; Nilsson, C.; Wiens, J.; Rafiq, S.; Lapalombella, R.; Muthusamy, N.; Byrd, J.C.; Wahl, A. Evaluation of the effect of TRU-16, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non- Hodgkin's lymphoma. J. Clin. Oncol., 2009, 27(15), 8571a
    • (2009) J. Clin. Oncol , vol.27 , Issue.15
    • Baum, P.R.1    Cerveny, C.2    Gordon, B.3    Nilsson, C.4    Wiens, J.5    Rafiq, S.6    Lapalombella, R.7    Muthusamy, N.8    Byrd, J.C.9    Wahl, A.10
  • 105
    • 77955176357 scopus 로고    scopus 로고
    • A Phase 1 Trial of TRU-016, An Anti- CD37 Small Modular Immunopharmaceutical (SMIPTM) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity
    • Andritsos, L.; Furman, R.R.; Flinn, I.W.; Foreno-Torres, A.; Flynn, J.M.; Muthusamy, N.; Rafiq, S.; Stromatt, S.; Byrd, J.C. A Phase 1 Trial of TRU-016, An Anti- CD37 Small Modular Immunopharmaceutical (SMIPTM) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity. Blood, 2009, 114(22), 3124a.
    • (2009) Blood , vol.114 , Issue.22
    • Andritsos, L.1    Furman, R.R.2    Flinn, I.W.3    Foreno-Torres, A.4    Flynn, J.M.5    Muthusamy, N.6    Rafiq, S.7    Stromatt, S.8    Byrd, J.C.9
  • 106
    • 76349120845 scopus 로고    scopus 로고
    • A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • Furman, R.R.; Forero-Torres, A.; Shustov, A.; Drachman, J.G. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk. Lymphoma., 2010, 51(2), 228-235.
    • (2010) Leuk. Lymphoma , vol.51 , Issue.2 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3    Drachman, J.G.4
  • 107
    • 70449559786 scopus 로고    scopus 로고
    • HCD122 an antagonist human anti-CD40 monoclonal antibody, inhibits tumor growth in xeno-graft models of human diffuse large B-cell lymphoma, a subsets of non-Hodgkin's lymphoma
    • Hsu, S.J.; Esposito, L.A.; Aukerman, S.L.; Kantak, S.; Mirza, A.M. HCD122 an antagonist human anti-CD40 monoclonal antibody, inhibits tumor growth in xeno-graft models of human diffuse large B-cell lymphoma, a subsets of non-Hodgkin's lymphoma. Blood, 2006, 108 (11), 2519a.
    • (2006) Blood , vol.108 , Issue.11
    • Hsu, S.J.1    Esposito, L.A.2    Aukerman, S.L.3    Kantak, S.4    Mirza, A.M.5
  • 108
    • 79959429444 scopus 로고    scopus 로고
    • A non-internalizing anti-CD40 antibody CHIR-0.12.12, blocks CD40 L-induced cytokine production and mediated greater ADCC than rituximab in primary CLL cells
    • Tong, X.; Aukerman, S.L.; Lin, K.; Aziz, N.; Goldbeck, C.; Georgakis, G.V.; Younes, A.; Weng, W.K. O'Brien, S.; Wierda, W.; Jallal, B.; Luqman, M. A non-internalizing anti-CD40 antibody CHIR-0.12.12, blocks CD40 L-induced cytokine production and mediated greater ADCC than rituximab in primary CLL cells. Blood, 2005, 106 (11), 2964a.
    • (2005) Blood , vol.106 , Issue.11
    • Tong, X.1    Aukerman, S.L.2    Lin, K.3    Aziz, N.4    Goldbeck, C.5    Georgakis, G.V.6    Younes, A.7    Weng, W.K.8    O'Brien, S.9    Wierda, W.10    Jallal, B.11    Luqman, M.12
  • 109
    • 65349169910 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody HCD122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia
    • Byrd, J.C.; Flinn, I.W.; Khan, K.D.; Kipps, T.J.; Aukerman, L.; Fox, J.; Girish, S.; Guzy, S.; Bilic S.; Solinger, A.; Dort, S.; Wang, Y.; Hurst, D.; O'Brien, S. Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody HCD122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia. Blood, 2006, 108 (11), 2837a.
    • (2006) Blood , vol.108 , Issue.11
    • Byrd, J.C.1    Flinn, I.W.2    Khan, K.D.3    Kipps, T.J.4    Aukerman, L.5    Fox, J.6    Girish, S.7    Guzy, S.8    Bilic, S.9    Solinger, A.10    Dort, S.11    Wang, Y.12    Hurst, D.13    O'Brien, S.14
  • 112
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
    • Carnahan, J.; Stein, R.; Qu, Z.; Hess, K.; Cesano, A.; Hansen, H.J.; Goldenberg, D.M. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol. Immunol., 2007, 44(6), 1331-1341.
    • (2007) Mol. Immunol , vol.44 , Issue.6 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3    Hess, K.4    Cesano, A.5    Hansen, H.J.6    Goldenberg, D.M.7
  • 114
    • 22344436992 scopus 로고    scopus 로고
    • Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory ollicular lymphoma
    • Czuczman, M.S.; Thall, A.; Witzig, T.E. Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory ollicular lymphoma. J. Clin. Oncol., 2005, 23, 4390-4403
    • (2005) J. Clin. Oncol , vol.23 , pp. 4390-4443
    • Czuczman, M.S.1    Thall, A.2    Witzig, T.E.3


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