-
1
-
-
31544434508
-
The German CLL Study Group. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
-
Eichhorst, B.F.; Busch, R.; Hopfinger, G.; Pasold, R.; Hensel, M.; Steinbrecher, C.; Siehl, S.; Jäger, U.; Bergmann M.; Stilgenbauer, S.; Schweighofer, S.; Wendtner, C.M.; Döhner, H.; Brittinger, G.; Emmerich, B.; Hallek, M. The German CLL Study Group. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood, 2006, 107, 885-891.
-
(2006)
Blood
, vol.107
, pp. 885-891
-
-
Eichhorst, B.F.1
Busch, R.2
Hopfinger, G.3
Pasold, R.4
Hensel, M.5
Steinbrecher, C.6
Siehl, S.7
Jäger, U.8
Bergmann, M.9
Stilgenbauer, S.10
Schweighofer, S.11
Wendtner, C.M.12
Döhner, H.13
Brittinger, G.14
Emmerich, B.15
Hallek, M.16
-
2
-
-
33947541773
-
Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
-
Flinn, I.W.; Neuberg, D.S.; Grever, M.R.; Dewald, G.W.; Bennett J.M.; Paietta, E.M.; Hussein, M.A.; Appelbaum, F.R.; Larson, R.A.; Moore, D.F.; Tallman, M.S. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J. Clin. Oncol., 2007, 25, 793-798.
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 793-798
-
-
Flinn, I.W.1
Neuberg, D.S.2
Grever, M.R.3
Dewald, G.W.4
Bennett, J.M.5
Paietta, E.M.6
Hussein, M.A.7
Appelbaum, F.R.8
Larson, R.A.9
Moore, D.F.10
Tallman, M.S.11
-
3
-
-
34447530283
-
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukemia (the LRF CLL4 Trial): A randomized controlled trial
-
Catovsky, D.; Richards, S., Matutes, E; Oscier, D.; Dyer, M.J.; Bezares, R.F.; Pettitt, A.R.; Hamblin, T.; Milligan, D.W.; Child, J.A.; Hamilton, M.S.; Dearden, C.E.; Smith A.G.; Bosanquet, A.G.; Davis, Z.; Brito-Babapulle, V.; Else, M.; Wade, R.; Hillmen, P. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukemia (the LRF CLL4 Trial): a randomized controlled trial. Lancet, 2007, 370, 230-239.
-
(2007)
Lancet
, vol.370
, pp. 230-239
-
-
Catovsky, D.1
Richards, S.2
Matutes, E.3
Oscier, D.4
Dyer, M.J.5
Bezares, R.F.6
Pettitt, A.R.7
Hamblin, T.8
Milligan, D.W.9
Child, J.A.10
Hamilton, M.S.11
Dearden, C.E.12
Smith, A.G.13
Bosanquet, A.G.14
Davis, Z.15
Brito-Babapulle, V.16
Else, M.17
Wade, R.18
Hillmen, P.19
-
4
-
-
33745942111
-
The Polish Leukemia Group (PALG CLL2). Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: Report of prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)
-
Robak, T.; Blonski, J.Z.; Gora-Tybor, J.; Jamroziak, K.; Dwilewicz-Trojaczek, J.; Tomaszewska, A.; Konopka, L.; Ceglarek, B.; Dmoszynska A.; Kowal, M.; Kloczko, J.; Holowiecka, B.S.; Sulek, K.; Calbecka M.; Zawilska, K.; Kuliczkowski, K.; Skotnicki, A.B.; Warzocha, K.; Kasznicki, M. The Polish Leukemia Group (PALG CLL2). Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2). Blood, 2006, 108, 473-479.
-
(2006)
Blood
, vol.108
, pp. 473-479
-
-
Robak, T.1
Blonski, J.Z.2
Gora-Tybor, J.3
Jamroziak, K.4
Dwilewicz-Trojaczek, J.5
Tomaszewska, A.6
Konopka, L.7
Ceglarek, B.8
Dmoszynska, A.9
Kowal, M.10
Kloczko, J.11
Holowiecka, B.S.12
Sulek, K.13
Calbecka, M.14
Zawilska, K.15
Kuliczkowski, K.16
Skotnicki, A.B.17
Warzocha, K.18
Kasznicki, M.19
-
5
-
-
40449108219
-
Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia
-
Robak, T. Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia. Curr. Cancer Drug Targets, 2008, 8, 156-171.
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 156-171
-
-
Robak, T.1
-
6
-
-
45149122101
-
Newer monoclonal antibodies for hematological malignancies
-
Castillo, J.; Winer, E.; Quesenberry, P. Newer monoclonal antibodies for hematological malignancies. Experimental Hematol., 2008, 36, 755-768.
-
(2008)
Experimental Hematol
, vol.36
, pp. 755-768
-
-
Castillo, J.1
Winer, E.2
Quesenberry, P.3
-
7
-
-
41149101246
-
Antibody Therapy for Chronic Lymphocytic Leukemia
-
Christian, B.A.; Lin, T.S. Antibody Therapy for Chronic Lymphocytic Leukemia. Semin. Hematol., 2008, 45(2), 95-103.
-
(2008)
Semin. Hematol
, vol.45
, Issue.2
, pp. 95-103
-
-
Christian, B.A.1
Lin, T.S.2
-
8
-
-
67949094458
-
Novel drugs for chronic lymphoid leukemias: Mechanism of action and therapeutic activity
-
Robak, T. Novel drugs for chronic lymphoid leukemias: mechanism of action and therapeutic activity. Curr. Med. Chem., 2009,16, 2212-2234.
-
(2009)
Curr. Med. Chem
, vol.16
, pp. 2212-2234
-
-
Robak, T.1
-
9
-
-
72149089893
-
Current and Emerging Treatments for Chronic Lymphocytic Leukaemia
-
Robak, T.; Jamroziak, K.; Robak, P. Current and Emerging Treatments for Chronic Lymphocytic Leukaemia. Drugs, 2009; 69 (17), 2415-2449.
-
(2009)
Drugs
, vol.69
, Issue.17
, pp. 2415-2449
-
-
Robak, T.1
Jamroziak, K.2
Robak, P.3
-
10
-
-
77956627474
-
Therapy of chronic lymphocytic leukaemia
-
Hallek, M. Therapy of chronic lymphocytic leukaemia. Best Pract. Res. Clin. Haematol., 2010, 23, 85-96.
-
(2010)
Best Pract. Res. Clin. Haematol
, vol.23
, pp. 85-96
-
-
Hallek, M.1
-
11
-
-
77956644535
-
Monoclonal antibody therapy of chronic lymphocytic leukaemia
-
Cheson, B.D. Monoclonal antibody therapy of chronic lymphocytic leukaemia. Best Pract. Res. Clin. Haematol., 2010, 23, 133-143.
-
(2010)
Best Pract. Res. Clin. Haematol
, vol.23
, pp. 133-143
-
-
Cheson, B.D.1
-
12
-
-
77956266018
-
Chemoimmunoterapy of chronic lymphocytic leukemia
-
Tam, C.S.; Keating, M.J. Chemoimmunoterapy of chronic lymphocytic leukemia. Clin Oncol., 2010, 7, 521-532
-
(2010)
Clin Oncol
, vol.7
, pp. 521-532
-
-
Tam, C.S.1
Keating, M.J.2
-
13
-
-
78149474940
-
The clinical application of monoclonal antibodies in chronic lymphocytic leukaemia
-
Jaglowski, S.M.; Alinari, L.; Lapalombella, R.; Muthusamy, N.; Byrd, J.C. The clinical application of monoclonal antibodies in chronic lymphocytic leukaemia. Blood, 2010, 116(19), 3705-3714
-
(2010)
Blood
, vol.116
, Issue.19
, pp. 3705-3714
-
-
Jaglowski, S.M.1
Alinari, L.2
Lapalombella, R.3
Muthusamy, N.4
Byrd, J.C.5
-
14
-
-
0037297117
-
The mechanisms of action of rituximab in the elimination of tumor cells
-
Johnson, P.; Glennie, M. The mechanisms of action of rituximab in the elimination of tumor cells. Semin. Oncol., 2003, 30(1 Suppl 2), 3-8.
-
(2003)
Semin. Oncol
, vol.30
, Issue.1 SUPPL 2
, pp. 3-8
-
-
Johnson, P.1
Glennie, M.2
-
15
-
-
33745324686
-
The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
-
Teeling, J.L.; Mackus, W.J.; Wiegman, L.J.; van den Brakel, J.H.; Beers, S.A.; French, R.R.; van Meerten, T.; Ebeling, S.; Vink, T.; Slootstra, J.W.; Parren, P.W.; Glennie, M.J.; van de Winkel, J.G. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J. Immunol., 2006, 177(1), 362-371.
-
(2006)
J. Immunol
, vol.177
, Issue.1
, pp. 362-371
-
-
Teeling, J.L.1
Mackus, W.J.2
Wiegman, L.J.3
van den Brakel, J.H.4
Beers, S.A.5
French, R.R.6
van Meerten, T.7
Ebeling, S.8
Vink, T.9
Slootstra, J.W.10
Parren, P.W.11
Glennie, M.J.12
van de Winkel, J.G.13
-
16
-
-
77951561987
-
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
-
Mossner, E.; Brunker, P.; Moser, S.; Pntener, U.; Schmidt, C.; Herter, S.; Grau R.; Gerdes, C.; Nopora, A.; van Puijenbroek, E.; Ferrara, C.; Sondermann, P.; Jager, C.; Strein, P.; Fertig G.; Friess, T.; Schull, C.; Bauer, S.; Dal Porto, J.; Del Nagro, C.; Dabbagh, K.; Dyer, M.J.S.; Poppema, S.; Klein, C.; Umana P. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood, 2010, 115, 4393-4402.
-
(2010)
Blood
, vol.115
, pp. 4393-4402
-
-
Mossner, E.1
Brunker, P.2
Moser, S.3
Pntener, U.4
Schmidt, C.5
Herter, S.6
Grau, R.7
Gerdes, C.8
Nopora, A.9
van Puijenbroek, E.10
Ferrara, C.11
Sondermann, P.12
Jager, C.13
Strein, P.14
Fertig, G.15
Friess, T.16
Schull, C.17
Bauer, S.18
dal Porto, J.19
del Nagro, C.20
Dabbagh, K.21
Dyer, M.J.S.22
Poppema, S.23
Klein, C.24
Umana, P.25
more..
-
17
-
-
7244248664
-
From the bench to the bedside: Ways to improve rituximab efficacy
-
Cartron, G.; Watier, H.; Golay, J.; Solal-Celigny, P. From the bench to the bedside: ways to improve rituximab efficacy. Blood, 2004, 104(9), 2635-2642.
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2635-2642
-
-
Cartron, G.1
Watier, H.2
Golay, J.3
Solal-Celigny, P.4
-
18
-
-
34548221347
-
Mechanisms of killing by anti-CD20 monoclonal antibodies
-
Glennie, M.J., French, R.R.; Cragg, M.S.; Taylor, R.P. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol. Immunol., 2007, 44(16), 3823-3837.
-
(2007)
Mol. Immunol
, vol.44
, Issue.16
, pp. 3823-3837
-
-
Glennie, M.J.1
French, R.R.2
Cragg, M.S.3
Taylor, R.P.4
-
19
-
-
48549100414
-
Immunotherapeutic Mechanisms of Anti-CD20 Monoclonal Antibodies
-
Taylor, R.P.; Lindorfer, M.A. Immunotherapeutic Mechanisms of Anti-CD20 Monoclonal Antibodies. Curr. Opin. Immunol., 2008, 20(4), 444-449.
-
(2008)
Curr. Opin. Immunol
, vol.20
, Issue.4
, pp. 444-449
-
-
Taylor, R.P.1
Lindorfer, M.A.2
-
20
-
-
0141704595
-
CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100-insoluble membrane rafts
-
Chan, H.T.; Hughes, D.; French, R.R.; Tutt, A.L.; Walshe, C.A.; Teeling, J.L.; Glennie, M.J.; Cragg, M.S. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100-insoluble membrane rafts. Cancer Res., 2003, 63(17), 5480-5489.
-
(2003)
Cancer Res
, vol.63
, Issue.17
, pp. 5480-5489
-
-
Chan, H.T.1
Hughes, D.2
French, R.R.3
Tutt, A.L.4
Walshe, C.A.5
Teeling, J.L.6
Glennie, M.J.7
Cragg, M.S.8
-
21
-
-
1642306050
-
Antibody specificity controls in vivo effector mechanisms of anti- CD20 reagents
-
Cragg, M.S.; Glennie, M.J. Antibody specificity controls in vivo effector mechanisms of anti- CD20 reagents. Blood, 2004, 103 (7), 2738-2743.
-
(2004)
Blood
, vol.103
, Issue.7
, pp. 2738-2743
-
-
Cragg, M.S.1
Glennie, M.J.2
-
22
-
-
47049124865
-
First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a phase 1/2 trial
-
Hagenbeek, A.; Gadeberg, O.; Johnson, P.; Moller Pedersen, L.; Walewski, J.; Hellmann, A.; Link, B.K.; Robak, T.; Wojtukiewicz, M.; Pfreundschuh, M.; Kneba, M.; Engert, A.; Sonneveld, P.; Flensburg, M.; Petersen, J.; Losic, N.; Radford, J. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial. Blood, 2008, 111(12), 5486-5495.
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5486-5495
-
-
Hagenbeek, A.1
Gadeberg, O.2
Johnson, P.3
Moller Pedersen, L.4
Walewski, J.5
Hellmann, A.6
Link, B.K.7
Robak, T.8
Wojtukiewicz, M.9
Pfreundschuh, M.10
Kneba, M.11
Engert, A.12
Sonneveld, P.13
Flensburg, M.14
Petersen, J.15
Losic, N.16
Radford, J.17
-
23
-
-
58149162030
-
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
-
Beers, S.A.; Chan, C.H.; James, S.: French, R.R; Attfield, K.E.; Brennan, C.M; Ahuja, A.; Shlomchik, M.J.; Cragg, M.S.; Glennie, M.G. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood, 2008; 112(10), 4170-4177.
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 4170-4177
-
-
Beers, S.A.1
Chan, C.H.2
James, S.3
French, R.R.4
Attfield, K.E.5
Brennan, C.M.6
Ahuja, A.7
Shlomchik, M.J.8
Cragg, M.S.9
Glennie, M.G.10
-
24
-
-
0034660092
-
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis
-
Golay, J.; Zaffaroni, L.; Vaccari, T.; Lazzari, M.; Borleri, G.M.; Bernasconi, S. Tedesco, F.; Rambaldi, A.; Introna, M. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis. Blood, 2000, 95, 3900-3908.
-
(2000)
Blood
, vol.95
, pp. 3900-3908
-
-
Golay, J.1
Zaffaroni, L.2
Vaccari, T.3
Lazzari, M.4
Borleri, G.M.5
Bernasconi, S.6
Tedesco, F.7
Rambaldi, A.8
Introna, M.9
-
25
-
-
0034999619
-
Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with Bcell malignancies
-
Treon, S.P.; Mitsiades, C.; Mitsiades, N.; Young, G.; Doss, D.; Schlossman, R.; Anderson, K.C: Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with Bcell malignancies. J. Immunother., 2001, 24, 263-271.
-
(2001)
J. Immunother
, vol.24
, pp. 263-271
-
-
Treon, S.P.1
Mitsiades, C.2
Mitsiades, N.3
Young, G.4
Doss, D.5
Schlossman, R.6
Anderson, K.C.7
-
26
-
-
0036464611
-
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
-
Byrd, J.C.; Kitada, S.; Flinn, I.W.; Aron, J.L.; Pearson, M.D.; Lucas, D.; Reed, J. C. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood, 2002, 99, 1038-1043.
-
(2002)
Blood
, vol.99
, pp. 1038-1043
-
-
Byrd, J.C.1
Kitada, S.2
Flinn, I.W.3
Aron, J.L.4
Pearson, M.D.5
Lucas, D.6
Reed, J.C.7
-
27
-
-
0037082469
-
The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cellchronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
-
Pedersen, I.M.; Buhl, A.M.; Klausen, P.; Geisler, C.H.; Jurlander, J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cellchronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. Blood, 2002, 99, 1314-1319.
-
(2002)
Blood
, vol.99
, pp. 1314-1319
-
-
Pedersen, I.M.1
Buhl, A.M.2
Klausen, P.3
Geisler, C.H.4
Jurlander, J.5
-
28
-
-
17144455839
-
IDECC2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
-
Maloney, D.G.; Grillo-López, A.J.; Bodkin, D.J.; White, C.A.; Liles, T.M.; Royston, I.; Varns, C.; Rosenberg, J.; Levy, R. IDECC2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J. Clin. Oncol., 1997, 15(10), 3266-74.
-
(1997)
J. Clin. Oncol
, vol.15
, Issue.10
, pp. 3266-3274
-
-
Maloney, D.G.1
Grillo-López, A.J.2
Bodkin, D.J.3
White, C.A.4
Liles, T.M.5
Royston, I.6
Varns, C.7
Rosenberg, J.8
Levy, R.9
-
29
-
-
0345337254
-
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma:Half of patients respond to a four-dose treatment program
-
McLaughlin, P.; Grill-Lopez, A.J.; Link, B.K.; Levy, R.; Czuczman, M.S.; Williams, M.E.; Heyman, M.R.; Bence-Bruckler, I.; White C.A.; Cabanillas, F.; Jain, V.; Ho A.D.; Lister, J.; Wey, K.; Shen, D.; Dallaire, B.K. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma:half of patients respond to a four-dose treatment program. J. Clin. Oncol., 1998, 16, 2825-2833.
-
(1998)
J. Clin. Oncol
, vol.16
, pp. 2825-2833
-
-
McLaughlin, P.1
Grill-Lopez, A.J.2
Link, B.K.3
Levy, R.4
Czuczman, M.S.5
Williams, M.E.6
Heyman, M.R.7
Bence-Bruckler, I.8
White, C.A.9
Cabanillas, F.10
Jain, V.11
Ho, A.D.12
Lister, J.13
Wey, K.14
Shen, D.15
Dallaire, B.K.16
-
30
-
-
0033016566
-
Rituximab therapy in hematologic malignancy patients with irculating blood tumor cells: Association with increased infusionrelated side effects and rapid blood tumor clearance
-
Byrd, J.C.; Waselenko, J.K.; Maneatis, T.J.; Murphy, T.; Ward, F.T.; Monahan, B.P.; Sipe, M.A.; Donegan, S.; White, C.A. Rituximab therapy in hematologic malignancy patients with irculating blood tumor cells: association with increased infusionrelated side effects and rapid blood tumor clearance. J. Clin. Oncol., 1999, 17(3), 791-795.
-
(1999)
J. Clin. Oncol
, vol.17
, Issue.3
, pp. 791-795
-
-
Byrd, J.C.1
Waselenko, J.K.2
Maneatis, T.J.3
Murphy, T.4
Ward, F.T.5
Monahan, B.P.6
Sipe, M.A.7
Donegan, S.8
White, C.A.9
-
31
-
-
0032931320
-
IDECC2B8 anti-CD20 (rituximab) immunotherapy in patients with low grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
-
Nguyen, D.T.; Amess, J.A.; Doughty, H.; Hendry, L.; Diamond, L.W. IDECC2B8 anti-CD20 (rituximab) immunotherapy in patients with low grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur. J. Haematol., 1999, 62, 76-82.
-
(1999)
Eur. J. Haematol
, vol.62
, pp. 76-82
-
-
Nguyen, D.T.1
Amess, J.A.2
Doughty, H.3
Hendry, L.4
Diamond, L.W.5
-
32
-
-
0038811776
-
Minnie Pearl Cancer Research Network. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
-
Hainsworth, J.D.; Litchy, S.; Barton, J.H.; Houston, G.A.; Hermann, R.C.; Bradof, J.E.; Greco, F.A.; Minnie Pearl Cancer Research Network. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J. Clin. Oncol. 2003, 21, 1746-1751.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 1746-1751
-
-
Hainsworth, J.D.1
Litchy, S.2
Barton, J.H.3
Houston, G.A.4
Hermann, R.C.5
Bradof, J.E.6
Greco, F.A.7
-
33
-
-
40449086383
-
Chronic lymphocytic leukaemia CD20 expressionis dependent on the genetic subtype: A study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients
-
Tam, C.S; Otero-Palacios, J.; Abruzzo, L.V.; Jorgensen, J.L.; Ferrajoli, A.; Wierda, W.G., Lerner, S.; O'Brien, S.; Keating, M.J. Chronic lymphocytic leukaemia CD20 expressionis dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients. Br. J. Hematol., 2008, 141, 36-40.
-
(2008)
Br. J. Hematol
, vol.141
, pp. 36-40
-
-
Tam, C.S.1
Otero-Palacios, J.2
Abruzzo, L.V.3
Jorgensen, J.L.4
Ferrajoli, A.5
Wierda, W.G.6
Lerner, S.7
O'Brien, S.8
Keating, M.J.9
-
34
-
-
0038446696
-
Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukaemia and is of prognostic significance
-
Manshouri, T. Do K.; Wang, X.; Giles, F.J.; O'Brien, S.M.; Saffer, H.; Thomas, D.; Jilani, I.; Kantarjian, H.M; Keating, M.J.; Albitar, M. Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukaemia and is of prognostic significance. Blood, 2003, 101, 2507-2513.
-
(2003)
Blood
, vol.101
, pp. 2507-2513
-
-
Manshouri, T.1
Do, K.2
Wang, X.3
Giles, F.J.4
O'Brien, S.M.5
Saffer, H.6
Thomas, D.7
Jilani, I.8
Kantarjian, H.M.9
Keating, M.J.10
Albitar, M.11
-
35
-
-
0035871445
-
Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
-
Byrd, J.C.; Murphy, T.; Howard, R.S.; Lucas, M.S.; Goodrich, A.; Park, K.; Pearson, M.; Waselenko, J.K.; Ling, G.; Grever, M.R.; Grillo-Lopez, A.J.; Rosenberg, J.; Kunkel, L.; Flinn, I.W. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J. Clin. Oncol., 2001, 19 (8), 2153-2164.
-
(2001)
J. Clin. Oncol
, vol.19
, Issue.8
, pp. 2153-2164
-
-
Byrd, J.C.1
Murphy, T.2
Howard, R.S.3
Lucas, M.S.4
Goodrich, A.5
Park, K.6
Pearson, M.7
Waselenko, J.K.8
Ling, G.9
Grever, M.R.10
Grillo-Lopez, A.J.11
Rosenberg, J.12
Kunkel, L.13
Flinn, I.W.14
-
36
-
-
0035871441
-
Rituximab dose-escalation trial in chronic lymphocytic leukaemia
-
O'Brien, S.M.; Kantarjian, H.; Thomas, D.A. Giles, F.J.; Freireich, E.J.; Cortes, J.; Lerner, S.; Keating, M.J. Rituximab dose-escalation trial in chronic lymphocytic leukaemia. J. Clin. Oncol. 2001, 19 (8), 2165-2170
-
(2001)
J. Clin. Oncol
, vol.19
, Issue.8
, pp. 2165-2170
-
-
O'Brien, S.M.1
Kantarjian, H.2
Thomas, D.A.3
Giles, F.J.4
Freireich, E.J.5
Cortes, J.6
Lerner, S.7
Keating, M.J.8
-
37
-
-
0036839469
-
German CLL Study Group. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
-
Schulz, H.; Klein, S.K.; Rehwald, U.; Reiser, M.; Hinke, A.; Knauf, W.U.; Aulitzky, W.E.; Hensel, M.; Herold, M.; Huhn, D.; Hallek, M.; Diehl, V.; Engert, A. German CLL Study Group. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood, 2002, 100(9), 3115-31120.
-
(2002)
Blood
, vol.100
, Issue.9
, pp. 3115-31120
-
-
Schulz, H.1
Klein, S.K.2
Rehwald, U.3
Reiser, M.4
Hinke, A.5
Knauf, W.U.6
Aulitzky, W.E.7
Hensel, M.8
Herold, M.9
Huhn, D.10
Hallek, M.11
Diehl, V.12
Engert, A.13
-
38
-
-
0037220152
-
Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
-
Byrd, J.C.; Peterson, B.L.; Morrison, V.A.; Park, K.; Jacobson, R.; Hoke, E.; Vardiman, J.W.; Rai, K.; Schiffer, C.A.; Larson, R.A.; Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood, 2003, 101(1), 6-14.
-
(2003)
Blood
, vol.101
, Issue.1
, pp. 6-14
-
-
Byrd, J.C.1
Peterson, B.L.2
Morrison, V.A.3
Park, K.4
Jacobson, R.5
Hoke, E.6
Vardiman, J.W.7
Rai, K.8
Schiffer, C.A.9
Larson, R.A.10
-
39
-
-
77950478885
-
Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
-
Robak, T.; Dmoszynska, A.; Solal-Céligny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Geisler, C.H.; Montillo, M.; Zyuzgin, I.; Ganly, P.S.; Dartigeas, C.; Rosta, A.; Maurer, J.; Mendila, M.; Saville, M.W.; Valente, N.; Wenger, M.K.; Moiseev, S.I. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J. Clin. Oncol., 2010, 28, 1756-1765.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1756-1765
-
-
Robak, T.1
Dmoszynska, A.2
Solal-Céligny, P.3
Warzocha, K.4
Loscertales, J.5
Catalano, J.6
Afanasiev, B.V.7
Larratt, L.8
Geisler, C.H.9
Montillo, M.10
Zyuzgin, I.11
Ganly, P.S.12
Dartigeas, C.13
Rosta, A.14
Maurer, J.15
Mendila, M.16
Saville, M.W.17
Valente, N.18
Wenger, M.K.19
Moiseev, S.I.20
more..
-
40
-
-
77957664665
-
International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek, M.; Fischer, K.; Fingerle-Rowson, G.; Fink A.M.; Busch, R.; Mayer, J.; Hensel, M.; Hopfinger, G.; Hess, G.; von Grünhagen, U.; Bergmann, M.; Catalano, J.; Zinzani, P.L.; Caligaris-Cappio, F.; Seymour, J.F.; Berrebi, A.; Jäger, U.; Cazin, B.; Trneny, M.; Westermann, A.; Wendtner, C.M.; Eichhorst, B.F.; Staib, P.; Bühler, A.; Winkler, D.; Zenz, T.; Böttcher, S.; Ritgen, M.; Mendila M.; Kneba, M.; Döhner, H.; Stilgenbauer, S. International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet, 2010, 376 (9747), 1164-1174.
-
(2010)
Lancet
, vol.376
, Issue.9747
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
Fink, A.M.4
Busch, R.5
Mayer, J.6
Hensel, M.7
Hopfinger, G.8
Hess, G.9
von Grünhagen, U.10
Bergmann, M.11
Catalano, J.12
Zinzani, P.L.13
Caligaris-Cappio, F.14
Seymour, J.F.15
Berrebi, A.16
Jäger, U.17
Cazin, B.18
Trneny, M.19
Westermann, A.20
Wendtner, C.M.21
Eichhorst, B.F.22
Staib, P.23
Bühler, A.24
Winkler, D.25
Zenz, T.26
Böttcher, S.27
Ritgen, M.28
Mendila, M.29
Kneba, M.30
Döhner, H.31
Stilgenbauer, S.32
more..
-
41
-
-
40949154401
-
Rituximab in the treatment of autoimmune haematological disorders
-
Garvey, B. Rituximab in the treatment of autoimmune haematological disorders. Br. J.Hematol., 2008, 141, 149-169.
-
(2008)
Br. J.Hematol
, vol.141
, pp. 149-169
-
-
Garvey, B.1
-
42
-
-
0035877988
-
Anti-CD20 monoclonal antibody for the treatment of severe, immunemediated, pure red cell aplasia and hemolytic anemia
-
Zecca, M.; De Stefano, P.; Nobili, B.; Locatelli, F. Anti-CD20 monoclonal antibody for the treatment of severe, immunemediated, pure red cell aplasia and hemolytic anemia. Blood, 2001, 97(12), 3995-3997.
-
(2001)
Blood
, vol.97
, Issue.12
, pp. 3995-3997
-
-
Zecca, M.1
de Stefano, P.2
Nobili, B.3
Locatelli, F.4
-
43
-
-
0037105458
-
Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia
-
Hegde, U.P.; Wilson, W.H.; White, T.; Cheson, B.D. Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia. Blood, 2002, 100(6), 2260-2262.
-
(2002)
Blood
, vol.100
, Issue.6
, pp. 2260-2262
-
-
Hegde, U.P.1
Wilson, W.H.2
White, T.3
Cheson, B.D.4
-
44
-
-
33646362290
-
B-cell targeting in rheumatoid arthritis and other autoimmune disease
-
Edwards, JCW, Cambridge, G. B-cell targeting in rheumatoid arthritis and other autoimmune disease. Nat. Rev. Immunol., 2006, 6, 394-403.
-
(2006)
Nat. Rev. Immunol
, vol.6
, pp. 394-403
-
-
Edwards, J.C.W.1
Cambridge, G.2
-
45
-
-
0035804282
-
Acute hepatitis B in a patients with antibodies to hepatitis B surface antigen who was receiving rituximab
-
Dervite, I.; Hober, D.; Morel, P. Acute hepatitis B in a patients with antibodies to hepatitis B surface antigen who was receiving rituximab. N. Engl. J. Med., 2001, 344, 68-69.
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 68-69
-
-
Dervite, I.1
Hober, D.2
Morel, P.3
-
46
-
-
67651158993
-
Monoclonal antibody-associated progressive multifocal leucoencephalopathy inpatients treated with rituximab, natalizumab, and efalizumab: A Review from the Research on Adverse Drug Events and Reports (RADAR) Project
-
Carson, K.R.; Focosi, D.; Major, E.O.; Petrini, M.; Richey, E.A.; West, D.P.; Bennett, C.L. Monoclonal antibody-associated progressive multifocal leucoencephalopathy inpatients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Lancet Oncol., 2009, 10, 816-824.
-
(2009)
Lancet Oncol
, vol.10
, pp. 816-824
-
-
Carson, K.R.1
Focosi, D.2
Major, E.O.3
Petrini, M.4
Richey, E.A.5
West, D.P.6
Bennett, C.L.7
-
47
-
-
48849109653
-
Alemtuzumab for B-cell chronic lymphocytic leukemia
-
Robak T. Alemtuzumab for B-cell chronic lymphocytic leukemia. Expert Rev. Anticancer Ther., 2008, 8, 1033-1051.
-
(2008)
Expert Rev. Anticancer Ther
, vol.8
, pp. 1033-1051
-
-
Robak, T.1
-
48
-
-
40349114506
-
FDA Drug Approval Summary: Alemtuzumab as Single-Agent Treatment for B-Cell Chronic Lymphocytic Leukemia
-
Demko, S.; Summers, J.; Keegan, P.; Pazdur, R. FDA Drug Approval Summary: Alemtuzumab as Single-Agent Treatment for B-Cell Chronic Lymphocytic Leukemia. The Oncol., 2008, 13, 167-174.
-
(2008)
The Oncol
, vol.13
, pp. 167-174
-
-
Demko, S.1
Summers, J.2
Keegan, P.3
Pazdur, R.4
-
49
-
-
70450265546
-
Management guidelines for the use of alemtuzumab in chronic lymphocytic leukaemia
-
Osterborg, A.; Foa, R.; Bezares, R.F.; Dearden, C.; Dyer, M.J.S.; Geisler, C.; Lin, T.S.; Montillo, M.; van Oers, M.H.J.; Wendtner, C.M.; Rai K.R. Management guidelines for the use of alemtuzumab in chronic lymphocytic leukaemia. Leukemia, 2009, 23, 1980-1988.
-
(2009)
Leukemia
, vol.23
, pp. 1980-1988
-
-
Osterborg, A.1
Foa, R.2
Bezares, R.F.3
Dearden, C.4
Dyer, M.J.S.5
Geisler, C.6
Lin, T.S.7
Montillo, M.8
van Oers, M.H.J.9
Wendtner, C.M.10
Rai, K.R.11
-
50
-
-
0023911111
-
Reshaping human antibodies for therapy
-
Riechmann, L.; Clark, M.; Waldmann, H.; Winter, G. Reshaping human antibodies for therapy. Nature, 1988, 332, 323-327.
-
(1988)
Nature
, vol.332
, pp. 323-327
-
-
Riechmann, L.1
Clark, M.2
Waldmann, H.3
Winter, G.4
-
51
-
-
0027283918
-
Efficient complementmediated lysis of cells containing the CAMPATH-1 (CDw52) antigen
-
Xia, M.Q.; Hale, G.; Waldmann, H. Efficient complementmediated lysis of cells containing the CAMPATH-1 (CDw52) antigen. Mol. Immunol., 1993, 30, 1089-1096.
-
(1993)
Mol. Immunol
, vol.30
, pp. 1089-1096
-
-
Xia, M.Q.1
Hale, G.2
Waldmann, H.3
-
52
-
-
31444453579
-
Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
-
Mone, A.P.; Cheney, C.; Banks, A.L.; Tridandapani, S.; Mehter, N.; Guster S.; Lin, T.; Eisenbeis, C.F.; Young, D.C.; Byrd, J.C. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia, 2006, 20, 272-279.
-
(2006)
Leukemia
, vol.20
, pp. 272-279
-
-
Mone, A.P.1
Cheney, C.2
Banks, A.L.3
Tridandapani, S.4
Mehter, N.5
Guster, S.6
Lin, T.7
Eisenbeis, C.F.8
Young, D.C.9
Byrd, J.C.10
-
53
-
-
12744279711
-
Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells
-
Smolewski, P.; Szmigielska-Kaplon, A.; Cebula, B.; Jamroziak, K.; Rogalinska, M.; Kilianska, Z.; Robak, T. Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. Leuk. Lymphoma., 2005, 46, 87-100.
-
(2005)
Leuk. Lymphoma
, vol.46
, pp. 87-100
-
-
Smolewski, P.1
Szmigielska-Kaplon, A.2
Cebula, B.3
Jamroziak, K.4
Rogalinska, M.5
Kilianska, Z.6
Robak, T.7
-
54
-
-
4844229401
-
Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in Blymphoid cell lines and in chronic lymphocytic leukemia cells
-
Stanglmaier, M.; Reis, S.; Hallek, M. Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in Blymphoid cell lines and in chronic lymphocytic leukemia cells. Ann. Hematol., 2004, 83, 634-645.
-
(2004)
Ann. Hematol
, vol.83
, pp. 634-645
-
-
Stanglmaier, M.1
Reis, S.2
Hallek, M.3
-
55
-
-
1842507429
-
Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium
-
Zent, C.S.; Chen, J.B.; Kurten, R.C.; Kaushal, G.P.; Lacy, H.M.; Schichman, S.A. Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium. Leuk. Res., 2004, 28, 495-507.
-
(2004)
Leuk. Res
, vol.28
, pp. 495-507
-
-
Zent, C.S.1
Chen, J.B.2
Kurten, R.C.3
Kaushal, G.P.4
Lacy, H.M.5
Schichman, S.A.6
-
56
-
-
51649110602
-
Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk early-intermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab
-
Zent, C.S.; Secreto, C.R.; Laplant, B.R.; Bone, N.D.; Call, T.G.; Shanafelt, T.D.; Jelinek, D.F.; Tschumper R.C.; Kay N.E. Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk early-intermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab. Leuk. Res., 2008, 32, 1849-1856.
-
(2008)
Leuk. Res
, vol.32
, pp. 1849-1856
-
-
Zent, C.S.1
Secreto, C.R.2
Laplant, B.R.3
Bone, N.D.4
Call, T.G.5
Shanafelt, T.D.6
Jelinek, D.F.7
Tschumper, R.C.8
Kay, N.E.9
-
57
-
-
0030897222
-
European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
-
Osterborg, A.; Dyer, M.J.; Bunjes, D.; Pangalis, G.A.; Bastion, Y.; Catovsky, D.; Mellstedt, H. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. J. Clin. Oncol., 1997, 15(4),1567-1574.
-
(1997)
J. Clin. Oncol
, vol.15
, Issue.4
, pp. 1567-1574
-
-
Osterborg, A.1
Dyer, M.J.2
Bunjes, D.3
Pangalis, G.A.4
Bastion, Y.5
Catovsky, D.6
Mellstedt, H.7
-
58
-
-
0037106502
-
Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
-
Rai, K.R.; Freter, C.E.; Mercier, R.J.; Cooper, M.R.; Mitchell, B.S.; Stadtmauer, E.A.; Santábarbara, P.; Wacker, B.; Brettman, L. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J. Clin. Oncol., 2002, 20(18), 3891-3897.
-
(2002)
J. Clin. Oncol
, vol.20
, Issue.18
, pp. 3891-3897
-
-
Rai, K.R.1
Freter, C.E.2
Mercier, R.J.3
Cooper, M.R.4
Mitchell, B.S.5
Stadtmauer, E.A.6
Santábarbara, P.7
Wacker, B.8
Brettman, L.9
-
59
-
-
0037092951
-
Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
-
Keating, M.J.; Flinn, I.; Jain, V. Binet, J.L; Hillmen, P.; Byrd, J.; Albitar, M.; Brettman, L.; Santabarbara, P.; Wacker, B.; Rai, K.R. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood, 2002, 99(10), 3554-35561.
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3554-35561
-
-
Keating, M.J.1
Flinn, I.2
Jain, V.3
Binet, J.L.4
Hillmen, P.5
Byrd, J.6
Albitar, M.7
Brettman, L.8
Santabarbara, P.9
Wacker, B.10
Rai, K.R.11
-
60
-
-
0037043653
-
Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy
-
Stilgenbauer S.; Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N. Engl. J. Med., 2002, 347(6), 452-453.
-
(2002)
N. Engl. J. Med
, vol.347
, Issue.6
, pp. 452-453
-
-
Stilgenbauer, S.1
Dohner, H.2
-
61
-
-
11144357657
-
Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
-
Lozanski, G.; Heerema, N.A., Flinn, I.W.; Smith, L.; Harbison, J.; Webb, J.; Moran, M.; Lucas, M.; Lin, T.; Hackbarth, M.L.; Proffitt, J.H.; Lucas, D.; Grever, M.R.; Byrd, J.C. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood, 2004, 103(9), 3278-3281.
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3278-3281
-
-
Lozanski, G.1
Heerema, N.A.2
Flinn, I.W.3
Smith, L.4
Harbison, J.5
Webb, J.6
Moran, M.7
Lucas, M.8
Lin, T.9
Hackbarth, M.L.10
Proffitt, J.H.11
Lucas, D.12
Grever, M.R.13
Byrd, J.C.14
-
62
-
-
6344292639
-
Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: Incidence and treatment with oral ganciclovir
-
Laurenti, L.; Piccioni, P.; Cattani, P.; Cingolani, A.; Efremov, D.G.; Chiusolo, P.; Tarnani, M.; Fadda, G.; Sica, S.; Leone, G. Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir. Haematologica, 2004, 89(10), 1248-1252.
-
(2004)
Haematologica
, vol.89
, Issue.10
, pp. 1248-1252
-
-
Laurenti, L.1
Piccioni, P.2
Cattani, P.3
Cingolani, A.4
Efremov, D.G.5
Chiusolo, P.6
Tarnani, M.7
Fadda, G.8
Sica, S.9
Leone, G.10
-
63
-
-
37649004407
-
Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
-
Hillmen, P.; Skotnicki, A.B.; Robak, T.; Jaksic, B.; Dmoszynska, A.; Wu, J.; Sirard, C.; Mayer, J. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J. Clin. Oncol., 2007, 25, 5616-5623.
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 5616-5623
-
-
Hillmen, P.1
Skotnicki, A.B.2
Robak, T.3
Jaksic, B.4
Dmoszynska, A.5
Wu, J.6
Sirard, C.7
Mayer, J.8
-
64
-
-
0036683449
-
Phase II trial of subcutaneous anti CD- 52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukaemia (B-CLL)
-
Lundin, J.; Kimby, E.; Björkholm, M.; Broliden, P.A.; Celsing, F.; Hjalmar, V.; Möllgård, L.; Rebello, P.; Hale, G.; Waldmann, H.; Mellstedt, H.; Österborg, A. Phase II trial of subcutaneous anti CD- 52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukaemia (B-CLL). Blood, 2002, 100, 768-773.
-
(2002)
Blood
, vol.100
, pp. 768-773
-
-
Lundin, J.1
Kimby, E.2
Björkholm, M.3
Broliden, P.A.4
Celsing, F.5
Hjalmar, V.6
Möllgård, L.7
Rebello, P.8
Hale, G.9
Waldmann, H.10
Mellstedt, H.11
Österborg, A.12
-
65
-
-
69849107362
-
German Chronic Lymphocytic Leukemia Study Group. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic ymphocytic Leukemia Study Group
-
Stilgenbauer, S.; Zenz, T.; Winkler, D.; Bühler, A.; Schlenk, R.F.; Groner, S.; Busch, R.; Hensel, M.; Dührsen, U.; Finke, J.; Dreger, P.; Jäger, U.; Lengfelder, E.; Hohloch, K.; Söling, U.; Schlag, R.; Kneba, M.; Hallek, M.; Döhner, H. German Chronic Lymphocytic Leukemia Study Group. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic ymphocytic Leukemia Study Group. J. Clin. Oncol., 2009, 27(24), 3994-4001.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.24
, pp. 3994-4001
-
-
Stilgenbauer, S.1
Zenz, T.2
Winkler, D.3
Bühler, A.4
Schlenk, R.F.5
Groner, S.6
Busch, R.7
Hensel, M.8
Dührsen, U.9
Finke, J.10
Dreger, P.11
Jäger, U.12
Lengfelder, E.13
Hohloch, K.14
Söling, U.15
Schlag, R.16
Kneba, M.17
Hallek, M.18
Döhner, H.19
-
66
-
-
70450267533
-
Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): Results of a prospective, single-arm multicentre study
-
Cortelezzi, A.; Pasquini, M.C.; Cardellini, A.; Granelli, U.; Bossi, A.; Reda, G.; Sarina, B.; Musto, P.; Barcellini, W.; Neri, A.; Deliliers, G.L. Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study. Leukemia, 2009, 23, 2027-2033.
-
(2009)
Leukemia
, vol.23
, pp. 2027-2033
-
-
Cortelezzi, A.1
Pasquini, M.C.2
Cardellini, A.3
Granelli, U.4
Bossi, A.5
Reda, G.6
Sarina, B.7
Musto, P.8
Barcellini, W.9
Neri, A.10
Deliliers, G.L.11
-
67
-
-
24944566741
-
Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience
-
Laurenti, L.; Piccioni, P.; Tarnani, M.; Efremov, D.G.; Fiorini, A.; Garzia, M.; Sica, S. Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience. Haematologica., 2005, 90(8), 1143-1145.
-
(2005)
Haematologica
, vol.90
, Issue.8
, pp. 1143-1145
-
-
Laurenti, L.1
Piccioni, P.2
Tarnani, M.3
Efremov, D.G.4
Fiorini, A.5
Garzia, M.6
Sica, S.7
-
68
-
-
77950928819
-
The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia
-
Tarnani, M.; D'Arena, G.; Efremov, D.G.; Marietti, S.; Leone, G., Laurenti, L. The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia. Leukemia, 2010, 24(4), 890-891.
-
(2010)
Leukemia
, vol.24
, Issue.4
, pp. 890-891
-
-
Tarnani, M.1
D'Arena, G.2
Efremov, D.G.3
Marietti, S.4
Leone, G.5
Laurenti, L.6
-
69
-
-
1542503801
-
Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
-
Lundin, J.; Porwit-MacDonald, A.; Rossmann, E.D.; Karlsson, C.; Edman, P.; Rezvany, M.R.; Kimby, E.; Osterborg, A.; Mellstedt, H. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia, 2004, 18(3), 484-490.
-
(2004)
Leukemia
, vol.18
, Issue.3
, pp. 484-490
-
-
Lundin, J.1
Porwit-Macdonald, A.2
Rossmann, E.D.3
Karlsson, C.4
Edman, P.5
Rezvany, M.R.6
Kimby, E.7
Osterborg, A.8
Mellstedt, H.9
-
70
-
-
11844288279
-
Immune recovery after lowdose Campath therapy in a group of pretreated patients affected by B-cell chronic lymphocytic leukemia
-
Laurenti, L.; Piccioni, P.; Tarnani, M.; Chiusolo P.; Piccirillo, N.; Rumi, C.; Sora, F.; Sica, S.; Leone, G. Immune recovery after lowdose Campath therapy in a group of pretreated patients affected by B-cell chronic lymphocytic leukemia. Leukemia., 2005, 19(1), 153-154.
-
(2005)
Leukemia
, vol.19
, Issue.1
, pp. 153-154
-
-
Laurenti, L.1
Piccioni, P.2
Tarnani, M.3
Chiusolo, P.4
Piccirillo, N.5
Rumi, C.6
Sora, F.7
Sica, S.8
Leone, G.9
-
71
-
-
77956205101
-
Improved progression-free survival (PFS) of alemtuzumab (Campath_, Mab-Campath_) plus fludarabine (Fludara_) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: Preliminary results from a phase III randomized trial
-
Engert, A.; Gercheva, L.; Robak, T.; Galina, P.; Wu, J.; Sirard, C.A.; Elter, T. Improved progression-free survival (PFS) of alemtuzumab (Campath_, Mab-Campath_) plus fludarabine (Fludara_) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: preliminary results from a phase III randomized trial. Blood., 2009, 114(22), 537a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Engert, A.1
Gercheva, L.2
Robak, T.3
Galina, P.4
Wu, J.5
Sirard, C.A.6
Elter, T.7
-
72
-
-
77953446272
-
Chemoimmuno-Therapy with Fludarabine, Cyclophosphamide and Alemtuzumab (FC-Cam) in Patients with Relapsed or Genetic High-Risk CLL: Final Analysis of the CLL2L Trial of the German CLL Study Group
-
Elter, T.; James R.; Stilgenbauer, S.; Boettcher, S.; Ritgen, M.; Doehner, H.; Hallek M.; Engert, A. Chemoimmuno-Therapy with Fludarabine, Cyclophosphamide and Alemtuzumab (FC-Cam) in Patients with Relapsed or Genetic High-Risk CLL: Final Analysis of the CLL2L Trial of the German CLL Study Group. Blood, 2009, 114, 209a.
-
(2009)
Blood
, vol.114
-
-
Elter, T.1
James, R.2
Stilgenbauer, S.3
Boettcher, S.4
Ritgen, M.5
Doehner, H.6
Hallek, M.7
Engert, A.8
-
73
-
-
38949185742
-
Safety and efficacy ofatumumab efficacy A fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. A phase 1-2 study
-
Coiffier, B.; Lepretre, S.; Pedersen, L.M.; Gadeberg, O.; Fredriksen, H.; van Oers, M.H.J; Wooldridge, J.; Kloczko, J.; Holowiecki, J.; Hellmann, A.; Walewski, J.; Flensburg, M.; Petersen, J.; Robak, T. Safety and efficacy ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. A phase 1-2 study. Blood, 2008; 11, 1094-1100.
-
(2008)
Blood
, vol.11
, pp. 1094-1100
-
-
Coiffier, B.1
Lepretre, S.2
Pedersen, L.M.3
Gadeberg, O.4
Fredriksen, H.5
van Oers, M.H.J.6
Wooldridge, J.7
Kloczko, J.8
Holowiecki, J.9
Hellmann, A.10
Walewski, J.11
Flensburg, M.12
Petersen, J.13
Robak, T.14
-
74
-
-
44849134493
-
Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders
-
Robak, T. Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders. Curr. Opin. Mol. Ther., 2008, 10, 294-309.
-
(2008)
Curr. Opin. Mol. Ther
, vol.10
, pp. 294-309
-
-
Robak, T.1
-
75
-
-
77950502126
-
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
-
Wierda, W.G.; Kipps, T.J.; Mayer, J. Stilgenbauer, S.; Williams, C.D.; Hellmann, A.; Robak, T.; Furman, R.R; Hillmen, P.; Trneny, M.; Dyer, M.J.S.; Padmanabhan S.; Piotrowska, M.; Kozak, T.; Chan, G.; Davis, R.; Losic, N.; Wilms, J.; Russell, C.A.; Österborg, A. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J. Clin. Oncol., 2010, 28, 1749-55.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1749-1755
-
-
Wierda, W.G.1
Kipps, T.J.2
Mayer, J.3
Stilgenbauer, S.4
Williams, C.D.5
Hellmann, A.6
Robak, T.7
Furman, R.R.8
Hillmen, P.9
Trneny, M.10
Dyer, M.J.S.11
Padmanabhan, S.12
Piotrowska, M.13
Kozak, T.14
Chan, G.15
Davis, R.16
Losic, N.17
Wilms, J.18
Russell, C.A.19
Österborg, A.20
more..
-
76
-
-
77952628343
-
Ofatumumab
-
Sanford, M.; McCormack, P.L. Ofatumumab. Drugs, 2010, 70(8), 1013-1019.
-
(2010)
Drugs
, vol.70
, Issue.8
, pp. 1013-1019
-
-
Sanford, M.1
McCormack, P.L.2
-
77
-
-
77956250271
-
U.S. Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab
-
Lemery, S.J.; Zhang, J.; Rothmann, M.D.; Yang, J.; Earp, J.; Zhao, H.; McDougal A.; Pilaro, A.; Chiang, R.; Gootenberg, J.E.; Keegan, P.; Pazdur, R. U.S. Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab. Clin. Cancer Res., 2010, 16(17), 4331-4338.
-
(2010)
Clin. Cancer Res
, vol.16
, Issue.17
, pp. 4331-4338
-
-
Lemery, S.J.1
Zhang, J.2
Rothmann, M.D.3
Yang, J.4
Earp, J.5
Zhao, H.6
McDougal, A.7
Pilaro, A.8
Chiang, R.9
Gootenberg, J.E.10
Keegan, P.11
Pazdur, R.12
-
78
-
-
18144368022
-
-
GlaxoSmithKline; Research Triangle Park (NC), Arzerra (ofatumumab). October 2009
-
GlaxoSmithKline; Research Triangle Park (NC). Prescribing information. Arzerra (ofatumumab). October 2009.
-
Prescribing Information
-
-
-
79
-
-
47949095894
-
Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis
-
Beum, P.V.; Lindorfer, M.A.; Beurskens, F.; Stukenberg, P.T.; Lokhorst, H.M.; Pawluczkowycz, A.W.; Parren, P.W.; van de Winkel, J.G.; Taylor, R.P. Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis. J. Immunol., 2008, 181, 822-832.
-
(2008)
J. Immunol
, vol.181
, pp. 822-832
-
-
Beum, P.V.1
Lindorfer, M.A.2
Beurskens, F.3
Stukenberg, P.T.4
Lokhorst, H.M.5
Pawluczkowycz, A.W.6
Parren, P.W.7
van de Winkel, J.G.8
Taylor, R.P.9
-
80
-
-
4444343395
-
Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
-
Teeling, J.L.; French, R.R.; Cragg, M.S.; van den Brakel, J.; Pluyter, M.; Huang, H.; Chan, C.; Parren, P.W.H.I.; Hack, C.E.; Dechant, M.; Valerius, T.; van de Winkel, J.G.J.; Glennie, M.J. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood, 2004, 104, 1793-1800.
-
(2004)
Blood
, vol.104
, pp. 1793-1800
-
-
Teeling, J.L.1
French, R.R.2
Cragg, M.S.3
van den Brakel, J.4
Pluyter, M.5
Huang, H.6
Chan, C.7
Parren, P.W.H.I.8
Hack, C.E.9
Dechant, M.10
Valerius, T.11
van de Winkel, J.G.J.12
Glennie, M.J.13
-
81
-
-
68949129063
-
Binding of submaximal C1q promotes complement dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX
-
Pawluczkowycz, A.; Beurskens, F.; Beum, P.V. Lindorfer, M.A., van de Winkel, J.G.; Parren, P.W.; Taylor, R.P. Binding of submaximal C1q promotes complement dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX. J. Immunol., 2009, 183, 749-758.
-
(2009)
J. Immunol
, vol.183
, pp. 749-758
-
-
Pawluczkowycz, A.1
Beurskens, F.2
Beum, P.V.3
Lindorfer, M.A.4
van de Winkel, J.G.5
Parren, P.W.6
Taylor, R.P.7
-
82
-
-
38349138517
-
Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
-
Bleeker, W.K.; Munk, M.E.; Mackus, W.J. van den Brakel, J.H.; Pluyter, M.; Glennie, M.J.; van de Winkel, J.G.; Parren, P.W. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br. J. Haematol., 2008, 140(3), 303-312.
-
(2008)
Br. J. Haematol
, vol.140
, Issue.3
, pp. 303-312
-
-
Bleeker, W.K.1
Munk, M.E.2
Mackus, W.J.3
van den Brakel, J.H.4
Pluyter, M.5
Glennie, M.J.6
van de Winkel, J.G.7
Parren, P.W.8
-
83
-
-
79959398254
-
-
GlaxoSmithKline, Accessed 2010 Jan 25
-
GlaxoSmithKline. Arzerra: prescribing information [online]. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125326lbl.pdf [Accessed 2010 Jan 25]
-
Arzerra: Prescribing Information [online]
-
-
-
84
-
-
76149128849
-
Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results From a Randomized, Multicenter, International, Two-Dose, Parallel Group, Phase II Trial
-
Wierda, W.G.; Kipps, T.J.; Durig J.; Griskevicius, L.; Stilgenbauer, S.; Mayer, J.; Smolej, L.; Hess, G.; Griniute, R.; Hernandez-Ilizaliturri, F.J.; Padmanabhan, S.; Gorczyca, M.; Chan, G.; Gupta, I.; Andersen, M.; Strange, C.; Nielsen, T.G.; Russell, C.A. Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results From a Randomized, Multicenter, International, Two-Dose, Parallel Group, Phase II Trial. Blood, 2009, 114(22), 207a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Wierda, W.G.1
Kipps, T.J.2
Durig, J.3
Griskevicius, L.4
Stilgenbauer, S.5
Mayer, J.6
Smolej, L.7
Hess, G.8
Griniute, R.9
Hernandez-Ilizaliturri, F.J.10
Padmanabhan, S.11
Gorczyca, M.12
Chan, G.13
Gupta, I.14
Andersen, M.15
Strange, C.16
Nielsen, T.G.17
Russell, C.A.18
-
85
-
-
79251473278
-
-
European Medicines Agency, Accessed 2010 Jan 25
-
European Medicines Agency. Arzerra: summary of opinion (initial authorisation) [online]. Available from URL: http://www.emea.europa.eu/pdfs/human/opinion/Arzerra_214261en.pdf [Accessed 2010 Jan 25]
-
Arzerra: Summary of Opinion (initial Authorisation) [online]
-
-
-
86
-
-
70449603373
-
GA101, a novel humanized type II CD20 antibody with glycoengineered Fc and anhanced cell death induction, exhibits superior anti-tumor efficacy and superior tissue B cell depletion in vivo
-
Umana, P.; Moessner, E.; Bruenker, P.; Gabriele, K.; Ursula, P.; Suter, T.; Grau, R.; Schmidt, C.; Herter, S.; Gerdes, C.; Nopora, A.; Patre, M.; Moser, S.; Sondermann, P.; Wheat, L.; Dyer, M.J.S.; Poppema, S.; Bauer, S.; Kubbies, M.; Strein, P.; Fertig, G.; Friess, T.; Dabbagh, K.; Dal Porto, J.; Klein, C. GA101, a novel humanized type II CD20 antibody with glycoengineered Fc and anhanced cell death induction, exhibits superior anti-tumor efficacy and superior tissue B cell depletion in vivo. Blood, 2007, 110, 2348a.
-
(2007)
Blood
, vol.110
-
-
Umana, P.1
Moessner, E.2
Bruenker, P.3
Gabriele, K.4
Ursula, P.5
Suter, T.6
Grau, R.7
Schmidt, C.8
Herter, S.9
Gerdes, C.10
Nopora, A.11
Patre, M.12
Moser, S.13
Sondermann, P.14
Wheat, L.15
Dyer, M.J.S.16
Poppema, S.17
Bauer, S.18
Kubbies, M.19
Strein, P.20
Fertig, G.21
Friess, T.22
Dabbagh, K.23
dal Porto, J.24
Klein, C.25
more..
-
87
-
-
67649575638
-
Aphase I/II study of RO5072759 (GA101) in patients with relapsed/refractory CD20_ malignant disease
-
Salles, G.; Morschhauser, F.; Cartron, G.; Lamy, T.; Milpied, N.J.; Thieblemont, C.; Tilly, H.; Birkett, J.; Burgess, M. Aphase I/II study of RO5072759 (GA101) in patients with relapsed/refractory CD20_ malignant disease. Blood, 2008, 112, 234a.
-
(2008)
Blood
, vol.112
-
-
Salles, G.1
Morschhauser, F.2
Cartron, G.3
Lamy, T.4
Milpied, N.J.5
Thieblemont, C.6
Tilly, H.7
Birkett, J.8
Burgess, M.9
-
88
-
-
67650657179
-
GA-101, a third-generation, humanized and glycoengineered anti CD20 mAb for the treatment of B-cell lymphoid malignancies
-
Robak, T. GA-101, a third-generation, humanized and glycoengineered anti CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr. Opin. Investig. Drugs, 2009, 10, 588-596.
-
(2009)
Curr. Opin. Investig. Drugs
, vol.10
, pp. 588-596
-
-
Robak, T.1
-
89
-
-
33646172632
-
The carbohydrate at FcgammaRIIIa Asn-162: An element required for high affinity binding to non-fucosylated IgG glycoforms
-
Ferrara, C.; Stuart, F.; Sondermann, P.; Brunker, P.; Umana, P.; The carbohydrate at FcgammaRIIIa Asn-162: an element required for high affinity binding to non-fucosylated IgG glycoforms. J. Biol. Chem., 2006, 281(8), 5032-5036.
-
(2006)
J. Biol. Chem
, vol.281
, Issue.8
, pp. 5032-5036
-
-
Ferrara, C.1
Stuart, F.2
Sondermann, P.3
Brunker, P.4
Umana, P.5
-
90
-
-
77950309251
-
Crystal Structure Analysis Reveals That the Novel Type II Anti-CD20 Antibody GA101 Interacts with a Similar Epitope as Rituximab and Ocrelizumab but in a Fundamentally Different Way
-
Niederfellner, G.J.; Lammens, A.; Schwaiger, M.; Georges, G.; Wiechmann, K.; Franke, A.; Schaefer, W.; Jenewein, S.; Slootstra, J.; Moessner, E.; Umana, P.; Hopfner, K.P; Klein, C. Crystal Structure Analysis Reveals That the Novel Type II Anti-CD20 Antibody GA101 Interacts with a Similar Epitope as Rituximab and Ocrelizumab but in a Fundamentally Different Way. Blood, 2009, 114(22), 3726a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Niederfellner, G.J.1
Lammens, A.2
Schwaiger, M.3
Georges, G.4
Wiechmann, K.5
Franke, A.6
Schaefer, W.7
Jenewein, S.8
Slootstra, J.9
Moessner, E.10
Umana, P.11
Hopfner, K.P.12
Klein, C.13
-
91
-
-
77950312458
-
New- Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma
-
Alduaij, W.; Potluri, S.; Ivanov, A.; Honeychurch, J.; Beers, S.A.; Chan C.; Shimada, K.; Glennie, M.J.; Cragg, M.S.; Illidge, T. New- Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma. Blood, 2009, 114(22), 725a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Alduaij, W.1
Potluri, S.2
Ivanov, A.3
Honeychurch, J.4
Beers, S.A.5
Chan, C.6
Shimada, K.7
Glennie, M.J.8
Cragg, M.S.9
Illidge, T.10
-
92
-
-
68849108368
-
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
-
Ivanov, A.; Beers, S.A.; Walshe, C.A.; Honeychurch, J.; Alduaij, W.; Cox, K.L.; Potter, K.N.; Murray, S.; Chan, C.H.; Klymenko, T.; Erenpreisa, J.; Glennie, M.J.; Illidge, T.M.; Cragg, M.S. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J. Clin. Invest., 2009, 19(8), 2143-2159.
-
(2009)
J. Clin. Invest
, vol.19
, Issue.8
, pp. 2143-2159
-
-
Ivanov, A.1
Beers, S.A.2
Walshe, C.A.3
Honeychurch, J.4
Alduaij, W.5
Cox, K.L.6
Potter, K.N.7
Murray, S.8
Chan, C.H.9
Klymenko, T.10
Erenpreisa, J.11
Glennie, M.J.12
Illidge, T.M.13
Cragg, M.S.14
-
93
-
-
77950303297
-
In Vitro Activity of the Type II Anti-CD20 Antibody GA101 in Refractory, Genetic High-Risk CLL
-
Zenz, T.; Volden, M.; Mast, T.; Sarno, A.; Winkler, D.; Schnaiter, A.; Bühler, A.; Klein, C.; Umana, P.; Döhner, H.; Stilgenbauer, S. In Vitro Activity of the Type II Anti-CD20 Antibody GA101 in Refractory, Genetic High-Risk CLL. Blood, 2009, 114(22), 2379a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Zenz, T.1
Volden, M.2
Mast, T.3
Sarno, A.4
Winkler, D.5
Schnaiter, A.6
Bühler, A.7
Klein, C.8
Umana, P.9
Döhner, H.10
Stilgenbauer, S.11
-
94
-
-
77950307720
-
Depletion of chronic lymphocytic leukemia cells from whole blood samples mediated by the anti-CD20 antibodies rituximab and GA101
-
Patz M.; Forcob N.; Muller B.; Klein C.; Umana P.; Hallek M.; Krause G. Depletion of chronic lymphocytic leukemia cells from whole blood samples mediated by the anti-CD20 antibodies rituximab and GA101. Blood, 2009, 114(22), 2365a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Patz, M.1
Forcob, N.2
Muller, B.3
Klein, C.4
Umana, P.5
Hallek, M.6
Krause, G.7
-
95
-
-
76949107685
-
Phase I Study of RO5072759 (GA101) in Relapsed/Refractory Chronic Lymphocytic Leukemia
-
Morschhauser, F.; Cartron, G.; Lamy, T.; Milpied, N.J., Thieblemont, C.; Tilly, H.; Weisser, M.; Birkett, J.; Salles, J.A. Phase I Study of RO5072759 (GA101) in Relapsed/Refractory Chronic Lymphocytic Leukemia. Blood, 2009, 114(22), 884a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Morschhauser, F.1
Cartron, G.2
Lamy, T.3
Milpied, N.J.4
Thieblemont, C.5
Tilly, H.6
Weisser, M.7
Birkett, J.8
Salles, J.A.9
-
96
-
-
0036166593
-
Surface antigen expression in chronic lymphocytic leukemia: Clustering analysis, interrelationships and effects of chromosomal abnormalities
-
Hulkkonen, J.; Vilpo, L.; Hurme, M.; Vilpo, J. Surface antigen expression in chronic lymphocytic leukemia: clustering analysis, interrelationships and effects of chromosomal abnormalities. Leukemia, 2002, 16(2), 178-185.
-
(2002)
Leukemia
, vol.16
, Issue.2
, pp. 178-185
-
-
Hulkkonen, J.1
Vilpo, L.2
Hurme, M.3
Vilpo, J.4
-
97
-
-
0035180896
-
Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/ small lymphocytic lymphoma
-
Gong, J.Z.; Lagoo, A.S.; Peters, D.; Horvatinovich, J.; Benz, P.; Buckley, P.J. Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/ small lymphocytic lymphoma. Am. J. Clin. Pathol., 2001, 116(6), 893-897.
-
(2001)
Am. J. Clin. Pathol
, vol.116
, Issue.6
, pp. 893-897
-
-
Gong, J.Z.1
Lagoo, A.S.2
Peters, D.3
Horvatinovich, J.4
Benz, P.5
Buckley, P.J.6
-
98
-
-
38949180269
-
Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23_ lymphoma cell lines
-
Pathan, N.I.; Chu, P.; Hariharan, K.; Cheny, C.; Molina, A.; Byrd, J. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23_ lymphoma cell lines. Blood, 2008, 111(3),1594-1602.
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1594-1602
-
-
Pathan, N.I.1
Chu, P.2
Hariharan, K.3
Cheny, C.4
Molina, A.5
Byrd, J.6
-
99
-
-
34547691135
-
Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
-
Byrd, JC.; O'Brien, S.; Flinn, IW.; Kipps, TJ.; Weiss, M.; Rai, K.; Lin, TS.; Woodworth, J.; Wynne, D.; Reid, J.; Molina, A.; Leigh, B.; Harris, S. Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin. Cancer Res., 2007, 13(15 pt 1), 4448-4455.
-
(2007)
Clin. Cancer Res
, vol.13
, Issue.15 PART 1
, pp. 4448-4455
-
-
Byrd, J.C.1
O'Brien, S.2
Flinn, I.W.3
Kipps, T.J.4
Weiss, M.5
Rai, K.6
Lin, T.S.7
Woodworth, J.8
Wynne, D.9
Reid, J.10
Molina, A.11
Leigh, B.12
Harris, S.13
-
100
-
-
77449133613
-
Phase study of lumiliximab combined with fludarabine, cyclophosphamide and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
-
Byrd, J.C.; Kipps, T.J.; Flinn, I.W.; Castro, J.; Lin, T.S.; Wierda, W.; Heerema, N.; Woodworth, J; Hughes, S.; Tangri, S.; Harris, S.; Wynne, D.; Molina, A.; Leigh, B.; O'Brien, S. Phase study of lumiliximab combined with fludarabine, cyclophosphamide and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood, 2010, 115, 489-495.
-
(2010)
Blood
, vol.115
, pp. 489-495
-
-
Byrd, J.C.1
Kipps, T.J.2
Flinn, I.W.3
Castro, J.4
Lin, T.S.5
Wierda, W.6
Heerema, N.7
Woodworth, J.8
Hughes, S.9
Tangri, S.10
Harris, S.11
Wynne, D.12
Molina, A.13
Leigh, B.14
O'Brien, S.15
-
101
-
-
71249091846
-
TRU-016, a humanized anti- CD37 IgG fusion protein for the potential treatment of B-cell malignancies
-
Robak, T.; Robak, P.; Smolewski, P. TRU-016, a humanized anti- CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr. Opin. Investig. Drugs, 2009, 10, 1383-90.
-
(2009)
Curr. Opin. Investig. Drugs
, vol.10
, pp. 1383-1390
-
-
Robak, T.1
Robak, P.2
Smolewski, P.3
-
102
-
-
72149102570
-
A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL
-
Andritsos, L.; Furman, R.; Flinn, I.W. A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL. J. Clin. Oncol., 2009, 27(15), 3017a.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.15
-
-
Andritsos, L.1
Furman, R.2
Flinn, I.W.3
-
103
-
-
34948858867
-
Targeting CD37- positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
-
Zhao, X.; Lapalombella, R.; Joshi, T.; Cheney, C.; Gowda, A.; Hayden-Ledbetter, M.S.; Baum, P.R.; Lin, T.S.; Jarjoura, D.; Lehman, A.; Kussewitt, D.; Lee, R.J, Caligiuri, M.A.; Tridandapani, S.; Muthusamy, N.; Byrd, J.C. Targeting CD37- positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood. 2007, 110(7), 2569-2577.
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2569-2577
-
-
Zhao, X.1
Lapalombella, R.2
Joshi, T.3
Cheney, C.4
Gowda, A.5
Hayden-Ledbetter, M.S.6
Baum, P.R.7
Lin, T.S.8
Jarjoura, D.9
Lehman, A.10
Kussewitt, D.11
Lee, R.J.12
Caligiuri, M.A.13
Tridandapani, S.14
Muthusamy, N.15
Byrd, J.C.16
-
104
-
-
77949421075
-
Evaluation of the effect of TRU-16, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non- Hodgkin's lymphoma
-
Baum, P.R.; Cerveny, C.; Gordon, B.; Nilsson, C.; Wiens, J.; Rafiq, S.; Lapalombella, R.; Muthusamy, N.; Byrd, J.C.; Wahl, A. Evaluation of the effect of TRU-16, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non- Hodgkin's lymphoma. J. Clin. Oncol., 2009, 27(15), 8571a
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.15
-
-
Baum, P.R.1
Cerveny, C.2
Gordon, B.3
Nilsson, C.4
Wiens, J.5
Rafiq, S.6
Lapalombella, R.7
Muthusamy, N.8
Byrd, J.C.9
Wahl, A.10
-
105
-
-
77955176357
-
A Phase 1 Trial of TRU-016, An Anti- CD37 Small Modular Immunopharmaceutical (SMIPTM) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity
-
Andritsos, L.; Furman, R.R.; Flinn, I.W.; Foreno-Torres, A.; Flynn, J.M.; Muthusamy, N.; Rafiq, S.; Stromatt, S.; Byrd, J.C. A Phase 1 Trial of TRU-016, An Anti- CD37 Small Modular Immunopharmaceutical (SMIPTM) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity. Blood, 2009, 114(22), 3124a.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Andritsos, L.1
Furman, R.R.2
Flinn, I.W.3
Foreno-Torres, A.4
Flynn, J.M.5
Muthusamy, N.6
Rafiq, S.7
Stromatt, S.8
Byrd, J.C.9
-
106
-
-
76349120845
-
A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
-
Furman, R.R.; Forero-Torres, A.; Shustov, A.; Drachman, J.G. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk. Lymphoma., 2010, 51(2), 228-235.
-
(2010)
Leuk. Lymphoma
, vol.51
, Issue.2
, pp. 228-235
-
-
Furman, R.R.1
Forero-Torres, A.2
Shustov, A.3
Drachman, J.G.4
-
107
-
-
70449559786
-
HCD122 an antagonist human anti-CD40 monoclonal antibody, inhibits tumor growth in xeno-graft models of human diffuse large B-cell lymphoma, a subsets of non-Hodgkin's lymphoma
-
Hsu, S.J.; Esposito, L.A.; Aukerman, S.L.; Kantak, S.; Mirza, A.M. HCD122 an antagonist human anti-CD40 monoclonal antibody, inhibits tumor growth in xeno-graft models of human diffuse large B-cell lymphoma, a subsets of non-Hodgkin's lymphoma. Blood, 2006, 108 (11), 2519a.
-
(2006)
Blood
, vol.108
, Issue.11
-
-
Hsu, S.J.1
Esposito, L.A.2
Aukerman, S.L.3
Kantak, S.4
Mirza, A.M.5
-
108
-
-
79959429444
-
A non-internalizing anti-CD40 antibody CHIR-0.12.12, blocks CD40 L-induced cytokine production and mediated greater ADCC than rituximab in primary CLL cells
-
Tong, X.; Aukerman, S.L.; Lin, K.; Aziz, N.; Goldbeck, C.; Georgakis, G.V.; Younes, A.; Weng, W.K. O'Brien, S.; Wierda, W.; Jallal, B.; Luqman, M. A non-internalizing anti-CD40 antibody CHIR-0.12.12, blocks CD40 L-induced cytokine production and mediated greater ADCC than rituximab in primary CLL cells. Blood, 2005, 106 (11), 2964a.
-
(2005)
Blood
, vol.106
, Issue.11
-
-
Tong, X.1
Aukerman, S.L.2
Lin, K.3
Aziz, N.4
Goldbeck, C.5
Georgakis, G.V.6
Younes, A.7
Weng, W.K.8
O'Brien, S.9
Wierda, W.10
Jallal, B.11
Luqman, M.12
-
109
-
-
65349169910
-
Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody HCD122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia
-
Byrd, J.C.; Flinn, I.W.; Khan, K.D.; Kipps, T.J.; Aukerman, L.; Fox, J.; Girish, S.; Guzy, S.; Bilic S.; Solinger, A.; Dort, S.; Wang, Y.; Hurst, D.; O'Brien, S. Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody HCD122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia. Blood, 2006, 108 (11), 2837a.
-
(2006)
Blood
, vol.108
, Issue.11
-
-
Byrd, J.C.1
Flinn, I.W.2
Khan, K.D.3
Kipps, T.J.4
Aukerman, L.5
Fox, J.6
Girish, S.7
Guzy, S.8
Bilic, S.9
Solinger, A.10
Dort, S.11
Wang, Y.12
Hurst, D.13
O'Brien, S.14
-
110
-
-
0035882549
-
Humanization and characterization of the anti-HLA-DR antibody 1D10
-
Kostelny, S.A.; Link, B.K.; Tso, J.Y.; Vasquez, M.; Jorgensen, B.H.; Wang, H.G.; Hall, W.C.; Weiner, G.J. Humanization and characterization of the anti-HLA-DR antibody 1D10. Int. J. Cancer, 2001, 93, 556-565.
-
(2001)
Int. J. Cancer
, vol.93
, pp. 556-565
-
-
Kostelny, S.A.1
Link, B.K.2
Tso, J.Y.3
Vasquez, M.4
Jorgensen, B.H.5
Wang, H.G.6
Hall, W.C.7
Weiner, G.J.8
-
111
-
-
72949111820
-
A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia
-
Lin, T.S.; Stock, W.; Xu, H.; Phelps, M.A.; Lucas, M.S.; Guster, S.K.; Briggs, B.R.; Cheney, C.; Porcu, P.; Flinn, I.W.; Grever, M.R.; Dalton, J.T.; Byrd, J.C. A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia. Leuk. Lymphoma., 2009, 50(12), 1958-1963.
-
(2009)
Leuk. Lymphoma
, vol.50
, Issue.12
, pp. 1958-1963
-
-
Lin, T.S.1
Stock, W.2
Xu, H.3
Phelps, M.A.4
Lucas, M.S.5
Guster, S.K.6
Briggs, B.R.7
Cheney, C.8
Porcu, P.9
Flinn, I.W.10
Grever, M.R.11
Dalton, J.T.12
Byrd, J.C.13
-
112
-
-
33748778482
-
Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
-
Carnahan, J.; Stein, R.; Qu, Z.; Hess, K.; Cesano, A.; Hansen, H.J.; Goldenberg, D.M. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol. Immunol., 2007, 44(6), 1331-1341.
-
(2007)
Mol. Immunol
, vol.44
, Issue.6
, pp. 1331-1341
-
-
Carnahan, J.1
Stein, R.2
Qu, Z.3
Hess, K.4
Cesano, A.5
Hansen, H.J.6
Goldenberg, D.M.7
-
113
-
-
12444270688
-
Epratuzumab, a humanized monoclonal antibody targeting CD22: Characterization of in vitro properties
-
Carnahan, J.; Wang, P.; Kendall, R.; Chen, C.; Hu, S.; Boone, T.; Juan, T.; Talvenheimo, J.; Montestruque, S.; Sun, J.; Elliott, G.; Thomas, J.; Ferbas, J.; Kern, B.; Briddell, R.; Leonard, J.P.; Cesano, A. Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties. Clin. Cancer Res., 2003, 9 (10), 3982a.
-
(2003)
Clin. Cancer Res
, vol.9
, Issue.10
-
-
Carnahan, J.1
Wang, P.2
Kendall, R.3
Chen, C.4
Hu, S.5
Boone, T.6
Juan, T.7
Talvenheimo, J.8
Montestruque, S.9
Sun, J.10
Elliott, G.11
Thomas, J.12
Ferbas, J.13
Kern, B.14
Briddell, R.15
Leonard, J.P.16
Cesano, A.17
-
114
-
-
22344436992
-
Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory ollicular lymphoma
-
Czuczman, M.S.; Thall, A.; Witzig, T.E. Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory ollicular lymphoma. J. Clin. Oncol., 2005, 23, 4390-4403
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 4390-4443
-
-
Czuczman, M.S.1
Thall, A.2
Witzig, T.E.3
-
115
-
-
0035469851
-
German Chronic Lymphocytic Leukemia Study Group. Rituximab therapy of patients with B-cell hronic lymphocytic leukemia
-
Huhn, D.; von Schilling, C.; Wilhelm, M.; Ho, A.D.; Hallek, M.; Kuse, R.; Knauf, W.; Riedel, U.; Hinke, A.; Srock, S.; Serke, S.; Peschel, C.; Emmerich, B. German Chronic Lymphocytic Leukemia Study Group. Rituximab therapy of patients with B-cell hronic lymphocytic leukemia. Blood, 2001, 98(5), 1326-13.
-
(2001)
Blood
, vol.98
, Issue.5
, pp. 1326-1413
-
-
Huhn, D.1
von Schilling, C.2
Wilhelm, M.3
Ho, A.D.4
Hallek, M.5
Kuse, R.6
Knauf, W.7
Riedel, U.8
Hinke, A.9
Srock, S.10
Serke, S.11
Peschel, C.12
Emmerich, B.13
-
116
-
-
33845543049
-
Chronic Leukemia Working Party of the EBMT. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
-
Dreger, P.; Corradini, P.; Kimby, E.; Michallet, M.; Milligan, D.; Schetelig, J.; Wiktor-Jedrzejczak, W.; Niederwieser, D.; Hallek, L.; Montserrat, E. Chronic Leukemia Working Party of the EBMT. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia, 2007, 21, 12-17.
-
(2007)
Leukemia
, vol.21
, pp. 12-17
-
-
Dreger, P.1
Corradini, P.2
Kimby, E.3
Michallet, M.4
Milligan, D.5
Schetelig, J.6
Wiktor-Jedrzejczak, W.7
Niederwieser, D.8
Hallek, L.9
Montserrat, E.10
|