-
1
-
-
33847010016
-
B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus
-
Eisenberg R., and Albert D. B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus. Nat Clin Pract Rheumatol 2 (2005) 1-8
-
(2005)
Nat Clin Pract Rheumatol
, vol.2
, pp. 1-8
-
-
Eisenberg, R.1
Albert, D.2
-
2
-
-
33751095383
-
B-cell-targeted therapy for systemic lupus erythematosus
-
Sabahi R., and Anolik J.H. B-cell-targeted therapy for systemic lupus erythematosus. Drugs 66 (2006) 1933-1948
-
(2006)
Drugs
, vol.66
, pp. 1933-1948
-
-
Sabahi, R.1
Anolik, J.H.2
-
3
-
-
38149138097
-
The effects of rituximab on immunocompetency in patients with autoimmune disease
-
Looney R.J., Srinivasan R., and Calabrese L.H. The effects of rituximab on immunocompetency in patients with autoimmune disease. Arthritis Rheum 58 (2008) 5-14
-
(2008)
Arthritis Rheum
, vol.58
, pp. 5-14
-
-
Looney, R.J.1
Srinivasan, R.2
Calabrese, L.H.3
-
4
-
-
34548221347
-
Mechanisms of killing by anti-CD20 monoclonal antibodies
-
This comprehensive review examines in detail the mechanisms by which RTX and other anti-CD20 mAbs mediate B cell killing. It provides a clear description of the differences between 'Type I' and 'Type II' anti-CD20 mAbs with respect to their binding to CD20 on the cells and their separate cytotoxic actions.
-
Glennie M.J., French R., Cragg M.S., and Taylor R.P. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol Immunol 44 (2007) 3823-3837. This comprehensive review examines in detail the mechanisms by which RTX and other anti-CD20 mAbs mediate B cell killing. It provides a clear description of the differences between 'Type I' and 'Type II' anti-CD20 mAbs with respect to their binding to CD20 on the cells and their separate cytotoxic actions.
-
(2007)
Mol Immunol
, vol.44
, pp. 3823-3837
-
-
Glennie, M.J.1
French, R.2
Cragg, M.S.3
Taylor, R.P.4
-
5
-
-
33847068351
-
On the mechanism of action of rituximab in autoimmune disease: the Immune Complex Decoy Hypothesis
-
This article evaluates the results of numerous clinical studies focused on the use of RTX in the treatment of autoimmune diseases. On the basis of analyses of these results, the Immune Complex Decoy Hypothesis is formulated and presented.
-
Taylor R.P., and Lindorfer M.A. On the mechanism of action of rituximab in autoimmune disease: the Immune Complex Decoy Hypothesis. Nat Clin Pract Rheumatol 3 (2007) 86-95. This article evaluates the results of numerous clinical studies focused on the use of RTX in the treatment of autoimmune diseases. On the basis of analyses of these results, the Immune Complex Decoy Hypothesis is formulated and presented.
-
(2007)
Nat Clin Pract Rheumatol
, vol.3
, pp. 86-95
-
-
Taylor, R.P.1
Lindorfer, M.A.2
-
6
-
-
0028057250
-
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
-
Reff M.E., Carner K., Chambers K.S., Chinn P.C., Leonard J.E., Raab R., Newman R.A., Hanna N., and Anderson D.R. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 83 (1994) 435-445
-
(1994)
Blood
, vol.83
, pp. 435-445
-
-
Reff, M.E.1
Carner, K.2
Chambers, K.S.3
Chinn, P.C.4
Leonard, J.E.5
Raab, R.6
Newman, R.A.7
Hanna, N.8
Anderson, D.R.9
-
7
-
-
0037306990
-
An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by Rituximab
-
Kennedy A.D., Solga M.D., Schuman T.A., Chi A.W., Lindorfer M.A., Sutherland W.M., Foley P.L., and Taylor R.P. An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by Rituximab. Blood 101 (2003) 1071-1079
-
(2003)
Blood
, vol.101
, pp. 1071-1079
-
-
Kennedy, A.D.1
Solga, M.D.2
Schuman, T.A.3
Chi, A.W.4
Lindorfer, M.A.5
Sutherland, W.M.6
Foley, P.L.7
Taylor, R.P.8
-
8
-
-
19944427673
-
Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
-
Gong Q., Ou Q., Ye S., Lee W.P., Cornelius J., Diehl L., Lin W.Y., Hu Z., Lu Y., Chen Y., et al. Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol 174 (2005) 817-826
-
(2005)
J Immunol
, vol.174
, pp. 817-826
-
-
Gong, Q.1
Ou, Q.2
Ye, S.3
Lee, W.P.4
Cornelius, J.5
Diehl, L.6
Lin, W.Y.7
Hu, Z.8
Lu, Y.9
Chen, Y.10
-
9
-
-
3042592452
-
The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
-
Uchida J., Hamaguchi Y., Oliver J.A., Ravetch J.V., Poe J.C., Haas K.M., and Tedder T.F. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 199 (2004) 1659-1669
-
(2004)
J Exp Med
, vol.199
, pp. 1659-1669
-
-
Uchida, J.1
Hamaguchi, Y.2
Oliver, J.A.3
Ravetch, J.V.4
Poe, J.C.5
Haas, K.M.6
Tedder, T.F.7
-
10
-
-
33645053518
-
Antibody isotype-specific engagement of Fcγ receptors regulates B lymphocyte depletion during CD20 immunotherapy
-
Hamaguchi Y., Xiu Y., Komura K., Nimmerjahn F., and Tedder T.F. Antibody isotype-specific engagement of Fcγ receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203 (2006) 743-753
-
(2006)
J Exp Med
, vol.203
, pp. 743-753
-
-
Hamaguchi, Y.1
Xiu, Y.2
Komura, K.3
Nimmerjahn, F.4
Tedder, T.F.5
-
11
-
-
33747880652
-
Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of Rituximab: mechanism of antibody-dependent cellular cytotoxicity and impact of human serum
-
This paper confirms that human macrophages can indeed kill RTX-opsonized cells, principally via phagocytosis.
-
Lefebvre M.-L., Krause S.W., Salcedo M., and Nardin A. Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of Rituximab: mechanism of antibody-dependent cellular cytotoxicity and impact of human serum. J Immunother 29 (2006) 388-397. This paper confirms that human macrophages can indeed kill RTX-opsonized cells, principally via phagocytosis.
-
(2006)
J Immunother
, vol.29
, pp. 388-397
-
-
Lefebvre, M.-L.1
Krause, S.W.2
Salcedo, M.3
Nardin, A.4
-
12
-
-
35648996524
-
Recombinant therapeutic monoclonal antibodies: mechanisms of action in relation to structural and functional duality
-
Congy-Jolivet N., Probst A., Watier H., and Thibault G. Recombinant therapeutic monoclonal antibodies: mechanisms of action in relation to structural and functional duality. Crit Rev Oncol Hematol 64 (2007) 226-233
-
(2007)
Crit Rev Oncol Hematol
, vol.64
, pp. 226-233
-
-
Congy-Jolivet, N.1
Probst, A.2
Watier, H.3
Thibault, G.4
-
13
-
-
0036179899
-
Binding to CD20 by anti-B1 antibody or F(ab′)2 is sufficient for induction of apoptosis in B-cell lines
-
Cardarelli P.M., Quinn M., Buckman D., Fang Y., Colcher D., King D., Bebbington C., and Yarranton G. Binding to CD20 by anti-B1 antibody or F(ab′)2 is sufficient for induction of apoptosis in B-cell lines. Cancer Immunol Immunother 51 (2002) 15-24
-
(2002)
Cancer Immunol Immunother
, vol.51
, pp. 15-24
-
-
Cardarelli, P.M.1
Quinn, M.2
Buckman, D.3
Fang, Y.4
Colcher, D.5
King, D.6
Bebbington, C.7
Yarranton, G.8
-
14
-
-
0037306893
-
In vitro mechanisms of action of rituximab on primary non-Hodgkin's lymphomas
-
Manches O., Lui G., Chaperot L., Gressin R., Molens J.P., Jacob M.C., Sotto J.J., Leroux D., Bensa J.C., and Plumas J. In vitro mechanisms of action of rituximab on primary non-Hodgkin's lymphomas. Blood 101 (2002) 949-954
-
(2002)
Blood
, vol.101
, pp. 949-954
-
-
Manches, O.1
Lui, G.2
Chaperot, L.3
Gressin, R.4
Molens, J.P.5
Jacob, M.C.6
Sotto, J.J.7
Leroux, D.8
Bensa, J.C.9
Plumas, J.10
-
15
-
-
35948989248
-
In vivo targeting of human neutralizing antibodies against CD55 and CD59 to lymphoma cells increases the antitumor activity of rituximab
-
Macor P., Tripodo C., Zorzet S., Piovan E., Bossi F., Marzari R., Amadori A., and Tedesco F. In vivo targeting of human neutralizing antibodies against CD55 and CD59 to lymphoma cells increases the antitumor activity of rituximab. Cancer Res 67 (2007) 10556-10563
-
(2007)
Cancer Res
, vol.67
, pp. 10556-10563
-
-
Macor, P.1
Tripodo, C.2
Zorzet, S.3
Piovan, E.4
Bossi, F.5
Marzari, R.6
Amadori, A.7
Tedesco, F.8
-
16
-
-
0034660092
-
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis
-
Golay J., Zaffaroni L., Vaccari T., Lazari M., Borleri G., Bernasconi S., Tedesco F., Rambaldi A., and Introna M. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement mediated cell lysis. Blood 95 (2000) 3900-3908
-
(2000)
Blood
, vol.95
, pp. 3900-3908
-
-
Golay, J.1
Zaffaroni, L.2
Vaccari, T.3
Lazari, M.4
Borleri, G.5
Bernasconi, S.6
Tedesco, F.7
Rambaldi, A.8
Introna, M.9
-
17
-
-
0141813574
-
Rituximab-mediated antibody-dependent cellular cytotoxicity against neoplastic B cells is stimulated strongly by interleukin-2
-
Golay J., Manganini M., Facchinetti V., Gramigna R., Broady R., Borleri G., Rambaldi A., and Introna M. Rituximab-mediated antibody-dependent cellular cytotoxicity against neoplastic B cells is stimulated strongly by interleukin-2. Haematologica 88 (2003) 1002-1012
-
(2003)
Haematologica
, vol.88
, pp. 1002-1012
-
-
Golay, J.1
Manganini, M.2
Facchinetti, V.3
Gramigna, R.4
Broady, R.5
Borleri, G.6
Rambaldi, A.7
Introna, M.8
-
18
-
-
3042743884
-
Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship
-
Dall'Ozzo S., Tartas S., Paintaud G., Cartron G., Colombat P., Bardos P., Watier H., and Thibault G. Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship. Cancer Res 64 (2004) 4664-4669
-
(2004)
Cancer Res
, vol.64
, pp. 4664-4669
-
-
Dall'Ozzo, S.1
Tartas, S.2
Paintaud, G.3
Cartron, G.4
Colombat, P.5
Bardos, P.6
Watier, H.7
Thibault, G.8
-
19
-
-
33646693879
-
The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells
-
Fischer L., Penack O., Gentilini C., Nogai A., Muessig A., Thiel E., and Uharek L. The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells. Exp Hematol 34 (2006) 753-759
-
(2006)
Exp Hematol
, vol.34
, pp. 753-759
-
-
Fischer, L.1
Penack, O.2
Gentilini, C.3
Nogai, A.4
Muessig, A.5
Thiel, E.6
Uharek, L.7
-
20
-
-
48549099675
-
Serial killing of tumor cells by human natural killer cells-enhancement by therapeutic antibodies
-
This article investigates the mechanisms that limit NK-cell-mediated ADCC. The results clearly indicate that killing can be exhausted at high substrate cell burden and that IL-2 treatment appears to allow the cells to 're-cycle' and resume ADCC.
-
Bhat R., and Watzl C. Serial killing of tumor cells by human natural killer cells-enhancement by therapeutic antibodies. PLoS ONE 2 (2007) 1-7. This article investigates the mechanisms that limit NK-cell-mediated ADCC. The results clearly indicate that killing can be exhausted at high substrate cell burden and that IL-2 treatment appears to allow the cells to 're-cycle' and resume ADCC.
-
(2007)
PLoS ONE
, vol.2
, pp. 1-7
-
-
Bhat, R.1
Watzl, C.2
-
21
-
-
34247847914
-
Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab
-
Berdeja J.G., Hess A., Lucas D.M., O'Donnell P., Ambinder R.F., Diehl L.F., Carter-Brookins D., Newton S., and Flinn I.W. Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab. Clin Cancer Res 13 (2007) 2392-2399
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2392-2399
-
-
Berdeja, J.G.1
Hess, A.2
Lucas, D.M.3
O'Donnell, P.4
Ambinder, R.F.5
Diehl, L.F.6
Carter-Brookins, D.7
Newton, S.8
Flinn, I.W.9
-
22
-
-
24344468297
-
CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells
-
Bowles J.A., and Weiner G.J. CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells. J Immunol Methods 304 (2005) 88-99
-
(2005)
J Immunol Methods
, vol.304
, pp. 88-99
-
-
Bowles, J.A.1
Weiner, G.J.2
-
23
-
-
1342282157
-
Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia
-
Kennedy A.D., Beum P.V., Solga M.D., DiLillo D.J., Lindorfer M.A., Hess C.E., Densmore J.J., Williams M.E., and Taylor R.P. Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia. J Immunol 172 (2004) 3280-3288
-
(2004)
J Immunol
, vol.172
, pp. 3280-3288
-
-
Kennedy, A.D.1
Beum, P.V.2
Solga, M.D.3
DiLillo, D.J.4
Lindorfer, M.A.5
Hess, C.E.6
Densmore, J.J.7
Williams, M.E.8
Taylor, R.P.9
-
24
-
-
33947491459
-
Addition of fresh frozen plasma as a source of complement to rituximab in advanced chronic lymphocytic leukemia
-
Klepfish A., Schattner A., Ghoti H., and Rachmilewitz E.A. Addition of fresh frozen plasma as a source of complement to rituximab in advanced chronic lymphocytic leukemia. Lancet Oncol 8 (2007) 361-362
-
(2007)
Lancet Oncol
, vol.8
, pp. 361-362
-
-
Klepfish, A.1
Schattner, A.2
Ghoti, H.3
Rachmilewitz, E.A.4
-
25
-
-
33750816429
-
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia
-
Williams M.E., Densmore J.J., Pawluczkowycz A.W., Beum P.V., Kennedy A.D., Lindorfer M.A., Hamil S.H., Eggleton J.C., and Taylor R.P. Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia. J Immunol 177 (2006) 7435-7443
-
(2006)
J Immunol
, vol.177
, pp. 7435-7443
-
-
Williams, M.E.1
Densmore, J.J.2
Pawluczkowycz, A.W.3
Beum, P.V.4
Kennedy, A.D.5
Lindorfer, M.A.6
Hamil, S.H.7
Eggleton, J.C.8
Taylor, R.P.9
-
26
-
-
32044464340
-
The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes
-
Beum P.V., Kennedy A.D., Williams M.E., Lindorfer M.A., and Taylor R.P. The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes. J Immunol 176 (2006) 2600-2609
-
(2006)
J Immunol
, vol.176
, pp. 2600-2609
-
-
Beum, P.V.1
Kennedy, A.D.2
Williams, M.E.3
Lindorfer, M.A.4
Taylor, R.P.5
-
27
-
-
34447518990
-
Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus
-
Although this paper does not investigate anti-CD20 mAbs, it summarizes and clarifies many of the questions concerning the activity of cells that express FcγR in SLE. This article is important in view of the increasing interest in the use of RTX in the treatment of SLE.
-
Kavai M., and Szegedi G. Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus. Autoimmun Rev 6 (2007) 497-502. Although this paper does not investigate anti-CD20 mAbs, it summarizes and clarifies many of the questions concerning the activity of cells that express FcγR in SLE. This article is important in view of the increasing interest in the use of RTX in the treatment of SLE.
-
(2007)
Autoimmun Rev
, vol.6
, pp. 497-502
-
-
Kavai, M.1
Szegedi, G.2
-
28
-
-
35748962939
-
Rituximab/CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models
-
Li Y., Williams M.E., Cousar J.B., Pawluczkowycz A.W., Lindorfer M.A., and Taylor R.P. Rituximab/CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models. J Immunol 179 (2007) 4263-4271
-
(2007)
J Immunol
, vol.179
, pp. 4263-4271
-
-
Li, Y.1
Williams, M.E.2
Cousar, J.B.3
Pawluczkowycz, A.W.4
Lindorfer, M.A.5
Taylor, R.P.6
-
29
-
-
38049053490
-
Characterization of bone marrow lymphoid infiltrates after immunochemotherapy for follicular lymphoma
-
Laurent C., de Paiva G.R., Ysebaert L., Laurent G., March M., Delsol G., and Brousset P. Characterization of bone marrow lymphoid infiltrates after immunochemotherapy for follicular lymphoma. Am J Pathol 128 (2007) 974-980
-
(2007)
Am J Pathol
, vol.128
, pp. 974-980
-
-
Laurent, C.1
de Paiva, G.R.2
Ysebaert, L.3
Laurent, G.4
March, M.5
Delsol, G.6
Brousset, P.7
-
30
-
-
33845596250
-
Bone marrow B-lineage cells in patients with rheumatoid arthritis following rituximab therapy
-
Leandro M.J., Cooper N., Cambridge G., Ehrenstein M.R., and Edwards J.C.W. Bone marrow B-lineage cells in patients with rheumatoid arthritis following rituximab therapy. Rheumatism 46 (2007) 29-36
-
(2007)
Rheumatism
, vol.46
, pp. 29-36
-
-
Leandro, M.J.1
Cooper, N.2
Cambridge, G.3
Ehrenstein, M.R.4
Edwards, J.C.W.5
-
31
-
-
37149010203
-
Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment
-
Teng Y.K.O., Levarht E.W.N., Hashemi M., Bajema I.M., Toes R.E.M., Huizinga T.W.J., and van Laar J.M. Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment. Arthritis Rheum 56 (2007) 3909-3918
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3909-3918
-
-
Teng, Y.K.O.1
Levarht, E.W.N.2
Hashemi, M.3
Bajema, I.M.4
Toes, R.E.M.5
Huizinga, T.W.J.6
van Laar, J.M.7
-
32
-
-
3142564395
-
Three new assays for rituximab based on its immunological activity or antigenic properties: analyses of sera and plasmas of RTX-treated patients with chronic lymphocytic leukemia and other B cell lymphomas
-
Beum P.V., Kennedy A.D., and Taylor R.P. Three new assays for rituximab based on its immunological activity or antigenic properties: analyses of sera and plasmas of RTX-treated patients with chronic lymphocytic leukemia and other B cell lymphomas. J Immunol Methods 289 (2004) 97-109
-
(2004)
J Immunol Methods
, vol.289
, pp. 97-109
-
-
Beum, P.V.1
Kennedy, A.D.2
Taylor, R.P.3
-
33
-
-
34948881806
-
Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism
-
Hatjiharissi E., Xu L., Santos D.D., Hunter Z.R., Ciccarelli B.T., Verselis S., Modica M., Cao Y., Manning R.J., and Leleu X.E.-A. Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism. Blood 110 (2007) 2561-2564
-
(2007)
Blood
, vol.110
, pp. 2561-2564
-
-
Hatjiharissi, E.1
Xu, L.2
Santos, D.D.3
Hunter, Z.R.4
Ciccarelli, B.T.5
Verselis, S.6
Modica, M.7
Cao, Y.8
Manning, R.J.9
Leleu, X.E.-A.10
-
34
-
-
33750622479
-
Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab
-
•] demonstrate that changes in the FcγR region of anti-CD20 mAbs can enhance ADCC owing to enhanced binding to FcγRIIIa on NK cells.
-
•] demonstrate that changes in the FcγR region of anti-CD20 mAbs can enhance ADCC owing to enhanced binding to FcγRIIIa on NK cells.
-
(2006)
Blood
, vol.108
, pp. 2648-2654
-
-
Bowles, J.A.1
Wang, S.-Y.2
Link, B.K.3
Beuerlein, G.4
Campbell, M.-A.5
Marquis, D.6
Ondek, B.7
Wooldridge, J.E.8
Smith, B.J.9
Breitmeyer, J.B.10
Weiner, G.J.11
-
35
-
-
34247215987
-
Enhanced binding affinity for FcγRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity
-
•].
-
•].
-
(2007)
Mol Immunol
, vol.44
, pp. 3122-3131
-
-
Masuda, K.1
Kubota, T.2
Kaneko, E.3
Iida, S.4
Wakitani, M.5
Kobayashi-Natsume, Y.6
Kubota, A.7
Shitara, K.8
Nakamura, K.9
-
36
-
-
39749086517
-
Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcγRIIIA/CD16
-
•].
-
•].
-
(2008)
Br J Haematol
, vol.140
, pp. 635-643
-
-
de Romeuf, C.1
Dutertre, C.A.2
Le Garff-Tavernier, M.3
Fournier, N.4
Gaucher, C.5
Glacet, A.6
Jorieux, S.7
Bihoreau, N.8
Behrens, C.K.9
Beliard, R.10
-
37
-
-
0035760902
-
CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59
-
Golay J., Lazzari M., Facchinetti V., Bernasconi S., Borleri G., Barbui T., Rambaldi A., and Introna M. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. Blood 98 (2001) 3383-3389
-
(2001)
Blood
, vol.98
, pp. 3383-3389
-
-
Golay, J.1
Lazzari, M.2
Facchinetti, V.3
Bernasconi, S.4
Borleri, G.5
Barbui, T.6
Rambaldi, A.7
Introna, M.8
-
38
-
-
4444343395
-
Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin's lymphomas
-
Teeling J., French R.R., Cragg M.S., van den Brakel J., Pluyter M., Huang H., Chan C., Parren P.W., Hack C.E., Dechant M., et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin's lymphomas. Blood 104 (2004) 1793-1800
-
(2004)
Blood
, vol.104
, pp. 1793-1800
-
-
Teeling, J.1
French, R.R.2
Cragg, M.S.3
van den Brakel, J.4
Pluyter, M.5
Huang, H.6
Chan, C.7
Parren, P.W.8
Hack, C.E.9
Dechant, M.10
-
39
-
-
33745324686
-
The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
-
This paper (and the earlier report by the same group) describes in detail the immunochemical characteristics of OFA, including why it is capable of enhanced CDC compared with RTX.
-
Teeling J.L., Mackus W.J.M., Wiegman L.J.J.M., van den Brakel J.H.N., Bees S.A., French R.R., van Meerten T., Ebeling S., Vink T., Slootstra J.W., et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol 177 (2006) 362-371. This paper (and the earlier report by the same group) describes in detail the immunochemical characteristics of OFA, including why it is capable of enhanced CDC compared with RTX.
-
(2006)
J Immunol
, vol.177
, pp. 362-371
-
-
Teeling, J.L.1
Mackus, W.J.M.2
Wiegman, L.J.J.M.3
van den Brakel, J.H.N.4
Bees, S.A.5
French, R.R.6
van Meerten, T.7
Ebeling, S.8
Vink, T.9
Slootstra, J.W.10
-
40
-
-
38349138517
-
Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
-
Bleeker W.K., Munk M.E., Mackus W.J.M., van den Brakel J.H.N., Pluyter M., Glennie M.J., van de Winkel J.G.J., and Parren P.W.H.I. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br J Haematol 140 (2008) 303-312
-
(2008)
Br J Haematol
, vol.140
, pp. 303-312
-
-
Bleeker, W.K.1
Munk, M.E.2
Mackus, W.J.M.3
van den Brakel, J.H.N.4
Pluyter, M.5
Glennie, M.J.6
van de Winkel, J.G.J.7
Parren, P.W.H.I.8
-
41
-
-
38949185742
-
Safety and efficacy of ofatumumab, a fully human monclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. A phase I-II study
-
Coiffier B., Lepretre S., Pedersen L.M., Gadeberg O., Fredriksen H., Van Oers M.H.J., Wooldridge J., Kloczko J., Holowiecki J., Hellman A., et al. Safety and efficacy of ofatumumab, a fully human monclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. A phase I-II study. Blood 111 (2008) 1094-1100
-
(2008)
Blood
, vol.111
, pp. 1094-1100
-
-
Coiffier, B.1
Lepretre, S.2
Pedersen, L.M.3
Gadeberg, O.4
Fredriksen, H.5
Van Oers, M.H.J.6
Wooldridge, J.7
Kloczko, J.8
Holowiecki, J.9
Hellman, A.10
-
42
-
-
33750964016
-
B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles
-
Cambridge G., Leandro M.J., Teodorescu M., Manson J., Rahman A., Isenberg D.A., and Edwards J.C. B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum 54 (2006) 3612-3622
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3612-3622
-
-
Cambridge, G.1
Leandro, M.J.2
Teodorescu, M.3
Manson, J.4
Rahman, A.5
Isenberg, D.A.6
Edwards, J.C.7
-
43
-
-
33646362290
-
B-cell targeting in rheumatoid arthritis and other autoimmune diseases
-
Edwards J.C.W., and Cambridge G. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol 6 (2006) 394-403
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 394-403
-
-
Edwards, J.C.W.1
Cambridge, G.2
-
44
-
-
33746447184
-
Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency
-
Levi M., Hack C.E., and Van Oers M.H. Rituximab-induced elimination of acquired angioedema due to C1-inhibitor deficiency. Am J Med 119 (2006) e3-e5
-
(2006)
Am J Med
, vol.119
-
-
Levi, M.1
Hack, C.E.2
Van Oers, M.H.3
-
45
-
-
4043179907
-
B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of Rituximab
-
Looney R.J., Anolik J.H., Campbell D., Felgar R.E., Young F., Arend L.J., Sloand J.A., Rosenblatt J., and Sanz I. B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of Rituximab. Arthritis Rheum 50 (2004) 2580-2589
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2580-2589
-
-
Looney, R.J.1
Anolik, J.H.2
Campbell, D.3
Felgar, R.E.4
Young, F.5
Arend, L.J.6
Sloand, J.A.7
Rosenblatt, J.8
Sanz, I.9
-
46
-
-
29344460633
-
The therapeutic potential of anti-CD20: what do B-cells do?
-
Eisenberg R., and Looney R.J. The therapeutic potential of anti-CD20: what do B-cells do?. Clin Immunol 117 (2005) 207-213
-
(2005)
Clin Immunol
, vol.117
, pp. 207-213
-
-
Eisenberg, R.1
Looney, R.J.2
-
47
-
-
13444252282
-
Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by downregulation of the T cell costimulatory molecule CD40 ligand
-
Sfikakis P.P., Boletis J.N., Lionaki S., Vigklis V., Fragiadaki K.G., Iniotaki A., and Moutsopoulos H.M. Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by downregulation of the T cell costimulatory molecule CD40 ligand. Arthritis Rheum 52 (2005) 501-513
-
(2005)
Arthritis Rheum
, vol.52
, pp. 501-513
-
-
Sfikakis, P.P.1
Boletis, J.N.2
Lionaki, S.3
Vigklis, V.4
Fragiadaki, K.G.5
Iniotaki, A.6
Moutsopoulos, H.M.7
-
48
-
-
0035883071
-
Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura
-
Stasi R., Pagano A., Stipa E., and Amadori S. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood 98 (2001) 952-957
-
(2001)
Blood
, vol.98
, pp. 952-957
-
-
Stasi, R.1
Pagano, A.2
Stipa, E.3
Amadori, S.4
-
49
-
-
0038100526
-
Rituximab: a new therapeutic tool for primary immune thrombocytopenic purpura?
-
Introna M., Golay J., and Barbui T. Rituximab: a new therapeutic tool for primary immune thrombocytopenic purpura?. Haematologica 88 (2003) 482-484
-
(2003)
Haematologica
, vol.88
, pp. 482-484
-
-
Introna, M.1
Golay, J.2
Barbui, T.3
-
50
-
-
38349056679
-
Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab
-
Ferraro A.J., Drayson M.T., Savage C.O.S., and MacLennan I.C.M. Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab. Eur J Immunol 38 (2008) 292-298
-
(2008)
Eur J Immunol
, vol.38
, pp. 292-298
-
-
Ferraro, A.J.1
Drayson, M.T.2
Savage, C.O.S.3
MacLennan, I.C.M.4
-
51
-
-
33749331884
-
Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis
-
Smith K.G.C., Jones R.B., Burns S.M., and Jayne D.R.W. Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis. Arthritis Rheum 54 (2006) 2970-2982
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2970-2982
-
-
Smith, K.G.C.1
Jones, R.B.2
Burns, S.M.3
Jayne, D.R.W.4
-
52
-
-
40449141768
-
Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
-
This definitive mouse model paper shows that anti-CD20 therapy has little, if any effect on the levels of existing antibodies in mice because long-lived plasma cells are not depleted by anti-CD20 mAbs. The paper has important implications for our understanding of how RTX may function in the therapy of autoimmune diseases, and why individuals who receive RTX therapy are generally not at increased risk for infections.
-
DiLillo D.J., Hamaguchi Y., Ueda Y., Yang K., Uchida J., Haas K.M., Kelsoe G., and Tedder T.F. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J Immunol 180 (2008) 361-371. This definitive mouse model paper shows that anti-CD20 therapy has little, if any effect on the levels of existing antibodies in mice because long-lived plasma cells are not depleted by anti-CD20 mAbs. The paper has important implications for our understanding of how RTX may function in the therapy of autoimmune diseases, and why individuals who receive RTX therapy are generally not at increased risk for infections.
-
(2008)
J Immunol
, vol.180
, pp. 361-371
-
-
DiLillo, D.J.1
Hamaguchi, Y.2
Ueda, Y.3
Yang, K.4
Uchida, J.5
Haas, K.M.6
Kelsoe, G.7
Tedder, T.F.8
-
53
-
-
34548715943
-
B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity
-
Yanaba K., Hamaguchi Y., Venturi G.M., Steeber D.A., St. Clair E.W., and Tedder T.F. B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. J Immunol 179 (2007) 1369-1380
-
(2007)
J Immunol
, vol.179
, pp. 1369-1380
-
-
Yanaba, K.1
Hamaguchi, Y.2
Venturi, G.M.3
Steeber, D.A.4
St. Clair, E.W.5
Tedder, T.F.6
-
54
-
-
33748788266
-
B-Lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
-
Hasegawa M., Hamaguchi Y., Yanaba K., Bouaziz J.-D., Uchida J., Fujimoto M., Matsushita T., Matsushita Y., Horikawa M., Komura K., et al. B-Lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol 169 (2006) 954-966
-
(2006)
Am J Pathol
, vol.169
, pp. 954-966
-
-
Hasegawa, M.1
Hamaguchi, Y.2
Yanaba, K.3
Bouaziz, J.-D.4
Uchida, J.5
Fujimoto, M.6
Matsushita, T.7
Matsushita, Y.8
Horikawa, M.9
Komura, K.10
-
55
-
-
36849090653
-
Depletion of B cells in murine lupus: efficacy and resistance
-
••], have important implications with respect to understanding the efficacy of B cell depletion therapies in human SLE.
-
••], have important implications with respect to understanding the efficacy of B cell depletion therapies in human SLE.
-
(2007)
J Immunol
, vol.179
, pp. 3351-3361
-
-
Ahuja, A.1
Shupe, J.2
Dunn, R.3
Kashgarian, M.4
Kehry, M.R.5
Shlomchik, M.J.6
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