메뉴 건너뛰기




Volumn 45, Issue 2, 2008, Pages 95-103

Antibody Therapy for Chronic Lymphocytic Leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; APOLIZUMAB; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; HUMAX; LUMILIXIMAB; MONOCLONAL ANTIBODY; OFATUMUMAB; PENTOSTATIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; UNCLASSIFIED DRUG; VALGANCICLOVIR;

EID: 41149101246     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2008.02.001     Document Type: Article
Times cited : (30)

References (64)
  • 1
    • 0032079746 scopus 로고    scopus 로고
    • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations witi in vitro and in vivo chemoresponses
    • Kitada S., Andersen J., Akar S., Zapata J.M., Takayama S., Krajewski S., et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations witi in vitro and in vivo chemoresponses. Blood 91 (1998) 3379-3389
    • (1998) Blood , vol.91 , pp. 3379-3389
    • Kitada, S.1    Andersen, J.2    Akar, S.3    Zapata, J.M.4    Takayama, S.5    Krajewski, S.6
  • 2
    • 0034660092 scopus 로고    scopus 로고
    • Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis
    • Golay J., Zaffaroni L., Vaccari T., Lazzari M., Borleri G.M., Bernasconi S., et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood 95 (2000) 3900-3908
    • (2000) Blood , vol.95 , pp. 3900-3908
    • Golay, J.1    Zaffaroni, L.2    Vaccari, T.3    Lazzari, M.4    Borleri, G.M.5    Bernasconi, S.6
  • 3
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai K.R., Peterson B.L., Appelbaum F.R., Kolitz J., Elias L., Shepherd L., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 343 (2000) 1750-1757
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3    Kolitz, J.4    Elias, L.5    Shepherd, L.6
  • 5
    • 0034999619 scopus 로고    scopus 로고
    • Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies
    • Treon S.P., Mitsiades C., Mitsiades N., Young G., Doss D., Schlossman R., et al. Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies. J Immunother 24 (2001) 263-271
    • (2001) J Immunother , vol.24 , pp. 263-271
    • Treon, S.P.1    Mitsiades, C.2    Mitsiades, N.3    Young, G.4    Doss, D.5    Schlossman, R.6
  • 6
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd J.C., Kitada S., Flinn I.W., Aron J.L., Pearson M.D., Lucas D., et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood 99 (2002) 1038-1043
    • (2002) Blood , vol.99 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3    Aron, J.L.4    Pearson, M.D.5    Lucas, D.6
  • 7
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen I.M., Buhl A.M., Klausen P., Geisler C.H., and Jurlander J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. Blood 99 (2002) 1314-1319
    • (2002) Blood , vol.99 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 8
    • 0035760902 scopus 로고    scopus 로고
    • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59
    • Golay J., Lazzari M., Facchinetti V., Bernasconi S., Borleri G.M., Barbui T., et al. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59. Blood 98 (2001) 3383-3389
    • (2001) Blood , vol.98 , pp. 3383-3389
    • Golay, J.1    Lazzari, M.2    Facchinetti, V.3    Bernasconi, S.4    Borleri, G.M.5    Barbui, T.6
  • 9
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P., Grillo-Lopez A.J., Link B.K., Levy R., Czuczman M.S., Williams M.E., et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J Clin Oncol 16 (1998) 2825-2833
    • (1998) J Clin Oncol , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3    Levy, R.4    Czuczman, M.S.5    Williams, M.E.6
  • 10
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • Nguyen D.T., Amess J.A., Doughty H., Hendry L., and Diamond L.W. IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients. Eur J Haematol 62 (1999) 76-82
    • (1999) Eur J Haematol , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3    Hendry, L.4    Diamond, L.W.5
  • 11
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)
    • Winkler U., Jensen M., Manzke O., Schulz H., Diehl V., and Engert A. Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood 94 (1999) 2217-2224
    • (1999) Blood , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3    Schulz, H.4    Diehl, V.5    Engert, A.6
  • 12
    • 0033837234 scopus 로고    scopus 로고
    • Rituximab anti-CD20 monoclonal antibody induces marked but transient reductions of peripheral blood lymphocytes in chronic lymphocytic leukaemia patients
    • Ladetto M., Bergui L., Ricca I., Campana S., Pileri A., and Tarella C. Rituximab anti-CD20 monoclonal antibody induces marked but transient reductions of peripheral blood lymphocytes in chronic lymphocytic leukaemia patients. Med Oncol 17 (2000) 203-210
    • (2000) Med Oncol , vol.17 , pp. 203-210
    • Ladetto, M.1    Bergui, L.2    Ricca, I.3    Campana, S.4    Pileri, A.5    Tarella, C.6
  • 13
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D., von Schilling C., Wilhelm M., Ho A.D., Hallek M., Kuse R., et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 98 (2001) 1326-1331
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3    Ho, A.D.4    Hallek, M.5    Kuse, R.6
  • 14
    • 0036757311 scopus 로고    scopus 로고
    • Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: Results from a Nordic multicentre study
    • Itala M., Geisler C.H., Kimby E., Juvonen E., Tjonnfjord G., Karlsson K., et al. Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: Results from a Nordic multicentre study. Eur J Haematol 69 (2002) 129-134
    • (2002) Eur J Haematol , vol.69 , pp. 129-134
    • Itala, M.1    Geisler, C.H.2    Kimby, E.3    Juvonen, E.4    Tjonnfjord, G.5    Karlsson, K.6
  • 16
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie earl Cancer Research Network
    • Hainsworth J.D., Litchy S., Barton J.H., Houston G.A., Hermann R.C., Bradof J.E., et al. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie earl Cancer Research Network. J Clin Oncol 21 (2003) 1746-1751
    • (2003) J Clin Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3    Houston, G.A.4    Hermann, R.C.5    Bradof, J.E.6
  • 17
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd J.C., Murphy T., Howard R.S., Lucas M.S., Goodrich A., Park K., et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 19 (2001) 2153-2164
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3    Lucas, M.S.4    Goodrich, A.5    Park, K.6
  • 18
    • 0037228952 scopus 로고    scopus 로고
    • Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab
    • Byrd J.C., Smith L., Hackbarth M.L., Flinn I.W., Young D., Proffitt J.H., et al. Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab. Cancer Res 63 (2003) 36-38
    • (2003) Cancer Res , vol.63 , pp. 36-38
    • Byrd, J.C.1    Smith, L.2    Hackbarth, M.L.3    Flinn, I.W.4    Young, D.5    Proffitt, J.H.6
  • 19
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd J.C., Peterson B.L., Morrison V.A., Park K., Jacobson R.J., Hoke E., et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 101 (2003) 6-14
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.J.5    Hoke, E.6
  • 20
    • 33644847307 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy
    • Byrd J.C., Gribben J.G., Peterson B.L., Grever M.R., Lozanski G., Lucas D.M., et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy. J Clin Oncol 24 (2006) 437-443
    • (2006) J Clin Oncol , vol.24 , pp. 437-443
    • Byrd, J.C.1    Gribben, J.G.2    Peterson, B.L.3    Grever, M.R.4    Lozanski, G.5    Lucas, D.M.6
  • 21
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previoulsy untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd J.C., Rai K., Peterson B.L., Appelbaum F.R., Morrison V.A., Kolitz J.E., et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previoulsy untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 105 (2005) 49-53
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6
  • 22
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • Schulz H., Klein S.K., Rehwald U., Reiser M., Hinke A., Knauf W.U., et al. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood 100 (2002) 3115-3120
    • (2002) Blood , vol.100 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3    Reiser, M.4    Hinke, A.5    Knauf, W.U.6
  • 23
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W., O'Brien S., Wen S., Faderl S., Garcia-Manero G., Thomas D.A., et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol 23 (2005) 4070-4078
    • (2005) J Clin Oncol , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3    Faderl, S.4    Garcia-Manero, G.5    Thomas, D.A.6
  • 24
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating M.J., O'Brien S., Albitar M., Lerner S., Plunkett W., Giles F.J., et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 23 (2005) 4079-4088
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3    Lerner, S.4    Plunkett, W.5    Giles, F.J.6
  • 25
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chroinc lymphocytic leukemia
    • Kay N.E., Geyer S.M., Call T.G., Shanafelt T.D., Zent C.S., Jelinek D.F., et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chroinc lymphocytic leukemia. Blood 109 (2007) 405-411
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3    Shanafelt, T.D.4    Zent, C.S.5    Jelinek, D.F.6
  • 26
    • 34249042684 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia
    • Shanafelt T.D., Lin T.S., Geyer S.M., Zent C.S., Leung N., Kabat B., et al. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer 109 (2007) 2291-2298
    • (2007) Cancer , vol.109 , pp. 2291-2298
    • Shanafelt, T.D.1    Lin, T.S.2    Geyer, S.M.3    Zent, C.S.4    Leung, N.5    Kabat, B.6
  • 27
    • 0034501632 scopus 로고    scopus 로고
    • Campath-1H monoclonal antibody therapy
    • Flynn J.M., and Byrd J.C. Campath-1H monoclonal antibody therapy. Curr Opin Oncol 12 (2000) 574-581
    • (2000) Curr Opin Oncol , vol.12 , pp. 574-581
    • Flynn, J.M.1    Byrd, J.C.2
  • 28
    • 0020591822 scopus 로고
    • Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement
    • Hale G., Bright S., Chumbley G., Hoang T., Metcalf D., Munro A.J., et al. Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood 62 (1983) 873-882
    • (1983) Blood , vol.62 , pp. 873-882
    • Hale, G.1    Bright, S.2    Chumbley, G.3    Hoang, T.4    Metcalf, D.5    Munro, A.J.6
  • 29
    • 0021813140 scopus 로고
    • Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation
    • Hale G., Swirsky D., Waldmann H., and Chan L.C. Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation. Br J Haematol 60 (1985) 41-48
    • (1985) Br J Haematol , vol.60 , pp. 41-48
    • Hale, G.1    Swirsky, D.2    Waldmann, H.3    Chan, L.C.4
  • 30
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
    • Hale G., Dyer M.J., Clark M.R., Phillips J.M., Marcus R., Riechmann L., et al. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 2 (1988) 1394-1399
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.J.2    Clark, M.R.3    Phillips, J.M.4    Marcus, R.5    Riechmann, L.6
  • 31
    • 0028352208 scopus 로고
    • Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas
    • Salisbury J.R., Rapson N.T., Codd J.D., Rogers M.V., and Nethersell A.B. Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas. J Clin Pathol 47 (1994) 313-317
    • (1994) J Clin Pathol , vol.47 , pp. 313-317
    • Salisbury, J.R.1    Rapson, N.T.2    Codd, J.D.3    Rogers, M.V.4    Nethersell, A.B.5
  • 32
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells
    • Rowan W., Tite J., Topley P., and Brett S.J. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells. Immunology 95 (1998) 427-436
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3    Brett, S.J.4
  • 33
    • 0031027623 scopus 로고    scopus 로고
    • Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia
    • Bowen A.L., Zomas A., Emmett E., Matutes E., Dyer M.J., and Catovsky D. Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia. Br J Haematol 96 (1997) 617-619
    • (1997) Br J Haematol , vol.96 , pp. 617-619
    • Bowen, A.L.1    Zomas, A.2    Emmett, E.3    Matutes, E.4    Dyer, M.J.5    Catovsky, D.6
  • 34
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating M.J., Flinn I., Jain V., Binet J.-L., Hillmen P., Byrd J.C., et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study. Blood 99 (2002) 3554-3561
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3    Binet, J.-L.4    Hillmen, P.5    Byrd, J.C.6
  • 35
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A., Fassas A.S., Anagnostopoulos A., Dyer M.J., Catovsky D., and Mellstedt H. Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol 93 (1996) 151-153
    • (1996) Br J Haematol , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.S.2    Anagnostopoulos, A.3    Dyer, M.J.4    Catovsky, D.5    Mellstedt, H.6
  • 36
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A., Dyer M.J., Bunjes D., Pangalis G.A., Bastion Y., Catovsky D., et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 15 (1997) 1567-1574
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6
  • 37
    • 79960971484 scopus 로고    scopus 로고
    • Efficacy and safety of alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis
    • Rai K.R., Coutre S., Rizzieri D., Gribben J.G., Flinn I., Rabinowe S., et al. Efficacy and safety of alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis. Blood 98 (2001) 365a
    • (2001) Blood , vol.98
    • Rai, K.R.1    Coutre, S.2    Rizzieri, D.3    Gribben, J.G.4    Flinn, I.5    Rabinowe, S.6
  • 38
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P., Kennedy B., Lucas G., Leach M., Rassam S.M., Haynes A.P., et al. Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol 23 (2005) 2971-2979
    • (2005) J Clin Oncol , vol.23 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3    Leach, M.4    Rassam, S.M.5    Haynes, A.P.6
  • 39
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H., Fischer K., Bentz M., Hansen K., Benner A., Cabot G., et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 85 (1995) 1580-1589
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3    Hansen, K.4    Benner, A.5    Cabot, G.6
  • 41
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G., Heerema N.A., Flinn I.W., Smith S., Harbison J., Webb J., et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 103 (2004) 3278-3281
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3    Smith, S.4    Harbison, J.5    Webb, J.6
  • 42
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy
    • Stilgenbauer S., and Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N Engl J Med 347 (2002) 452-453
    • (2002) N Engl J Med , vol.347 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 43
    • 33746839511 scopus 로고    scopus 로고
    • 17p deletion predicts for inferior overall survival after fludarabine - based first line therapy in chronic lymphocytic leukemia: First analysis of genetics in the CLL4 trial of the GCLLSG
    • (abstr)
    • Stilgenbauer S., Krober A., Busch R., Eichhorst B.F., Kienle D., Winkler D., et al. 17p deletion predicts for inferior overall survival after fludarabine - based first line therapy in chronic lymphocytic leukemia: First analysis of genetics in the CLL4 trial of the GCLLSG. Blood 106 (2005) 715 (abstr)
    • (2005) Blood , vol.106 , pp. 715
    • Stilgenbauer, S.1    Krober, A.2    Busch, R.3    Eichhorst, B.F.4    Kienle, D.5    Winkler, D.6
  • 44
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J., Kimby E., Bjorkholm M., Broliden P.A., Celsing F., Hjalmar V., et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 100 (2002) 768-773
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3    Broliden, P.A.4    Celsing, F.5    Hjalmar, V.6
  • 45
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P., Skotnicki A., Robak T., Jaksic B., Dmoszynska A., Sirard C., et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 25 (2007) 5616-5623
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.2    Robak, T.3    Jaksic, B.4    Dmoszynska, A.5    Sirard, C.6
  • 46
    • 0037085770 scopus 로고    scopus 로고
    • Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B., Rawstron A., Carter C., Ryan M., Speed K., Lucas G., et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood 99 (2002) 2245-2247
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1    Rawstron, A.2    Carter, C.3    Ryan, M.4    Speed, K.5    Lucas, G.6
  • 47
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial
    • Elter T., Borchmann P., Schulz H., Reiser M., Trelle S., Schnell R., et al. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial. J Clin Oncol 23 (2005) 7024-7031
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3    Reiser, M.4    Trelle, S.5    Schnell, R.6
  • 48
    • 38049094162 scopus 로고    scopus 로고
    • Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active regimen for heavily treated patients with CLL
    • Wierda W.G., O'Brien S., Faderl S., Ferrajoli A., Ravandi-Kashani F., Cortes J., et al. Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active regimen for heavily treated patients with CLL. Blood 108 (2006) 14a
    • (2006) Blood , vol.108
    • Wierda, W.G.1    O'Brien, S.2    Faderl, S.3    Ferrajoli, A.4    Ravandi-Kashani, F.5    Cortes, J.6
  • 49
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien S.M., Kantarjian H.M., Thomas D.A., Cortes J., Giles F.J., Wierda W.G., et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer 98 (2003) 2657-2663
    • (2003) Cancer , vol.98 , pp. 2657-2663
    • O'Brien, S.M.1    Kantarjian, H.M.2    Thomas, D.A.3    Cortes, J.4    Giles, F.J.5    Wierda, W.G.6
  • 50
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission: Experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • Wendtner C.M., Ritgen M., Schweighofer C.D., Fingerle-Rowson G., Campe H., Jager G., et al. Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission: Experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia 18 (2004) 1093-1101
    • (2004) Leukemia , vol.18 , pp. 1093-1101
    • Wendtner, C.M.1    Ritgen, M.2    Schweighofer, C.D.3    Fingerle-Rowson, G.4    Campe, H.5    Jager, G.6
  • 51
    • 38049002872 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG)
    • Schweighofer C., Ritgen M., Eichhorst B.F., Busch R., Kneba M., Hallek M., et al. Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG). Blood 108 (2006) 14a
    • (2006) Blood , vol.108
    • Schweighofer, C.1    Ritgen, M.2    Eichhorst, B.F.3    Busch, R.4    Kneba, M.5    Hallek, M.6
  • 52
    • 14244262359 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL): CALGB study 19901
    • (abstr)
    • Rai K.R., Byrd J.C., Peterson B.L., Gautier M., and Larson R.A. Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL): CALGB study 19901. Blood 102 (2003) 2506 (abstr)
    • (2003) Blood , vol.102 , pp. 2506
    • Rai, K.R.1    Byrd, J.C.2    Peterson, B.L.3    Gautier, M.4    Larson, R.A.5
  • 53
    • 27144510745 scopus 로고    scopus 로고
    • Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL: Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG)
    • (abstr)
    • Stilgenbauer S., Winkler D., Krober A., Kienle D., Hallek M., Hensel M., et al. Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL: Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG). Blood 104 (2004) 478 (abstr)
    • (2004) Blood , vol.104 , pp. 478
    • Stilgenbauer, S.1    Winkler, D.2    Krober, A.3    Kienle, D.4    Hallek, M.5    Hensel, M.6
  • 54
    • 41149106510 scopus 로고    scopus 로고
    • Induction of apoptosis by IDEC-152 (anti-CD23) in chronic lymphocytic leukemia
    • Pathan N., Hopkins M., Saven A., Reff M.E., Grint P., and Hariharan K. Induction of apoptosis by IDEC-152 (anti-CD23) in chronic lymphocytic leukemia. Leuk Lymphoma 42 suppl 1 (2001) 133N
    • (2001) Leuk Lymphoma , vol.42 , Issue.SUPPL. 1
    • Pathan, N.1    Hopkins, M.2    Saven, A.3    Reff, M.E.4    Grint, P.5    Hariharan, K.6
  • 55
    • 34547691135 scopus 로고    scopus 로고
    • Phase I study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd J.C., O'Brien S., Flinn I.W., Kipps T.J., Weiss M.A., Rai K., et al. Phase I study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res 13 (2007) 4448-4455
    • (2007) Clin Cancer Res , vol.13 , pp. 4448-4455
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.W.3    Kipps, T.J.4    Weiss, M.A.5    Rai, K.6
  • 56
    • 38949216227 scopus 로고    scopus 로고
    • Comparison of results from a phase 1/2 study of lumiliximab (anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results
    • Byrd J.C., Castro J., O'Brien S., Flinn I.W., Forero-Torres A., Kipps T.J., et al. Comparison of results from a phase 1/2 study of lumiliximab (anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results. Blood 108 (2006) 14a
    • (2006) Blood , vol.108
    • Byrd, J.C.1    Castro, J.2    O'Brien, S.3    Flinn, I.W.4    Forero-Torres, A.5    Kipps, T.J.6
  • 57
    • 34547753160 scopus 로고    scopus 로고
    • Significant correlation between survival endpoints and exposure to ofatumumab (HuMax-CD20) in chronic lymphocytic leukemia
    • Coiffier B., Tilly H., Pedersen L.M., Plesner T., Frederiksen H., van Oers M.H.J., et al. Significant correlation between survival endpoints and exposure to ofatumumab (HuMax-CD20) in chronic lymphocytic leukemia. Blood 108 (2006) 804a-805a
    • (2006) Blood , vol.108
    • Coiffier, B.1    Tilly, H.2    Pedersen, L.M.3    Plesner, T.4    Frederiksen, H.5    van Oers, M.H.J.6
  • 58
  • 59
    • 0042413843 scopus 로고    scopus 로고
    • Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma
    • Leonard J.P., Coleman M., Ketas J.C., Chadburn A., Ely S., Furman R.R., et al. Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma. J Clin Oncol 21 (2003) 3051-3059
    • (2003) J Clin Oncol , vol.21 , pp. 3051-3059
    • Leonard, J.P.1    Coleman, M.2    Ketas, J.C.3    Chadburn, A.4    Ely, S.5    Furman, R.R.6
  • 61
    • 0025372280 scopus 로고
    • Identification and characterization of a new surface membrane antigen found predominantly on malignant B lymphocytes
    • Gingrich R.D., Dahle C.E., Hoskins K.F., and Senneff M.J. Identification and characterization of a new surface membrane antigen found predominantly on malignant B lymphocytes. Blood 75 (1990) 2375-2387
    • (1990) Blood , vol.75 , pp. 2375-2387
    • Gingrich, R.D.1    Dahle, C.E.2    Hoskins, K.F.3    Senneff, M.J.4
  • 63
    • 79960970576 scopus 로고    scopus 로고
    • A phase II study of Remitogen (Hu1D10), a humanized monoclonal antibody in patients with relapsed or refractory follicular, small lymphocytic, or marginal zone/MALT B-cell lymphoma
    • Link B.K., Kahl B., Czuczman M.S., Powell B.L., Bartlett N., Leonard J.P., et al. A phase II study of Remitogen (Hu1D10), a humanized monoclonal antibody in patients with relapsed or refractory follicular, small lymphocytic, or marginal zone/MALT B-cell lymphoma. Blood 98 (2001) 606a
    • (2001) Blood , vol.98
    • Link, B.K.1    Kahl, B.2    Czuczman, M.S.3    Powell, B.L.4    Bartlett, N.5    Leonard, J.P.6
  • 64
    • 0041632659 scopus 로고    scopus 로고
    • A phase I dose escalation study of apolizumab (Hu1D10) using a stepped up dosing schedule in patients with chronic lymphocytic leukemia (CLL) and acute lymphocytic leukemia (ALL)
    • Lin T.S., Stock W., Lucas M.S., Porcu P., Abhyankar V.V., Jefferson S.K., et al. A phase I dose escalation study of apolizumab (Hu1D10) using a stepped up dosing schedule in patients with chronic lymphocytic leukemia (CLL) and acute lymphocytic leukemia (ALL). Blood 100 (2002) 802a
    • (2002) Blood , vol.100
    • Lin, T.S.1    Stock, W.2    Lucas, M.S.3    Porcu, P.4    Abhyankar, V.V.5    Jefferson, S.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.