Brain mechanism underlying food intake regulation

Brain and Nerve

Volumn 63, Issue 6, 2011, Pages 597-604

  Minokoshi, Yasuhiko ^a,b  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

5 adenosine monophosphate activated protein kinase; Food intake; Ghrelin; Hypothalamus; Leptin

Indexed keywords

ADENYLATE KINASE; FATTY ACID; NEUROTRANSMITTER; REACTIVE OXYGEN METABOLITE;

BODY WEIGHT; BRAIN FUNCTION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID METABOLISM; FEEDING BEHAVIOR; FOOD INTAKE; FOREBRAIN; HOMEOSTASIS; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS FUNCTION; LIPID DIET; MAMMAL; NERVE CELL; NEUROMODULATION; NONHUMAN; NUTRIENT; OBESITY; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; YEAST;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; EATING; HUMANS; HYPOTHALAMUS;

EID: 79959461338     PISSN: 18816096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Coll AP, Farooqi SI, O'Rahilly S : The hormonal control of food intake. Cell 129: 251-262, 2007 (Pubitemid 46574977)
2. Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, et al: Acivation of central melanocortin pathway by fenfluramine. Science 297: 609-611, 2002 (Pubitemid 34815346)
3. Kojima M, Kangawa K: Ghrelin: structure and function. Physiol Rev 85: 495-522, 2005 (Pubitemid 40404635)
4. Bouret SG, Simerly RB: Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology 145: 2621-2626, 2007 (Pubitemid 38686206)
5. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, et al: J Clin Invest 117: 2325-2336, 2007
6. Myers MG, Cowley MA, Münzberg H: Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537-556, 2008 (Pubitemid 351738191)
7. Zhang X, Zhang G, Zhang H, Karin M, Bai H, et al: Hypothalamic IKKβ/NF-κB and ER stress link over-nutrition to energy imbalance and obesity. Cell 135: 61-73, 2008
8. Hardie DG: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8: 774-785, 2007
9. Towler MC, Hardie DG: AMP-activated protein kinase in metabolic control and insulin signaling. Cir Res 100: 328-341, 2007
10. Minokoshi Y, Kim YB, Peroni OD, Fryer LGD, Müller C, et al: Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343, 2002 (Pubitemid 34087557)
11. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, et al: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-573, 2004
12. Xue B, Kahn BB: AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 574: 77-83, 2006
13. Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S: Role of hypothalamic AMP-kinase in food intake regulation. Nutrition 24: 786-790, 2008
14. Lamia K, Sachdeva UM, DiTacchio L, Williams EC, Alvarex JG, et al: AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326: 437-440, 2009
15. Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, et al: Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 7: 377-388, 2007
16. + metabolism and SIRT1 activity. Nature 458: 1056-1060, 2009
17. Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, et al: Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329: 1201-1205, 2010
18. He W, Lam TKT, Obici S, Rossetti L: Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 9: 227-233, 2006 (Pubitemid 43164546)
19. Wolfgang MJ, Kurama T, Suwa A, Asaumi M, Matsumoto S, et al: The brain-specific carnitine palmitoyltrasnferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A 103: 7282-7287, 2006 (Pubitemid 43727824)
20. Gao S, Kinzig KP, Aja S, Scott KA, Keung W, et al: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A 104: 17358-17363, 2007 (Pubitemid 350219847)
21. López M, Lage R, Saha AK, Pérex-Tilve D, Vázquez MJ, et al: Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 7: 389-399, 2008 (Pubitemid 351618114)
22. El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, et al: Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108: 849-863, 2002 (Pubitemid 34327535)
23. Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, et al: UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-851, 2008
24. Cota D, Proulx K, Smith KAB, Kozma SC, Thomas G, et al: Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930, 2006 (Pubitemid 43727328)