Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: Insights into the molecular basis of kynureninase substrate specificity

Journal of Medicinal Chemistry

Volumn 52, Issue 2, 2009, Pages 389-396

  Lima, Santiago ^a   Kumar, Sunil ^b   Gawandi, Vijay ^b   Momany, Cory ^b   Phillips, Robert S ^a,b  

^a University of Georgia ^*  (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYHIPPURIC ACID; ALANINE; ASPARAGINE; EXCITOTOXIN; HIPPURIC ACID DERIVATIVE; HISTIDINE; KYNURENINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRIDOXAL 5 PHOSPHATE; QUINOLINIC ACID; SERINE; TRYPTOPHAN; UNCLASSIFIED DRUG; 3-HYDROXYHIPPURIC ACID; HYDROLASE; PRIMER DNA;

ALZHEIMER DISEASE; ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; HUMAN; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; TRYPTOPHAN METABOLISM; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HYDROGEN BOND; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; HIPPURATES; HUMANS; HYDROGEN BONDING; HYDROLASES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 60549096522     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8010806     Document Type: Article

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