-
1
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei, A. A., Cohen, R. B., Franklin, W., et al. (2008). Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 26 (13), 2139-2146.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.13
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
-
2
-
-
76649113485
-
The first-in-human study of the solid oral dosage form of AZD6244 (ARRY-142886): a Phase I trial in patients (pts) with advanced cancer
-
May 20
-
Agarwal, R., Banerji, U., Camidge, D., et al. (2008). The first-in-human study of the solid oral dosage form of AZD6244 (ARRY-142886): a Phase I trial in patients (pts) with advanced cancer. J Clin Oncol. 26 (May 20 Suppl), Abst 3535.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 3535
-
-
Agarwal, R.1
Banerji, U.2
Camidge, D.3
-
3
-
-
0028884033
-
PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi, D. R., Cuenda, A., Cohen, P., et al. (1995). PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem. 270 (46), 27489-27494.
-
(1995)
J Biol Chem.
, vol.270
, Issue.46
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
-
4
-
-
10044239249
-
Halogen bonds in biological molecules
-
Auffinger, P., Hays, F. A., Westhof, E., et al. (2004). Halogen bonds in biological molecules. Proc Natl Acad Sci USA. 101 (48), 16789-16794.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, Issue.48
, pp. 16789-16794
-
-
Auffinger, P.1
Hays, F.A.2
Westhof, E.3
-
5
-
-
1242290740
-
Mek2 is dispensable for mouse growth and development
-
Belanger, L. F., Roy, S., Tremblay, M., et al. (2003). Mek2 is dispensable for mouse growth and development. Mol Cell Biol. 23 (14), 4778-4787.
-
(2003)
Mol Cell Biol.
, vol.23
, Issue.14
, pp. 4778-4787
-
-
Belanger, L.F.1
Roy, S.2
Tremblay, M.3
-
6
-
-
0024376173
-
Ras Oncogenes in human cancer: a review
-
Bos, J. L. (1989). ras Oncogenes in human cancer: a review. Cancer Res. 49 (17), 4682-4689.
-
(1989)
Cancer Res.
, vol.49
, Issue.17
, pp. 4682-4689
-
-
Bos, J.L.1
-
7
-
-
60649117312
-
ARRY-162, a novel inhibitor of MEK kinase: Phase 1A-1B pharmacokinetic and pharmacodynamic results
-
Carter, L., Brown, S., Klopfenstein, N., et al. (2008). ARRY-162, a novel inhibitor of MEK kinase: Phase 1A-1B pharmacokinetic and pharmacodynamic results. Ann Rheum Dis. 67 (Suppl II), 87.
-
(2008)
Ann Rheum Dis.
, vol.67
, Issue.SUPPL. II
, pp. 87
-
-
Carter, L.1
Brown, S.2
Klopfenstein, N.3
-
8
-
-
60549117062
-
Correlation of KRAS status (wild type [wt] vs. mutant [mt]) with efficacy to first-line cetuximab in a study of cetuximab single agent followed by cetuximab + FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC)
-
May 20
-
Cervantes, A., Macarulla, T., Martinelli, E., et al. (2008). Correlation of KRAS status (wild type [wt] vs. mutant [mt]) with efficacy to first-line cetuximab in a study of cetuximab single agent followed by cetuximab + FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 26 (May 20 suppl; Abst 4129).
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 4129
-
-
Cervantes, A.1
Macarulla, T.2
Martinelli, E.3
-
9
-
-
33644797160
-
Extracellular signal-regulated kinases and AP-1 mediate the up-regulation of vascular endothelial growth factor by PDGF in human vascular smooth muscle cells
-
Chang, H. J., Park, J. S., Kim, M. H., et al. (2006). Extracellular signal-regulated kinases and AP-1 mediate the up-regulation of vascular endothelial growth factor by PDGF in human vascular smooth muscle cells. Int J Oncol. 28 (1), 135-141.
-
(2006)
Int J Oncol.
, vol.28
, Issue.1
, pp. 135-141
-
-
Chang, H.J.1
Park, J.S.2
Kim, M.H.3
-
10
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen, Y., Xing, M., Mambo, E., et al. (2003). BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst. 95 (8), 625-627.
-
(2003)
J Natl Cancer Inst.
, vol.95
, Issue.8
, pp. 625-627
-
-
Cohen, Y.1
Xing, M.2
Mambo, E.3
-
11
-
-
34548097240
-
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
-
Davies, B. R., Logie, A., McKay, J. S., et al. (2007). AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther. 6 (8), 2209-2219.
-
(2007)
Mol Cancer Ther.
, vol.6
, Issue.8
, pp. 2209-2219
-
-
Davies, B.R.1
Logie, A.2
McKay, J.S.3
-
12
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H., Bignell, G. R., Cox, C., et al. (2002). Mutations of the BRAF gene in human cancer. Nature. 417 (6892), 949-954.
-
(2002)
Nature.
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
13
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
Dhillon, A. S., Hagan, S., Rath, O., et al. (2007). MAP kinase signalling pathways in cancer. Oncogene. 26 (22), 3279-3290.
-
(2007)
Oncogene.
, vol.26
, Issue.22
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
-
14
-
-
33244460258
-
Validation and use of a biomarker for clinical development of the MEK1/2 inhibitor ARRY-142886 (AZD6244)
-
S, Part I of II, June 1
-
Doyle, M., Yeh, T., Brown, S., et al. (2005). Validation and use of a biomarker for clinical development of the MEK1/2 inhibitor ARRY-142886 (AZD6244). J Clin Oncol. 23 (16 S, Part I of II (June 1 Suppl)), 3075.
-
(2005)
J Clin Oncol.
, vol.23
, Issue.16 SUPPL.
, pp. 3075
-
-
Doyle, M.1
Yeh, T.2
Brown, S.3
-
15
-
-
84889767045
-
Biologically driven interpretation reveals molecular signatures predictive of oncogenic addiction to MEK signaling and cell line response to the MEK1/2 inhibitor AZD6244 (ARRY-142886)
-
Dry, J., Harbron, C., Hickinson, M., et al. (2008). Biologically driven interpretation reveals molecular signatures predictive of oncogenic addiction to MEK signaling and cell line response to the MEK1/2 inhibitor AZD6244 (ARRY-142886). Proc Am Assoc Cancer Res. 49, Abst 913.
-
(2008)
Proc Am Assoc Cancer Res.
, vol.49
, pp. 913
-
-
Dry, J.1
Harbron, C.2
Hickinson, M.3
-
16
-
-
0029166667
-
A synthetic inhibitor of the mitogen-activated protein kinase cascade
-
Dudley, D. T., Pang, L., Decker, S. J., et al. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA. 92 (17), 7686-7689.
-
(1995)
Proc Natl Acad Sci USA.
, vol.92
, Issue.17
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
-
17
-
-
65649108998
-
AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, Phase II study
-
May 20
-
Dummer, R., Robert, C., Chapman, P., et al. (2008). AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, Phase II study. J Clin Oncol. 26 (May 20 Suppl), Abst 9033.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 9033
-
-
Dummer, R.1
Robert, C.2
Chapman, P.3
-
18
-
-
0032552994
-
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products
-
Duncia, J. V., Santella, J. B. 3rd, Higley, C. A., et al. (1998). MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 8 (20), 2839-2844.
-
(1998)
Bioorg Med Chem Lett.
, vol.8
, Issue.20
, pp. 2839-2844
-
-
Duncia, J.V.1
Santella III, J.B.2
Higley, C.A.3
-
19
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata, M. F., Horiuchi, K. Y., Manos, E. J., et al. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 273 (29), 18623-18632.
-
(1998)
J Biol Chem.
, vol.273
, Issue.29
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
-
20
-
-
12144289984
-
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
-
Friesner, R. A., Banks, J. L., Murphy, R. B., et al. (2004). Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem. 47 (7), 1739-1749.
-
(2004)
J Med Chem.
, vol.47
, Issue.7
, pp. 1739-1749
-
-
Friesner, R.A.1
Banks, J.L.2
Murphy, R.B.3
-
21
-
-
0033535584
-
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
-
Giroux, S., Tremblay, M., Bernard, D., et al. (1999). Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol. 9 (7), 369-372.
-
(1999)
Curr Biol.
, vol.9
, Issue.7
, pp. 369-372
-
-
Giroux, S.1
Tremblay, M.2
Bernard, D.3
-
22
-
-
1642310340
-
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
-
Halgren, T. A., Murphy, R. B., Friesner, R. A., et al. (2004). Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem. 47 (7), 1750-1759.
-
(2004)
J Med Chem.
, vol.47
, Issue.7
, pp. 1750-1759
-
-
Halgren, T.A.1
Murphy, R.B.2
Friesner, R.A.3
-
23
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., and Weinberg, R. A. (2000). The hallmarks of cancer. Cell. 100 (1), 57-70.
-
(2000)
Cell.
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
24
-
-
0033590636
-
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
-
Hoshino, R., Chatani, Y., Yamori, T., et al. (1999). Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene. 18 (3), 813-822.
-
(1999)
Oncogene.
, vol.18
, Issue.3
, pp. 813-822
-
-
Hoshino, R.1
Chatani, Y.2
Yamori, T.3
-
25
-
-
0034673214
-
Inhibition of MAP kinase kinase (MEK) results in an anti-inflammatory response in vivo
-
Jaffee, B. D., Manos, E. J., Collins, R. J., et al. (2000). Inhibition of MAP kinase kinase (MEK) results in an anti-inflammatory response in vivo. Biochem Biophys Res Commun. 268 (2), 647-651.
-
(2000)
Biochem Biophys Res Commun.
, vol.268
, Issue.2
, pp. 647-651
-
-
Jaffee, B.D.1
Manos, E.J.2
Collins, R.J.3
-
26
-
-
0037080003
-
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
-
Ji, R. R., Befort, K., Brenner, G. J., et al. (2002). ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci. 22 (2), 478-485.
-
(2002)
J Neurosci.
, vol.22
, Issue.2
, pp. 478-485
-
-
Ji, R.R.1
Befort, K.2
Brenner, G.J.3
-
27
-
-
0033215389
-
Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells
-
Jung, Y. D., Nakano, K., Liu, W., et al. (1999). Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. Cancer Res. 59 (19), 4804-4807.
-
(1999)
Cancer Res.
, vol.59
, Issue.19
, pp. 4804-4807
-
-
Jung, Y.D.1
Nakano, K.2
Liu, W.3
-
28
-
-
20244380435
-
Synthesis and SAR development of PD0325901, a potent and highly bioavailable MEK inhibitor
-
Kaufman, M. D., Barrett, S. D., Flamme, C. M., et al. (2004). Synthesis and SAR development of PD0325901, a potent and highly bioavailable MEK inhibitor. Proc Am Assoc Cancer Res. 45, Abst 2477.
-
(2004)
Proc Am Assoc Cancer Res.
, vol.45
, pp. 2477
-
-
Kaufman, M.D.1
Barrett, S.D.2
Flamme, C.M.3
-
29
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford, S., Garrett, C. R., Meropol, N. J., et al. (2007). Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol. 25 (22), 3230-3237.
-
(2007)
J Clin Oncol.
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
30
-
-
84889852082
-
ARRY-438162, a selective, potent inhibitor of MEK 1/2 in clinical development for the treatment of inflammatory disease
-
Presented at the 14th International Inflammation Research Association Conference, Cambridge, MD
-
Koch, K. (2006). ARRY-438162, a selective, potent inhibitor of MEK 1/2 in clinical development for the treatment of inflammatory disease. Presented at the 14th International Inflammation Research Association Conference, Cambridge, MD.
-
(2006)
-
-
Koch, K.1
-
31
-
-
72449200292
-
AZD6244 (ARRY-142886) versus capecitabine (CAP) in patients (pts) with metastatic colorectal cancer (mCRC) who have failed prior chemotherapy
-
May 20
-
Lang, I., Adenis, A., Boer, K., et al. (2008). AZD6244 (ARRY-142886) versus capecitabine (CAP) in patients (pts) with metastatic colorectal cancer (mCRC) who have failed prior chemotherapy. J Clin Oncol. 26 (May 20 Suppl), Abst 4114.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 4114
-
-
Lang, I.1
Adenis, A.2
Boer, K.3
-
32
-
-
17144375950
-
ARRY-142886, a potent and selective MEK inhibitor: III. Efficacy against human xenograft models correlates with decreased ERK phosphorylaiton
-
Lee, P., Wallace, E., Yeh, T., et al. (2004). ARRY-142886, a potent and selective MEK inhibitor: III. Efficacy against human xenograft models correlates with decreased ERK phosphorylaiton. Proc Am Assoc Cancer Res. 45, Abst 3890.
-
(2004)
Proc Am Assoc Cancer Res.
, vol.45
, pp. 3890
-
-
Lee, P.1
Wallace, E.2
Yeh, T.3
-
33
-
-
23944439944
-
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
-
LoRusso, P. M., Adjei, A. A., Varterasian, M., et al. (2005). Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies . J Clin Oncol. 23 (23), 5281-5293.
-
(2005)
J Clin Oncol.
, vol.23
, Issue.23
, pp. 5281-5293
-
-
LoRusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
-
34
-
-
23644449569
-
The ERK/MAPK pathway, as a target for the treatment of neuropathic pain
-
Ma, W., and Quirion, R. (2005). The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert Opin Ther Targets. 9 (4), 699-713.
-
(2005)
Expert Opin Ther Targets.
, vol.9
, Issue.4
, pp. 699-713
-
-
Ma, W.1
Quirion, R.2
-
35
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
Marks, J. L., Gong, Y., Chitale, D., et al. (2008). Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res. 68 (14), 5524-5528.
-
(2008)
Cancer Res.
, vol.68
, Issue.14
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
-
36
-
-
34248563290
-
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition
-
Meloche, S., and Pouyssegur, J. (2007). The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition. Oncogene. 26 (22), 3227-3239.
-
(2007)
Oncogene.
, vol.26
, Issue.22
, pp. 3227-3239
-
-
Meloche, S.1
Pouyssegur, J.2
-
37
-
-
41149097557
-
Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib
-
Miller, V. A., Riely, G. J., Zakowski, M. F., et al. (2008). Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J Clin Oncol. 26 (9), 1472-1478.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.9
, pp. 1472-1478
-
-
Miller, V.A.1
Riely, G.J.2
Zakowski, M.F.3
-
38
-
-
34748888432
-
Deaths: final data for 2004
-
Minino, A. M., Heron, M. P., Murphy, S. L., et al. (2007). Deaths: final data for 2004. Natl Vital Stat Rep. 55 (19), 1-119.
-
(2007)
Natl Vital Stat Rep.
, vol.55
, Issue.19
, pp. 1-119
-
-
Minino, A.M.1
Heron, M.P.2
Murphy, S.L.3
-
39
-
-
34848848499
-
Fluorine in pharmaceuticals: looking beyond intuition
-
Muller, K., Faeh, C., and Diederich, F. (2007). Fluorine in pharmaceuticals: looking beyond intuition. Science. 317 (5846), 1881-1886.
-
(2007)
Science.
, vol.317
, Issue.5846
, pp. 1881-1886
-
-
Muller, K.1
Faeh, C.2
Diederich, F.3
-
40
-
-
15744380263
-
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
-
Ohren, J. F., Chen, H., Pavlovsky, A., et al. (2004). Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 11 (12), 1192-1197.
-
(2004)
Nat Struct Mol Biol.
, vol.11
, Issue.12
, pp. 1192-1197
-
-
Ohren, J.F.1
Chen, H.2
Pavlovsky, A.3
-
41
-
-
0037975671
-
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes
-
Pelletier, J. P., Fernandes, J. C., Brunet, J., et al. (2003). In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis Rheum. 48 (6), 1582-1593.
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.6
, pp. 1582-1593
-
-
Pelletier, J.P.1
Fernandes, J.C.2
Brunet, J.3
-
42
-
-
33846413174
-
A new method of estimating United States and state-level cancer incidence counts for the current calendar year
-
Pickle, L. W., Hao, Y., Jemal, A., et al. (2007). A new method of estimating United States and state-level cancer incidence counts for the current calendar year. CA Cancer J Clin. 57, 30-42.
-
(2007)
CA Cancer J Clin.
, vol.57
, pp. 30-42
-
-
Pickle, L.W.1
Hao, Y.2
Jemal, A.3
-
43
-
-
0038792224
-
Map kinase signaling pathways and hematologic malignancies
-
Platanias, L. C. (2003). Map kinase signaling pathways and hematologic malignancies. Blood. 101 (12), 4667-4679.
-
(2003)
Blood.
, vol.101
, Issue.12
, pp. 4667-4679
-
-
Platanias, L.C.1
-
44
-
-
14844285975
-
Multicenter Phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
Rinehart, J., Adjei, A. A., LoRusso, P. M., et al. (2004). Multicenter Phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol. 22 (22), 4456-4462.
-
(2004)
J Clin Oncol.
, vol.22
, Issue.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
LoRusso, P.M.3
-
45
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts, P. J., and Der, C. J. (2007). Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26 (22), 3291-3310.
-
(2007)
Oncogene.
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
46
-
-
27144450593
-
Effects of active MEK1 expression in vivo
-
Scholl, F. A., Dumesic, P. A., and Khavari, P. A. (2005). Effects of active MEK1 expression in vivo. Cancer Lett. 230 (1), 1-5.
-
(2005)
Cancer Lett.
, vol.230
, Issue.1
, pp. 1-5
-
-
Scholl, F.A.1
Dumesic, P.A.2
Khavari, P.A.3
-
47
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold, J. S., Dudley, D. T., Herrera, R., et al. (1999). Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 5 (7), 810-816.
-
(1999)
Nat Med.
, vol.5
, Issue.7
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
-
48
-
-
84889837696
-
Combining the potent MEK1/2 inhibitor AZD6244 (ARRY-142886) with radiotherapy in a lung tumor xenograft model; pharmacodynamic effects, therapeutic benefits and the hypoxia response
-
Shannon, A., Telfer, B., Babur, M., et al. (2008). Combining the potent MEK1/2 inhibitor AZD6244 (ARRY-142886) with radiotherapy in a lung tumor xenograft model; pharmacodynamic effects, therapeutic benefits and the hypoxia response. Proc Am Assoc Cancer Res. 49, Abst 2568.
-
(2008)
Proc Am Assoc Cancer Res.
, vol.49
, pp. 2568
-
-
Shannon, A.1
Telfer, B.2
Babur, M.3
-
49
-
-
84889842100
-
The development of kinase inhibitors with unusual mechanism of action: CI-1040, a selective, non-ATP competitive MEK inhibitor in the clinic
-
Presented at the IBC 2nd International Conference on Protein Kinases: Target Validation, Drug Discovery and Clinical Development of Kinase Therapeutics, Boston, MA
-
Tecle, H. (2002). The development of kinase inhibitors with unusual mechanism of action: CI-1040, a selective, non-ATP competitive MEK inhibitor in the clinic. Presented at the IBC 2nd International Conference on Protein Kinases: Target Validation, Drug Discovery and Clinical Development of Kinase Therapeutics, Boston, MA.
-
(2002)
-
-
Tecle, H.1
-
50
-
-
35348923750
-
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms
-
Thiel, M. J., Schaefer, C. J., Lesch, M. E., et al. (2007). Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms. Arthritis Rheum. 56 (10), 3347-3357.
-
(2007)
Arthritis Rheum.
, vol.56
, Issue.10
, pp. 3347-3357
-
-
Thiel, M.J.1
Schaefer, C.J.2
Lesch, M.E.3
-
51
-
-
34248572839
-
MAP kinases and the control of nuclear events
-
Turjanski, A. G., Vaque, J. P., and Gutkind, J. S. (2007). MAP kinases and the control of nuclear events. Oncogene. 26 (22), 3240-3253.
-
(2007)
Oncogene.
, vol.26
, Issue.22
, pp. 3240-3253
-
-
Turjanski, A.G.1
Vaque, J.P.2
Gutkind, J.S.3
-
52
-
-
65649152804
-
Efficacy and safety of AZD6244 (ARRY-142886) as second/third-line treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
May 20
-
Tzekova, V., Cebotaru, C., Ciuleanu, T., et al. (2008). Efficacy and safety of AZD6244 (ARRY-142886) as second/third-line treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 26 (May 20 Suppl), Abst 8029.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 8029
-
-
Tzekova, V.1
Cebotaru, C.2
Ciuleanu, T.3
-
53
-
-
6344235546
-
MEK1 and MEK2, different regulators of the G1/S transition
-
Ussar, S., and Voss, T. (2004). MEK1 and MEK2, different regulators of the G1/S transition. J Biol Chem. 279 (42), 43861-43869.
-
(2004)
J Biol Chem.
, vol.279
, Issue.42
, pp. 43861-43869
-
-
Ussar, S.1
Voss, T.2
-
54
-
-
51649120733
-
KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience
-
May 20
-
Van Custem, E., Lang, I., D'haens, G., et al. (2008). KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience. J Clin Oncol. 26 (May 20 Suppl; Abst 2).
-
(2008)
J Clin Oncol.
, vol.26
, Issue.SUPPL.
, pp. 2
-
-
Van Custem, E.1
Lang, I.2
D'haens, G.3
-
55
-
-
10344231333
-
Preclinical development of ARRY-142886, a potent and selective MEK inhibitor
-
Wallace, E., Yeh, T., Lyssikatos, J., et al. (2004). Preclinical development of ARRY-142886, a potent and selective MEK inhibitor. Proc Am Assoc Cancer Res. 45, Abst 3891.
-
(2004)
Proc Am Assoc Cancer Res.
, vol.45
, pp. 3891
-
-
Wallace, E.1
Yeh, T.2
Lyssikatos, J.3
-
56
-
-
84889816933
-
4-(4-Bromo-2-fluorophenylamino)-1-methyl-pyridin-2(1H)ones: potent and selective MEK 1,2 inhibitors
-
Presented at the 17th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Philadelphia, PA
-
Wallace, E., Lyssikatos, J., Blake, J., et al. (2005). 4-(4-Bromo-2-fluorophenylamino)-1-methyl-pyridin-2(1H)ones: potent and selective MEK 1,2 inhibitors. Presented at the 17th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Philadelphia, PA.
-
(2005)
-
-
Wallace, E.1
Lyssikatos, J.2
Blake, J.3
-
57
-
-
31544446922
-
Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitor. 1. 4-(4-Bromo-2-fluorophenylamino)-1-methylpyridin-2(1 H)-ones
-
Wallace, E. M., Lyssikatos, J., Blake, J. F., et al. (2006). Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitor. 1. 4-(4-Bromo-2-fluorophenylamino)-1-methylpyridin-2(1 H)-ones. J Med Chem. 49 (2), 441-444.
-
(2006)
J Med Chem.
, vol.49
, Issue.2
, pp. 441-444
-
-
Wallace, E.M.1
Lyssikatos, J.2
Blake, J.F.3
-
58
-
-
0037216665
-
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis
-
Wang, X., Wang, H., Xu, L., et al. (2003). Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther. 304 (1), 172-178.
-
(2003)
J Pharmacol Exp Ther.
, vol.304
, Issue.1
, pp. 172-178
-
-
Wang, X.1
Wang, H.2
Xu, L.3
-
59
-
-
44849093562
-
Oncogene addiction
-
discussion 3080
-
Weinstein, I. B., and Joe, A. (2008). Oncogene addiction. Cancer Res. 68 (9), 3077-3080; discussion 3080.
-
(2008)
Cancer Res.
, vol.68
, Issue.9
, pp. 3077-3080
-
-
Weinstein, I.B.1
Joe, A.2
-
60
-
-
84877715511
-
Activity of the MEK1/2 inhibitor AZD6244 (ARRY-142886) in combination with standard and approved therapies:impact of in vivo sequencing of drug administration
-
Wilkinson, R., Logie, A., Haupt, N., et al. (2008). Activity of the MEK1/2 inhibitor AZD6244 (ARRY-142886) in combination with standard and approved therapies:impact of in vivo sequencing of drug administration. Proc Am Assoc Cancer Res. 49, Abst 4012.
-
(2008)
Proc Am Assoc Cancer Res.
, vol.49
, pp. 4012
-
-
Wilkinson, R.1
Logie, A.2
Haupt, N.3
-
61
-
-
0041589377
-
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
-
Xu, X., Quiros, R. M., Gattuso, P., et al. (2003). High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res. 63 (15), 4561-4567.
-
(2003)
Cancer Res.
, vol.63
, Issue.15
, pp. 4561-4567
-
-
Xu, X.1
Quiros, R.M.2
Gattuso, P.3
-
62
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh, T. C., Marsh, V., Bernat, B. A., et al. (2007). Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 13 (5), 1576-1583.
-
(2007)
Clin Cancer Res.
, vol.13
, Issue.5
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
|