The use of autologous blood-derived growth factors in bone regeneration

Clinical Cases in Mineral and Bone Metabolism

Volumn 8, Issue 1, 2011, Pages 25-31

  Civinini, Roberto ^a   Macera, Armando ^a   Nistri, Lorenzo ^a   Redl, Birgit ^a   Innocenti, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Bone regeneration; Growth factors; Platelet Rich Plasma

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; FIBRIN; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT OSTEOGENIC PROTEIN 1; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ACHILLES TENDON RUPTURE; ANALYTIC METHOD; ANTERIOR CRUCIATE LIGAMENT RUPTURE; BONE MARROW CELL; BONE REGENERATION; CARTILAGE DEGENERATION; CELL SAVER; CELL SEPARATION; CLINICAL STUDY; COMPARATIVE EFFECTIVENESS; COMPARATIVE STUDY; ELBOW DISEASE; FRACTURE HEALING; FRACTURE NONUNION; GRAVITATIONAL PLATELET SEQUESTRATION SYSTEM; HUMAN; LEG LENGTH INEQUALITY; NONHUMAN; PSEUDARTHROSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); ROTATOR CUFF RUPTURE; SELECTIVE FILTRATION TECHNOLOGY; SHORT SURVEY; SPINE FUSION; TENDINITIS; THROMBOCYTE; THROMBOCYTE RICH PLASMA; VARUS DEFORMITY;

EID: 79959434594     PISSN: 17248914     EISSN: 19713266     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (71)

1. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001;10(4): 225-228.
2. Kumar V, Cotran RS, Robbins SL. Tissue repair: cell regeneration and fibrosis. Basic pathology. 7th ed. Philadelphia: Saunders; 2003: 61-78.
3. Harrison P, Cramer EM. Platelet alpha-granules. Blood Rev 1993;7:52-62.
4. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;91:4-15. (Pubitemid 38111215)
5. Bucholz RW, Einhorn TA, Marsh JL. Bone and joint healing. In: Bucholz RW, Heckman JD, Court-Brown C, eds. Rockwood & Green's fractures in adults. Sixth ed. Lippincott Williams & Wilkins, 2006:300-11.
6. Schliephake H. Bone growth factors in maxillofacial skeletal reconstruction. Int J Oral Maxillofac Surg 2002;31:469-84.
7. Sanchez AR, Sheridan PJ, Kupp LI. Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 2003;18:93-103. (Pubitemid 37140458)
8. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46. (Pubitemid 128641964)
9. Van den Dolder J, Mooren R, Vloon AP, Stoelinga PJ, Jansen JA. Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. Tissue Eng 2006;12:3067-73. (Pubitemid 44846412)
10. Eppley BL, Woodel JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004;114:1502-8. (Pubitemid 40361959)
11. Polasek J, Richardson M, Moore MA, Blajchman MJ. Evidence for an alternative mechanism of platelet secretion involving peripheralization of secretory granules and formation of membrane associated multivesicular structures. Thrombosis Research 1987;45:771-82. (Pubitemid 17053698)
12. Raines EW, Ross R. Purification of human platelet-derived growth factor. Methods Enzymol 1985;109:749-73. (Pubitemid 15136069)
13. Ross R, Raines EW, Bowen-Pope DF. The biology of platelet-derived growth factor. Cell 1986;46:155-69. (Pubitemid 16031684)
14. Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006;81(9):1241-57. (Pubitemid 44316290)
15. Andrew JG, Hoyland JA, Freemont AJ, et al. Platelet-derived growth factor expression in normally healing human fractures. Bone 1995;16(4):455-460.
16. Canalis E. Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. Metabolism 30(10):970-975.
17. Canalis E, McCarthy TL, Centrella M. Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol 1989;140(3):530-537. (Pubitemid 19241771)
18. Massague J, Gomis RR. The logic of TGFbeta signaling. FEBS Lett 2006;580(12):2811-20.
19. Duke PT, Hansen P, Iwata KK, Pieler C, Foulkes JG. Identification of another member of the transforming growth factor type b gene family. Proc Natl Acad Sci USA 1988;85:4715-19.
20. Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontal 1993;64:142-8.
21. Wrana JL, Macho M, Hawrylyshyn B, et al. Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. J Cell Biol 1988;106:915-24. (Pubitemid 18089991)
22. Bonewald LF, Mundy GR. Role of transforming growth factor-beta in bone remodeling. Clin Orthop 1990;250:261-76. (Pubitemid 20033993)
23. Mohan S, Baylink DJ. Bone growth factors. Clin Orthop 1991;263:30-48.
24. Trippel SB. Potential role of insulinlike growth factors in fracture healing. Clin Orthop Related Res 1998;(355 Suppl.):S301-13.
25. Conover CA. In vitro studies of insulin-like growth factor I and bone. Growth Horm IGF Res 2000;10(Suppl. B):S107-10.
26. Canalis E. Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria. J Clin Invest 1980;66(4):709-19. (Pubitemid 10060939)
27. Gale NW, Yancopoulos GD. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev 1999;13(9):1055-66. (Pubitemid 29233137)
28. Kubota S, Kawata K, Yanagita T, Doi H, Kitoh T, Takigawa M. Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. J Biochem. (Tokyo). 2004;136: 279-82. (Pubitemid 39545786)
29. Cicha I, Garlichs CD, Daniel WG, Goppelt-Struebe M. Activated human platelets release connective tissue growth factor. Thromb Haemost 2004;91: 755-60. (Pubitemid 38477456)
30. Everts PAM, Brown Mahoney C, Hoffmann JJML, Schönberger JPAM, Box HAM, van Zundert A and Knape JTA. Platelet-rich plasma preparation using three devices: Implications for platelet activation and platelet growth factor release. 2006;24,(3):165-171.
31. Kevy SV, Jacobson MS. Comparison of methods for point of care preparation of autologous platelet gel. J Extra Corp Technol 2004;36:28-35. (Pubitemid 38392711)
32. Choi BH, Zhu SJ, Kim BY, et al. Effect of platelet rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. Int J Oral Maxillofac Surg 2005;34:420-4.
33. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 2004;34:665-71. (Pubitemid 38393802)
34. Schoendorfer DW, Williamson LH, Sheckler VL, Fitzgerald BP. Platelet collection with the autopheresis-C apheresis system. Vix Sang 1990;58:100-5. (Pubitemid 20121368)
35. Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg 2005;16:1043-54. (Pubitemid 44383894)
36. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:498-93.
37. Carroll RJ, Arnoczky SP, Graham S, O'Connell SM. Characterization of Autologous Growth Factors.Cascade Platelet-Rich Fibrin Matrix (PRFM). Edison, NJ: Musculoskeletal Transplant Foundation; 2005.
38. Tayapongsak P, O'Brien DA, Monteiro CB, Arceo-Diaz LY. Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg 1994;52:161-5.
39. Kon E, Filardo G, Di Martino A, Marcacci M. Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use. Knee Surg Sports Traumatol Arthrosc 2010, Nov 17.
40. Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 2010;26(2):269-78.
41. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 2009;37(11):2259-72.
42. Scott A. Rodeo, MD, Demetris Delos, MD, Alex Weber, MD, Xiaodong Ju, MD, Matthew E. Cunningham, What's New in Orthopaedic Research. J Bone Joint Surg Am 2010;92:2491-501.
43. Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15(2):203-8. (Pubitemid 24116085)
44. Kim SG, Chung CH, Kim YK, Park JC, Lim SC. Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants. Int J Oral Maxillofac Implants 2002;17(1):86-94.
45. Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, Guldberg RE.Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. 2007;81(4):888-99.
46. Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R et al. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in criticalsize defects. Clin Oral Implants Res 2004;15(2):187-93. (Pubitemid 40109803)
47. Al Sukhun J, Helenius M, Lindqvist C, Thoren H. Use of platelet rich plasma (PRP) in the reconstruction of mandibular bony defects: clinical and radiographic follow-up. Br J Oral Maxillofac Surg 2007, Jan 6 [Epub ahead of print].
48. Dugrillon A, Klüter H. Topical application of platelets for improved wound healing. Blood Ther Med 2002;3(1):21-6.
49. Thor A, Franke-Stenport V, Johansson CB, et al. 2007. Early bone formation in human bone grafts treated with plateletrich plasma: Preliminary histomorphometric results. Int J Oral Maxillofac Surg 36:1164-1171. (Pubitemid 350138397)
50. Ranly DM, Lohmann CH, Andreacchio D, Boyan BD, Schwartz Z. Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice. J Bone Joint Surg Am 2007;89(1):139-47. (Pubitemid 46059153)
51. Ranly DM, McMillan J, Keller T, Lohmann CH, Meunch T, Cochran DL, Schwartz Z, Boyan BD.Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J Bone Joint Surg Am 2005;87(9):2052-64. (Pubitemid 41279137)
52. Chaput CD, Patel KV, Brindley GW, Roux MA, Hu N, Dmitriev A, Cunningham B. Influence of a platelet concentrate on prosthetic bone ingrowth in a rabbit model. J Surg Orthop Adv 2007;16(4):159-63.
53. Cenni E, Avnet S, Fotia C, Salerno M, Baldini N ,Platelet-Rich Plasma Impairs Osteoclast Generation from Human Precursors of Peripheral Blood. J Orthop Res 2010;28:792-797.
54. Broggini N, Hofstetter W, Hunziker E, Bosshardt DD, Bornstein MM, Seto I, Weibrich G, Buser D. The Influence of PRP on Early Bone Formation in Membrane Protected Defects. A Histological and Histomorphometric Study in the Rabbit Calvaria. Clin Implant Dent Relat Res. 2010, Feb 11.
55. Sarkar MR, Augat P, Shefelbine SJ, et al. Bone formation in a long bone defect model using a platelet-rich plasmaloaded collagen scaffold. Biomaterials 2006;27:1817-1823. (Pubitemid 41759476)
56. Kasten P, Vogel J, Geiger F, et al. The effect of platelet rich plasma on healing in critical-size long-bone defects. Biomaterials 2008;29:3983-3992.
57. Pascal Jungbluth, Michael Wild, Jan-Peter Grassmann, Ebru Ar, Martin Sager, Monika Herten, Marcus Jager, Juergen Becker, Joachim Windolf, Mohssen Hakimi. Platelet-Rich Plasma on Calcium Phosphate Granules Promotes Metaphyseal Bone Healing in Mini-Pigs. Journal of Orthopaedic Research 2010: 1448-1455.
58. Bi L, Cheng W, Fan H, Pei G. Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet rich plasma. Biomaterials 2010;31:3201-11.
59. Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp J, Schelling SH, Wang E. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Relat Res 1993;(293):317-26. (Pubitemid 23242887)
60. Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal fusion. Bone 1999;25(Suppl. 2):47-50.
61. Dallari D, Savarino L, Stagni C, Cenni E, Cenacchi A, Fornasari PM, Albisinni U, Rimondi E, Baldini N, Giunti A. Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells. J Bone Joint Surg Am. 2007;89(11):2413-20. (Pubitemid 350086330)
62. Kitoh H, Kitakoji T, Tsuchiya H, Katoh M, Ishiguro N. Distraction osteogenesis of the lower extremity in patients with achondroplasia/ hypochondroplasia treated with transplantation of culture-expanded bone marrow cells and platelet-rich plasma. J Pediatr Orthop 2007;27(6):629-34. (Pubitemid 47312264)
63. Bibbo C, Bono CM, Lin SS. Union rates using autologous platelet concentrate alone and with bone graft in high-risk foot and ankle surgery patients. J Surg Orthop Adv 2005;14(1):17-22.
64. Bielecki T, Gazdzik TS, Szczepanski T. Benefit of percutaneous injection of autologous platelet-leukocyte-rich gel in patients with delayed union and nonunion. Eur Surg Res 2008;40:289.
65. Gandhi A, Doumas C, O'Connor JP, Parsons JR, Lin SS. The effects of local platelet rich plasma delivery on diabetic fracture healing. Bone 2006;38:540-6.
66. Tyndall WA, Beam HA, Zarro C, O'Connor JP, Lin SS. Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop 2003;408:319-30. (Pubitemid 36307525)
67. Grant WP, Jerlin EA, Pietrzak WS, Tam HS. The utilization of autologous growth factors for the facilitation of fusion in complex neuropathic fractures in the diabetic population. Clin Pediatr Med Surg 2005;22:561-84. (Pubitemid 41423560)
68. Calori GM, D'Avino M, Tagliabue L, Albisetti W, d'Imporzano M, Peretti G. An ongoing research for evaluation of treatment with BMPs or AGFs in long bone non-union: protocol description and preliminary results. Injury 2006;37 Suppl. 3:S43-50.
69. Calori GM, Tagliabue L, Gala L, d'Imporzano M, Peretti G, Albisetti W. Application of rhBMP7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients Injury. 2008;39(12):1391-402.
70. Nauth A, Giannoudis P.V, Einhorn T.A, Hankenson K.D, Friedlaender G.E, Li R, Schemitsch E.H. Growth Factors: Beyond Bone Morphogenetic Proteins. J Orthop Trauma 2010;24(9): 543-546.
71. Hollinger JO, Hart CE, Hirsch SN, et al. Recombinant human platelet derived growth factor: biology and clinical applications. J Bone Joint Surg Am. 2008;90(Suppl. 1):48-54. (Pubitemid 351329121)