Iron-Regulated lysis of recombinant Escherichia coli in host releases protective antigen and confers biological containment

Infection and Immunity

Volumn 79, Issue 7, 2011, Pages 2608-2618

  Guan, Lingyu ^a   Mu, Wei ^a   Champeimont, Jonathan ^b   Wang, Qiyao ^a   Wu, Haizhen ^a   Xiao, Jingfan ^a   Lubitz, Werner ^b   Zhang, Yuanxing ^a   Liu, Qin ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 2,3 DIHYDROXYBENZOATE DEHYDROGENASE; BACTERIAL VECTOR; ESCHERICHIA COLI PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEME TRANSPORTING PROTEIN; IRON REGULATORY FACTOR; OUTER MEMBRANE HEME RECEPTOR PROTEIN; UNCLASSIFIED DRUG; VIBRIOBACTIN OUTER MEMBRANE RECEPTOR;

AEROMONAS HYDROPHILA; ARTICLE; ESCHERICHIA COLI; IMMUNITY; IN VITRO STUDY; LYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; TURBOT; ZEBRA FISH;

AEROMONAS HYDROPHILA; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; BACTERIOLYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLATFISHES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GRAM-NEGATIVE BACTERIAL INFECTIONS; GREEN FLUORESCENT PROTEINS; IRON; ISOPROPYL THIOGALACTOSIDE; PLASMIDS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; VACCINES, SYNTHETIC; ZEBRAFISH;

EID: 79959391563     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01219-10     Document Type: Article

References (67)

1. Alice, A., C. López, and J. Crosa. 2005. Plasmid- and chromosome-encoded redundant and specific functions are involved in biosynthesis of the siderophore anguibactin in Vibrio anguillarum 775: a case of chance and necessity? J. Bacteriol. 187:2209-2214.
2. Andrews, S., A. Robinson, and F. Rodríguez-Quiones. 2003. Bacterial iron homeostasis. FEMS Microbiol. Rev. 27:215-237.
3. Barry, E., Z. Altboum, G. Losonsky, and M. Levine. 2003. Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains. Vaccine 21:333-340.
4. Braun, V. 2003. Iron uptake by Escherichia coli. Front. Biosci. 8:1409-1421.
5. Bury, N., and M. Grosell. 2003. Waterborne iron acquisition by a freshwater teleost fish, zebrafish Danio rerio. J. Exp. Biol. 206:3529-3535.
6. Butterton, J., and S. Calderwood. 1994. Identification, cloning, and sequencing of a gene required for ferric vibriobactin utilization by Vibrio cholerae. J. Bacteriol. 76:5631-5638.
7. Butterton, J., M. Choi, P. Watnick, P. Carroll, and S. Calderwood. 2000. Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases. J. Bacteriol. 182:1731- 1738.
8. Castagliuolo, I., et al. 2005. Engineered E. coli delivers therapeutic genes to the colonic mucosa. Gene Ther. 12:1070-1078.
9. Chai, S., T. Welch, and J. Crosa. 1998. Characterization of the interaction between Fur and the iron transport promoter of the virulence plasmid in Vibrio anguillarum. J. Biol. Chem. 273:33841-33847.
10. Christman, M., R. Morgan, F. Jacobson, and B. Ames. 1985. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 41:753-762.
11. Christoffersen, C., T. Brickman, I. Hook-Barnard, and M. McIntosh. 2001. Regulatory architecture of the iron-regulated fepD-ybdA bidirectional promoter region in Escherichia coli. J. Bacteriol. 183:2059-2070.
12. Critchley, R., et al. 2004. Potential therapeutic applications of recombinant, invasive E. coli. Gene Ther. 11:1224-1233.
13. Curtiss, R., III, et al. 2010. New technologies in using recombinant attenuated Salmonella vaccine vectors. Crit. Rev. Immunol. 30:255-270.
14. Fluri, D. A., C. Kemmer, M. Daoud-El Baba, and M. Fussenegger. 2008. A novel system for trigger-controlled drug release from polymer capsules. J. Control Release 31:211-219.
15. Funahashi, T., et al. 2003. An iron-regulated gene required for utilization of aerobactin as an exogenous siderophore in Vibrio parahaemolyticus. Microbiology 149:1217-225.
16. Galen, J., and M. Levine. 2001. Can a 'flawless' live vector vaccine strain be engineered? Trends Microbiol. 9:372-376.
17. Galen, J., et al. 2009. Salmonella enterica serovar Typhi live vector vaccines finally come of age. Immunol. Cell Biol. 87:400-412.
18. Galen, J., et al. 2010. A new generation of stable, nonantibiotic, low-copynumber plasmids improves immune responses to foreign antigens in Salmonella enterica serovar Typhi live vectors. Infect. Immun. 78:337-347.
19. Gamer, M., D. Frode, R. Biedendieck, S. Stammen, and D. Jahn. 2009. A T7 RNA polymerase-dependent gene expression system for Bacillus megaterium. Appl. Microbiol. Biotechnol. 82:1195-1203.
20. 2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84: 165-174.
21. Gentschev, I., et al. 1996. Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway. Gene 179:133-140.
22. Georgiou, G., et al. 1996. Display of beta-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp'-OmpA'-beta-lactamase fusions. Protein Eng. Des. Sel. 9:239-247.
23. Gunn, B., S. Wanda, D. Burshell, C. Wang, and R. Curtiss III. 2010. Construction of recombinant attenuated Salmonella enterica serovar Typhimurium vaccine vector strains for safety in newborn and infant mice. Clin. Vaccine Immunol. 17:354-362.
24. Henderson, D., and S. Payne. 1994. Characterization of the Vibrio cholerae outer membrane heme transport protein HutA: sequence of the gene, regulation of expression, and homology to the family of TonB-dependent proteins. J. Bacteriol. 176:3269-3277.
25. Hoffelner, H., G. Rieder, and R. Haas. 2008. Helicobacter pylori vaccine development: optimisation of strategies and importance of challenging strain and animal model. Int. J. Med. Microbiol. 298:151-159.
26. Hunt, M., G. Pettis, and M. McIntosh. 1994. Promoter and operator determinants for fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. J. Bacteriol. 176: 3944-3955.
27. Isoda, R., S. Simanski, L. Pathangey, A. Stone, and T. Brown. 2007. Expression of a Porphyromonas gingivalis hemagglutinin on the surface of a Salmonella vaccine vector. Vaccine 25:117-126.
28. Kang, H., and R. Curtiss III. 2003. Immune responses dependent on antigen location in recombinant attenuated Salmonella typhimurium vaccines following oral immunization. FEMS Immunol. Med. Microbiol. 37:99-104.
29. Karlsson, J., J. von Hofsten, and P. Olsson. 2001. Generating transparent zebrafish: a refined method to improve detection of gene expression during embryonic development. Mar. Biotechnol. 3:522-527.
30. Knudsen, S., and O. Karlstrom. 1991. Development of efficient suicide mechanisms for biological containment of bacteria. Appl. Environ. Microbiol. 57:85-92.
31. Kuo, C., S. Sinha, J. Jazayeri, and C. Pouton. 2009. A stably engineered, suicidal strain of Listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers. Mol. Pharm. 6:1052-1061.
32. Kur, M., R. Piatek, and J. Kur. 2007. A two-plasmid Escherichia coli system for expression of Dr adhesins. Protein expression and purification. 55:361- 367.
33. Leibiger, R., K. Niedung, G. Geginat, J. Heesemann, and K. Trülzsch. 2008. Yersinia enterocolitica Yop mutants as oral live carrier vaccines. Vaccine 26:6664-6670.
34. Lim, J., S. Hyun, and A. Kwon. 2008. Iron chelator-inducible expression system for Escherichia coli. J. Microbiol. Biotechnol. 18:1357-1363.
35. Litwin, C., S. Boyko, and S. Calderwood. 1992. Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene. J. Bacteriol. 174: 1897-1903.
36. Loessner, H., et al. 2008. Improving live attenuated bacterial carriers for vaccination and therapy. Int. J. Med. Microbiol. 298:21-26.
37. Marchart, J., et al. 2003. Pasteurella multocida- and Pasteurella haemolyticaghosts: new vaccine candidates. Vaccine 21:3988-3997.
38. Mayr, U., et al. 2005. Bacterial ghosts as antigen delivery vehicles. Adv. Drug Deliv. Rev. 57:1381-1391.
39. McHugh, J., et al. 2003. Global iron-dependent gene regulation in Escherichia coli: a new mechanism for iron homeostasis. J. Biol. Chem. 278:29478- 29486.
40. Mey, A., E. Wyckoff, V. Kanukurthy, C. Fisher, and S. Payne. 2005. Iron and fur regulation in Vibrio cholerae and the role of fur in virulence. Infect. Immun. 73:8167-178.
41. Moreno, M., M. Kramer, L. Yim, and J. Chabalgoity. 2010. Salmonella as live Trojan horse for vaccine development and cancer gene therapy. Curr. Gene Ther. 10:56-76.
42. Morin, C., and J. Kaper. 2009. Use of stabilized luciferase-expressing plasmids to examine in vivo-induced promoters in the Vibrio cholerae vaccine strain CVD 103-HgR. FEMS Immunol. Med. Microbiol. 57:69-79.
43. Mourino, S., C. Osorio, M. Lemos, and J. Crosa. 2006. Transcriptional organization and regulation of the Vibrio anguillarum heme uptake gene cluster. Gene 374:68-76.
44. Müller, K., B. Matzanke, V. Schünemann, A. Trautwein, and K. Hantke. 1998. FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center. Eur. J. Biochem. 258:1001-1008.
45. Nakano, M., et al. 2008. Hfq regulates the expression of the thermostable direct hemolysin gene in Vibrio parahaemolyticus. BMC Microbiol. 8:155.
46. Newman, S. G. 1993. Bacterial vaccines for fish. Annu. Rev. Fish Dis. 3:145- 185.
47. Occhino, D., E. Wyckoff, D. Henderson, T. Wrona, and S. Payne. 1998. Vibrio cholerae iron transport: haem transport genes are linked to one of two sets of tonB, exbB, exbD genes. Mol. Microbiol. 29:1493-1507.
48. O'Toole, R., J. von Hofsten, R. Rosqvist, P.-E. Olsson, and H. Wolf-Watz. 2004. Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum. Microb. Pathog. 7:41-46.
49. Outten, F., O. Djaman, and G. Storz. 2004. A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli. Mol. Microbiol. 52:861-872.
50. Payne, S. 1993. Iron acquisition in microbial pathogenesis. Trends Microbiol. 1:66-69.
51. Radford, K., et al. 2002. A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation application to cancer immunotherapy. Gene Ther. 9:1455-463.
52. 8+ T cells. Int. J. Cancer 105:811-819.
53. Rogers, M., J. Sexton, G. DeCastro, and S. Calderwood. 2000. Identification of an operon required for ferrichrome iron utilization in Vibrio cholerae. J. Bacteriol. 82:2350-2353.
54. Salam, M., J. Katz, P. Zhang, G. Hajishengallis, and S. Michalek. 2006. Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system. Vaccine 24:5003-5015.
55. Seegers, J. 2002. Lactobacilli as live vaccine delivery vectors: progress and prospects. Trends Biotechnol. 20:508-515.
56. Shi, H., and W. Wen Su. 2001. Display of green fluorescent protein on Escherichia coli cell surface. Enzyme Microb. Technol. 28:25-34.
57. Stiefel, A., et al. 2001. Control of the ferric citrate transport system of Escherichia coli: mutations in region 2.1 of the FecI extracytoplasmic-function sigma factor suppress mutations in the FecR transmembrane regulatory protein. J. Bacteriol. 183:162-170.
58. Stojiljkovic, I., A. J. Baüumler, and K. Hantke. 1994. Fur regulon in gramnegative bacteria: identification and characterization of new iron-regulated Escherichia coli genes by a fur titration assay. J. Mol. Biol. 236:531-545.
59. Stork, M., M. Di Lorenzo, T. Welch, L. Crosa, and J. Crosa. 2002. Plasmidmediated iron uptake and virulence in Vibrio anguillarum. Plasmid 48:222- 228.
60. Tanabe, T., et al. 2003. Identification and characterization of genes required for biosynthesis and transport of the siderophore vibrioferrin in Vibrio parahaemolyticus. J. Bacteriol. 185:6938-6949.
61. Thune, R., L. Stanley, and R. Cooper. 1993. Pathogenesis of gram-negative bacterial infections in warmwater fish. Annu. Rev. Fish Dis. 3:37-68.
62. Torres, B., S. Jaenecke, K. Timmis, J. Garcia, and E. Diaz. 2000. A gene containment strategy based on a restriction modification system. Environ. Microbiol. 2:555-563.
63. Torres, B., S. Jaenecke, K. N. Timmis, J. L. Garcia, and E. Diaz. 2003. A dual lethal system to enhance containment of recombinant micro-organisms. Microbiology 49:3595-3601.
64. Witte, A., E. Brand, P. Mayrhofer, F. Narendja, and W. Lubitz. 1998. Mutations in cell division proteins FtsZ and FtsA inhibit PhiX174 protein-Emediated lysis of Escherichia coli. Arch. Microbiol. 170:259-268.
65. Wyckoff, E., M. Schmitt, A. Wilks, and S. Payne. 2004. HutZ is required for efficient heme utilization in Vibrio cholerae. J. Bacteriol. 186:4142-4151.
66. Zheng, M., B. Doan, T. Schneider, and G. Storz. 1999. OxyR and SoxRS regulation of fur. J. Bacteriol. 181:4639-4643.
67. Zhou, L., et al. 2010. A novel multivalent vaccine based on secretory antigendelivery induces protective immunity against Vibrio anguillarum and Aeromonas hydrophila. J. Biotechnol. 146:25-30.