A recombinant E. Coli vaccine to promote MHC class I-dependent antigen presentation: Application to cancer immunotherapy

Gene Therapy

Volumn 9, Issue 21, 2002, Pages 1455-1463

  Radford, K J ^a,d   Higgins, D E ^c   Pasquini, S ^a   Cheadle, E J ^b   Carta, L ^a   Jackson, A M ^b   Lemoine, N R ^a   Vassaux, G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MATER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Cancer antigens; Dendritic cells; E. Coli; Listeriolysin O; MHC

Indexed keywords

EPITOPE; ESCHERICHIA COLI VACCINE; LISTERIOLYSIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; PARAFORMALDEHYDE; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; MELANOMA; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGEN PRESENTATION; BACTERIAL TOXINS; ESCHERICHIA COLI VACCINES; FEMALE; GENE THERAPY; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HYBRIDOMAS; IMMUNOTHERAPY, ADOPTIVE; MICE; MICE, INBRED C57BL; NEOPLASMS; TUMOR CELLS, CULTURED; VACCINES, DNA;

ANIMALIA; ESCHERICHIA COLI; MURINAE;

EID: 0036847666     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301812     Document Type: Article

References (31)

1. Timmerman JM, Levy R. Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med 1999; 50: 507-529.
2. Fong L, Engleman EG. Dendritic cells in cancer immunotherapy. Annu Rev Immunol 2000; 18: 245-273.
3. Schadendorf D, Nestle FO. Autologous dendritic cells for treatment of advanced cancer - an update. Rec Res Cancer Res 2001; 158: 236-248.
4. Nestle FO et al. Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat Med 1998; 4: 328-332.
5. Kugler A et al. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat Med 2000; 6: 332-336.
6. Panelli MC et al. Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. J Immunother 2000; 23: 487-498.
7. Thurner B et al. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 1999; 190: 1669-1678.
8. Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol 1999; 17: 739-779.
9. Dallal RM, Lotze MT. The dendritic cell and human cancer vaccines. Curr Opin Immunol 2000; 12: 583-588.
10. Falo Jr. LD et al. Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nat Med 1995; 1: 649-653.
11. Cho HJ et al. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat Biotechnol 2000; 18: 509-514.
12. Dhodapkar MV et al. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001; 193: 233-238.
13. Winzler C et al. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med 1997; 185: 317-328.
14. Henderson RA, Watkins SC, Flynn JL. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J Immunol 1997; 159: 635-643.
15. Rescigno M et al. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells (published erratum appears in Proc Natl Acad Sci USA 1999; 96: 9666). Proc Natl Acad Sci USA 1998; 95: 5229-5234.
16. Higgins DE, Shastri N, Portnoy DA. Delivery of protein to the cytosol of macrophages using Escherichia coli K-12. Mol Microbiol 1999; 31: 1631-1641.
17. Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res 1975; 35: 218-224.
18. Karttunen J, Sanderson S, Shastri N. Detection of rare antigen-presenting cells by the LacZ T cell activation assay suggests an expression cloning strategy for T cell antigens. Proc Natl Acad Sci USA 1992; 89: 6020-6024.
19. Braciale TJ et al. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol Rev 1987; 98: 95-114.
20. Lappin MB et al. Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 1999; 98: 181-188.
21. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
22. Banchereau J et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767-811.
23. Guzman CA et al. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Mol Microbiol 1996; 20: 119-126.
24. Rosenblum MG, Horn SA, Cheung LH. A novel recombinant fusion toxin targeting HER-2/NEU-over-expressing cells and containing human tumor necrosis factor. Int J Cancer 2000; 88: 267-273.
25. Kawakami Y et al. Production of recombinant MART-1 proteins and specific antiMART-1 polyclonal and monoclonal antibodies: use in the characterization of the human melanoma antigen MART-1. J Immunol Meth 1997; 202: 13-25.
26. Fenton RG et al. Induction of T cell immunity against Ras oncoproteins by soluble protein or Ras-expressing Escherichia coli. J Natl Cancer Inst 1995; 87: 1853-1861.
27. Alderson MR et al. Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4(+) T cells. J Exp Med 2000; 191: 551-560.
28. + T cell-stimulating antigen of pathogenic bacteria by expression cloning. J Exp Med 1995; 182: 1751-1757.
29. Hugo P et al. A cell line that can induce thymocyte positive selection. Nature 1992; 360: 679-682.
30. Inaba K. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693-1702.
31. Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Meth 1994; 171: 131-137.