Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 6, 2011, Pages 613-626

  Van Crombruggen, Koen ^a   Van Nassauw, L ^b,c   Derycke, L ^a   Timmermans, J P ^c   Holtappels, G ^a   Hall, D ^d   Bachert, C ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b Lab of Human Anatomy and Embryology   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Capsaicin; COX 2; Human nasal mucosa; Neurogenic inflammation; PGE2; Vasodilatation

Indexed keywords

1 ACETYL 2 (8 CHLORO 10,11 DIHYDRODIBENZ[B,F][1,4]OXAZEPINE 10 CARBONYL)HYDRAZINE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CAPSAICIN; CAPSAZEPINE; CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; SULPROSTONE; VOFOPITANT;

ARTICLE; BLOOD VESSEL TONE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME REGULATION; EX VIVO STUDY; HUMAN; HUMAN TISSUE; MOLECULAR MECHANICS; MUSCLE ISOMETRIC CONTRACTION; PROSTAGLANDIN RELEASE; SIGNAL TRANSDUCTION; VASODILATATION;

CAPSAICIN; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NASAL MUCOSA; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; TRPV CATION CHANNELS; VASODILATION;

EID: 79959380447     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0638-6     Document Type: Article

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