Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb

Molecular Reproduction and Development

Volumn 78, Issue 6, 2011, Pages 415-425

  Sinnar, Shamim A ^a   Small, Christopher L ^b   Evanoff, Ryan M ^b   Reinholdt, Laura G ^c   Griswold, Michael D ^b   Kopito, Ron R ^a   Ryu, Kwon Yul ^d  

^a STANFORD UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c JACKSON LABORATORY   (United States)

^d University of Seoul   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2A; POLYUBIQUITIN; PROTEASOME; TRANSCRIPTOME; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE LOSS; HISTONE UBIQUITINATION; MALE; MALE FERTILITY; METABOLISM; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TESTIS; TRANSCRIPTION REGULATION; UBB GENE; WILD TYPE;

ANIMALS; FEMALE; FERTILITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GERM CELLS; HISTONES; INFERTILITY; MALE; MEIOTIC PROPHASE I; MICE; MICE, KNOCKOUT; MICROARRAY ANALYSIS; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; TESTIS; UBIQUITIN; UBIQUITINATION;

EUKARYOTA; MURINAE; MUS;

EID: 79959376850     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.21318     Document Type: Article

References (26)

1. Baarends WM, Hoogerbrugge JW, Roest HP, Ooms M, Vreeburg J, Hoeijmakers JH, Grootegoed JA. 1999. Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. Dev Biol 207: 322-333.
2. Cao R, Tsukada Y, Zhang Y. 2005. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 20: 845-854.
3. Dantuma NP, Groothuis TA, Salomons FA, Neefjes J. 2006. A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling. J Cell Biol 173: 19-26.
4. Emre NC, Berger SL. 2004. Histone H2B ubiquitylation and deubiquitylation in genomic regulation. Cold Spring Harb Symp Quant Biol 69: 289-299.
5. Finley D, Bartel B, Varshavsky A. 1989. The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature 338: 394-401.
6. Groothuis TA, Dantuma NP, Neefjes J, Salomons FA. 2006. Ubiquitin crosstalk connecting cellular processes. Cell Div 1: 21.
7. Hershko A, Ciechanover A. 1998. The ubiquitin system. Annu Rev Biochem 67: 425-479.
8. Hicke L. 2001. Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol 2: 195-201.
9. Hochstrasser M. 1996. Ubiquitin-dependent protein degradation. Annu Rev Genet 30: 405-439.
10. Jason LJ, Moore SC, Lewis JD, Lindsey G, Ausio J. 2002. Histone ubiquitination: A tagging tail unfolds? BioEssays 24: 166-174.
11. Minsky N, Oren M. 2004. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell 16: 631-639.
12. Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. 2006. Postmeiotic sex chromatin in the male germline of mice. Curr Biol 16: 660-667.
13. Pickart CM, Fushman D. 2004. Polyubiquitin chains: Polymeric protein signals. Curr Opin Chem Biol 8: 610-616.
14. Pittman DL, Cobb J, Schimenti KJ, Wilson LA, Cooper DM, Brignull E, Handel MA, Schimenti JC. 1998. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol Cell 1: 697-705.
15. Robzyk K, Recht J, Osley MA. 2000. Rad6-dependent ubiquitination of histone H2B in yeast. Science 287: 501-504.
16. Ryu KY, Garza JC, Lu XY, Barsh GS, Kopito RR. 2008a. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Proc Natl Acad Sci USA 105: 4016-4021.
17. Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR. 2008b. The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol 28: 1136-1146.
18. Ryu KY, Fujiki N, Kazantzis M, Garza JC, Bouley DM, Stahl A, Lu XY, Nishino S, Kopito RR. 2010. Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice. Neuropathol Appl Neurobiol 36: 285-299.
19. Shima JE, McLean DJ, McCarrey JR, Griswold MD. 2004. The murine testicular transcriptome: Characterizing gene expression in the testis during the progression of spermatogenesis. Biol Reprod 71: 319-330.
20. van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Koycu S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM. 1998. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 279: 242-247.
21. Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y. 2004. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431: 873-878.
22. Wei J, Zhai L, Xu J, Wang H. 2006. Role of Bmi1 in H2A ubiquitylation and Hox gene silencing. J Biol Chem 281: 22537-22544.
23. West MH, Bonner WM. 1980a. Histone 2A, a heteromorphous family of eight protein species. Biochemistry 19: 3238-3245.
24. West MH, Bonner WM. 1980b. Histone 2B can be modified by the attachment of ubiquitin. Nucleic Acids Res 8: 4671-4680.
25. Wiborg O, Pedersen MS, Wind A, Berglund LE, Marcker KA, Vuust J. 1985. The human ubiquitin multigene family: Some genes contain multiple directly repeated ubiquitin coding sequences. EMBO J 4: 755-759.
26. Yoshida K, Kondoh G, Matsuda Y, Habu T, Nishimune Y, Morita T. 1998. The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell 1: 707-718.