Regulation gone wrong: A subset of sézary patients have malignant regulatory t cells

Journal of Investigative Dermatology

Volumn 129, Issue 12, 2009, Pages 2747-2750

  Clark, Rachael A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NOTE; REGULATORY T LYMPHOCYTE; SEZARY SYNDROME; SKIN TUMOR;

HUMANS; IMMUNE TOLERANCE; SEZARY SYNDROME; SKIN NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 79959366649     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.290     Document Type: Note

References (40)

1. Adams KM, Yan Z, Stevens AM, Nelson JL (2007) The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus. Placenta 28:378-82
2. Axelrod PI, Lorber B, Vonderheid EC (1992) Infections complicating mycosis fungoides and Sezary syndrome. J Am Med Assoc 267:1354-8
3. Bacchetta R, Passerini L, Gambineri E, Dai M, Allan SE, Perroni L et al. (2006) Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest 116:1713-22
4. Baecher-Allan C, Anderson DE (2006) Regulatory cells and human cancer. Semin Cancer Biol 16:98-105
5. Baron U, Floess S, Wieczorek G, Baumann K, Grutzkau A, Dong J et al. (2007) DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 37:2378-89
6. Berger CL, Tigelaar R, Cohen J, Mariwalla K, Trinh J, Wang N et al. (2005) Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. Blood 105:1640-7
7. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27:68-73
8. Calarese AW, Lichtman M, Kupper TS, Clark RA (2009) Skin resident T cells producing IL-13 and TNFα: a possible role in the initiation of cutaneous sclerosis. J Invest Dermatol 129:S14
9. Campbell JJ, Murphy KE, Kunkel EJ, Brightling CE, Soler D, Shen Z et al. (2001) CCR7 expression and memory T cell diversity in humans. J Immunol 166:877-84
10. Campbell JJ, Soler D, Clark RA, Kupper TS (2009) Malignant clonal T cells in leukemic (L-)CTCL/Sezary syndrome (SS) exhibit a unique cell surface profile: high and uniform expression of CCR4 and central memory markers CCR7, L-selectin, and CD27. J Invest Dermatol 129:S54
11. Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK et al. (2006) The vast majority of CLA+ T cells are resident in normal skin. J Immunol 176:4431-9
12. Clark RA, Kupper TS (2007) IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109:194-202
13. Clark RA, Mollet IG, Hijnen D, Calarese AW, Purwar R, Lichtman M et al. (2009) Skin resident T cells producing TNFα but not Th1, Th2, or Th17 cytokines: their possible role as immune sentinels in skin. J Invest Dermatol 129:S110
14. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330-6
15. Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 103:6659-64
16. Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR (2009) Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 10:524-30
17. Gjerdrum LM, Woetmann A, Odum N, Burton CM, Rossen K, Skovgaard GL et al. (2007) FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. Leukemia 21:2512-8
18. Heid JB, Schmidt A, Oberle N, Goerdt S, Krammer PH, Suri-Payer E et al. (2009) FOXP3+CD25? tumor cells with regulatory function in Sézary syndrome. J Invest Dermatol 129:2875-85
19. Janson PC, Winerdal ME, Marits P, Thorn M, Ohlsson R, Winqvist O (2008) FOXP3 promoter demethylation reveals the committed Treg population in humans. PloS One 3:e1612
20. Kaltoft K, Hansen BH, Thestrup-Pedersen K (1994) Cytogenetic findings in cell lines from cutaneous T-cell lymphoma. Dermatol Clin 12:295-304
21. Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4:337-42
22. Klemke CD, Fritzsching B, Franz B, Kleinmann EV, Oberle N, Poenitz N et al. (2006) Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sezary syndrome from other cutaneous T-cell lymphomas. Leukemia 20:1123-9
23. Krejsgaard T, Gjerdrum LM, Ralfkiaer E, Lauenborg B, Eriksen KW, Mathiesen AM et al. (2008) Malignant Tregs express low molecular splice forms of FOXP3 in Sezary syndrome. Leukemia 22:2230-9
24. Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS et al. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128:1207-11
25. Marcus Muche J, Karenko L, Gellrich S, Karhu R, Kytola S, Kahkonen M et al. (2004) Cellular coincidence of clonal T cell receptor rearrangements and complex clonal chromosomal aberrations-a hallmark of malignancy in cutaneous T cell lymphoma. J Invest Dermatol 122:574-8
26. Morelli AE, Thomson AW (2007) Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7:610-21
27. Padilla-Nash HM, Wu K, Just H, Ried T, Thestrup-Pedersen K (2007) Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma. Exp Dermatol 16:98-103
28. Pillai V, Ortega SB, Wang CK, Karandikar NJ (2007) Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 123:18-29
29. Powell BR, Buist NR, Stenzel P (1982) An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. J Pediatr 100:731-7
30. Sakaguchi S (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6:345-52
31. Satake N, Nakanishi M, Okano M, Tomizawa K, Ishizaka A, Kojima K et al. (1993) A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy. Eur J Pediatr 152:313-5
32. Shiue LH, Aakhus E, Arias-Mendoza P, Duvic M, Ni X (2009) Increased levels of CD4+25high regulatory T cells in patients with cutaneous T-cell lymphoma after extracorporeal photopheresis. J Invest Dermatol 129:S46
33. Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21:685-711
34. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13:1299-307
35. Teraki Y, Shiohara T (2003) IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. J Allergy Clin Immunol 112:609-15
36. Thestrup-Pedersen K, Kaltoft K (1994) Genotraumatic T cells and cutaneous T-cell lymphoma. A causal relationship? Arch Dermatol Res 287:97-101
37. Tiemessen MM, Mitchell TJ, Hendry L, Whittaker SJ, Taams LS, John S (2006) Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma. J Invest Dermatol 126:2217-23
38. Whang-Peng J, Bunn PA, Jr., Knutsen T, Matthews MJ, Schechter G, Minna JD (1982) Clinical implications of cytogenetic studies in cutaneous T-cell lymphoma (CTCL). Cancer 50:1539-53.
39. Yamanaka K, Yawalkar N, Jones DA, Hurwitz D, Ferenczi K, Eapen S et al. (2005) Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma. Clin Cancer Res 11:5748-55
40. Yawalkar N, Ferenczi K, Jones DA, Yamanaka K, Suh K-Y, Sadat S et al. (2003) Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 102:4059-66