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Volumn 22, Issue 12, 2008, Pages 2230-2239

Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; JANUS KINASE 3; PROTEIN ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 57849154832     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.224     Document Type: Article
Times cited : (80)

References (47)
  • 1
    • 16544365656 scopus 로고    scopus 로고
    • Advances in understanding the immunobiology and immunotherapy of cutaneous T-cell lymphoma
    • Berger CL, Mariwalla K, Girardi M, Edelson RL. Advances in understanding the immunobiology and immunotherapy of cutaneous T-cell lymphoma. Adv Dermatol 2004; 20: 217-235.
    • (2004) Adv Dermatol , vol.20 , pp. 217-235
    • Berger, C.L.1    Mariwalla, K.2    Girardi, M.3    Edelson, R.L.4
  • 2
    • 33644503152 scopus 로고    scopus 로고
    • Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL)
    • Dummer R. Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL). Semin Oncol 2006; 33: S33-S36.
    • (2006) Semin Oncol , vol.33
    • Dummer, R.1
  • 7
    • 0032898785 scopus 로고    scopus 로고
    • Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma
    • Lee BN, Duvic M, Tang CK, Bueso-Ramos C, Estrov Z, Reuben JM. Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma. Clin Diagn Lab Immunol 1999; 6: 79-84.
    • (1999) Clin Diagn Lab Immunol , vol.6 , pp. 79-84
    • Lee, B.N.1    Duvic, M.2    Tang, C.K.3    Bueso-Ramos, C.4    Estrov, Z.5    Reuben, J.M.6
  • 9
    • 0035138437 scopus 로고    scopus 로고
    • Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries
    • Linnemann T, Tumenjargal S, Gellrich S, Wiesmuller K, Kaltoft K, Sterry W et al. Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries. Eur J Immunol 2001; 31: 156-165.
    • (2001) Eur J Immunol , vol.31 , pp. 156-165
    • Linnemann, T.1    Tumenjargal, S.2    Gellrich, S.3    Wiesmuller, K.4    Kaltoft, K.5    Sterry, W.6
  • 10
    • 33750067975 scopus 로고    scopus 로고
    • Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma
    • Krejsgaard T, Vetter-Kauczok CS, Woetmann A, Lovato P, Labuda T, Eriksen KW et al. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. Leukemia 2006; 20: 1759-1766.
    • (2006) Leukemia , vol.20 , pp. 1759-1766
    • Krejsgaard, T.1    Vetter-Kauczok, C.S.2    Woetmann, A.3    Lovato, P.4    Labuda, T.5    Eriksen, K.W.6
  • 11
    • 0029834676 scopus 로고    scopus 로고
    • Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
    • Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC et al Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 1996; 93: 9148-9153.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9148-9153
    • Zhang, Q.1    Nowak, I.2    Vonderheid, E.C.3    Rook, A.H.4    Kadin, M.E.5    Nowell, P.C.6
  • 12
    • 0030978808 scopus 로고    scopus 로고
    • Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
    • Nielsen M, Kaltoft K, Nordahl M, Ropke C, Geisler C, Mustelin T et al Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc Natl Acad Sci USA 1997; 94: 6764-6769.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6764-6769
    • Nielsen, M.1    Kaltoft, K.2    Nordahl, M.3    Ropke, C.4    Geisler, C.5    Mustelin, T.6
  • 13
    • 0035865517 scopus 로고    scopus 로고
    • STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma
    • Brender C, Nielsen M, Kaltoft K, Mikkelsen G, Zhang Q, Wasik M et al STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood 2001; 97: 1056-1062.
    • (2001) Blood , vol.97 , pp. 1056-1062
    • Brender, C.1    Nielsen, M.2    Kaltoft, K.3    Mikkelsen, G.4    Zhang, Q.5    Wasik, M.6
  • 14
    • 33748343624 scopus 로고    scopus 로고
    • Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma
    • Krishnadasan R, Bifulco C, Kim J, Rodov S, Zieske AW, Vanasse GJ. Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma. Br J Haematol 2006; 135: 72-75.
    • (2006) Br J Haematol , vol.135 , pp. 72-75
    • Krishnadasan, R.1    Bifulco, C.2    Kim, J.3    Rodov, S.4    Zieske, A.W.5    Vanasse, G.J.6
  • 15
    • 0026595065 scopus 로고
    • Infections complicating mycosis fungoides and Sezary syndrome
    • Axelrod PI, Lorber B, Vonderheid EC. Infections complicating mycosis fungoides and Sezary syndrome. JAMA 1992; 267: 1354-1358.
    • (1992) JAMA , vol.267 , pp. 1354-1358
    • Axelrod, P.I.1    Lorber, B.2    Vonderheid, E.C.3
  • 16
    • 13544265305 scopus 로고    scopus 로고
    • Cutaneous T-cell lymphoma: Malignant proliferation of T-regulatory cells
    • Berger CL, Tigelaar R, Cohen J, Mariwalla K, Trinh J, Wang N et al Cutaneous T-cell lymphoma: Malignant proliferation of T-regulatory cells. Blood 2005; 105: 1640-1647.
    • (2005) Blood , vol.105 , pp. 1640-1647
    • Berger, C.L.1    Tigelaar, R.2    Cohen, J.3    Mariwalla, K.4    Trinh, J.5    Wang, N.6
  • 17
    • 33646593910 scopus 로고    scopus 로고
    • Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sezary syndrome from other cutaneous T-cell lymphomas
    • Klemke CD, Fritzsching B, Franz B, Kleinmann EV, Oberle N, Poenitz N et al. Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sezary syndrome from other cutaneous T-cell lymphomas. Leukemia 2006; 20: 1123-1129.
    • (2006) Leukemia , vol.20 , pp. 1123-1129
    • Klemke, C.D.1    Fritzsching, B.2    Franz, B.3    Kleinmann, E.V.4    Oberle, N.5    Poenitz, N.6
  • 18
  • 19
    • 36348953150 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: Association with disease stage and survival
    • Gjerdrum LM, Woetmann A, Odum N, Burton CM, Rossen K, Skovgaard GL et al. FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. Leukemia 2007; 21 2512-2518.
    • (2007) Leukemia , vol.21 , pp. 2512-2518
    • Gjerdrum, L.M.1    Woetmann, A.2    Odum, N.3    Burton, C.M.4    Rossen, K.5    Skovgaard, G.L.6
  • 20
    • 33947576560 scopus 로고    scopus 로고
    • FOXP3 modifies the phenotypic and functional properties of regulatory T cells
    • Campbell DJ, Ziegler SF. FOXP3 modifies the phenotypic and functional properties of regulatory T cells. Nat Rev Immunol 2007; 7: 305-310.
    • (2007) Nat Rev Immunol , vol.7 , pp. 305-310
    • Campbell, D.J.1    Ziegler, S.F.2
  • 22
    • 33748751458 scopus 로고    scopus 로고
    • Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation
    • Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK. Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation. Immunology 2006; 119: 203-211.
    • (2006) Immunology , vol.119 , pp. 203-211
    • Smith, E.L.1    Finney, H.M.2    Nesbitt, A.M.3    Ramsdell, F.4    Robinson, M.K.5
  • 23
    • 33747762947 scopus 로고    scopus 로고
    • Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
    • Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD et al. Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J Immunol 2006; 177 3133-3142.
    • (2006) J Immunol , vol.177 , pp. 3133-3142
    • Lopes, J.E.1    Torgerson, T.R.2    Schubert, L.A.3    Anover, S.D.4    Ocheltree, E.L.5    Ochs, H.D.6
  • 24
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA 2005; 102: 5138-5143.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 25
    • 44449131480 scopus 로고    scopus 로고
    • Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3
    • Du J, Huang C, Zhou B, Ziegler SF. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol 2008; 180: 4785-4792.
    • (2008) J Immunol , vol.180 , pp. 4785-4792
    • Du, J.1    Huang, C.2    Zhou, B.3    Ziegler, S.F.4
  • 27
    • 0033809993 scopus 로고    scopus 로고
    • Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter
    • Zhang Q, Raghunath PN, Vonderheid E, Odum N, Wasik MA. Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Am J Pathol 2000; 157: 1137-1146.
    • (2000) Am J Pathol , vol.157 , pp. 1137-1146
    • Zhang, Q.1    Raghunath, P.N.2    Vonderheid, E.3    Odum, N.4    Wasik, M.A.5
  • 30
    • 0028274867 scopus 로고
    • Cytogenetic findings in cell lines from cutaneous T-cell lymphoma
    • Kaltoft K, Hansen BH, Thestrup-Pedersen K. Cytogenetic findings in cell lines from cutaneous T-cell lymphoma. Dermatol Clin 1994; 12 295-304.
    • (1994) Dermatol Clin , vol.12 , pp. 295-304
    • Kaltoft, K.1    Hansen, B.H.2    Thestrup-Pedersen, K.3
  • 31
    • 0025081064 scopus 로고
    • Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain
    • Geisler C, Scholler J, Wahi MA, Rubin B, Weiss A. Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain. J Immunol 1990; 145: 1761-1767.
    • (1990) J Immunol , vol.145 , pp. 1761-1767
    • Geisler, C.1    Scholler, J.2    Wahi, M.A.3    Rubin, B.4    Weiss, A.5
  • 32
    • 0025005197 scopus 로고
    • A bioassay for the measurement of human interleukin-4
    • Siegel JP, Mostowski HS. A bioassay for the measurement of human interleukin-4. J Immunol Methods 1990; 132: 287-295.
    • (1990) J Immunol Methods , vol.132 , pp. 287-295
    • Siegel, J.P.1    Mostowski, H.S.2
  • 33
    • 0030024007 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2
    • Von Willebrand M, Jascur T, Bonnefoy-Berard N, Yano H, Altman A, Matsuda Y et al. Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2. Eur J Biochem 1996; 235: 828-835.
    • (1996) Eur J Biochem , vol.235 , pp. 828-835
    • Von Willebrand, M.1    Jascur, T.2    Bonnefoy-Berard, N.3    Yano, H.4    Altman, A.5    Matsuda, Y.6
  • 34
    • 3142735120 scopus 로고    scopus 로고
    • In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3
    • Sommer VH, Clemmensen OJ, Nielsen O, Wasik M, Lovato P, Brender C et al. In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3. Leukemia 2004; 18: 1288-1295.
    • (2004) Leukemia , vol.18 , pp. 1288-1295
    • Sommer, V.H.1    Clemmensen, O.J.2    Nielsen, O.3    Wasik, M.4    Lovato, P.5    Brender, C.6
  • 35
    • 34147163008 scopus 로고    scopus 로고
    • Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins
    • Woetmann A, Lovato P, Eriksen KW, Krejsgaard T, Labuda T, Zhang Q et al. Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins. Blood 2007; 109: 3325-3332.
    • (2007) Blood , vol.109 , pp. 3325-3332
    • Woetmann, A.1    Lovato, P.2    Eriksen, K.W.3    Krejsgaard, T.4    Labuda, T.5    Zhang, Q.6
  • 36
    • 33746651038 scopus 로고    scopus 로고
    • STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
    • Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik MA. STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood 2006; 108: 1058-1064.
    • (2006) Blood , vol.108 , pp. 1058-1064
    • Zhang, Q.1    Wang, H.Y.2    Woetmann, A.3    Raghunath, P.N.4    Odum, N.5    Wasik, M.A.6
  • 37
    • 0035017383 scopus 로고    scopus 로고
    • Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells
    • Eriksen KW, Kaltoft K, Mikkelsen G, Nielsen M, Zhang Q, Geisler C et al. Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 2001; 15: 787-793.
    • (2001) Leukemia , vol.15 , pp. 787-793
    • Eriksen, K.W.1    Kaltoft, K.2    Mikkelsen, G.3    Nielsen, M.4    Zhang, Q.5    Geisler, C.6
  • 38
    • 34247564147 scopus 로고    scopus 로고
    • Nonredundant roles for Stat5a/b in directly regulating Foxp3
    • Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 2007; 109: 4368-4375.
    • (2007) Blood , vol.109 , pp. 4368-4375
    • Yao, Z.1    Kanno, Y.2    Kerenyi, M.3    Stephens, G.4    Durant, L.5    Watford, W.T.6
  • 39
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 40
    • 0033909601 scopus 로고    scopus 로고
    • Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis
    • Echchakir H, Bagot M, Dorothee G, Martinvalet D, Le Gouvello S, Boumsell L et al. Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis. J Invest Dermatol 2000; 115: 74-80.
    • (2000) J Invest Dermatol , vol.115 , pp. 74-80
    • Echchakir, H.1    Bagot, M.2    Dorothee, G.3    Martinvalet, D.4    Le Gouvello, S.5    Boumsell, L.6
  • 41
    • 0028308531 scopus 로고
    • Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile
    • Saed G, Fivenson DP, Naidu Y, Nickoloff BJ. Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol 1994; 103: 29-33.
    • (1994) J Invest Dermatol , vol.103 , pp. 29-33
    • Saed, G.1    Fivenson, D.P.2    Naidu, Y.3    Nickoloff, B.J.4
  • 42
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182: 18-32.
    • (2001) Immunol Rev , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3    Yamazaki, S.4    Sakihama, T.5    Itoh, M.6
  • 43
    • 34447330895 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T cells: Proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
    • Kubach J, Lutter P, Bopp T, Stoll S, Becker C, Huter E et al. Human CD4+CD25+ regulatory T cells: Proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 2007; 110: 1550-1558.
    • (2007) Blood , vol.110 , pp. 1550-1558
    • Kubach, J.1    Lutter, P.2    Bopp, T.3    Stoll, S.4    Becker, C.5    Huter, E.6
  • 44
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci USA 2004; 101: 10398-10403.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 45
    • 33644755512 scopus 로고    scopus 로고
    • Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis
    • Sors A, Jean-Louis F, Pellet C, Laroche L, Dubertret L, Courtois G et al. Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis. Blood 2006; 107: 2354-2363.
    • (2006) Blood , vol.107 , pp. 2354-2363
    • Sors, A.1    Jean-Louis, F.2    Pellet, C.3    Laroche, L.4    Dubertret, L.5    Courtois, G.6
  • 46
    • 0037295377 scopus 로고    scopus 로고
    • Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation
    • Tobe M, Isobe Y, Tomizawa H, Nagasaki T, Takahashi H, Fukazawa T et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. Bioorg Med Chem 2003; 11 383-391.
    • (2003) Bioorg Med Chem , vol.11 , pp. 383-391
    • Tobe, M.1    Isobe, Y.2    Tomizawa, H.3    Nagasaki, T.4    Takahashi, H.5    Fukazawa, T.6


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