Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma

Experimental Dermatology

Volumn 16, Issue 2, 2007, Pages 98-103

  Padilla Nash, Hesed M ^a   Wu, Kaida ^b   Just, Helle ^b   Ried, Thomas ^a   Thestrup Pedersen, Kristian ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cutaneous T cell lymphoma; Cytogenetic analysis; Genomicin stability; Mycosis fungoides; Spectral karyotyping

Indexed keywords

CHLORMETHINE; PHYTOHEMAGGLUTININ; RETINOID; STEROID;

AGED; ARTICLE; ATOPIC DERMATITIS; CANCER STAGING; CELL LINE; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 17; CHROMOSOME 17P; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 5P; CHROMOSOME 6; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; KARYOTYPE; KARYOTYPING; LOW DRUG DOSE; LYMPHOCYTE CLONE; LYMPHOCYTE CULTURE; LYMPHOCYTE HOMING; MALE; METAPHASE; MONOSOMY; MONOTHERAPY; NUMERICAL CHROMOSOME ABERRATION; PSORIASIS; RECIPROCAL CHROMOSOME TRANSLOCATION; SKIN BIOPSY; STRUCTURAL CHROMOSOME ABERRATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRISOMY 21;

ADULT; AGED; AGED, 80 AND OVER; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; LYMPHOMA, T-CELL, CUTANEOUS; MALE; SKIN NEOPLASMS; SPECTRAL KARYOTYPING; T-LYMPHOCYTES;

EID: 33845979092     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2006.00507.x     Document Type: Article

References (24)

1. van Doorn R, Van Haselen C W, van Voorst Vader P C et al. Mycosis fungoides: Disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 2000: 136: 504-510.
2. Willemze R, Kerl H, Sterry W et al. EORTC classification for primary cutaneous lymphomas: A proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 1997: 90: 354-371.
3. van Vloten W A, van Duijn P, Schaberg A. Cytodiagnostic use of Feulgen-DNA measurements in cell imprints from the skin of patients with mycosis fungoides. Br J Dermatol 1974: 91: 365-371.
4. Whang-Peng J, Bunn P Jr, Knutsen T, Matthews M J, Schechter G, Minna J D. Clinical implications of cytogenetic studies in cutaneous T-cell lymphoma (CTCL). Cancer 1992: 50: 1539-1547.
5. Karenko L, Hyytinen E, Saran S, Ranki A. Chromosomal abnormalities in cutaneous T-cell lymphoma and in it's premalignant conditions as detected by G-banding and interphase cytogenetic methods. J Invest Dermatol 1997: 108: 22-29.
6. Karenko L, Sarna S, Kähkönen M, Ranki A. Chromosomal abnormalities in relation to clinical disease in patients with cutaneous T-cell lymphoma: A 5-year follow-up study. Br J Dermatol 2003: 148: 55-64.
7. Thangavelu M, Finn W, Yelavarthi K, Roenigk H. Recurring structural chromosomal abnormalities in peripheral blood lymphocytes of patients with mycosis fungoides/Sézary syndrome. Blood 1997: 89: 3371-3377.
8. Scarisbrick J, Woolford A, Russell-Jones R, Whittaker S. Loss of heterozygosity on 10q and microsatellite instability in primary cutaneous T-cell lymphoma is found in advanced disease and may be associated with homozygous deletion of PTEN. Blood 2000: 95: 2937-2942.
9. Batista D, Vonderheid E, Hawkins A et al. Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sézary syndrome: Search for recurrent chromosome abnormalities. Genes Chromosomes Cancer 2005: 45: 383-391.
10. Mao X, Lillington D, Scarisbrick J et al. Molecular cytogenetic analysis of cutaneous T-cell lymphoms: Identification of common genetic alterations in Sézary syndrome and mycosis fungoides. J Invest Dermatol 2002: 147: 464-475.
11. Scarisbrick J, Woolford A, Russell Jones R, Whittaker S. Allelotyping in mycosis fungoides and Sezary syndrome. Common regions of allelic loss identified on 1p, 9p, 10q and 17p. J Invest Dermatol 2001: 117: 663-670.
12. Kaltoft K, Bisballe S, Sterry W, Søgaard H, Thestrup-Pedersen K. Cutaneous T-cell lymphoma is defined by a geno-traumatic T-cell clone. In: Van Vloten W A, Lambert W C, eds. Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. New York: Plenum Pub Corp, 1994: 401-418.
13. Thestrup-Pedersen K, Kaltoft K. Geno-traumatic T cells and cutaneous T cell lymphoma. A causal relationship ? Arch Dermatol Res 1994; 287: 97-101.
14. Hartwell L, Kastan M B. Cell cycle control and cancer. Science 1994; 266: 1821-1828.
15. Schröck E, du Manoir S, Veldman T et al. Multicolor spectral karyotyping of human chromosomes. Science 1996: 273: 494-497.
16. Veldman T, Vignon C, Schröck E, Rowley J D, Ried T. Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. Nat Genet 1997: 15: 406-410.
17. Padilla-Nash H M, Nash W G, Padilla G M et al. Molecular cytogenetic analysis of the bladder carcinoma cell line BK-1 spectral karyotyping. Genes Chromosomes Cancer 1999: 25: 53-59.
18. Molin L, Thomsen K, Volden G et al. Aspects of the treatment of mycosis fungoides. Cutis 1980: 25: 155-163.
19. Kaltoft K, Hansen B H, Thestrup-Pedersen K. Cytogenetic findings in cell lines from cutaneous T-cell lymphoma. Dermatol Clin 1994: 12(4): 295-304.
20. Macville M, Veldman T, Padilla-Nash H et al. Spectral karyotyping, a 24-colour FISH technique for the identification of chromosome rearrangements. Histochem Cell Biol 1997; 108: 299-305.
21. ISCN. In: Shaffer L G, Tommerup N, eds. An International System for Human Nomenclature. Basel: S. Karger, 2005.
22. Mao X, Lillington D, Czepulkowski B, Russell-Jones R, Young B, Whittaker S. Molecular cytogenetic characterization of Sezary syndrome. Genes Chromosomes Cancer 2003; 36: 250-260.
23. Bang K, Lund M, Mogensen S C, Thestrup-Pedersen K. In vitro culture of skin-homing T lymphocytes from inflammatory skin diseases. Exp Dermatol 2005; 14: 391-397.
24. Navas I C, Ortiz-Romero P L, Villuendas R et al. P16 INK4a gene alterations are frequent in lesions of mycosis foungoides. Am J Pathol 2000; 156: 1565-1572.