Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles

Physiological Genomics

Volumn 43, Issue 11, 2011, Pages 674-684

  Donowitz, M ^a   Singh, S ^a   Singh, P ^a   Chakraborty, M ^a   Chen, Y ^a   Murtazina, R ^a   Gucek, M ^a   Cole, R N ^a   Zachos, N C ^a   Salahuddin, F F ^a   Kovbasnjuk, O ^a   Broere, N ^b   Smalley Freed, W G ^c   Reynolds, A B ^c   Hubbard, A L ^a   Seidler, U ^d   Weinman, E ^e   De Jonge, H R ^b   Hogema, B M ^b   Li, X ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Absorption; Jejunum; Na+ H+ exchanger regulatory factor; Proteome

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; BETA CATENIN; BROXURIDINE; CALNEXIN; CARRIER PROTEIN; COFILIN 1; CORONIN 2A; CORONIN 3; CRUMBS PROTEIN HOMOLOG 3 PRECURSOR; CYTOKERATIN 8; CYTOSKELETON PROTEIN; EMBRYONIC ALKALINE PHOSPHATASE PRECURSOR; EZRIN; HEPHAESTIN PRECURSOR; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; JUNCTIONAL PROTEIN; METABOLIC PROTEIN; MONOCARBOXYLATE TRANSPORTER 1; PROTEIN; PROTEOME; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 2; TRANSMEMBRANE PROTEIN 16F; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER VESICLE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; ELECTRON MICROSCOPY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTESTINE BRUSH BORDER MEMBRANE; INTESTINE EPITHELIUM CELL; JEJUNAL BRUSH BORDER MEMBRANE VESICLE; JEJUNUM; KNOCKOUT MOUSE; LIQUID CHROMATOGRAPHY; MALE; MICROVILLUS; MOUSE; NONHUMAN; PANETH CELL; PDZ DOMAIN; PRIORITY JOURNAL; PROTEOMICS; SMALL INTESTINE; TANDEM MASS SPECTROMETRY; WILD TYPE;

ANIMALS; BETA CATENIN; CADHERINS; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; CYTOSKELETON; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; JEJUNUM; MALE; MICE; MICE, KNOCKOUT; MICROVILLI; PHOSPHOPROTEINS; PROTEOME; SODIUM-HYDROGEN ANTIPORTER;

MUS;

EID: 79959337007     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00258.2010     Document Type: Article

References (54)

1. Arnaud C, Sebbagh M, Nola S, Audebert S, Bidaut G, Hermant A, Gayet O, Dusetti NJ, Ollendorff V, Santoni MJ, Borg JP, Lécine P. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Lett 583: 2326-2332, 2009.
2. Baribault H, Penner J, Iozzo RV, Wilson-Heiner M. Colorectal hyperplasia, and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 8: 2964-2973, 1994.
3. Broere N, Chen M, Cinar A, Singh AK, Hillesheim J, Riederer B, Lünnemann M, Rottinghaus I, Krabbenhöft A, Engelhardt R, Rausch B, Weinman EJ, Donowitz M, Hubbard A, Kocher O, de Jonge HR, Hogema BM, Seidler U. Defective jejunal, and colonic salt absorption and altered Na(+)/H(+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflügers Arch 457: 1079-1091, 2009.
4. + exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. J Biol Chem 282: 37575-37584, 2007.
5. Choi JW, Lee-Kwon W, Jeon ES, Kang YJ, Kawano K, Kim HS, Suh PG, Donowitz M, Kim JH. Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochim Biophys Acta 1683: 59-68, 2004.
6. del Amo EM, Urtti A, Yliperttula M. Pharmacokinetic role of L-type amino acid transporters LAT1, and LAT2. Eur J Pharm Sci 35: 161-174, 2008.
7. Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. NHERF family, and NHE3 regulation. J Physiol 567: 3-11, 2005.
8. Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X. Proteome of murine jejunal brush border membrane vesicles. J Proteome Res 6: 4068-4079, 2007.
9. Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler UE, Weinman E, de Jonge HR, Hogema BM, Li X. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics 42A: 200-210, 2010.
10. Dveksler GS, Dieffenbach CW, Cardellichio CB, McCuaig K, pensiero MN, Jiang GS, Beauchemin N, Holmes KV. Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J Virol 67: 1-8, 1993.
11. 2+ channel TRPV5 by the NHE regulating factor NHERF2, and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes. Cell Physiol Biochem 14: 203-212, 2004.
12. Favia M, Fanelli T, Bagorda A, Di Sole F, Reshkin SJ, Suh PG, Guerra L, Casavola V. NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions. Biochem Biophys Res Commun 347: 452-459, 2006.
13. Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramaswamy K, Dudeja PK. Expression, and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol 289: C846-C852, 2005.
14. + exchange. Nature 392: 626-630, 1998.
15. Hasse A, Rosentreter A, Spoerl Z, Stumpf M, Noegel AA, Clemen CS. Coronin 3, and its role in murine brain morphogenesis. Eur J Neurosci 21: 1155-1168, 2005.
16. Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O, Seidler U. Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice. Pflügers Arch 454: 575-586, 2007.
17. + exchange regulatory factor-2 with ClC-5. J Biol Chem 281: 16068-16077, 2006.
18. Hryciw DH, Wang Y, Devuyst O, Pollock CA, Poronnik P, Guggino WB. Cofilin interacts with ClC-5, and regulates albumin uptake in proximal tubule cell lines. J Biol Chem 278: 40169-40176, 2003.
19. Humphries CL, Balcer HI, D'Agostino JL, Winsor B, Drubin DG, Barnes G, Andrews BJ, Goode BL. Direct regulation of Arp2/3 complex activity, and function by the actin binding protein coronin. J Cell Biol 159: 993-1004, 2002.
20. Jones AR, Orchard S. Minimum reporting guidelines for proteomics released by the Proteomics Standards Initiative. Mol Cell Proteomics 7: 2067-2068, 2008.
21. Jung Kang Y, Su Jeon E, Jin Lee H, Oh YS, Suh PG, Sup Jung J, Donowitz M, Ho Kim J. NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway. Cell Signal 16: 791-800, 2004.
22. Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3, and PDZ domain proteins. EMBO J 19: 6778-6791, 2000.
23. + exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization, and endocytosis. J Biol Chem 277: 23714-23724, 2002.
24. Kreimann EL, Morales FC, de Orbeta-Cruz J, Takahashi Y, Adams H, Liu TJ, McCrea PD, Georgescu MM. Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. Oncogene 26: 5290-5299, 2007.
25. + exchange. Biochemistry 41: 12336-12342, 2002.
26. Lamprecht G, Seidler U. The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol 291: G766-G777, 2006.
27. + exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. J Biol Chem 278: 16494-16501, 2003.
28. Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3, and fluid absorption via LPA(5) and NHERF2. Gastroenterology 138: 649-658, 2010.
29. Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417: 858-861, 2002.
30. Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Tissue-specific regulation of sodium/ proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem 282: 25141-25151, 2007.
31. 2+-dependent chloride transport. J Biol Chem 284: 28698-28703, 2009.
32. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell 143: 761-773, 2010.
33. Quaroni A, Calnek D, Quaroni E, Chandler JS. Keratin expression in rat intestinal crypt, and villus cells. Analysis with a panel of monoclonal antibodies. J Biol Chem 266: 11923-11931, 1991.
34. Roman LM, Hubbard AL. A domain-specific marker for the hepatocyte plasma membrane. II. Ultrastructural localization of leucine aminopeptidase to the bile canalicular domain of isolated rat liver plasma membranes. J Cell Biol 98: 1488-1496, 1984.
35. Rosentreter A, Hofmann A, Xavier CP, Stumpf M, Noegel AA, Clemen CS. Coronin 3 involvement in Factin-dependent processes at the cell cortex. Exp Cell Res 313: 878-895, 2007.
36. Salvarezza SB, Deborde S, Schreiner R, Campagne F, Kessels MM, Qualmann B, Caceres A, Kreitzer G, Rodriguez-Boulan E. LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network. Mol Biol Cell 20: 438-451, 2009.
37. Sargent PJ, Farnaud S, Evans RW. Structure/function overview of proteins involved in iron storage, and transport. Curr Med Chem 12: 2683-2693, 2005.
38. Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K. Expression, and function of epithelial anoctamins. J Biol Chem 285: 7838-7845, 2010.
39. Seidler U, Singh A, Chen M, Cinar A, Bachmann O, Zheng W, Wang J, Yeruva S, Riederer B. Knockout mouse models for intestinal electrolyte transporters, and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhea and fructose-induced hypertension. Exp Physiol 94: 175-179, 2009.
40. Seidler U, Singh AK, Cinar A, Chen M, Hillesheim J, Hogema B, Riederer B. The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt, and water transport. Ann NY Acad Sci 1165: 249-260, 2009.
41. Shenolikar S, Voltz JW, Cunningham R, Weinman EJ. Regulation of ion transport by the NHERF family of PDZ proteins. Physiology 19: 362-369, 2004.
42. Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest 119: 540-550, 2009.
43. Takahashi Y, Morales FC, Kreimann EL, Georgescu MM. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 25: 910-920, 2006.
44. Thelin WR, Hodson CA, Milgram SL. Beyond the brush border: NHERF4 blazes new NHERF turf. J Physiol 567: 13-19, 2005.
45. Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F. NHERF2/SIP1 interacts with mouse SRY via a different mechanism than human SRY. J Biol Chem 280: 38625-38630, 2005.
46. Uetrecht AC, Bear JE. Coronins: the return of the crown. Trends Cell Biol 16: 421-426, 2006.
47. Wade JB, Welling PA, Donowitz M, Shenolikar S, Weinman EJ. Differential renal distribution of NHERF isoforms, and their colocaliza-tion with NHE3, ezrin, and ROMK. Am J Physiol Cell Physiol 280: C192-C198, 2001.
48. Wald FA, Oriolo AS, Casanova ML, Salas PJ. Intermediate filaments interact with dormant ezrin in intestinal epithelial cells. Mol Biol Cell 16: 4096-4107, 2005.
49. Walker NM, Simpson JE, Yen PF, Gill RK, Rigsby EV, Brazill JM, Dudeja PK, Schweinfest CW, Clarke LL. Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine. Gastroenterology 135: 1645-1653, 2008.
50. Weinman EJ, Biswas RS, Peng G, Shen L, Turner CL, EX, Steplock D, Shenolikar S, Cunningham R. Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest 117: 3412-3420, 2007.
51. Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors, and receptor tyrosine kinases. Annu Rev Physiol 68: 491-505, 2006.
52. Wessling-Resnick M. Iron imports. III. Transfer of iron from the mucosa into circulation. Am J Physiol Gastrointest Liver Physiol 290: G1-G6, 2006.
53. Yun CC, Chen Y, Lang F. Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem 277: 7676-7683, 2002.
54. + exchanger NHE3, and the cytoskeletal protein ezrin. J Biol Chem 273: 25856-25863, 1998.