Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine

Gastroenterology

Volumn 135, Issue 5, 2008, Pages

  Walker, Nancy M ^a   Simpson, Janet E ^a,b   Yen, Pei Fen ^a,b   Gill, Ravinder K ^c   Rigsby, Elizabeth V ^a   Brazill, Jennifer M ^a   Dudeja, Pradeep K ^c   Schweinfest, Clifford W ^d   Clarke, Lane L ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; BICARBONATE CHLORIDE ANTIPORTER; PROTEIN SLC26A3; PROTEIN SLC26A6; SODIUM CHLORIDE; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FLUOROSCOPY; GENE DELETION; IMMUNOFLUORESCENCE; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 55249127294     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.07.083     Document Type: Article

References (42)

1. Turnberg L.A., Bieberdorf F.A., Morawski S.G., et al. Interrelationship of chloride, bicarbonate, sodium and hydrogen transport in human ileum. J Clin Invest 49 (1970) 557-567
2. 3 exchange and mechanism of coupling. Am J Physiol 249 (1985) G236-G245
3. Gawenis L.R., Stien X., Shull G.E., et al. Intestinal NaCl transport in NHE2 and NHE3 knockout mice. Am J Physiol (2001) G776-G784
4. + absorption in vivo. Gastroenterology 112 (1997) 174-183
5. + exchanger. Nat Genet 19 (1998) 282-285
6. +-dependent acid extrusion mechanism is up-regulated in NHE2-null mice. Am J Physiol 291 (2006) G689-G699
7. Xu H.C.H., Dong J., Lynch R., et al. Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8). Cell Physiol Biochem 21 (2008) 109-116
8. Kere J., Lohi H., and Hoglund P. Genetic disorders of membrane transport III. Congenital chloride diarrhea. Am J Physiol 276 (1999) G7-G13
9. Moseley R.H., Hoglund P., Wu G.D., et al. Down-regulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea. Am J Physiol 276 (1999) G185-G192
10. Chernova M.N., Jiang L., Shmukler B.E., et al. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol (Lond) 549 (2003) 1:3-19
11. Jiang Z., Grichtchenko I.I., Boron W.F., et al. Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem 277 (2002) 33963-33967
12. Xie Q., Welch R., Mercado A., et al. Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol 283 (2002) F826-F838
13. Mount D.B., and Romero M.F. The SLC26 gene family of multifunctional anion exchangers. Pfluegers Arch 447 (2004) 710-721
14. Chernova M.N., Jiang L., Friedman D.J., et al. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem 280 (2005) 8564-8580
15. - exchange by slc26a3 and slc26a6. J Gen Physiol 127 (2006) 511-524
16. Chang E.B., and Rao M.C. Intestinal water and electrolyte transport. In: Johnson L.R. (Ed). Physiology of the gastrointestinal tract (1994), Raven Press, New York 2027-2081
17. Schweinfest C.W., Spyropoulos D.D., Henderson K.W., et al. slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem 281 (2006) 37962-37971
18. + exchanger. J Biol Chem 274 (1999) 22855-22861
19. - exchanger in the small intestine. Am J Physiol 282 (2002) G573-G579
20. + absorption in a cystic fibrosis mouse model. Am J Physiol 270 (1996) G259-G267
21. Powell D.W. Intestinal water and electrolyte transport. In: Johnson L.R. (Ed). Physiology of the gastrointestinal tract (1987), Raven Press, New York 1267-1306
22. - conductance. Am J Physiol 242 (1982) G272-G280
23. Wang Z., Wang T., Petrovic S., et al. Renal and intestine transport defects in Slc26a6-null mice. Am J Physiol 288 (2005) C957-C965
24. Gawenis L.R., Boyle K.T., Palmer B.A., et al. Lateral intercellular space volume as a determinant of CFTR-mediated anion secretion across small intestinal mucosa. Am J Physiol 286 (2004) G1015-G1023
25. Sheldon R.J., Malarchik M.E., Fox D.A., et al. Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum. J Pharmacol Exp Ther 249 (1988) 572-582
26. 2α concentrations on ion transport across human jejunal mucosa. Gastroenterology 78 (1980) 32-42
27. - exchange in the villous epithelium of intact murine duodenum. Am J Physiol 288 (2005) 1241-1251
28. - exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol 292 (2007) G1079-G1088
29. - exchange following infection with enteropathogenic E coli. J Clin Invest 117 (2007) 428-437
30. Alrefai W.A., Wen X., Jiang W., et al. Molecular cloning and promoter analysis of downregulated in adenoma (DRA). Am J Physiol 293 (2007) G923-G934
31. Donowitz M., and Welsh M.J. Regulation of mammalian small intestinal electrolyte secretion. In: Johnson L.R. (Ed). Physiology of the gastrointestinal tract (1987), Raven Press, New York 1351-1388
32. Seidler U., Rottinghaus I., Hillesheim J., et al. Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice. Pflugers Arch 455 (2008) 757-766
33. Field M., Rao M.C., and Chang E.B. Intestinal water and electrolyte transport and diarrheal disease. N Engl J Med 321 (1989) 800-806
34. Hubel K.A. Effect of luminal sodium concentration on bicarbonate absorption in rat jejunum. J Clin Invest 52 (1973) 3172-3179
35. Turnberg L.A., Fordtran J.S., Carter N.W., et al. Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J Clin Invest 49 (1970) 548-556
36. + exchangers, NHE-1 and NHE-3, of rat intestine. J Clin Invest 93 (1994) 106-113
37. - exchange in rabbit, rat, and human duodenum. Gastroenterology 122 (2002) 709-724
38. Barmeyer C., Ye J.H., Sidani S., et al. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells. Pflugers Arch 454 (2007) 441-450
39. Vaandrager A.B., Bot A.G.M., Ruth P., et al. Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon. Gastroenterology 118 (2000) 108-114
40. - transport in cystic fibrosis. EMBO J 21 (2002) 5662-5672
41. + exchanger gene family: structure and function studies. Am J Physiol 269 (1995) G1-G11
42. Duffey M.E., and Devor D.C. Intracellular pH and membrane potassium conductance in rabbit distal colon. Am J Physiol 258 (1990) C336-C343