Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22570-22579

  Kukimoto Niino, Mutsuko ^a   Yoshikawa, Seiko ^a   Takagi, Tetsuo ^a   Ohsawa, Noboru ^a   Tomabechi, Yuri ^a   Terada, Takaho ^a   Shirouzu, Mikako ^a   Suzuki, Atsushi ^b   Lee, Suni ^b   Yamauchi, Toshimasa ^c   Okada Iwabu, Miki ^c   Iwabu, Masato ^c   Kadowaki, Takashi ^c   Minokoshi, Yasuhiko ^b   Yokoyama, Shigeyuki ^a,d  

^a RIKEN   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; ACTIVATION LOOPS; AMINO ACID RESIDUES; AUTOINHIBITION; BIOCHEMICAL PROPERTIES; IN-VITRO ANALYSIS; INTRACELLULAR CA; INTRINSIC ACTIVITIES; ISOFORMS; KINASE ACTIVITY; KINASE DOMAINS; MOLECULAR BASIS; MOLECULAR SURFACES; PHOSPHORYLATION SITES; PROTEIN KINASE; SELECTIVE INHIBITION; SELECTIVE INHIBITORS; SEQUENCE ANALYSIS; SUBSTRATE RECOGNITION;

AMINO ACIDS; BINDING SITES; CALCIUM; CALMODULIN; ENZYMES; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

CRYSTAL STRUCTURE;

AMINO ACID; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; ISOPROTEIN; PROLINE; PROTEIN KINASE INHIBITOR; STO 609; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BENZIMIDAZOLES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAPHTHALIMIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 79959335754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.251710     Document Type: Article

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