Brain-derived neurotrophic factor and neuralplasticity in a rat model of spinal cord transection

Neural Regeneration Research

Volumn 6, Issue 13, 2011, Pages 1017-1022

  Xing, Ruxin ^a   Liu, Jia ^b   Jin, Hua ^b   Dai, Ping ^b   Wang, Tinghua ^a  

^a SICHUAN UNIVERSITY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Brain derived neurotrophic factor; Extracellular signal regulated kinase1 2; Neuroplasticity; Replication defective herpes simplex virus vector; Replication incompetent herpes simplex virus vector; Spinal cord transection

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HERPESVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; HERPES SIMPLEX VIRUS; HINDLIMB; LOCOMOTION; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD TRANSSECTION; SUBARACHNOID SPACE; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

EID: 79959321056     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. O'Carroll SJ, Alkadhi M, Nicholson LF, et al. Connexin 43 mimeticpeptides reduce swelling, astrogliosis, and neuronal cell deathafter spinal cord injury. Cell Commun Adhes. 2008;15(1):27-42.
2. Can M, Gul S, Bektas S, et al. Effects of dexmedetomidine ormethylprednisolone on inflammatory responses in spinal cordinjury. Acta Anaesthesiol Scand. 2009;53(8):1068-1072.
3. Genovese T, Menegazzi M, Mazzon E, et al. Glycyrrhizin reducessecondary inflammatory process after spinal cord compressioninjury in mice. Shock. 2009;31(4):367-375.
4. Schwab JM, Brechtel K, Mueller CA, et al. Experimental strategiesto promote spinal cord regeneration-an integrative perspective.Prog Neurobiol. 2006;78(2):91-116.
5. Raineteau O, Schwab ME. Plasticity of motor systems afterincomplete spinal cord injury. Nat Rev Neurosci. 2001;2(4):263-273.
6. Bareyre FM, Kerschensteiner M, Raineteau O, et al. The injuredspinal cord spontaneously forms a new intraspinal circuit in adultrats. Nat Neurosci. 2004;7(3):269-277.
7. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, et al. Synergisticeffects of transplanted adult neural stem/progenitor cells,chondroitinase, and growth factors promote functional repair andplasticity of the chronically injured spinal cord. J Neurosci. 2010;30(5):1657-1676.
8. Namiki J, Kojima A, Tator CH. Effect of brain-derived neurotrophicfactor, nerve growth factor, and neurotrophin-3 on functionalrecovery and regeneration after spinal cord injury in adult rats. JNeurotrauma. 2000;17(12):1219-1231.
9. Esquenazi S, Bazan HE, Bui V, et al. Topical combination of NGFand DHA increases rabbit corneal nerve regeneration afterphotorefractive keratectomy. Invest Ophthalmol Vis Sci. 2005;46(9):3121-3127.
10. Qin DX, Zou XL, Luo W, et al. Expression of some neurotrophinsin the spinal motoneurons after cord hemisection in adult rats.Neurosci Lett. 2006;410(3):222-227.
11. DiStefano PS, Friedman B, Radziejewski C, et al. Theneurotrophins BDNF, NT-3 and NGF display distinct patterns ofretrograde axonal transport in peripheral and central neurons.Neuron. 1992;8(5):983-993.
12. Fortun J, Puzis R, Pearse DD, et al. Muscle injection of AAV-NT3promotes anatomical reorganization of CST axons and improvesbehavioral outcome following SCI. J Neurotrauma. 2009;26(7):941-953.
13. Sharma HS. A select combination of neurotrophins enhancesneuroprotection and functional recovery following spinal cordinjury. Ann N Y Acad Sci. 2007;1122:95-111.
14. Carvalho AL, Caldeira MV, Santos SD, et al. Role of thebrain-derived neurotrophic factor at glutamatergic synapses. Br JPharmacol. 2008;153(Suppl 1):S310-324.
15. Hashimoto T, Bergen SE, Nguyen QL, et al. Relationship ofbrain-derived neurotrophic factor and its receptor TrkB to alteredinhibitory prefrontal circuitry in schizophrenia. J Neurosci. 2005;25(2):372-383.
16. Aid T, Kazantseva A, Piirsoo M, et al. Mouse and rat BDNF genestructure and expression revisited. J Neurosci Res. 2007;85(3):525-535.
17. Tabuchi A, Sakaya H, Kisukeda T, et al. Involvement of anupstream stimulatory factor as well as cAMP-responsive elementbinding protein in the activation of brain-derived neurotrophicfactor gene promoter I. J Biol Chem. 2002;277(39):35920-35931.
18. Widenfalk J, Lundstromer K, Jubran M, et al. Neurotrophic factorsand receptors in the immature and adult spinal cord aftermechanical injury or kainic acid. J Neurosci. 2001;21(10):3457-3475.
19. Matsuda N, Lu H, Fukata Y, et al. Differential activity-dependentsecretion of brain-derived neurotrophic factor from axon anddendrite. J Neurosci. 2009;29(45):14185-14198.
20. Koopmans GC, Brans M, Gomez-Pinilla F, et al. Circulatinginsulin-like growth factor I and functional recovery from spinalcord injury under enriched housing conditions. Eur J Neurosci.2006;23(4):1035-1046.
21. Kohara K, Kitamura A, Morishima M, et al. Activity-dependenttransfer of brain-derived neurotrophic factor to postsynapticneurons. Science. 2001;291(5512):2419-2423.
22. Sasaki M, Radtke C, Tan AM, et al. BDNF-hypersecreting humanmesenchymal stem cells promote functional recovery, axonalsprouting, and protection of corticospinal neurons after spinal cordinjury. J Neurosci. 2009;29(47):14932-14941.
23. Ying Z, Roy RR, Zhong H, et al. BDNF-exercise interactions in therecovery of symmetrical stepping after a cervical hemisection inrats. Neuroscience. 2008;155(4):1070-1078.
24. Ikeda O, Murakami M, Ino H, et al. Acute up-regulation ofbrain-derived neurotrophic factor expression resulting fromexperimentally induced injury in the rat spinal cord. ActaNeuropathol. 2001;102(3):239-245.
25. Perrin FE, Boniface G, Serguera C, et al. Grafted humanembryonic progenitors expressing neurogenin-2 stimulate axonalsprouting and improve motor recovery after severe spinal cordinjury. PLoS One. 2010;5(12):e15914.
26. Fan J, Xiao Z, Zhang H, et al. Linear ordered collagen scaffoldsloaded with collagen-binding neurotrophin-3 promote axonalregeneration and partial functional recovery after complete spinalcord transection. J Neurotrauma. 2010;27(9):1671-1683.
27. Ni YQ, Gan DK, Xu HD, et al. Neuroprotective effect oftranscorneal electrical stimulation on light-induced photoreceptordegeneration. Exp Neurol. 2009;219(2):439-452.
28. Heimburger RF. Return of function after spinal cord transection.Spinal Cord. 2005;43(7):438-440.
29. Grossman SD, Rosenberg LJ, Wrathall JR. Relationship ofaltered glutamate receptor subunit mRNA expression to acute cellloss after spinal cord contusion. Exp Neurol. 2001;168(2):283-289.
30. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliablelocomotor rating scale for open field testing in rats. J Neurotrauma.1995;12(1):1-21.
31. Gulino R, Lombardo SA, Casabona A, et al. Levels ofbrain-derived neurotrophic factor and neurotrophin-4 in lumbarmotoneurons after low-thoracic spinal cord hemisection. BrainRes. 2004;1013(2):174-181.
32. Levine ES, Dreyfus CF, Black IB, et al. Selective role for trkBneurotrophin receptors in rapid modulation of hippocampalsynaptic transmission. Brain Res Mol Brain Res. 1996;38(2):300-303.
33. Shen RY, Altar CA, Chiodo LA. Brain-derived neurotrophic factorincreases the electrical activity of pars compacta dopamineneurons in vivo. Proc Natl Acad Sci U S A. 1994;91(19):8920-8924.
34. Iarikov DE, Kim BG, Dai HN, et al. Delayed transplantation withexogenous neurotrophin administration enhances plasticity ofcorticofugal projections after spinal cord injury. J Neurotrauma.2007;24(4):690-702.
35. Vavrek R, Girgis J, Tetzlaff W, et al. BDNF promotes connectionsof corticospinal neurons onto spared descending interneurons inspinal cord injured rats. Brain. 2006;129(Pt 6):1534-1545.
36. Song XY, Li F, Zhang FH, et al. Peripherally-derived BDNFpromotes regeneration of ascending sensory neurons after spinalcord injury. PLoS One. 2008;3(3):e1707.
37. Kadoya K, Tsukada S, Lu P, et al. Combined intrinsic and extrinsicneuronal mechanisms facilitate bridging axonal regeneration oneyear after spinal cord injury. Neuron. 2009;64(2):165-172.
38. Almeida RD, Manadas BJ, Melo CV, et al. Neuroprotection byBDNF against glutamate-induced apoptotic cell death is mediatedby ERK and PI3-kinase pathways. Cell Death Differ. 2005;12(10):1329-1343.
39. Kwon BK, Liu J, Lam C, et al. Brain-derived neurotrophic factorgene transfer with adeno-associated viral and lentiviral vectorsprevents rubrospinal neuronal atrophy and stimulatesregeneration-associated gene expression after acute cervicalspinal cord injury. Spine. 2007;32 (11):1164-1173.
40. Liu Y, Kim D, Himes BT, et al. Transplants of fibroblastsgenetically modified to express BDNF promote regeneration ofadult rat rubrospinal axons and recovery of forelimb function. JNeurosci. 1999;19(11):4370-4387.
41. Touyz RM. Intracellular mechanisms involved in vascularremodelling of resistance arteries in hypertension: role ofangiotensin II. Exp Physiol. 2005;90(4):449-455.
42. Kishino A, Ishige Y, Tatsuno T, et al. BDNF prevents and reversesadult rat motor neuron degeneration and induces axonaloutgrowth. Exp Neurol. 1997;144(2): 273-286.
43. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases:specific messages from ubiquitous messengers. Mol Cell Biol.1999;19(4):2435-2444.
44. Santos AR, Duarte CB. Validation of internal control genes forexpression studies: effects of the neurotrophin BDNF onhippocampal neurons. J Neurosci Res. 2008;86(16):3684-3692.
45. Genovese T, Esposito E, Mazzon E, et al. Beneficial effects ofethyl pyruvate in a mouse model of spinal cord injury. Shock.2009;32(2):217-227.
46. The Ministry of Science and Technology of the People's Republicof China. Guidance Suggestions for the Care and Use ofLaboratory Animals. 2006-09-30.
47. Li XL, Zhang W, Zhou X, et al. Temporal changes in theexpression of some neurotrophins in spinal cord transected adultrats. Neuropeptides. 2007;41(3):135-143.
48. Shibata T, Tamura M, Kabashima N, et al. Fluvastatin attenuatesIGF-1-induced ERK1/2 activation and cell proliferation bymevalonic acid depletion in human mesangial cells. Life Sci. 2009;84(21-22):725-731.
49. Smith PK, Krohn RI, Hermanson GT, et al. Measurement ofprotein using bicinchoninic acid. Anal Biochem. 1985;150(1):76-85.