Generation of neutralizing aptamers against herpes simplex virus type 2: Potential components of multivalent microbicides

Journal of General Virology

Volumn 92, Issue 7, 2011, Pages 1493-1499

  Moore, M D ^a   Bunka, D H J ^b   Forzan, M ^a   Spear, P G ^c   Stockley, P G ^b   Mcgowan, I ^d   James, W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; GLYCOPROTEIN D; HERPESVIRUS ENTRY MEDIATOR; MICROBICIDE; NECTIN 1; NEUTRALIZING APTAMER; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ARTICLE; DISEASE ASSOCIATION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IC 50; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS ISOLATION;

ANIMALS; ANTIVIRAL AGENTS; APTAMERS, NUCLEOTIDE; BASE SEQUENCE; CELL ADHESION MOLECULES; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA;

HUMAN HERPESVIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79959297547     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.030601-0     Document Type: Article

References (25)

1. Bunka, D. H., Mantle, B. J., Morten, I. J., Tennent, G. A., Radford, S. E. & Stockley, P. G. (2007). Production and characterization of RNA aptamers specific for amyloid fibril epitopes. J Biol Chem 282, 34500-34509.
2. Bunka, D. H., Platonova, O. & Stockley, P. G. (2010). Development of aptamer therapeutics. Curr Opin Pharmacol 10, 557-562.
3. Derdeyn, C. A., Decker, J. M., Sfakianos, J. N., Wu, X., O'Brien, W. A., Ratner, L., Kappes, J. C., Shaw, G. M. & Hunter, E. (2000). Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp 120. J Virol 74, 8358-8367.
4. Ellington, A. D. & Szostak, J. W. (1990). In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818-822.
5. Freeman, E. E., Weiss, H. A., Glynn, J. R., Cross, P. L., Whitworth, J. A. & Hayes, R. J. (2006). Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and metaanalysis of longitudinal studies. AIDS 20, 73-83.
6. Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J. & Spear, P. G. (1998). Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280, 1618-1620.
7. James, W. (2001). Nucleic acid and polypeptide aptamers: a powerful approach to ligand discovery. Curr Opin Pharmacol 1, 540-546.
8. Khati, M., Schüman, M., Ibrahim, J., Sattentau, Q., Gordon, S. & James, W. (2003). Neutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 29 F-RNA aptamers. J Virol 77, 12692-12698.
9. Looker, K. J., Garnett, G. P. & Schmid, G. P. (2008). An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ 86, 805-812. (A.).
10. Manoj, S., Jogger, C. R., Myscofski, D., Yoon, M. & Spear, P. G. (2004). Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci U S A 101, 12414-12421.
11. Mathews, D. H., Sabina, J., Zuker, M. & Turner, D. H. (1999). Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol 288, 911-940.
12. Montgomery, R. I., Warner, M. S., Lum, B. J. & Spear, P. G. (1996). Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87, 427-436.
13. Moore, M. D., Cookson, J., Coventry, V. K., Sproat, B., Rabe, L., Cranston, R. D., McGowan, I. & James, W. (2011). Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: implications for RNA-based therapeutics. J Biol Chem 286, 2526-2535.
14. Para, M. F., Parish, M. L., Noble, A. G. & Spear, P. G. (1985). Potent neutralizing activity associated with anti-glycoprotein D specificity among monoclonal antibodies selected for binding to herpes simplex virions. J Virol 55, 483-488.
15. Renzi, C., Douglas, J. M., Jr, Foster, M., Critchlow, C. W., Ashley- Morrow, R., Buchbinder, S. P., Koblin, B. A., McKirnan, D. J., Mayer, K. H. & Celum, C. L. (2003). Herpes simplex virus type 2 infection as a risk factor for human immunodeficiency virus acquisition in men who have sex with men. J Infect Dis 187, 19-25.
16. Rhie, A., Kirby, L., Sayer, N., Wellesley, R., Disterer, P., Sylvester, I., Gill, A., Hope, J., James, W. & Tahiri-Alaoui, A. (2003). Characterization of 29-fluoro-RNA aptamers that bind preferentially to diseaseassociated conformations of prion protein and inhibit conversion. J Biol Chem 278, 39697-39705.
17. Robertson, D. L. & Joyce, G. F. (1990). Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 344, 467-468.
18. Sousa, R. & Padilla, R. (1995). A mutant T7 RNA polymerase as a DNA polymerase. EMBO J 14, 4609-4621.
19. Spear, P. G. (2004). Herpes simplex virus: receptors and ligands for cell entry. Cell Microbiol 6, 401-410.
20. Spear, P. G.,Manoj, S., Yoon,M., Jogger, C. R., Zago, A. & Myscofski, D. (2006). Different receptors binding to distinct interfaces on herpes simplex virus gD can trigger events leading to cell fusion and viral entry. Virology 344, 17-24.
21. Taylor, J. M., Lin, E., Susmarski, N., Yoon, M., Zago, A., Ware, C. F., Pfeffer, K., Miyoshi, J., Takai, Y. & Spear, P. G. (2007). Alternative entry receptors for herpes simplex virus and their roles in disease. Cell Host Microbe 2, 19-28.
22. Tuerk, C. & Gold, L. (1990). Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505-510.
23. Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M. & Kappes, J. C. (2002). Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 46, 1896-1905.
24. Yoon, M., Zago, A., Shukla, D. & Spear, P. G. (2003). Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-Osulfated heparan sulfate but not with nectin-1. J Virol 77, 9221-9231.
25. Zuker, M. (2003). Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31, 3406-3415.