Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: Implications for RNA-based therapeutics

Journal of Biological Chemistry

Volumn 286, Issue 4, 2011, Pages 2526-2535

  Moore, Michael D ^a   Cookson, Jonathan ^a   Coventry, Veronica K ^a   Sproat, Brian ^b   Rabe, Lorna ^c   Cranston, Ross D ^c   McGowan, Ian ^c   James, William ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Chemconsilium GCV ^*  (Belgium)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL ACTIVITIES; APTAMERS; BROAD SPECTRUM; CHEMICALLY MODIFIED; CLINICAL TRIAL; IN-VIVO; MODIFIED NUCLEOTIDES; PRE-EXPOSURE; TENOFOVIR;

CHEMICAL ATTACK; CHEMICAL MODIFICATION; CHEMICAL STABILITY; DISEASES; PROTEINS;

RNA;

APTAMER; MICROBICIDE; NUCLEASE; RNA BASED APTAMER; UNCLASSIFIED DRUG; ZINC ION;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LAVAGE; PRIORITY JOURNAL; PROTECTION; RECTAL LAVAGE; RNA DEGRADATION; VAGINAL LAVAGE; VIRUS NEUTRALIZATION;

ANTIVIRAL AGENTS; APTAMERS, NUCLEOTIDE; DRUG EVALUATION, PRECLINICAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; RECTUM; RIBONUCLEASES; VAGINA;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78951493762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.178426     Document Type: Article

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