메뉴 건너뛰기




Volumn 78, Issue 2, 2011, Pages 90-98

Kidney cancer pathology in the new context of targeted therapy

Author keywords

HIF; mTOR; Renal cell carcinoma; Targeted therapy; VEGF; VHL

Indexed keywords

AXITINIB; BEVACIZUMAB; EVEROLIMUS; HYPOXIA INDUCIBLE FACTOR; INTERFERON; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PAZOPANIB; SCATTER FACTOR RECEPTOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VON HIPPEL LINDAU PROTEIN;

EID: 79959287950     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000315543     Document Type: Review
Times cited : (25)

References (58)
  • 4
    • 65949107302 scopus 로고    scopus 로고
    • Treatment selection for patients with metastatic renal cell carcinoma
    • Atkins MB, Choueiri TK, Cho D, Regan M, Signoretti S: Treatment selection for patients with metastatic renal cell carcinoma. Cancer 2009; 115: 2327-2333.
    • (2009) Cancer , vol.115 , pp. 2327-2333
    • Atkins, M.B.1    Choueiri, T.K.2    Cho, D.3    Regan, M.4    Signoretti, S.5
  • 5
    • 33846878502 scopus 로고    scopus 로고
    • Genomics of renal cell cancer: The biology behind and the therapy ahead
    • Jones J, Libermann TA: Genomics of renal cell cancer: the biology behind and the therapy ahead. Clin Cancer Res 2007; 13: 685s-692s.
    • (2007) Clin Cancer Res , vol.13
    • Jones, J.1    Libermann, T.A.2
  • 6
    • 37849001813 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    • Choueiri TK, Plantade A, Elson P, Negrier S, Ravaud A, Oudard S, et al: Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 2008; 26: 127-131.
    • (2008) J Clin Oncol , vol.26 , pp. 127-131
    • Choueiri, T.K.1    Plantade, A.2    Elson, P.3    Negrier, S.4    Ravaud, A.5    Oudard, S.6
  • 7
    • 67651056360 scopus 로고    scopus 로고
    • Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies
    • Dutcher JP, de Souza P, McDermott D, Figlin RA, Berkenblit A, Thiele A, et al: Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies. Med Oncol 2009; 26: 202-209.
    • (2009) Med Oncol , vol.26 , pp. 202-209
    • Dutcher, J.P.1    De Souza, P.2    McDermott, D.3    Figlin, R.A.4    Berkenblit, A.5    Thiele, A.6
  • 8
    • 67149123373 scopus 로고    scopus 로고
    • Uncommon and recently described renal carcinomas
    • Srigley JR, Delahunt B: Uncommon and recently described renal carcinomas. Mod Pathol 2009; 22(suppl 2):S2-S23.
    • (2009) Mod Pathol , vol.22 , Issue.SUPPL. 2
    • Srigley, J.R.1    Delahunt, B.2
  • 10
    • 56249126012 scopus 로고    scopus 로고
    • Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms
    • Cheng L, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R: Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol 2009; 40: 10-29.
    • (2009) Hum Pathol , vol.40 , pp. 10-29
    • Cheng, L.1    Zhang, S.2    MacLennan, G.T.3    Lopez-Beltran, A.4    Montironi, R.5
  • 11
    • 73349089306 scopus 로고    scopus 로고
    • Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma
    • Young AC, Craven RA, Cohen D, Taylor C, Booth C, Harnden P, et al: Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma. Clin Cancer Res 2009; 15: 7582-7592.
    • (2009) Clin Cancer Res , vol.15 , pp. 7582-7592
    • Young, A.C.1    Craven, R.A.2    Cohen, D.3    Taylor, C.4    Booth, C.5    Harnden, P.6
  • 12
    • 33846879810 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
    • Kaelin WG: The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007; 13: 680s-684s.
    • (2007) Clin Cancer Res , vol.13
    • Kaelin, W.G.1
  • 13
    • 33847250856 scopus 로고    scopus 로고
    • Identification of deregulated oncogenic pathways in renal cell carcinoma: An integrated oncogenomic approach based on gene expression profiling
    • DOI 10.1038/sj.onc.1210256, PII 1210256
    • Furge KA, Tan MH, Dykema K, Kort E, Stadler W, Yao X, et al: Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profiling. Oncogene 2007; 26: 1346-1350. (Pubitemid 46328469)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1346-1350
    • Furge, K.A.1    Tan, M.H.2    Dykema, K.3    Kort, E.4    Stadler, W.5    Yao, X.6    Zhou, M.7    Teh, B.T.8
  • 14
    • 66349100709 scopus 로고    scopus 로고
    • Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney
    • Beroukhim R, Brunet J, Di Napoli A, Mertz KD, Seeley A, Pires MM, et al: Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 2009; 69: 4674-4681.
    • (2009) Cancer Res , vol.69 , pp. 4674-4681
    • Beroukhim, R.1    Brunet, J.2    Di Napoli, A.3    Mertz, K.D.4    Seeley, A.5    Pires, M.M.6
  • 17
    • 24344488419 scopus 로고    scopus 로고
    • The HIF pathway in cancer
    • Maxwell PH: The HIF pathway in cancer. Semin Cell Dev Biol 2005; 16: 523-530.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 523-530
    • Maxwell, P.H.1
  • 18
    • 65349117540 scopus 로고    scopus 로고
    • Clinical implications of hypoxia inducible factor in renal cell carcinoma
    • Smaldone MC, Maranchie JK: Clinical implications of hypoxia inducible factor in renal cell carcinoma. Urol Oncol 2009; 27: 238-245.
    • (2009) Urol Oncol , vol.27 , pp. 238-245
    • Smaldone, M.C.1    Maranchie, J.K.2
  • 19
    • 65949112237 scopus 로고    scopus 로고
    • Treatment of kidney cancer: Insights provided by the VHL tumor-suppressor protein
    • Kaelin WG: Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer 2009; 115: 2262-2272.
    • (2009) Cancer , vol.115 , pp. 2262-2272
    • Kaelin, W.G.1
  • 23
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, et al: Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009; 27: 3312-3318.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 26
    • 48649098245 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    • Choueiri TK, Vaziri SAJ, Jaeger E, Elson P, Wood L, Bhalla IP, et al: von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008; 180: 860-865.
    • (2008) J Urol , vol.180 , pp. 860-865
    • Choueiri, T.K.1    Vaziri, S.A.J.2    Jaeger, E.3    Elson, P.4    Wood, L.5    Bhalla, I.P.6
  • 27
    • 33748526494 scopus 로고    scopus 로고
    • Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status
    • DOI 10.1111/j.1464-410X.2006.06376.x
    • Rini BI, Jaeger E, Weinberg V, Sein N, Chew K, Fong K, et al: Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 2006; 98: 756-762. (Pubitemid 44368020)
    • (2006) BJU International , vol.98 , Issue.4 , pp. 756-762
    • Rini, B.I.1    Jaeger, E.2    Weinberg, V.3    Sein, N.4    Chew, K.5    Fong, K.6    Simko, J.7    Small, E.J.8    Waldman, F.M.9
  • 29
    • 67651204610 scopus 로고    scopus 로고
    • Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
    • Sudarshan S, Sourbier C, Kong H, Block K, Valera Romero VA, Yang Y, et al: Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 2009; 29: 4080-4090.
    • (2009) Mol Cell Biol , vol.29 , pp. 4080-4090
    • Sudarshan, S.1    Sourbier, C.2    Kong, H.3    Block, K.4    Valera Romero, V.A.5    Yang, Y.6
  • 31
    • 77950553262 scopus 로고    scopus 로고
    • Fumarase: A mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response
    • Yogev O, Yogev O, Singer E, Shaulian E, Goldberg M, Fox TD, et al: Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. PLoS Biol 2010; 8:e1000328.
    • (2010) PLoS Biol , vol.8
    • Yogev, O.1    Yogev, O.2    Singer, E.3    Shaulian, E.4    Goldberg, M.5    Fox, T.D.6
  • 32
    • 65949091346 scopus 로고    scopus 로고
    • Targeting mTOR in renal cell carcinoma
    • Hudes GR: Targeting mTOR in renal cell carcinoma. Cancer 2009; 115: 2313-2320.
    • (2009) Cancer , vol.115 , pp. 2313-2320
    • Hudes, G.R.1
  • 33
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al: Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebocontrolled phase III trial. Lancet 2008; 372: 449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 38
    • 68549092780 scopus 로고    scopus 로고
    • Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha
    • Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, et al: Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer 2009; 115: 3651-3660.
    • (2009) Cancer , vol.115 , pp. 3651-3660
    • Figlin, R.A.1    De Souza, P.2    McDermott, D.3    Dutcher, J.P.4    Berkenblit, A.5    Thiele, A.6
  • 39
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    • Toschi A, Lee E, Gadir N, Ohh M, Foster DA: Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem 2008; 283: 34495-34499.
    • (2008) J Biol Chem , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3    Ohh, M.4    Foster, D.A.5
  • 40
    • 55849108854 scopus 로고    scopus 로고
    • Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
    • Chen J, Futami K, Petillo D, Peng J, Wang P, Knol J, et al: Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One 2008; 3:e3581.
    • (2008) PLoS One , vol.3
    • Chen, J.1    Futami, K.2    Petillo, D.3    Peng, J.4    Wang, P.5    Knol, J.6
  • 42
    • 73249138930 scopus 로고    scopus 로고
    • Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
    • Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, et al: Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci USA 2009; 106: 18722-18727.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18722-18727
    • Hasumi, Y.1    Baba, M.2    Ajima, R.3    Hasumi, H.4    Valera, V.A.5    Klein, M.E.6
  • 43
    • 77949681085 scopus 로고    scopus 로고
    • Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin
    • Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, et al: Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. J Med Genet 2010; 47: 182-189.
    • (2010) J Med Genet , vol.47 , pp. 182-189
    • Hudon, V.1    Sabourin, S.2    Dydensborg, A.B.3    Kottis, V.4    Ghazi, A.5    Paquet, M.6
  • 45
    • 56849096837 scopus 로고    scopus 로고
    • HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
    • Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, et al: HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008; 14: 435-446.
    • (2008) Cancer Cell , vol.14 , pp. 435-446
    • Gordan, J.D.1    Lal, P.2    Dondeti, V.R.3    Letrero, R.4    Parekh, K.N.5    Oquendo, C.E.6
  • 46
    • 34248168006 scopus 로고    scopus 로고
    • Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma
    • DOI 10.1158/0008-5472.CAN-06-4571
    • Furge KA, Chen J, Koeman J, Swiatek P, Dykema K, Lucin K, et al: Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma. Cancer Res 2007; 67: 3171-3176. (Pubitemid 46724854)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3171-3176
    • Furge, K.A.1    Chen, J.2    Koeman, J.3    Swiatek, P.4    Dykema, K.5    Lucin, K.6    Kahnoski, R.7    Yang, X.J.8    Bin, T.T.9
  • 48
    • 63149193393 scopus 로고    scopus 로고
    • Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma
    • Klatte T, Pantuck AJ, Said JW, Seligson DB, Rao NP, LaRochelle JC, et al: Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma. Clin Cancer Res 2009; 15: 1162-1169.
    • (2009) Clin Cancer Res , vol.15 , pp. 1162-1169
    • Klatte, T.1    Pantuck, A.J.2    Said, J.W.3    Seligson, D.B.4    Rao, N.P.5    LaRochelle, J.C.6
  • 49
    • 41449107739 scopus 로고    scopus 로고
    • C-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations
    • Bellon SF, Kaplan-Lefko P, Yang Y, Zhang Y, Moriguchi J, Rex K, et al: c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem 2008; 283: 2675-2683.
    • (2008) J Biol Chem , vol.283 , pp. 2675-2683
    • Bellon, S.F.1    Kaplan-Lefko, P.2    Yang, Y.3    Zhang, Y.4    Moriguchi, J.5    Rex, K.6
  • 50
    • 77950517630 scopus 로고    scopus 로고
    • Dependence receptors: A new paradigm in cell signaling and cancer therapy
    • Goldschneider D, Mehlen P: Dependence receptors: a new paradigm in cell signaling and cancer therapy. Oncogene 2010; 29: 1865-1882.
    • (2010) Oncogene , vol.29 , pp. 1865-1882
    • Goldschneider, D.1    Mehlen, P.2
  • 51
    • 55949101858 scopus 로고    scopus 로고
    • Kinase requirements in human cells. 3. Altered kinase requirements in VHL-/- Cancer cells detected in a pilot synthetic lethal screen
    • Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, et al: Kinase requirements in human cells. 3. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci USA 2008; 105: 16484-16489.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16484-16489
    • Bommi-Reddy, A.1    Almeciga, I.2    Sawyer, J.3    Geisen, C.4    Li, W.5    Harlow, E.6
  • 52
    • 77955815630 scopus 로고    scopus 로고
    • Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis
    • DOI: 10.1096/fj.09-146928
    • Costa B, Dettori D, Lorenzato A, Bardella C, Coltella N, Martino C, et al: Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J 2010; 24: 2680-2688. DOI: 10.1096/fj.09-146928.
    • (2010) FASEB J , vol.24 , pp. 2680-2688
    • Costa, B.1    Dettori, D.2    Lorenzato, A.3    Bardella, C.4    Coltella, N.5    Martino, C.6
  • 53
    • 0033847587 scopus 로고    scopus 로고
    • Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
    • Fisher RI, Rosenberg SA, Fyfe G: Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J Sci Am 2000; 6:S55-S57.
    • (2000) Cancer J Sci Am , vol.6
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 56
    • 38849190223 scopus 로고    scopus 로고
    • Proteomic identification of interleukin-2 therapy response in metastatic renal cell cancer
    • Jones J, Otu HH, Grall F, Spentzos D, Can H, Aivado M, et al: Proteomic identification of interleukin-2 therapy response in metastatic renal cell cancer. J Urol 2008 ;179: 730-736.
    • (2008) J Urol , vol.179 , pp. 730-736
    • Jones, J.1    Otu, H.H.2    Grall, F.3    Spentzos, D.4    Can, H.5    Aivado, M.6
  • 58
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
    • DOI 10.1200/JCO.2005.05.179
    • Mekhail TM, Abou-Jawde RM, Boumerhi G, Malhi S, Wood L, Elson P, et al: Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2005; 23: 832-841. (Pubitemid 46224183)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.4 , pp. 832-841
    • Mekhail, T.M.1    Abou-Jawde, R.M.2    BouMerhi, G.3    Malhi, S.4    Wood, L.5    Elson, P.6    Bukowski, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.