Pathogenicity of misfolded and dimeric HLA-B27 molecules

International Journal of Rheumatology

Volumn 2011, Issue , 2011, Pages

  Antoniou, Antony N ^a   Lenart, Izabela ^a   Guiliano, David B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; HLA B27 ANTIGEN; MONOMER;

ANKYLOSING SPONDYLITIS; AUTOIMMUNE DISEASE; CHRONIC INFLAMMATION; HUMAN; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN FOLDING; REACTIVE ARTHRITIS; REVIEW; SPONDYLOARTHROPATHY; UNFOLDED PROTEIN RESPONSE;

EID: 79959275247     PISSN: 16879260     EISSN: 16879279     Source Type: Journal    
DOI: 10.1155/2011/486856     Document Type: Review

References (76)

1. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M., High association of an HL-A antigen, W27, with ankylosing spondylitis The New England Journal of Medicine 1973 288 14 704 706
2. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D., Ankylosing spondylitis and HL-A 27 The Lancet 1973 1 7809 904 907
3. Brewerton D. A., Nicholls A., Caffrey M., Walters D., James D. C. O., Acute anterior uveitis and HL-A 27 The Lancet 1973 2 7836 994 996
4. Antoniou A. N., Powis S. J., Elliott T., Assembly and export of MHC class I peptide ligands Current Opinion in Immunology 2003 15 1 75 81 (Pubitemid 35454196)
5. Hammer R. E., Maika S. D., Richardson J. A., Tang J. P., Taurog J. D., Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human m: an animal model of HLA-B27-associated human disorders Cell 1990 63 5 1099 1112 (Pubitemid 120034950)
6. Taurog J. D., Maika S. D., Satumtira N., Dorris M. L., McLean I. L., Yanagisawa H., Sayad A., Stagg A. J., Fox G. M., O'Brien A. L., Rehman M., Zhou M., Weiner A. L., Splawski J. B., Richardson J. A., Hammer R. E., Inflammatory disease in HLA-B27 transgenic rats Immunological Reviews 1999 169 209 223 (Pubitemid 29338734)
7. Burton P. R., Clayton D. G., Cardon L. R., Craddock N., Deloukas P., Duncanson A., Kwiatkowski D. P., McCarthy M. I., Ouwehand W. H., Samani N. J., Todd J. A., Donnelly P., Barrett J. C., Davison D., Easton D., Evans D. M., Leung H. T., Marchini J. L., Morris A. P., Spencer C. C. A., Tobin M. D., Attwood A. P., Boorman J. P., Cant B., Everson U., Hussey J. M., Jolley J. D., Knight A. S., Koch K., Meech E., Nutland S., Prowse C. V., Stevens H. E., Taylor N. C., Walters G. R., Walker N. M., Watkins N. A., Winzer T., Jones R. W., McArdle W. L., Ring S. M., Strachan D. P., Pembrey M., Breen G., Clair D. ST., Caesar S., Gordon-Smith K., Jones L., Fraser C., Green E. K., Grozeva D., Hamshere M. L., Holmans P. A., Jones I. R., Kirov G., Moskivina V., Nikolov I., O'Donovan M. C., Owen M. J., Collier D. A., Elkin A., Farmer A., Williamson R., McGuffin P., Young A. H., Ferrier I. N., Ball S. G., Balmforth A. J., Barrett J. H., Bishop T. D., Iles M. M., Maqbool A., Yuldasheva N., Hall A. S., Braund P. S., Dixon R. J., Mangino M., Stevens S., Thompson J. R., Bredin F., Tremelling M., Parkes M., Drummond H., Lees C. W., Nimmo E. R., Satsangi J., Fisher S. A., Forbes A., Lewis C. M., Onnie C. M., Prescott N. J., Sanderson J., Matthew C. G., Barbour J., Mohiuddin M. K., Todhunter C. E., Mansfield J. C., Ahmad T., Cummings F. R., Jewell D. P., Webster J., Brown M. J., Lathrop M. G., Connell J., Dominiczak A., Marcano C. A. B., Burke B., Dobson R., Gungadoo J., Lee K. L., Munroe P. B., Newhouse S. J., Onipinla A., Wallace C., Xue M., Caulfield M., Farrall M., Barton A., Bruce I. N., Donovan H., Eyre S., Gilbert P. D., Hilder S. L., Hinks A. M., John S. L., Potter C., Silman A. J., Symmons D. P. M., Thomson W., Worthington J., Dunger D. B., Widmer B., Frayling T. M., Freathy R. M., Lango H., Perry J. R. B., Shields B. M., Weedon M. N., Hattersley A. T., Hitman G. A., Walker M., Elliott K. S., Groves C. J., Lindgren C. M., Rayner N. W., Timpson N. J., Zeggini E., Newport M., Sirugo G., Lyons E., Vannberg F., Hill A. V. S., Bradbury L. A., Farrar C., Pointon J. J., Wordsworth P., Brown M. A., Franklyn J. A., Heward J. M., Simmonds M. J., Gough S. C. L., Seal S., Stratton M. R., Rahman N., Ban M., Goris AN., Sawcer S. J., Compston A., Conway D., Jallow M., Rockett K. A., Bumpstead S. J., Chaney A., Downes K., Ghori M. J. R., Gwilliam R., Hunt S. E., Inouye M., Keniry A., King E., McGinnis R., Potter S., Ravindrarajah R., Whittaker P., Widden C., Withers D., Cardin N. J., Ferreira T., Pereira-Gale J., Hallgrimsdttir I. B., Howie B. N., Su Z., Teo Y. Y., Vukcevic D., Bentley D., Mitchell S. L., Newby P. R., Brand O. J., Carr-Smith J., Pearce S. H. S., Gough S. C. L., McGinnis R., Keniry A., Deloukas P., Reveille J. D., Zhou X., Sims A. M., Dowling A., Taylor J., Doan T., Davis J. C., Savage L., Ward M. M., Learch T. L., Weisman M. H., Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Nature Genetics 2007 39 11 1329 1337 (Pubitemid 350041542)
8. Benjamin R., Parham P., Guilt by association: HLA-B27 and ankylosing spondylitis Immunology Today 1990 11 4 137 141 (Pubitemid 20095098)
9. Mear J. P., Schreiber K. L., Mnz C., Zhu X., Stevanovi S., Rammensee H. G., Rowland-Jones S. L., Colbert R. A., Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies Journal of Immunology 1999 163 12 6665 6670
10. Colbert R. A., HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum? Molecular Medicine Today 2000 6 6 224 230 (Pubitemid 30394908)
11. Colbert R. A., HLA-B27 misfolding and spondyloarthropathies: not so groovy after all? Journal of Rheumatology 2000 27 5 1107 (Pubitemid 30262489)
12. Masters S. L., Simon A., Aksentijevich I., Kastner D. L., Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease Annual Review of Immunology 2009 27 621 668
13. Kozutsumi Y., Segal M., Normington K., Gething M. J., Sambrook J., The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins Nature 1988 332 6163 462 464 (Pubitemid 18090252)
14. Welihinda A. A., Tirasophon W., Kaufman R. J., The cellular response to protein misfolding in the endoplasmic reticulum Gene Expression 1999 7 4-6 293 300 (Pubitemid 29372073)
15. Zhang K., Kaufman R. J., The unfolded protein response: a stress signaling pathway critical for health and disease Neurology 2006 66 2, supplement 1 S102 S109
16. Foti D. M., Welihinda A., Kaufman R. J., Lee A. S., Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1 Journal of Biological Chemistry 1999 274 43 30402 30409
17. Shen J., Chen X., Hendershot L., Prywes R., ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of golgi localization signals Developmental Cell 2002 3 1 99 111 (Pubitemid 34778399)
18. Hendershot L. M., The ER chaperone BiP is a master regulator of ER function Mount Sinai Journal of Medicine 2004 71 5 289 297 (Pubitemid 39440150)
19. Bertolotti A., Zhang Y., Hendershot L. M., Harding H. P., Ron D., Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Nature Cell Biology 2000 2 6 326 332
20. Haze K., Yoshida H., Yanagi H., Yura T., Mori K., Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress Molecular Biology of the Cell 1999 10 11 3787 3799 (Pubitemid 29534025)
21. Ye J., Rawson R. B., Komuro R., Chen XI., Dav U. P., Prywes R., Brown M. S., Goldstein J. L., ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Molecular Cell 2000 6 6 1355 1364 (Pubitemid 32045928)
22. Yoshida H., Matsui T., Hosokawa N., Kaufman R. J., Nagata K., Mori K., A time-dependent phase shift in the mammalian unfolded protein response Developmental Cell 2003 4 2 265 271 (Pubitemid 36221802)
23. Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K., XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell 2001 107 7 881 891 (Pubitemid 34084979)
24. Lee A. H., Iwakoshi N. N., Glimcher L. H., XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response Molecular and Cellular Biology 2003 23 21 7448 7459 (Pubitemid 37271447)
25. Harding H. P., Zhang Y., Bertolotti A., Zeng H., Ron D., Perk is essential for translational regulation and cell survival during the unfolded protein response Molecular Cell 2000 5 5 897 904
26. Koumenis C., Naczki C., Koritzinsky M., Rastani S., Diehl A., Sonenberg N., Koromilas A., Wouters B. G., Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2 Molecular and Cellular Biology 2002 22 21 7405 7416
27. Ma Y., Brewer J. W., Diehl J. A., Hendershot L. M., Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response Journal of Molecular Biology 2002 318 5 1351 1365 (Pubitemid 34754003)
28. Song B., Scheuner D., Ron D., Pennathur S., Kaufman R. J., Chop deletion reduces oxidative stress, improves cell function, and promotes cell survival in multiple mouse models of diabetes Journal of Clinical Investigation 2008 118 10 3378 3389
29. Wang X. Z., Lawson B., Brewer J. W., Zinszner H., Sanjay A., Mi LI. J., Boorstein R., Kreibich G., Hendershot L. M., Ron D., Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153) Molecular and Cellular Biology 1996 16 8 4273 4280 (Pubitemid 26251229)
30. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R. T., Remotti H., Stevens J. L., Ron D., CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes and Development 1998 12 7 982 995 (Pubitemid 28204605)
31. Pahl H. L., Baeurle P. A., A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF- B The EMBO Journal 1995 14 11 2580 2588
32. Pahl H. L., Baeuerle P. A., Activation of NF- B by ER stress requires both Ca 2+ and reactive oxygen intermediates as messengers FEBS Letters 1996 392 2 129 136 (Pubitemid 26276734)
33. Zhang K., Shen X., Wu J., Sakaki K., Saunders T., Rutkowski D. T., Back S. H., Kaufman R. J., Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Cell 2006 124 3 587 599 (Pubitemid 43199443)
34. Martinon F., Chen X., Lee A. H., Glimcher L. H., TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages Nature Immunology 2010 11 5 411 418
35. Goodall J. C., Wu C., Zhang Y., McNeill L., Ellis L., Saudek V., Gaston J. S.H., Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression Proceedings of the National Academy of Sciences of the United States of America 2010 107 41 17698 17703
36. Xue X., Piao J.-H., Nakajima A., Sakon-Komazawa S., Kojima Y., Mori K., Yagita H., Okumura K., Harding H., Nakano H., Tumor necrosis factor (TNF ) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNF Journal of Biological Chemistry 2005 280 40 33917 33925 (Pubitemid 41443111)
37. Hu P., Han Z., Couvillon A. D., Kaufman R. J., Exton J. H., Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1 -mediated NF- B activation and down-regulation of TRAF2 expression Molecular and Cellular Biology 2006 26 8 3071 3084
38. Taurog J. D., Maika S. D., Simmons W. A., Breban M., Hammer R. E., Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression Journal of Immunology 1993 150 9 4168 4178 (Pubitemid 23129798)
39. Cauli A., Dessole G., Fiorillo M. T., Vacca A., Mameli A., Bitti P., Passiu G., Sorrentino R., Mathieu A., Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease Rheumatology 2002 41 12 1375 1379 (Pubitemid 36004313)
40. Breban M., Hammer R. E., Richardson J. A., Taurog J. D., Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment Journal of Experimental Medicine 1993 178 5 1607 1616 (Pubitemid 23318439)
41. Breban M., Fernndez-Sueiro J. L., Richardson J. A., Hadavand R. R., Maika S. D., Hammer R. E., Taurog J. D., T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats Journal of Immunology 1996 156 2 794 803 (Pubitemid 26028940)
42. May E., Dorris M. L., Satumtira N., Iqbal I., Rehman M. I., Lightfoot E., Taurog J. D., CD8 T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats Journal of Immunology 2003 170 2 1099 1105 (Pubitemid 36070566)
43. Taurog J. D., Dorris M. L., Satumtira N., Tran T. M., Sharma R., Dressel R., van den Brandt J., Reichardt H. M., Spondylarthritis in HLA-B27/human -microglobulin-transgenic rats is not prevented by lack of CD8 Arthritis and Rheumatism 2009 60 7 1977 1984
44. Turner M. J., Sowders D. P., DeLay M. L., Mohapatra R., Bai S., Smith J. A., Brandewie J. R., Taurog J. D., Colbert R. A., HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response Journal of Immunology 2005 175 4 2438 2448 (Pubitemid 41113854)
45. Tran T. M., Dorris M. L., Satumtira N., Richardson J. A., Hammer R. E., Shang J., Taurog J. D., Additional human -microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats Arthritis and Rheumatism 2006 54 4 1317 1327 (Pubitemid 43672945)
46. Turner M. J., DeLay M. L., Bai S., Klenk E., Colbert R. A., HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: implications for the pathogenesis of spondylarthritis-like disease Arthritis and Rheumatism 2007 56 1 215 223 (Pubitemid 46106195)
47. Weinreich S., Eulderink F., Capkova J., Pla M., Gaede K., Heesemann J., van Alphen L., Zurcher C., Hoebe-Hewryk B., Kievits F., Ivanyi P., HLA-B27 as a relative risk factor in ankylosing enthesopathy in transgenic mice Human Immunology 1995 42 2 103 115
48. Weinreich S., Hoebe B., Ivanyi P., Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice Annals of the Rheumatic Diseases 1995 54 9 754 756
49. Weinreich S. S., Hoebe-Hewryk B., van der Horst A. R., Boog C. J. P., Ivanyi P., The role of MHC class I heterodimer expression in mouse ankylosing enthesopathy Immunogenetics 1997 46 1 35 40 (Pubitemid 27234793)
50. Kingsbury D. J., Mear J. P., Witte D. P., Taurog J. D., Roopenian D. C., Colbert R. A., Development of spontaneous arthritis in 2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression Arthritis and Rheumatism 2000 43 10 2290 2296
51. Allen R. L., O'Callaghan C. A., McMichael A. J., Bowness P., Cutting edge: HLA-b27 can form a novel -microglobulin-free heavy chain homodimer structure Journal of Immunology 1999 162 9 5045 5048 (Pubitemid 29307101)
52. Antoniou A. N., Ford S., Taurog J. D., Butcher G. W., Powis S. J., Formation of HLA-B27 homodimers and their relationship to assembly kinetics Journal of Biological Chemistry 2004 279 10 8895 8902 (Pubitemid 38295950)
53. Ramos M., Lpez de Castro J. A., HLA-B27 and the pathogenesis of spondyloarthritis Tissue Antigens 2002 60 3 191 205 (Pubitemid 35398822)
54. Ramos M., Paradela A., Vazquez M., Marina A., Vazquez J., Lopez de Castro J. A., Differential association of HLA-B2705 and B2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability Journal of Biological Chemistry 2002 277 32 28749 28756
55. Ziegler A., Loll B., Misselwitz R., Uchanska-Ziegler B., Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis Advances in Experimental Medicine and Biology 2009 649 177 195
56. Blanco-Gelaz M. A., Surez-Alvarez B., Daz-Pea R., Lpez-Larrea C., HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formation Molecular Immunology 2009 46 7 1304 1311
57. Goodall J. C., Ellis L., Gaston J. S. H., Spondylarthritis-associated and non-spondylarthritis-associated B27 subtypes differ in their dependence upon tapasin for surface expression and their incorporation into the peptide loading complex Arthritis and Rheumatism 2006 54 1 138 147 (Pubitemid 43122196)
58. Brown M. A., Breakthroughs in genetic studies of ankylosing spondylitis Rheumatology 2008 47 2 132 137 (Pubitemid 351168219)
59. Bird L. A., Peh C. A., Kollnbeger S., Elliott T., McMichael A. J., Bowness P., Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling European Journal of Immunology 2003 33 3 748 759 (Pubitemid 36367678)
60. Kollnberger S., Bird L. A., Roddis M., Hacquard-Bouder C., Kubagawa H., Bodmer H. C., Breban M., McMichael A. J., Bowness P., HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors Journal of Immunology 2004 173 3 1699 1710 (Pubitemid 38971601)
61. Dangoria N. S., Delay M. L., Kingsbury D. J., Mear J. P., Uchanska-Ziegler B., Ziegler A., Colbert R. A., HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum Journal of Biological Chemistry 2002 277 26 23459 23468 (Pubitemid 34952180)
62. Tran T. M., Satumtira N., Dorris M. L., May E., Wang A., Furuta E., Taurog J. D., HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP Journal of Immunology 2004 172 8 5110 5119 (Pubitemid 38456440)
63. Santos S. G., Lynch S., Campbell E. C., Antoniou A. N., Powis S. J., Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells Arthritis Research and Therapy 2008 10 4, article R100
64. Lynch S., Santos S. G., Campbell E. C., Nimmo A. M. S., Botting C., Prescott A., Antoniou A. N., Powis S. J., Novel MHC class I structures on exosomes Journal of Immunology 2009 183 3 1884 1891
65. Herczenik E., Gebbink M. F. B. G., Molecular and cellular aspects of protein misfolding and disease FASEB Journal 2008 22 7 2115 2133 (Pubitemid 351948631)
66. Fussell H., Nesbeth D., Lenart I., Campbell E. C., Lynch S., Santos S., Gould K., Powis S. J., Antoniou A. N., Novel detection of in vivo HLA-B27 conformations correlates with ankylosing spondylitis association Arthritis and Rheumatism 2008 58 11 3419 3424
67. Whelan M. A., Archer J. R., Chemical reactivity of an HLA-B27 thiol group European Journal of Immunology 1993 23 12 3278 3285 (Pubitemid 23353779)
68. Cresswell P., Dawson J. R., Dimeric and monomeric forms of HL-A antigens solubilized by detergent Journal of Immunology 1975 114 1, part 2 523 525
69. Capps G. G., Robinson B. E., Lewis K. D., Zuniga M. C., In vivo dimeric association of class I MHC heavy chains: possible relationship to class I MHC heavy chain- -microglobulin dissociation Journal of Immunology 1993 151 1 159 169 (Pubitemid 23206981)
70. Boyson J. E., Erskine R., Whitman M. C., Chiu M., Lau J. M., Koopman L. A., Valter M. M., Angelisova P., Horejs V., Strominger J. L., Disulfide bond-mediated dimerization of HLA-G on the cell surface Proceedings of the National Academy of Sciences of the United States of America 2002 99 25 16180 16185 (Pubitemid 35462769)
71. Hughes E. A., Hammond C., Cresswell P., Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome Proceedings of the National Academy of Sciences of the United States of America 1997 94 5 1896 1901 (Pubitemid 27113933)
72. Tortorella D., Gewurz B. E., Furman M. H., Schust D. J., Ploegh H. L., Viral subversion of the immune system Annual Review of Immunology 2000 18 861 926 (Pubitemid 30365400)
73. Lilley B. N., Ploegh H. L., A membrane protein required for dislocation of misfolded proteins from the ER Nature 2004 429 6994 834 840 (Pubitemid 38843291)
74. Loureiro J., Lilley B. N., Spooner E., Noriega V., Tortorella D., Ploegh H. L., Signal peptide peptidase is required for dislocation from the endoplasmic reticulum Nature 2006 441 7095 894 897
75. Stagg H. R., Thomas M., van den Boomen D., Wiertz E. J. H. J., Drabkin H. A., Gemmill R. M., Lehner P. J., The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER Journal of Cell Biology 2009 186 5 685 692
76. Saleki K., Hartigan N., van Lith M., Bulleid N., Benham A. M., Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cells Antioxidants and Redox Signaling 2006 8 3-4 292 299 (Pubitemid 43741300)