Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases

Journal of the American Chemical Society

Volumn 133, Issue 24, 2011, Pages 9430-9440

  Minnihan, Ellen C ^a   Seyedsayamdost, Mohammad R ^a,c   Uhlin, Ulla ^b   Stubbe, Joanne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC EFFECTORS; BIPHASIC; COFACTORS; DIPHOSPHATES; INTERMEDIATE FORMATION; KINETIC MODELS; PROTON-COUPLED ELECTRON TRANSFER; RATE LIMITING; RIBONUCLEOTIDE REDUCTASE; SLOW PHASE; STRUCTURAL CHANGE; TRANSIENT OXIDATIONS; TURNOVER NUMBER; TYROSYL RADICALS; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; CATALYST ACTIVITY; ENZYME ACTIVITY; ESCHERICHIA COLI; KINETICS; OXIDATION; POLYPEPTIDES;

FREE RADICAL REACTIONS;

3 AMINOTYROSINE; AMINO ACID; DEOXYRIBONUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE; TYROSINE; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; KINETICS; NONHUMAN; OXIDATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SUBSTITUTION; BIOCATALYSIS; ESCHERICHIA COLI; FREE RADICALS; KINETICS; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN CONFORMATION; RIBONUCLEOTIDE REDUCTASES; SPECTRUM ANALYSIS; TYROSINE;

EID: 79959241252     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201640n     Document Type: Article

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