Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Klein, Michael ^a   Morillas, Montse ^b   Vendrell, Alexandre ^b   Brive, Lars ^a   Gebbia, Marinella ^c   Wallace, Iain M ^c   Giaever, Guri ^c   Nislow, Corey ^c   Posas, Francesc ^b   Grøtli, Morten ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 ISOPROPYL 3 (PHENYLETHYNYL) 1H PYRAZOL[3,4 D]PYRIMIDIN 4 AMINE; GENE PRODUCT; HOG1 KINASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL FUNCTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME ENGINEERING; GENE EXPRESSION; STRESS; STRUCTURE ANALYSIS; SYNTHESIS; YEAST; CELL CYCLE; CHEMISTRY; DRUG DESIGN; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CELL CYCLE; DRUG DESIGN; GENE EXPRESSION; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN KINASE INHIBITORS;

EID: 79959208638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020789     Document Type: Article

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