Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain

Pain

Volumn 102, Issue 1-2, 2003, Pages 17-25

  Veneroni, O ^a   Maj, R ^a   Calabresi, M ^a   Faravelli, L ^a   Fariello, R G ^a   Salvati, P ^a  

^a Newron Pharmaceuticals SpA   (Italy)

Author keywords

Chronic constriction injury; Complete Freund's adjuvant; Inflammatory pain; Mechanical allodynia; Na+ channel blocker; Neuropathic pain

Indexed keywords

RALFINAMIDE; SODIUM CHANNEL BLOCKING AGENT;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; INFLAMMATION; INJURY; LICKING; MALE; MENTAL HEALTH; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

EID: 0037333191     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0304-3959(02)00183-5     Document Type: Article

References (32)

1. Anger T., Madje D.J., Mulla M., Riddall D. Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 44:(2):2001;115-137.
2. Bennet G.J., Xie Y-K. A peripheral mononeuropathy in rat produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
3. Butler S.H., Godefroy F., Besson J.M., Weil-Fugazza J.A. Limited arthritic model for chronic pain studies in the rat. Pain. 48:1992;73-81.
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 53:1994;55-63.
5. Coward K., Plumpton C., Facer P., Birch R., Carlstedt T., Tate S., Bountra C., Anand P. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain. 85:(1-2):2000;41-50.
6. Dallel R., Raboisson O., Clavelou P., Saade M., Woda A. Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin. Pain. 61:1995;11-16.
7. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J Pharmacol Exp Ther. 72:1941;74-79.
8. Dixon W. The up-and-down method for small sample. J Am Stat Assoc. 60:1965;967-978.
9. + channel blocker with analgesic activity in animal models. Society for Neuroscience 30th Annual Meeting, New Orleans, LA. 2000;. 26(1) 1218 (454.9).
10. Finney D.J. Probit analysis. 1964;Cambridge University Press, Cambridge.
11. Goldin A.L. Resurgence of sodium channel research. Annu Rev Physiol. 63:2001;871-894.
12. Hammer N.A., Lilleso J., Pederson J.L., Kehlet H. Effect of riluzole on acute pain and hyperalgesia in humans. Br J Anaesth. 82:(5):1999;718-722.
13. Hunter J.C., Loghhead D. Voltage-gated sodium channel blockers for treatment of chronic pain. Curr Opin Cent Periph Nerv Syst Invest Drugs. 1:(1):1999;72-81.
14. Jones B.J., Roberts D.J. The quantitative measurement of motor inco-ordination in naive mice using an accelereting rota-rod. J Pharm Pharmacol. 20:1968;302-304.
15. Lai J., Gold M.S., Kim C-S., Bian D., Ossipov M.H., Hunter J.C., Porreca F. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain. 95:2002;143-152.
16. 2 and in the chronic hyperalgesia in rats with streptozocin-induced diabetes. Pain. 63:1995;33-37.
17. Novakovic S.D., Tzoumaka E., McGivern J.G., Haraguchi M., Sangameswaran L., Gogas K.R., Eglen R.M., Hunter J.C. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci. 18:1998;2174-2187.
18. + channel distribution in the nervous system. Trends Neurosci. 24:(8):2001;473-478.
19. Pevarello P., Bonsignori A., Doster P., Heidempergher F., Pinciroli V., Colombo M., McArthur R.A., Salvati P., Post C., Fariello R.G., Varasi M. Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives. J Med Chem. 41:1998;579-590.
20. Porreca F., Lai J., Bian D., Wegert S., Ossipov M.H., Eglen R.E., Kassotakis L., Novakovic S., Rabert D.K., Sangameswaran L. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc Natl Acad Sci USA. 96:1999;7640-7644.
21. Price D.D. Selective activation of A-delta and C nociceptive afferents by different parameters of nociceptive heat stimulation: a tool for analysis of central mechanisms of pain. Pain. 68:1996;1-3.
22. Puig S., Sorkin L.S. Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain. 64:1995;345-355.
23. Rosland J.H., Tjolsen A., Maehle B., Hole K. The formalin test in mice: effect of formalin concentration. Pain. 42:1990;235-242.
24. Schmidt J.W., Catterall W.A. Biosynthesis and processing of the α subunit of voltage-sensitive sodium channel in rat brain neurons. Cell. 46:1986;437-444.
25. Shibata M., Ohkubo T., Takahashi H., Inoki R. Modified formalin test: characteristic biphasic pain response. Pain. 38:1989;347-352.
26. Shimoyama N., Shimoyama M., Davis A.M., Inturrisi C.E., Elliott K.J. Spinal gabapentin is antinociceptive in the rat formalin test. Neurosci Lett. 222:1997;65-67.
27. Stefani A., Spadoni F., Bernardi G. Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies. Exp Neurol. 147:1997;115-122.
28. Tjolsen A., Berge O.G., Hunskaar S., Rosland J.H., Hole K. The formalin test: an evaluation of the method. Pain. 51:1992;5-17.
29. Waxman S.G., Dib-Hajj S., Cummins T.R., Black J.A. Sodium channels and pain. Proc Natl Acad Sci USA. 96:1999;7635-7639.
30. Woolfe G., MacDonald A.D. The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther. 80:1944;300-307.
31. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.
32. Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol. 429:2001;23-37.