Shear stress induces the release of an endothelial elastase: Role in integrin α vβ 3-mediated FGF-2 release

Journal of Vascular Research

Volumn 48, Issue 6, 2011, Pages 453-464

  Hennig, Theres ^a   Mogensen, Christina ^a   Kirsch, Julian ^a   Pohl, Ulrich ^a   Gloe, Torsten ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Elastase; Fibroblast growth factor 2; Integrin v 3; Mechanotransduction; Shear stress

Indexed keywords

ELASTASE; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE P38; VITRONECTIN RECEPTOR;

ANIMAL CELL; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME RELEASE; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; INTEGRIN ALPHAVBETA3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREATIC ELASTASE; STRESS, MECHANICAL; SWINE; VASOCONSTRICTION;

EID: 79959202840     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000327009     Document Type: Article

References (47)

1. Busse R, Fleming I: Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces. Trends Pharmacol Sci 2003; 24: 24-29. (Pubitemid 36009286)
2. Pohl U, Holtz J, Busse R, Bassenge E: Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 8: 37-44. (Pubitemid 16161419)
3. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG: Regulation of endothelial cell nitric oxide synthase mrna expression by shear stress. Am J Physiol 1995; 269:C1371-C1378.
4. Passerini AG, Milsted A, Rittgers SE: Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. J Vasc Surg 2003; 37: 182-190. (Pubitemid 36236964)
5. Lehoux S, Tedgui A: Cellular mechanics and gene expression in blood vessels. J Biomech 2003; 36: 631-643. (Pubitemid 36407615)
6. Langille BL: Blood flow-induced remodeling of arteries in health and disease. Cardiovasc Pathol 1992; 1: 245-251.
7. De Mey JGR, Schiffers PM, Hilgers RHP, Sanders MMW: Toward functional genomics of flow-induced outward remodeling of resistance arteries. Am J Physiol Heart Circ Physiol 2005; 288:H1022-H1027. (Pubitemid 40270002)
8. Hudlicka O, Brown MD: Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor. J Vasc Res 2009; 46: 504-512.
9. Wang JH, Thampatty BP: An introductory review of cell mechanobiology. Biomech Model Mechanobiol 2006; 5: 1-16. (Pubitemid 43261226)
10. Tarbell JM, Pahakis MY: Mechanotransduction and the glycocalyx. J Intern Med 2006; 259: 339-350. (Pubitemid 43384225)
11. Traub O, Berk BC: Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 1998; 18: 677-685. (Pubitemid 28267645)
12. Alenghat FJ, Ingber DE: Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE 2002; 119:pe6.
13. Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, De-Lisser H, Schwartz MA: A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005; 437: 426-431. (Pubitemid 41613506)
14. Platt MO, Ankeny RF, Jo H: Laminar shear stress inhibits cathepsin l activity in endothelial cells. Arterioscler Thromb Vasc Biol 2006; 26: 1784-1790. (Pubitemid 44305332)
15. Platt MO, Xing Y, Jo H, Yoganathan AP: Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves. J Heart Valve Dis 2006; 15: 622-629.
16. Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR, Jo H: Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. Am J Physiol Heart Circ Physiol 2007; 292:H1479-H1486. (Pubitemid 46377136)
17. Magid R, Murphy TJ, Galis ZS: Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress. Role of c-myc. J Biol Chem 2003; 278: 32994-32999. (Pubitemid 37055744)
18. Chiquet M: Regulation of extracellular matrix gene expression by mechanical stress. Matrix Biol 1999; 18: 417-426.
19. Gupta V, Grande-Allen KJ: Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res 2006; 72: 375-383. (Pubitemid 44755053)
20. Orr AW, Sanders JM, Bevard M, Coleman E, Sarembock IJ, Schwartz MA: The subendothelial extracellular matrix modulates NF-κB activation by flow: a potential role in atherosclerosis. J Cell Biol 2005; 169: 191-202. (Pubitemid 40562925)
21. Gloe T, Riedmayr S, Sohn HY, Pohl U: The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitricoxide synthase expression. J Biol Chem 1999; 274: 15996-16002.
22. Gloe T, Sohn HY, Meininger GA, Pohl U: Shear stress-induced release of basic fibroblast growth factor from endothelial cells is mediated by matrix interaction via integrinα(v)β3. J Biol Chem 2002; 277: 23453-23458. (Pubitemid 34952179)
23. Linhardt RJ, Turnbull JE, Wang HM, Loganathan D, Gallagher JT: Examination of the substrate specificity of heparin and heparan sulfate lyases. Biochemistry 1990; 29: 2611-2617. (Pubitemid 20100860)
24. Malek AM, Gibbons GH, Dzau VJ, Izumo S: Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest 1993; 92: 2013-2021. (Pubitemid 23304572)
25. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy JY, Chien S: Integrinmediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci USA 2001; 98: 1042-1046. (Pubitemid 32121183)
26. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA: Activation of integrins in endothelial cells by fluid shear stress mediates rho-dependent cytoskeletal alignment. EMBO J 2001; 20: 4639-4647. (Pubitemid 32848617)
27. Powers JC, Gupton BF, Harley AD, Nishino N, Whitley RJ: Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones. Biochim Biophys Acta 1977; 485: 156-166. (Pubitemid 8219539)
28. Castillo MJ, Nakajima K, Zimmerman M, Powers JC: Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem 1979; 99: 53-64. (Pubitemid 10197705)
29. Nakajima K, Powers JC, Ashe BM, Zimmerman M: Mapping the extended substrate binding site of cathepsin g and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site. J Biol Chem 1979; 254: 4027-4032. (Pubitemid 9178816)
30. Hornebeck W, Derouette JC, Robert L: Isolation, purification and properties of aortic elastase. FEBS Lett 1975; 58: 66-70.
31. Vaday GG, Lider O: Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation. J Leukoc Biol 2000; 67: 149-159.
32. Bank U, Ansorge S: More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control. J Leukoc Biol 2001; 69: 197-206. (Pubitemid 32163431)
33. Buczek-Thomas JA, Nugent MA: Elastasemediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures. A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bfgf binding following elastase-induced injury. J Biol Chem 1999; 274: 25167-25172.
34. Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA: Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol 2004; 31: 344-350. (Pubitemid 39180305)
35. Thompson K, Rabinovitch M: Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor. J Cell Physiol 1996; 166: 495-505. (Pubitemid 26095476)
36. Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavsky I: Basic fibroblast growth-factor binds to subendothelial extracellular-matrix and is released by heparitinase and heparin-like molecules. Biochemistry 1989; 28: 1737-1743. (Pubitemid 19072047)
37. Si-Tahar M, Pidard D, Balloy V, Moniatte M, Kieffer N, Van Dorsselaer A, Chignard M: Human neutrophil elastase proteolytical-ly activates the platelet integrinαIIbβ3 through cleavage of the carboxyl terminus of theαIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation. J Biol Chem 1997; 272: 11636-11647. (Pubitemid 27184177)
38. Takahashi M, Berk BC: Mitogen-activated protein kinase (erk1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase. J Clin Invest 1996; 98: 2623-2631. (Pubitemid 26415085)
39. Giancotti FG, Ruoslahti E: Integrin signaling. Science 1999; 285: 1028-1032.
40. Davis GE: Matricryptic sites control tissue injury responses in the cardiovascular system: relationships to pattern recognition receptor regulated events. J Mol Cell Cardiol 2010; 48: 454-460.
41. Davis GE, Bayless KJ, Davis MJ, Meininger GA: Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules. Am J Pathol 2000; 156: 1489-1498. (Pubitemid 30646688)
42. Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ: Exposure of cryptic domains in theα1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-expression. J Biol Chem 2002; 277: 13778-13786. (Pubitemid 34967981)
43. Koshikawa N, Giannelli G, Cirulli V, Miyazaki K, Quaranta V: Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol 2000; 148: 615-624.
44. Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM: Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. J Biol Chem 2008; 283: 9513-9522.
45. Lee DY, Yeh CR, Chang SF, Lee PL, Chien S, Cheng CK, Chiu JJ: Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. J Bone Miner Res 2008; 23: 1140-1149. (Pubitemid 351915736)
46. 3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for HSP90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003; 8: 37-52. (Pubitemid 36444089)
47. Chen J, Baskerville C, Han Q, Pan ZK, Huang S:α(v) integrin, p38 mitogen-activated protein kinase, and urokinase plasminogen activator are functionally linked in invasive breast cancer cells. J Biol Chem 2001; 276: 47901-47905.