More than destructive: Neutrophil-derived serine proteases in cytokine bioactivity control

Journal of Leukocyte Biology

Volumn 69, Issue 2, 2001, Pages 197-206

  Bank, Ute ^a   Ansorge, Siegfried ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cathepsin G; Elastase; Growth factors; Interleukins; Proteinase 3

Indexed keywords

CATHEPSIN G; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOBLASTIN; NEUTROPHIL DERIVED SERINE PROTEASE; SERINE PROTEINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; INFLAMMATION; NEUTROPHIL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

CYTOKINES; HUMANS; HYDROLYSIS; INFLAMMATION; NEUTROPHILS; SERINE ENDOPEPTIDASES;

EID: 0035112806     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

1. Degranulation and secretion by phagocytic cells
2. Cell surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
3. Comparison of properties of membranebound versus soluble forms of human leukocytic elastase and cathepsin G
4. Neutrophil proteases in inflammation
5. Proteases and antiproteases in cystic fibrosis: Pathogenetic considerations and therapeutic strategies
6. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters
7. The role of neutrophil elastase in chronic inflammation
8. Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (caspase-1)
9. Characterization of the tumour necrosis factor alpha-converting enzyme, TACE/ADAM17
10. Leukocyte elastase
11. Cathepsin G
12. Myeloblastin
13. Interleukin-8 and markers of neutrophil degranulation in pleural effusions
14. Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock
15. Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: Evidence for neutrophils as mediators in fatal sepsis
16. Granulocyte elastase, tumor necrosis factor-alpha and urokinase levels as prognostic markers in severe infection
17. Peritoneal interleukin-6, interleukin-8 and granulocyte elastase activity after elective abdominal surgery
18. Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release
19. Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin
20. Inactivation of recombinant human tumor necrosis factor-alpha by proteolytie enzymes released from stimulated human neutrophils
21. Enzymatic degradation of tumor necrosis factor by activated human neutrophils: Role of elastase
22. Inactivation of interleukin-6 in vitro by monoblastic U937 cell plasma membranes involves both protease and peptidyltransferase activities
23. Regulation of cytokine secretion by cystic fibrosis airway epithelial cells
24. Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation
25. Interleukin-6 augments neutrophil cytotoxic potential via selective enhancement of elastase release
26. The local role of tumor necrosis factor alpha in the modulation of neutrophil function at sites of inflammation
27. Tumor necrosis factor and endotoxin can cause neutrophil activation through separate pathways
28. The combined inactivation of tumor necrosis factor and interleukin-6 prevents the induction of the major acute phase proteins by endotoxin
29. IL-6 and APPs: Anti-inflammatory and immunosuppression mediators
30. Effect of recombinant human interleukin 2 on neutrophil adherence to endothelial cells in vitro
31. Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2
32. IL-2 induces T cell adherence to extracellular matrix: Inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase
33. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3
34. Human neutrophil elastase abolishes interleukin-8 chemotactic activity
35. Amino-terminal processing of chemokine ENA-78 regulates biological activity
36. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
37. A metalloproteinase disintegrin that releases tumour necrosis factor-alpha from cells
38. Processing of precursor interleukin 1 beta and inflammatory disease
39. In vivo evidence for protease-catalysed mechanism providing bioactive tumor necrosis factor alpha
40. Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active species by human mast cell chymase
41. The proteolytic activation of interleukin-1 beta
42. Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor
43. In vitro processing of human tumor necrosis factor-alpha
44. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
45. Congress communication, International Cytokine Society Meeting, Jerusalem 1998
46. Interleukin-18
47. Transforming growth factor alpha in arterioles: Cell surface processing of 1st precursor by elastases
48. Polymorphonuclear leukocytes induce PDGF release from IL-1beta-treated endothelial cells: Role of adhesion molecules and serine proteases
49. Dissociation of the chemotactic and mitogenic activities of platelet-derived growth factor by human neutrophil elastase
50. Formation of neutrophil-activating peptide 2 from platelet-derived connective-tissue-activating peptide III by different tissue proteinases
51. Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III
52. Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets
53. Connective tissue-activating peptide III desensitizes chemokine receptors on neutrophils. Requirement for proteolytic formation of the neutrophil-activating peptide 2
54. Soluble cytokine receptors: Basic immunology and clinical applications
55. The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
56. Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch
57. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity
58. Novel pathogenic mechanism of microbial metalloproteinases: Liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human receptor
59. Determination of soluble interleukin-2 receptor in human seminal plasma
60. Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation
61. Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils
62. The potential biological and clinical significance of the soluble tumor necrosis factor receptors
63. Human neutrophil elastase proteolyrically activates the platelet integrin alphaIIb beta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation
64. Elastase and metalloproteinase activities regulate soluble complement receptor 1 release
65. Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation
66. Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis
67. Proteolytic cleavage of ICAM-1 by human neutrophil elastase
68. Regulation of the structure and activity of platelet adhesion receptors by leukocyte proteinases
69. The circulating common gamma chain (CD132) in inflammatory bowel disease
70. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
71. The immune-inflammatory pathophysiology of fibromyalgia: Increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines
72. Synthesis and release of platelet-activating factor is inhibited by plasma alpha1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases
73. Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
74. Neutrophils synthesize and activate TGFbeta 2
75. Polymorphonuclear leukocytes enhance release of growth factors by cultured endothelial cells
76. Proteolytic control of growth factor availability
77. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells
78. Proteolytic inactivation of transforming growth factor beta 3 by elastase in venous leg ulcers: Implications for clinical trials using topically applied peptide growth factors
79. Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: Accumulation in actinic damage and absence in anetoderma
80. Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release
81. Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
82. IGFBP-3 and IGFBP-5 association with endothelial cells: Role of C-terminal heparin binding domain
83. Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix
84. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures. A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bfgf binding following elastase-induced injury
85. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor
86. Occupational lung disease and the role of peptide growth factors
87. Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in down-regulation of elastin gene transcription. A role for basic fibroblast growth factor in regulating lung repair
88. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
89. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries
90. Effects of interleukin-6 and transforming growth factor-β on neutrophil elastase release
91. Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids
92. Cytokines - Protein structure and biological activity: A complex relationship with implications for biological assays and standardization
93. Pitfalls in measuring cytokines
94. Acute phase protein stimulation by alpha1-antichymotrpsin-cathepsin G complexes. Evidence for the involvement of interleukin-6
95. Enhancement of the synthesis and secretion of nerve growth factor in primal, cultures of glial cells by proteases: A possible involvement of thrombin
96. Role of inflammation in respiratory tract infections
97. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
98. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro
99. Effects of tumor necrosis factor on PMN chemotaxis, chemiluminescence, and elastase activity
100. Activation of neutrophils by recombinant interleukin 6
101. IL-1 beta primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux
102. Cytokines regulate membrane-bound leukocyte elastase on neutrophils: A novel mechanism for effector activity
103. Oncostatin M is a potent stimulator of alpha1-antitrypsin secretion in lung epithelial cells: Modulation by transforming growth factor-beta and interferon-gamma
104. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes
105. Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B
106. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes